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World Journal of Surgery
Erschienen in: World Journal of Surgery 10/2009

01.10.2009

Molecular Mechanisms of Obesity and Diabetes: At the Intersection of Weight Regulation, Inflammation, and Glucose Homeostasis

verfasst von: Robert W. O’Rourke

Erschienen in: World Journal of Surgery | Ausgabe 10/2009

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Abstract

Obesity is a major health crisis, and diabetes is one of its most serious sequelae. Obesity is associated with a state of chronic systemic inflammation that is a primary etiologic factor in the development of insulin resistance and diabetes. This inflammatory state is based in adipose tissue and mediated in large part by tissue macrophages and their cytokine and adipokine products. Recent research has identified specific molecular mediators of the link between inflammation and insulin resistance in obesity. Study of these mediators and the specific mechanisms underlying inflammation and insulin resistance in obesity holds the promise for novel pharmacotherapy for obesity-related metabolic disease.
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Metadaten
Titel
Molecular Mechanisms of Obesity and Diabetes: At the Intersection of Weight Regulation, Inflammation, and Glucose Homeostasis
verfasst von
Robert W. O’Rourke
Publikationsdatum
01.10.2009
Verlag
Springer-Verlag
Erschienen in
World Journal of Surgery / Ausgabe 10/2009
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-009-0067-6

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