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01.12.2017 | Review | Ausgabe 1/2017 Open Access

Arthritis Research & Therapy 1/2017

Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB

Zeitschrift:
Arthritis Research & Therapy > Ausgabe 1/2017
Autoren:
Taku Saito, Sakae Tanaka

Abstract

Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since the establishment of murine surgical knee OA models in 2005, many of the key molecules and signalling pathways responsible for OA development have been identified. Here we review the roles of two multi-functional signalling pathways in OA development: Notch and nuclear factor kappa-light-chain-enhancer of activated B cells. Previous studies have identified various aspects of articular chondrocyte regulation by these pathways. However, comprehensive understanding of the molecular networks regulating articular cartilage homeostasis and OA pathogenesis is needed.
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