Skip to main content

17.10.2016 | Adjuvant Therapy for Colon Cancers (AB Benson III and A de Gramont, Section Editors) | Ausgabe 6/2016

Current Colorectal Cancer Reports 6/2016

Molecular Classification of Colon Cancer: Perspectives for Personalized Adjuvant Therapy

Current Colorectal Cancer Reports > Ausgabe 6/2016
Elisa Fontana, Krisztian Homicsko, Katherine Eason, Anguraj Sadanandam
Wichtige Hinweise
This article is part of the Topical Collection on Adjuvant Therapy for Colon Cancers


Although surgery for early-stage colorectal cancer (CRC) is often curative, many patients require adjuvant chemotherapy to treat micrometastatic disease and to reduce the risk of recurrence. Targeted therapies have improved outcomes for patients with metastatic disease but, in the adjuvant setting, options are limited to a fluoropyrimidine alone or in combination with oxaliplatin. There is an unmet need for new predictive biomarkers to personalise treatment in the adjuvant setting. With goals to address this gap and to better characterise disease heterogeneity, several groups including our own have identified three to six gene expression subtypes that were later consolidated into consensus molecular subtypes as part of the Colorectal Cancer Subtyping Consortium (CRCSC) effort. In this review, we discuss the differences and similarities between these subtypes and their potential prognostic and predictive values. We question whether a personalised treatment approach based on CRC subtypes might be beneficial in the adjuvant setting to improve treatment options and ultimately patient outcomes.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf

Weitere Produktempfehlungen anzeigen
Über diesen Artikel

Weitere Artikel der Ausgabe 6/2016

Current Colorectal Cancer Reports 6/2016 Zur Ausgabe

Localized Colorectal Cancer (RD Kim, Section Editor)

The Role of Adjuvant Treatment in Resected T3N0 Rectal Cancer

Adjuvant Therapy for Colon Cancers (AB Benson III and A de Gramont, Section Editors)

Adjuvant Chemotherapy for Colon Cancer: Guidelines and Clinical Trials in Japan

Molecular Epidemiology (L Jiao and CR Daniel-MacDougall, Section Editors)

Molecular Biomarkers of Colorectal Cancer and Cancer Disparities: Current Status and Perspective

Prevention and Early Detection (R Benamouzig, Section Editor)

What Is the Best Approach to Avoid Colorectal Cancer Risk in Inflammatory Bowel Disease?

Adjuvant Therapy for Colon Cancers (AB Benson III and A de Gramont, Section Editors)

Ongoing Adjuvant/Neoadjuvant Trials in Resectable Metastatic Colorectal Cancer

  1. Sie können e.Med Innere Medizin 14 Tage kostenlos testen (keine Print-Zeitschrift enthalten). Der Test läuft automatisch und formlos aus. Es kann nur einmal getestet werden.

  2. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

Neu im Fachgebiet Onkologie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Onkologie und bleiben Sie gut informiert – ganz bequem per eMail.