Ausgabe 1/2009
Inhalt (55 Artikel)
Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells
Jaya RP Prasanthi, Amber Huls, Sarah Thomasson, Alex Thompson, Eric Schommer, Othman Ghribi
Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification
Alicia N Minniti, Daniela L Rebolledo, Paula M Grez, Ricardo Fadic, Rebeca Aldunate, Irene Volitakis, Robert A Cherny, Carlos Opazo, Colin Masters, Ashley I Bush, Nibaldo C Inestrosa
The gene coding for PGC-1α modifies age at onset in Huntington's Disease
Patrick Weydt, Selma M Soyal, Cinzia Gellera, Stefano DiDonato, Claus Weidinger, Hannes Oberkofler, G Bernhard Landwehrmeyer, Wolfgang Patsch
Insulin-degrading enzyme is exported via an unconventional protein secretion pathway
Ji Zhao, Lilin Li, Malcolm A Leissring
Independent component analysis of Alzheimer's DNA microarray gene expression data
Wei Kong, Xiaoyang Mou, Qingzhong Liu, Zhongxue Chen, Charles R Vanderburg, Jack T Rogers, Xudong Huang
Linkage of cDNA expression profiles of mesencephalic dopaminergic neurons to a genome-wide in situ hybridization database
Kambiz N Alavian, Horst H Simon
"What kills neurons in neurodegenerative diseases?", a review series in an open access journal
Todd E Golde, Leonard Petrucelli
The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease
Todd E Golde
PGC-1alphaas modifier of onset age in Huntington disease
Elahe Taherzadeh-Fard, Carsten Saft, Jürgen Andrich, Stefan Wieczorek, Larissa Arning
Inducible mutant huntingtin expression in HN10 cells reproduces Huntington's disease-like neuronal dysfunction
Andreas Weiss, Ana Roscic, Paolo Paganetti
Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
Stéphanie Baulac, Hope Lu, Jennifer Strahle, Ting Yang, Matthew S Goldberg, Jie Shen, Michael G Schlossmacher, Cynthia A Lemere, Qun Lu, Weiming Xia
The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events
Kiran Bhaskar, Megan Miller, Alexandra Chludzinski, Karl Herrup, Michael Zagorski, Bruce T Lamb
Calnuc plays a role in dynamic distribution of Gαi but not Gβ subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells
Ping Lin, Thierry Fischer, Christine Lavoie, Haining Huang, Marilyn Gist Farquhar
All-you-can-eat: autophagy in neurodegeneration and neuroprotection
Philipp A Jaeger, Tony Wyss-Coray
LRP1 shedding in human brain: roles of ADAM10 and ADAM17
Qiang Liu, Juan Zhang, Hien Tran, Marcel M Verbeek, Karina Reiss, Steven Estus, Guojun Bu
GSK-3β phosphorylation of functionally distinct tau isoforms has differential, but mild effects
Kellen Voss, T Chris Gamblin
Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575
Monica Garcia-Alloza, Meenakshi Subramanian, Diana Thyssen, Laura A Borrelli, Abdul Fauq, Pritam Das, Todd E Golde, Bradley T Hyman, Brian J Bacskai
Calcium signaling in neurodegeneration
Philippe Marambaud, Ute Dreses-Werringloer, Valérie Vingtdeux
ApoE isoform-dependent changes in hippocampal synaptic function
Kimberly M Korwek, Justin H Trotter, Mary Jo LaDu, Patrick M Sullivan, Edwin J Weeber
An exo-cell assay for examining real-time γ-secretase activity and inhibition
Christopher C Shelton, Yuan Tian, Mark G Frattini, Yue-Ming Li
Dissembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients
Hikmet Nural, Ping He, Thomas Beach, Lucia Sue, Weiming Xia, Yong Shen
Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle
Kristen A Malkus, Elpida Tsika, Harry Ischiropoulos
Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation
Javorina Milosevic, Sigrid C Schwarz, Vera Ogunlade, Anne K Meyer, Alexander Storch, Johannes Schwarz
Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy
Patricia A Trimmer, Kathleen M Schwartz, M Kathleen Borland, Luis De Taboada, Jackson Streeter, Uri Oron
Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence
Dale E Bredesen
The interactome of the amyloid β precursor protein family members is shaped by phosphorylation of their intracellular domains
Robert Tamayev, Dawang Zhou, Luciano D'Adamio
Nucleation of protein aggregation kinetics as a basis for genotype-phenotype correlations in polyglutamine diseases
Keizo Sugaya, Shiro Matsubara
Erratum to: Disassembled DJ-1 high molecular weight complex in cortex mitochondria from Parkinson's disease patients
Zhenyu Zhong, Hikmet Nural, Ping He, Gina Civarella, Thomas Beach, Lucia Sue, Charles Adler, Holly Shill, John Caviness, Weiming Xia, Yong Shen
Experimental models for the study of neurodegeneration in amyotrophic lateral sclerosis
Luis B Tovar-y-Romo, Luz Diana Santa-Cruz, Ricardo Tapia
Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease
Bo Su, Haihua Liu, Xinglong Wang, Shu G Chen, Sandra L Siedlak, Eisaku Kondo, Raymond Choi, Atsushi Takeda, Rudy J Castellani, George Perry, Mark A Smith, Xiongwei Zhu, Hyoung-gon Lee
Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide
Rina Yamin, Cheng Zhao, Peter B O'Connor, Ann C McKee, Carmela R Abraham
Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons
João Paulo L Daher, Mingyao Ying, Rebecca Banerjee, Rebecca S McDonald, Myriam Dumas Hahn, Lichuan Yang, M Flint Beal, Bobby Thomas, Valina L Dawson, Ted M Dawson, Darren J Moore
Apolipoprotein E4 (1–272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
Toshiyuki Nakamura, Atsushi Watanabe, Takahiro Fujino, Takashi Hosono, Makoto Michikawa
Upregulation of miRNA hsa-miR-342-3p in experimental and idiopathic prion disease
Judith Montag, Reiner Hitt, Lennart Opitz, Walter J Schulz-Schaeffer, Gerhard Hunsmann, Dirk Motzkus
Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance
Charles R Arthur, Stephanie L Morton, Lisa D Dunham, Paula M Keeney, James P Bennett Jr
What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases?
Dawn Teschendorf, Christopher D Link
Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme
Anthony DelleDonne, Naomi Kouri, Lael Reinstatler, Tomoko Sahara, Lilin Li, Ji Zhao, Dennis W Dickson, Nilufer Ertekin-Taner, Malcolm A Leissring
Dietary composition modulates brain mass and solubilizable Aβ levels in a mouse model of aggressive Alzheimer's amyloid pathology
Steve Pedrini, Carlos Thomas, Hannah Brautigam, James Schmeidler, Lap Ho, Paul Fraser, David Westaway, Peter StGeorge Hyslop, Ralph N Martins, Joseph D Buxbaum, Giulio M Pasinetti, Dara L Dickstein, Patrick R Hof, Michelle E Ehrlich, Sam Gandy
CD74 interacts with APP and suppresses the production of Aβ
Shuji Matsuda, Yukiko Matsuda, Luciano D'Adamio
Novel cerebrovascular pathology in mice fed a high cholesterol diet
Sonia Franciosi, Miguel A Gama Sosa, Daniel F English, Elizabeth Oler, Twethida Oung, William GM Janssen, Rita De Gasperi, James Schmeidler, Dara L Dickstein, Christoph Schmitz, Sam Gandy, Patrick R Hof, Joseph D Buxbaum, Gregory A Elder
Meeting report: 2009 international conference on molecular neurodegeneration May 18-20, 2009, Xiamen, China
Yunwu Zhang, Lisa Owens, Guojun Bu
Neuroprotective effects of blockers for T-type calcium channels
Norelle C Wildburger, Avary Lin-Ye, Michelle A Baird, Debin Lei, Jianxin Bao
Retraction Note: Dopaminergic regeneration by neurturin-overexpressing c17.2 neural stem cells in a rat model of Parkinson's disease
Wei-Guo Liu, Xi-Jing Wang, Guo-Qiang Lu, Biao Li, Gang Wang, Sheng-Di Chen
Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain
Karrie E Grear, I-Fang Ling, James F Simpson, Jennifer L Furman, Christopher R Simmons, Shawn L Peterson, Frederick A Schmitt, William R Markesbery, Qiang Liu, Julia E Crook, Steven G Younkin, Guojun Bu, Steven Estus
Does neuroinflammation fan the flame in neurodegenerative diseases?
Tamy C Frank-Cannon, Laura T Alto, Fiona E McAlpine, Malú G Tansey
Alzheimer's disease: synaptic dysfunction and Aβ
Ganesh M Shankar, Dominic M Walsh
Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease
Torsten Falk, Shiling Zhang, Scott J Sherman
The neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line
R Scott Duncan, Kent D Chapman, Peter Koulen
Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo
John W Steele, Soong H Kim, John R Cirrito, Deborah K Verges, Jessica L Restivo, David Westaway, Paul Fraser, Peter St George Hyslop, Mary Sano, Ilya Bezprozvanny, Michelle E Ehrlich, David M Holtzman, Sam Gandy
Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF
Se Hoon Choi, Yun Li, Luis F Parada, Sangram S Sisodia
ZnT3 mRNA levels are reduced in Alzheimer's disease post-mortem brain
Nancy Beyer, David TR Coulson, Shirley Heggarty, Rivka Ravid, G Brent Irvine, Jan Hellemans, Janet A Johnston
Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment
Suzanne M de la Monte, Ming Tong, Margot Lawton, Lisa Longato
Effects of chronic low dose rotenone treatment on human microglial cells
Shamim B Shaikh, Louise FB Nicholson