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Erschienen in: Archives of Virology 3/2013

01.03.2013 | Original Article

Molecular epidemiology of hepatitis C virus among different groups of people in the province of Fujian, China

verfasst von: Ying Ye, Yan-sheng Yan, Ge Chen, Ping-ping Yan, Wu-xiong Zheng, Yan-qin Deng, Xiu-hui Yang, Shou-li Wu, Zhi-shan Zhang

Erschienen in: Archives of Virology | Ausgabe 3/2013

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Abstract

Genotyping of hepatitis C virus (HCV) can provide valuable information for prognosis and treatment duration prediction. To explore the genetic diversity of HCV in Fujian Province, China, 112, 104 and 48 anti-HCV-positive serum samples were collected from volunteer blood donors, IDUs and patients, respectively, from Jan 2008 to Dec 2008 and were genotyped through sequence analysis, followed by phylogenetic analysis in the C/E1 and NS5B regions. Genotypes could be determined for 85.61 and 84.85 % of samples in the C/E1 and NS5B region, respectively. 6a was the most prevalent subtype, which accounted for 42.04 and 43.75 % in the C/E1 and NS5B region, respectively. Mixed infection and potential recombination were detected in this study. Kappa tests indicated that similar results were obtained by two genotyping methods targeting the C/E1 and NS5B regions. The differences in the main prevalent subtype between the three target groups suggest diversity of HCV prevalence in different populations.
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Metadaten
Titel
Molecular epidemiology of hepatitis C virus among different groups of people in the province of Fujian, China
verfasst von
Ying Ye
Yan-sheng Yan
Ge Chen
Ping-ping Yan
Wu-xiong Zheng
Yan-qin Deng
Xiu-hui Yang
Shou-li Wu
Zhi-shan Zhang
Publikationsdatum
01.03.2013
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 3/2013
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-012-1513-6

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