Ausgabe Sonderheft 1/2013
Molecular Neurodegeneration: Basic biology and disease pathways
Inhalt (92 Artikel)
Decoding Alzheimer’s in the age of genome-wide analyses
Rudolph E Tanzi
Functional genetics – an approach to mechanisms in Alzheimer’s disease
Mikko Hiltunen
Proteomics in neurons and animals: substrates and therapeutic potential of alpha-and beta-secretase
Stefan Lichtenthaler
BACE1, the Alzheimer’s beta-secretase enzyme, in health and disease
Robert Vassar
Regulation of dynamic BACE1 trafficking in neurons
Virginie Buggia-Prévot, Celia G Fernandez, Sean Riordan, Kulandaivelu S Vetrivel, Vinod Udayar, Aureliane Elie, Margaret Lefkow, Jelita Roseman, Xavier Meckler, Sohinee Bhattacharyya, Manju George, Jack Waters, Vytautas P Bindokas, Angèle T Parent, Lawrence Rajendran, Hamid Band, Robert Vassar, Gopal Thinakaran
Function and dysfunction of presenilin in Alzheimer’s disease
Jie Shen
Regulation of mitochondrial function by PINK1, Parkin and DJ-1
Emilie Giaime, Jie Shen
Expanded G4C2 repeats linked to C9ORF72ALS and FTD form length-dependent RNA foci, sequester RNA binding proteins and are neurotoxic
Youn-Bok Lee, Han-Jou Chen, João N Peres, Jorge Gomez, Valentina Sardone, Agnes L Nishimura, Emma Scotter, Caroline Vance, Maja Štalekar, Yoshitsugu Adachi, Claire Troakes, Jack Miller, Bradley Smith, Frank Hirth, Boris Rogelj, Corinne Houart, Christopher E Shaw
In situstudies of protein aggregation kinetics with multiparametric and superresolution imaging
Gabriele Kaminski Schierle, Claire Michel, Eric Rees, Dorothea Pinotsi, Clemens Kaminski
Designing nanoparticles for delivery of neurotrophic proteins
Angelina Angelova, Borislav Angelov, Sylviane Lesieur
Novel non-carbohydrate O-GlcNAcase inhibitors with CNS drug properties as potential treatment for Alzheimer’s disease and tauopathies
Heike Hering, Danielle Graham, Solenne Ousson, Maud Neny, Audrey Gray, Brandy Giacomozzi, John Joyce, Vikram Dutt, Michael Busch, Andrew Cameron, Leslie Liu-Bujalski, Henry Yu, Hui Tian, Mark Shearman, Anna Quattropani, Bruno Permanne, Christoph Wiessner, Dirk Beher
Super-resolution fluorescence imaging of intracellular mutant huntingtin protein reveals a population of fibrillar aggregates co-existing with compact perinuclear inclusion bodies
Steffen J Sahl, Lucien E Weiss, Lana Lau, Judith Frydman, WE Moerner
Vascular hypothesis of Alzheimer’s disease: role of apoE and apoE receptors
Guojun Bu, Chia-Chen Liu, Takahisa Kanekiyo
Prion-like aspects of cerebral amyloidosis
Mathias Jucker, Lan Ye, Sarah Fritschi
Secretases: potential and roadblocks on the way to therapy
Bart De Strooper
A novel mechanism underlying pathogenesis of Down syndrome
Xin Wang, Yingjun Zhao, Xiaofei Zhang, Ying Zhou, Barbara Ranscht, Fred H Gage, William C Mobley, Yun-wu Zhang, Stuart A Lipton, Wanjin Hong, Huaxi Xu
The transcription factor XBP-1 in neurodegenerative diseases
Frédéric Checler, Eric Duplan, Cristine Alves da Costa
Transmission of alpha-synuclein in Parkinson’s disease
Virginia M-Y Lee
Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of AD
Stephanie Fowler, Angie Chiang, Ricky Savjani, Megan Larson, Dorothy Schuler, John Cirrito, Sylvain Lesne, Joanna Jankowsky
Excitotoxicity increases the release of 24S-hydroxycholesterol via CYP46A1 activation
Alejandro Sodero, Joris Vriens, Debapriya Ghosh, David Stegner, Anna Brachet, Marta Pallotto, Marco Sassoe-Pognetto, Jos Brouwers, Bernd Helms, Bernard Nieswandt, Thomas Voets, Carlos Dotti
Identifying dominant modifiers of mutant FUS toxicity in vivo
J Gavin Daigle, Nicholas A Lanson, Ian Casci, John Monaghan, Charles Nichols, Dimitri Kryndushkin, Frank Shewmaker, Udai Pandey
Harnessing endogenous pathways and metabolites to treat or prevent neurodegenerative disease
Todd E Golde, Kevin Felsenstein, Paramita Chakrabarty, Andy Li, Brenda Moore, Jung Joo In, Pedor Cruz, Ashely Price, David Borchelt, Christopher Janus, Carolina Cebballos-Diaz, Awilda Rosario
Tau-focused therapy and tau transmission: Implications for Alzheimer’s Disease and related tauopathies
John Q Trojanowski
Methylene blue decreases brain mitochondrial ABAD and amyloid beta levels protecting mitochondrial functions in LPS-mouse model
Reham M Abdel-Kader, Aya Zakaria, Nabila Hamdi
The composition of the γ-secretase complex defines its Aβ product profile
Hermien Acx, Lucía Chávez Gutiérrez, Lutgarde Serneels, Bart De Strooper
dld-1 suppression attenuates the detrimental effects of amyloid beta deposition in a Caenorhabditis elegansmodel of Alzheimer’s disease
Waqar Ahmad, Paul Ebert
A new transgenic mouse model for studying the neurotoxicity of spermine oxidase dosage in the response to excitotoxic injury
Emanuela Angelucci, Sandra Moreno, Marcello D’Amelio, Roberta Nardacci, Francesco Cecconi, Paolo Mariottini, Manuela Cervelli
RAGE targeted strategies for Alzheimer’s amyloid β peptide induced blood brain barrier dysfunctions
Sholpan Askarova, Andrey Tsoy, James C-M Lee
Development of a paradigm to investigate mechanisms of divided and selective attention impairment in the rodent models of Alzheimer’s disease
Gytis Baranauskas, Natasa Svirskiene, Gytis Svirskis
Neurochemical changes in animal models of Parkinson’s disease
Mária Baranyi, Elisaveta Milusheva, Beáta Sperlágh
CYP2E1 and Parkinson’s disease in a MPTP-induced C57BL/6 mouse model
Rahman Basaran, Elcin Deniz Ozdamar, Benay Can-Eke
The pro-neurotrophin receptor sortilin is a major neuronal APOE receptor for catabolism of amyloid-β peptide in the brain
Anne-Sophie Carlo, Camilla Gustafsen, Guido Mastrobuoni, Morten Nielsen, Stefan Kempa, Claus Munck Petersen, Thomas Willnow
Posterior cortical atrophy: correlation between clinical, neuropsychological, magnetic resonance and positron emission tomography Imaging
Tinatin Chabrashvili, Haley Lamonica, Bassel Sawaya
Using Caenorhabditis elegans to fight human neurodegenerative diseases
Xi Chen, Brian Kraemer, Jeff Barclay, Robert Burgoyne, Alan Morgan
The dishomeostasis of metal ions plays an important role for the cognitive impartment
Dehua Chui, Huan Yang, Hecheng Wang, Tuo JI, Jia Yu, Shouzi Zhang, Zheng Chen, WeiZhong Xiao
Platelet BACE1 levels as a possible biomarker for Alzheimer’s disease
Boris Decourt, Aaron Walker, Amanda Gonzales, Michael Malek-Ahmadi, Carolyn Liesback, Kathryn Davis, Christine Belden, Sandra Jacobson, Marwan Sabbagh
Altered expression of antioxidant enzymes and autophagic proteins in transglutaminase 2 knockout mice
Barbara D’Orio, Luana Barone, Anna Fracassi, Francesca Fanelli, Sara Sepe, Marco Segatto, Mauro Piacentini, Roberta Nardacci, Sandra Moreno
Corynoxine isomers decrease levels of amyloid-β peptide and amyloid-β precursor protein by promoting autophagy and lysosome biogenesis
Siva Sundara Kumar Durairajan, Yingyu Huang, Leilei Chen, Juxian Song, Liangfeng Liu, Min Li
A cell-based model of pathological tau uptake and propagation
Ben Falcon, Rachel Angers, Michel Goedert
Serum from Parkinson’s disease patients presents excess of protein halogenation and nitrosylation, with anomalous nitrosylation of serum α-synuclein as potentially etiological factor
Emilio Fernandez, Jose-Manuel Garcia-Moreno, Angel Martin de Pablos, Jose Chacon
The role of SorLA in neurotrophic activity and complex behavior
Simon Glerup, Mart Saarma, Anders Nykjaer
Regulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1
Mari Takalo, Jayashree Viswanathan, Teemu Natunen, Kaisa MA Kurkinen, Heikki Tanila, Hilkka Soininen, Rudolph E Tanzi, Mikko Hiltunen, Annakaisa Haapasalo
O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP)
Kristin Jacobsen, Kerstin Iverfeldt
FcgRIIb mediates amyloid-β neurotoxicity and memory impairment in a model of Alzheimer’s disease
Yong-Keun Jung
Analysis of TDP-43 and its binding partners in neurodegenerative diseases
Wejdan Kattuah, Claire Troakes, Tibor Hortobagyi, Boris Rogelj, Christopher Shaw
Regulation of Fe65 during neuronal differentiation
Niina Koistinen, Kristin Jacobsen, Kerstin Iverfeldt
Cytoprotective functions of amyloid precursor protein family members in stress signaling and aging
Arpita Kundu, Andreas Zymny, Steffi Chang, Nelli Röhner, Donat Kögel
Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain
Aurélien Lathuilière, Stéphanie Papin, Matthias Cacquevel, Paolo Paganetti, Andreas Muhs, Graham Knott, Bernard Schneider, Patrick Aebischer
Identification of potent inhibitors of microtubule affinity regulating kinase for inhibition of tau hyperphosphorylation
Alison Levy, Michelle Newman, Janet Brownlees, Denise Harding, Joanne Osborne, Stephen Lewis, Kevin Gillen, Gareth Hall, Chido Mpamhanga, Andy Merritt, Debra Taylor, Ed Mclver
Amyloid-β drives a type-1 interferon mediated neuro-inflammatory response in Alzheimer’s disease
Myles Minter, Juliet Taylor, Moses Zhang, Paul Adlard, Peter Crack
Glutathion-S-Transferases (GSTs) and Parkinson’s disease in a MPTP-induced C57BL/6 mouse model
Elcin Deniz Ozdamar, Benay Can-Eke
Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism
François Mouton-Liger, Anne-Sophie Rebillat, Sarah Gourmaud, Audrey Leguen, Claire Paquet, Laurent Pradier, Thomas Rooney, Jacques Hugon
Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid β production in wild-type mice
François Mouton-Liger, Anne-Sophie Rebillat, Clarisse Pace, Sarah Gourmaud, Mariko Taga, Claire Paquet, Jacques Hugon
LRP1 plays a major role in the amyloid-β clearance in microglia
Aurelie N’Songo, Takahisa Kanekiyo, Guojun Bu
Abeta is prerequisite, but insufficient to cause tau phosphorylation in vivo: tau phosphorylation in APP mice by diabetes
Naoyuki Sato
Identification of proteins potentially involved in the formation of Lafora bodies, a hallmark of Lafora disease
Elham Schokraie, Oliver Kötting, Matthew S Gentry
Analysis of the protein network of cholesterol homeostasis maintenance in a mouse model of Alzheimer’s disease
Marco Segatto, Pamela Rosso, Sandra Moreno, Valentina Pallottini
Neuronal MHC-I display in T-cell mediated neurodegeneration
Carolina Cebrián, Fabio Zucca, Luigi Zecca, John Loike, David Sulzer
Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs
Ina Tesseur, Adrian Lo, Anouk Roberfroid, Sofie Dietvorst, Bianca Van Broeck, Marianne Borgers, Harrie Gijsen, Diederik Moechars, Marc Mercken, John Kemp, Rudi D’Hooge, Bart De Strooper
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer’s disease
Amantha Thathiah, Katrien Horre, An Snellinx, Elke Vandewyer, Yunhong Huang, Marta Ciesielska, Gerdien De Kloe, Sebastian Munck, Bart De Strooper
Exposure to the saturated free fatty acid palmitate alters microglia inflammatory response
Linda Tracy, Filip Bergqvist, Elena Ivanova, Kristin Jacobsen, Kerstin Iverfeldt
Cysteine-rich domain of scavenger receptor Al modulates the efficacy of surface targeting and mediates internalization of oligomeric beta amyloid
Huey-Jen Tsay
Role of ROS in Aβ42 mediated cell surface P-selectin expression and actin polymerization
Andrey Tsoy, Sholpan Askarova, Tamara Shalakhmetova, Bauyrzhan Umbayev, Shalkar Adambekov, Zhaksybay Zhumadilov
Phosphorylation of hnRNP K controls cytosolic accumulation of TDP-43
Anthony White, Diane Moujalled, Janine James, Alexandra Grubman, Katja Kanninen, Peter Crouch
A driver or a passenger? D421-caspase cleaved tau is associated with aggregated and insoluble tau
Yolanda Gibson, Katya Garn, Clare Hardy, Manuela Piarulli, Sarah Glover, Mark Ward, Emily McNaughton, Michael Hutton, Michael O’Neill, Joanna Wolak
Differential pathways for the interleukin-1β production activated by chromogranin A and Aβ in microglia
Zhou Wu, Hiroshi Nakanishi
Histone deacetylase inhibition leads to neuroprotection through regulation on glial function
Xuefei Wu, Shao Li, Qiong Wu, Yan Peng, Deqin Yu, Hecheng Wang, Dehua Chui, Jie Zhao
Mechanism of tau transfer: insights from cell culture and animal models
Jessica Wu, Dara Dickstein, Karen Duff
Ataxia-telangiectasia paradoxes: spotlight on post-zygotic chromosome instability in the brain and its contribution to neurodegeneration pathways
Yuri Yurov, Svetlana Vorsanova, Thomas Liehr, Ivan Yurov
Aneuploidy-driven non-heritable genomic variations demonstrate area-specific distribution in the Alzheimer’s disease brain
Ivan lourov, Svetlana Vorsanova, Thomas Liehr, Yuri Yurov
Generation and characterization of individual-specific induced pluripotent cells from patient-derived lymphoblastoid cell lines
Shadaan Zulfiqar, Radhika Menon, Tara Atmaram, Meera Purushottam, Matthew Varghese, Sanjeev Jain, Mitradas Panicker, Odity Mukherjee
Leaky Ryanodine receptors increases Amyloid-beta load and induces memory impairments in Tg2576 mouse model of Alzheimer disease
Bénédicte Oulès, Dolores Del Prete, Barbara Greco, Xuexin Zhang, Inger Lauritzen, Mohamed Trebak, Fabio Benfenati, Frédéric Checler, Mounia Chami
The overall structure of the multi-domain amyloid precursor protein
Ina Coburger, Sven O Dahms, Manuel E Than
Parkin acts as a transcription factor modulating presenilin-1 and presenilin-2 promoter transactivations
Eric Duplan, Jean Sévalle, Julien Viotti, Thomas Goiran, Charlotte Bauer, Paul Renbaum, Ephrat Levy-Lahad, Clément A Gautier, Olga Corti, Nathalie Leroudier, Frédéric Checler, Cristine Alves da Costa
Tauopathy-induced retinal dysfunction in the P301S mutant human tau transgenic mouse
Nadia Mazzaro, Erica Barini, Michel Goedert, Maria Grazia Spillantini, Paolo Medini, Laura Gasparini
Late neurodegeneration in the Tau transgenic mouse model rTg4510
Lone Helboe, Christiane Volbracht
Structure-function-relationship of the APP-E1-domain
Sandra Hoefgen, Sven O Dahms, Dirk Roeser, Manuel E Than
A familial FTD associated with C9orf72 repeat expansion and dysplastic gangliocytoma
Mia Kero, Raffaele Ferrari, Kin Mok, Anders Paetau, Pentti J Tienari, Olli Tynninen, John Hardy, Parastoo Momeni, Auli Verkkoniemi-Ahola, Liisa Myllykangas
Tau-Hsp70 interaction on the single molecule level
Franziska Kundel, Magnus Kjaergaard, Sarah Shammas, Sophie Jackson, David Klenerman
Early hippocampal synaptic plasticity and episodic like-memory deficits in a transgenic mouse model of Alzheimer disease - involvment of corticosterone
Fabien Lanté, Magda Chafai, Elisabeth Raymond, Ana Rita Salgueiro Peirera, Ingrid Bethus, Helene Marie
The beta-secretase-derived C-terminal fragment of APP (C99): a key determinant for intraneuronal pathology in the 3xTgAD mouse
Inger Lauritzen, Raphaelle Pardossi-Piquard, Charlotte Druon, Elizabeth Brigham, Daniel Abraham, Sébatien Ranaldi, Linda Chami, Julie Dunys, Fréderic Checler
Misfolding and interactions of Aß proteins: Insight from single molecule experiments and computational analyses
Lv Zhengjian, Yuliang Zhang, Alexey Krasnoslobodsev, Robin Roychaudhuri, Margaret Condron, David Teplow, Sandor Lovas, Luda Shlyakhtenko, Yuri Lyubchenko
Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model
Aamir Nazir, Pooja Jadiya
Insulin resistance and obesity: how do they affect tau pathology?
Maud Gratuze, Noura El Khoury, Maya DicklerI, Marie-Amélie Papon, Carl Julien, François Marcouiller, Françoise Morin, Emmanuel Planel
p53-mediated disruption of FIP200 function cause autophagic dysregulation in a SCA7 polyglutamine disease model
Xin Yu, Andrés Muñoz Alarcón, Abiodun Ajayi, Kristin Webling, Anne Steinhof, Ülo Langel, Anna-Lena Ström
Monoamine oxidase B is associated with γ-secretase in cultured neurons and in brain
Sophia Schedin Weiss, Birgitta Wiehager, Bengt Winblad, Susanne Frykman, Lars Tjernberg
Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1
Sarah Pickles, Laurie Destroismaisons, Sarah Peyrard, Sarah Cadot, Guy Rouleau, Robert Brown Jr., Jean-Pierre Julien, Nathalie Arbour, Christine Vande Velde