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Erschienen in: Archives of Virology 10/2017

22.06.2017 | Original Article

Molecular characteristics and prevalence of small ruminant lentiviruses in goats in Japan

verfasst von: Saki Kokawa, Mami Oba, Teppei Hirata, Shiro Tamaki, Miki Omura, Shinobu Tsuchiaka, Makoto Nagai, Tsutomu Omatsu, Tetsuya Mizutani

Erschienen in: Archives of Virology | Ausgabe 10/2017

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Abstract

Small ruminant lentiviruses (SRLVs), which comprise caprine arthritis-encephalitis virus (CAEV) and maedi-visna virus (MVV), are prevalent in goats and sheep worldwide, including in Japan. However, little is known about the molecular characteristics of goat lentiviruses in Japan. In this study, a molecular and phylogenetic analysis of the long gag region was performed. The phylogenic tree demonstrated that all samples belonged to SRLV subtype B1. Two clusters were identified, with one cluster distinct from previously reported strains of subtype B1. In addition, several alterations in the amino acid sequence were detected in immunodominant epitopes of the gag region. To gain a deeper understanding of the genetic diversity of SRLVs in Japan, it will be necessary to increase the sample size and conduct a broader survey. The present report is important for establishing baseline information on the prevalence of SRLV in Japan and providing data to develop a new, more sensitive diagnostic test for effective control of SRLV.
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Metadaten
Titel
Molecular characteristics and prevalence of small ruminant lentiviruses in goats in Japan
verfasst von
Saki Kokawa
Mami Oba
Teppei Hirata
Shiro Tamaki
Miki Omura
Shinobu Tsuchiaka
Makoto Nagai
Tsutomu Omatsu
Tetsuya Mizutani
Publikationsdatum
22.06.2017
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 10/2017
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-017-3447-5

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