Skip to main content
Erschienen in: Current Cardiovascular Imaging Reports 2/2010

01.04.2010

Molecular Imaging of Stem Cell Transplantation in Myocardial Disease

verfasst von: Jaehoon Chung, Phillip C. Yang

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 2/2010

Einloggen, um Zugang zu erhalten

Abstract

Stem cell therapy has been heralded as a novel therapeutic option for cardiovascular disease. In vivo molecular imaging has emerged as an indispensible tool in investigating stem cell biology post-transplantation into the myocardium and in evaluating the therapeutic efficacy. This review highlights the features of each molecular imaging modality and discusses how these modalities have been applied to evaluate stem cell therapy.
Literatur
1.
Zurück zum Zitat Wollert KC, Meyer GP, Lotz J, et al.: Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004, 364:141–148.CrossRefPubMed Wollert KC, Meyer GP, Lotz J, et al.: Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004, 364:141–148.CrossRefPubMed
2.
Zurück zum Zitat Stamm C, Kleine HD, Westphal B, et al.: CABG and bone marrow stem cell transplantation after myocardial infarction. Thorac Cardiovasc Surg 2004, 52:152–158.CrossRefPubMed Stamm C, Kleine HD, Westphal B, et al.: CABG and bone marrow stem cell transplantation after myocardial infarction. Thorac Cardiovasc Surg 2004, 52:152–158.CrossRefPubMed
3.
Zurück zum Zitat Assmus B, Schachinger V, Teupe C, et al.: Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 2002, 106:3009–3017.CrossRefPubMed Assmus B, Schachinger V, Teupe C, et al.: Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 2002, 106:3009–3017.CrossRefPubMed
4.
Zurück zum Zitat Perin EC, Dohmann HF, Borojevic R, et al.: Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003, 107:2294–2302.CrossRefPubMed Perin EC, Dohmann HF, Borojevic R, et al.: Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003, 107:2294–2302.CrossRefPubMed
5.
Zurück zum Zitat Orlic D, Kajstura J, Chimenti S, et al.: Bone marrow cells regenerate infarcted myocardium. Nature 2001, 410:701–705.CrossRefPubMed Orlic D, Kajstura J, Chimenti S, et al.: Bone marrow cells regenerate infarcted myocardium. Nature 2001, 410:701–705.CrossRefPubMed
6.
Zurück zum Zitat Nygren JM, Jovinge S, Breitbach M, et al.: Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 2004, 10:494–501.CrossRefPubMed Nygren JM, Jovinge S, Breitbach M, et al.: Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 2004, 10:494–501.CrossRefPubMed
7.
Zurück zum Zitat Murry CE, Soonpaa MH, Reinecke H, et al.: Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004, 428:664–668.CrossRefPubMed Murry CE, Soonpaa MH, Reinecke H, et al.: Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004, 428:664–668.CrossRefPubMed
8.
Zurück zum Zitat Laflamme MA, Chen KY, Naumova AV, et al.: Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 2007, 25:1015–1024.CrossRefPubMed Laflamme MA, Chen KY, Naumova AV, et al.: Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 2007, 25:1015–1024.CrossRefPubMed
9.
Zurück zum Zitat Liang HD, Blomley MJ: The role of ultrasound in molecular imaging. Br J Radiol 2003, 76:S140–S150.CrossRefPubMed Liang HD, Blomley MJ: The role of ultrasound in molecular imaging. Br J Radiol 2003, 76:S140–S150.CrossRefPubMed
10.
Zurück zum Zitat Morawski AM, Lanza GA, Wickline SA: Targeted contrast agents for magnetic resonance imaging and ultrasound. Curr Opin Biotechnol 2005, 16:89–92.CrossRefPubMed Morawski AM, Lanza GA, Wickline SA: Targeted contrast agents for magnetic resonance imaging and ultrasound. Curr Opin Biotechnol 2005, 16:89–92.CrossRefPubMed
11.
Zurück zum Zitat Villanueva FS, Jankowski RJ, Klibanov S, et al.: Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation 1998, 98:1–5.PubMed Villanueva FS, Jankowski RJ, Klibanov S, et al.: Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation 1998, 98:1–5.PubMed
12.
Zurück zum Zitat Demos SM, Dagar S, Klegerman M, et al.: In vitro targeting of acoustically reflective immunoliposomes to fibrin under various flow conditions. J Drug Target 1998, 5:507–518.CrossRefPubMed Demos SM, Dagar S, Klegerman M, et al.: In vitro targeting of acoustically reflective immunoliposomes to fibrin under various flow conditions. J Drug Target 1998, 5:507–518.CrossRefPubMed
13.
Zurück zum Zitat Bara C, Ghodsizad A, Niehaus M, et al.: In vivo echocardiographic imaging of transplanted human adult stem cells in the myocardium labeled with clinically applicable CliniMACS nanoparticles. J Am Soc Echocardiogr 2006, 19:563–568.CrossRefPubMed Bara C, Ghodsizad A, Niehaus M, et al.: In vivo echocardiographic imaging of transplanted human adult stem cells in the myocardium labeled with clinically applicable CliniMACS nanoparticles. J Am Soc Echocardiogr 2006, 19:563–568.CrossRefPubMed
14.
Zurück zum Zitat Aicher A, Brenner W, Zuhayra M, et al.: Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation 2003, 107:2134–2139.CrossRefPubMed Aicher A, Brenner W, Zuhayra M, et al.: Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation 2003, 107:2134–2139.CrossRefPubMed
15.
Zurück zum Zitat Hofmann M, Wollert KC, Meyer GP, et al.: Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation 2005, 111:2198–2202.CrossRefPubMed Hofmann M, Wollert KC, Meyer GP, et al.: Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation 2005, 111:2198–2202.CrossRefPubMed
16.
Zurück zum Zitat Cao F, Lin S, Xie X, et al.: In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation 2006, 113:1005–1014.CrossRefPubMed Cao F, Lin S, Xie X, et al.: In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation 2006, 113:1005–1014.CrossRefPubMed
17.
Zurück zum Zitat Cao YA, Wagers AJ, Beilhack A, et al.: Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A 2004, 101:221–226.CrossRefPubMed Cao YA, Wagers AJ, Beilhack A, et al.: Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci U S A 2004, 101:221–226.CrossRefPubMed
18.
Zurück zum Zitat • Hendry SL 2nd, van der Bogt KE, Sheikh AY, et al.: Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells. J Thorac Cardiovasc Surg 2008, 136:1028–1037; e1021. This study shows significance of transplanted cell viability to get therapeutic benefit.CrossRefPubMed • Hendry SL 2nd, van der Bogt KE, Sheikh AY, et al.: Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells. J Thorac Cardiovasc Surg 2008, 136:1028–1037; e1021. This study shows significance of transplanted cell viability to get therapeutic benefit.CrossRefPubMed
19.
Zurück zum Zitat Hung TC, Suzuki Y, Urashima T, et al.: Multimodality evaluation of the viability of stem cells delivered into different zones of myocardial infarction. Circ Cardiovasc Imaging 2008, 1:6–13.CrossRefPubMed Hung TC, Suzuki Y, Urashima T, et al.: Multimodality evaluation of the viability of stem cells delivered into different zones of myocardial infarction. Circ Cardiovasc Imaging 2008, 1:6–13.CrossRefPubMed
20.
Zurück zum Zitat Massoud TF, Singh A, Gambhir SS: Noninvasive molecular neuroimaging using reporter genes: part II, experimental, current, and future applications. AJNR Am J Neuroradiol 2008, 29:409–418.CrossRefPubMed Massoud TF, Singh A, Gambhir SS: Noninvasive molecular neuroimaging using reporter genes: part II, experimental, current, and future applications. AJNR Am J Neuroradiol 2008, 29:409–418.CrossRefPubMed
21.
Zurück zum Zitat Bulte JW, Douglas T, Witwer B, et al.: Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 2001, 19:1141–1147.CrossRefPubMed Bulte JW, Douglas T, Witwer B, et al.: Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 2001, 19:1141–1147.CrossRefPubMed
22.
Zurück zum Zitat Aikawa E, Nahrendorf M, Sosnovik D, et al.: Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 2007, 115:377–386.CrossRefPubMed Aikawa E, Nahrendorf M, Sosnovik D, et al.: Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 2007, 115:377–386.CrossRefPubMed
23.
Zurück zum Zitat Schellenberger EA, Hogemann D, Josephson L, et al.: Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Acad Radiol 2002, 9(Suppl 2):S310–S311.CrossRefPubMed Schellenberger EA, Hogemann D, Josephson L, et al.: Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Acad Radiol 2002, 9(Suppl 2):S310–S311.CrossRefPubMed
24.
Zurück zum Zitat • Suzuki Y, Zhang S, Kundu P, et al.: In vitro comparison of the biological effects of three transfection methods for magnetically labeling mouse embryonic stem cells with ferumoxides. Magn Reson Med 2007, 57:1173–1179. This study shows SPIO labeling of stem cells does not affect the viability of cells.CrossRefPubMed • Suzuki Y, Zhang S, Kundu P, et al.: In vitro comparison of the biological effects of three transfection methods for magnetically labeling mouse embryonic stem cells with ferumoxides. Magn Reson Med 2007, 57:1173–1179. This study shows SPIO labeling of stem cells does not affect the viability of cells.CrossRefPubMed
25.
Zurück zum Zitat Kostura L, Kraitchman DL, Mackay AM, et al.: Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis. NMR Biomed 2004, 17:513–517.CrossRefPubMed Kostura L, Kraitchman DL, Mackay AM, et al.: Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis. NMR Biomed 2004, 17:513–517.CrossRefPubMed
26.
Zurück zum Zitat Arai T, Kofidis T, Bulte JW, et al.: Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 t. Magn Reson Med 2006, 55:203–209.CrossRefPubMed Arai T, Kofidis T, Bulte JW, et al.: Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 t. Magn Reson Med 2006, 55:203–209.CrossRefPubMed
27.
Zurück zum Zitat • Chen IY, Greve JM, Gheysens O, et al.: Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation. Mol Imaging Biol 2009, 11:178–187. This study demonstrates SPIO direct labeling does not tell viability of transplanted cells.CrossRefPubMed • Chen IY, Greve JM, Gheysens O, et al.: Comparison of optical bioluminescence reporter gene and superparamagnetic iron oxide MR contrast agent as cell markers for noninvasive imaging of cardiac cell transplantation. Mol Imaging Biol 2009, 11:178–187. This study demonstrates SPIO direct labeling does not tell viability of transplanted cells.CrossRefPubMed
28.
Zurück zum Zitat Kraitchman DL, Heldman AW, Atalar E, et al.: In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction. Circulation 2003, 107:2290–2293.CrossRefPubMed Kraitchman DL, Heldman AW, Atalar E, et al.: In vivo magnetic resonance imaging of mesenchymal stem cells in myocardial infarction. Circulation 2003, 107:2290–2293.CrossRefPubMed
29.
Zurück zum Zitat Lin YJ, Koretsky AP: Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function. Magn Reson Med 1997, 38:378–388.CrossRefPubMed Lin YJ, Koretsky AP: Manganese ion enhances T1-weighted MRI during brain activation: an approach to direct imaging of brain function. Magn Reson Med 1997, 38:378–388.CrossRefPubMed
30.
Zurück zum Zitat • Yamada M, Gurney PT, Chung J, et al.: Manganese-guided cellular MRI of human embryonic stem cell and human bone marrow stromal cell viability. Magn Reson Med 2009, 62:1047–1054. This study shows manganese labeling of stem cells does not affect biologic property of human embryonic and mesenchymal stem cells.CrossRefPubMed • Yamada M, Gurney PT, Chung J, et al.: Manganese-guided cellular MRI of human embryonic stem cell and human bone marrow stromal cell viability. Magn Reson Med 2009, 62:1047–1054. This study shows manganese labeling of stem cells does not affect biologic property of human embryonic and mesenchymal stem cells.CrossRefPubMed
31.
Zurück zum Zitat Bruvold M, Nordhoy W, Anthonsen HW, et al.: Manganese-calcium interactions with contrast media for cardiac magnetic resonance imaging: a study of manganese chloride supplemented with calcium gluconate in isolated Guinea pig hearts. Invest Radiol 2005, 40:117–125.CrossRefPubMed Bruvold M, Nordhoy W, Anthonsen HW, et al.: Manganese-calcium interactions with contrast media for cardiac magnetic resonance imaging: a study of manganese chloride supplemented with calcium gluconate in isolated Guinea pig hearts. Invest Radiol 2005, 40:117–125.CrossRefPubMed
32.
Zurück zum Zitat Bulte JW, Zhang S, van Gelderen P, et al.: Neurotransplantation of magnetically labeled oligodendrocyte progenitors: magnetic resonance tracking of cell migration and myelination. Proc Natl Acad Sci U S A 1999, 96:15256–15261.CrossRefPubMed Bulte JW, Zhang S, van Gelderen P, et al.: Neurotransplantation of magnetically labeled oligodendrocyte progenitors: magnetic resonance tracking of cell migration and myelination. Proc Natl Acad Sci U S A 1999, 96:15256–15261.CrossRefPubMed
33.
Zurück zum Zitat So PW, Hotee S, Herlihy AH, et al.: Generic method for imaging transgene expression. Magn Reson Med 2005, 54:218–221.CrossRefPubMed So PW, Hotee S, Herlihy AH, et al.: Generic method for imaging transgene expression. Magn Reson Med 2005, 54:218–221.CrossRefPubMed
34.
Zurück zum Zitat Weissleder R, Tung CH, Mahmood U, et al.: In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999, 17:375–378.CrossRefPubMed Weissleder R, Tung CH, Mahmood U, et al.: In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol 1999, 17:375–378.CrossRefPubMed
35.
Zurück zum Zitat • Chung J, Kee K, Rajesh D, et al.: In vivo molecular MRI of embryonic stem cell survival kinetics following transplantation into murine injured myocardium. Circulation 2009, 120:A32. This is the first study to show in vivo viability of embryonic stem cells using an MRI reporter gene.CrossRef • Chung J, Kee K, Rajesh D, et al.: In vivo molecular MRI of embryonic stem cell survival kinetics following transplantation into murine injured myocardium. Circulation 2009, 120:A32. This is the first study to show in vivo viability of embryonic stem cells using an MRI reporter gene.CrossRef
Metadaten
Titel
Molecular Imaging of Stem Cell Transplantation in Myocardial Disease
verfasst von
Jaehoon Chung
Phillip C. Yang
Publikationsdatum
01.04.2010
Verlag
Current Science Inc.
Erschienen in
Current Cardiovascular Imaging Reports / Ausgabe 2/2010
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-009-9001-4

Weitere Artikel der Ausgabe 2/2010

Current Cardiovascular Imaging Reports 2/2010 Zur Ausgabe

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.