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Erschienen in: Archives of Virology 5/2020

06.03.2020 | Original Article

Molecular epidemiology of respiratory syncytial virus for 28 consecutive seasons (1990-2018) and genetic variability of the duplication region in the G gene of genotypes ON1 and BA in South Korea

verfasst von: Ki Wook Yun, Eun Hwa Choi, Hoan Jong Lee

Erschienen in: Archives of Virology | Ausgabe 5/2020

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Abstract

We investigated the molecular epidemiology of respiratory syncytial virus (RSV) isolated from children during 28 consecutive seasons (1990-2018) and the genetic variability of the duplication region of RSV genotypes ON1 and BA in South Korea. RSV was identified using culture-based methods in Hep-2 cells and was grouped as RSV-A or RSV-B by an immunofluorescence assay. The second hypervariable region of the G gene was sequenced for genotyping. The nucleotide and deduced amino acid sequences of the duplication region of RSV ON1 and BA were analyzed. A total of 670 RSV-A and 233 RSV-B isolates were obtained. For RSV-A, the NA1 genotype predominated during the 2004/2005-2011/2012 seasons. The ON1 genotype was first detected in 2011 and has since replaced all other genotypes. For RSV-B, the GB3 genotype predominated during the 1999/2000-2005/2006 seasons, but the BA genotype also replaced all other genotypes of RSV-B after the first season in which it was isolated (2005/2006). In ON1 and BA genotype RSV strains, novel sequence types of the duplication region of the G gene were identified in 50-95% and 33-80% of the isolates, respectively, in each season. The ON1 and BA9 genotypes are responsible for the current epidemics of RSV infection in South Korea. The sequences in the duplication region of the G gene have evolved continuously and might be sufficient for the identification of specific strains of the RSV-A ON1 and RSV-B BA genotypes.
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Literatur
7.
Zurück zum Zitat Sullender WM (2000) Respiratory syncytial virus genetic and antigenic diversity. Clin Microbiol Rev 13:1–15CrossRef Sullender WM (2000) Respiratory syncytial virus genetic and antigenic diversity. Clin Microbiol Rev 13:1–15CrossRef
9.
Zurück zum Zitat Johnson PR, Spriggs MK, Olmsted RA, Collins PL (1987) The G glycoprotein of human respiratory syncytial viruses of subgroups A and B: extensive sequence divergence between antigenically related proteins. Proc Natl Acad Sci USA 84:5625–5629CrossRef Johnson PR, Spriggs MK, Olmsted RA, Collins PL (1987) The G glycoprotein of human respiratory syncytial viruses of subgroups A and B: extensive sequence divergence between antigenically related proteins. Proc Natl Acad Sci USA 84:5625–5629CrossRef
10.
Zurück zum Zitat Cane PA, Pringle CR (1995) Evolution of subgroup A respiratory syncytial virus: evidence for progressive accumulation of amino acid changes in the attachment protein. J Virol 69:2918–2925CrossRef Cane PA, Pringle CR (1995) Evolution of subgroup A respiratory syncytial virus: evidence for progressive accumulation of amino acid changes in the attachment protein. J Virol 69:2918–2925CrossRef
14.
Zurück zum Zitat Park JY, Lee HJ (1999) Development of monoclonal antibodies to respiratory syncytial virus (RSV) and application for study of antigenic variation of RSV. Korean J Infect Dis 31:111–121 Park JY, Lee HJ (1999) Development of monoclonal antibodies to respiratory syncytial virus (RSV) and application for study of antigenic variation of RSV. Korean J Infect Dis 31:111–121
15.
19.
Metadaten
Titel
Molecular epidemiology of respiratory syncytial virus for 28 consecutive seasons (1990-2018) and genetic variability of the duplication region in the G gene of genotypes ON1 and BA in South Korea
verfasst von
Ki Wook Yun
Eun Hwa Choi
Hoan Jong Lee
Publikationsdatum
06.03.2020
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 5/2020
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-020-04580-z

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