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Molecular Imaging and Biology

Molecular Imaging and Biology OnlineFirst articles

31.07.2020 | Research Article Open Access

Tracking of Tumor Cell–Derived Extracellular Vesicles In Vivo Reveals a Specific Distribution Pattern with Consecutive Biological Effects on Target Sites of Metastasis

Cancer cells rely on the recruitment and activation of various benign, physiological cells, most prominently immune cells, to facilitate and support growth, invasion, and finally metastasis. Mediators of the required cell-cell interaction have …

23.07.2020 | Research Article Open Access

Granzyme B PET Imaging of Immune Checkpoint Inhibitor Combinations in Colon Cancer Phenotypes

Immune checkpoint receptors are crucial molecules that regulate the immune system, dampening T cell activation. Tumours exploit these checkpoints to evade the immune system. Immune checkpoint inhibitors (ICIs) have changed the landscape of cancer …

22.07.2020 | Research Article

Cross-Species Physiological Assessment of Brain Estrogen Receptor Expression Using 18F-FES and 18F-4FMFES PET Imaging

The estrogen receptor (ER) is expressed in a wide array of tissues and mediates a plethora of important physiological roles [ 1 ]. The brain has many localized sites of variable ERα and ERβ expression [ 2 ], foretelling the crucial role of …

20.07.2020 | Research Article

Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging

Reporter gene-based molecular imaging, including positron emission tomography (PET) with the appropriate reporter probes, is a noninvasive and quantitative imaging tool for monitoring specific biological process, investigating protein-protein …

13.07.2020 | Research Article

Evaluation of [131I]I- and [177Lu]Lu-DTPA-A11 Minibody for Radioimmunotherapy in a Preclinical Model of PSCA-Expressing Prostate Cancer

While the majority of prostate cancer patients have localized disease at diagnosis, which can be treated with prostatectomy or radiation therapy, 27–53 % will experience biochemical recurrence [ 1 ]. Treatment for these patients includes …

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Über diese Zeitschrift

Molecular Imaging and Biology presents original research contributions on the utilization of molecular imaging in problems of relevance in biology and medicine. The primary objective of the journal is to provide a forum for the discovery of molecular mechanisms of health and disease through the use of imaging techniques.

Among the topics covered are molecular imaging investigations of macromolecular targets involved in significant biological processes; design and evaluation of molecular probes used to investigate macromolecular targets and their functions; and study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics.

The overall goal is to translate basic science discoveries into molecular imaging of disease in patients, both to investigate the biological nature of disease in actual patients and to establish new molecular imaging diagnostic procedures.

Molecular Imaging and Biology is the official journal of the World Molecular Imaging Society and the European Society for Molecular Imaging.

Molecular Imaging and Biology is ranked #12 in the Google Scholar H-5 Index of Nuclear Medicine and Radiotherapy, with a 2016 H-5 Index of 33.

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