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Zeitschrift

Molecular Neurodegeneration

Molecular Neurodegeneration 1/2017

Ausgabe 1/2017

Inhaltsverzeichnis ( 90 Artikel )

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice

Emily J. Koller, Mieu M. T. Brooks, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa, Yoshiaki Furukawa

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

Thiyagaragan M. Achariyar, Baoman Li, Weiguo Peng, Philip B. Verghese, Yang Shi, Evan McConnell, Abdellatif Benraiss, Tristan Kasper, Wei Song, Takahiro Takano, David M. Holtzman, Maiken Nedergaard, Rashid Deane

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment

Jianmin Chen, Yanping Chen, Graham Vail, Heiman Chow, Yang Zhang, Lauren Louie, Jiali Li, Ronald P. Hart, Mark R. Plummer, Karl Herrup

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The release and trans-synaptic transmission of Tau via exosomes

Yipeng Wang, Varun Balaji, Senthilvelrajan Kaniyappan, Lars Krüger, Stephan Irsen, Katharina Tepper, RamReddy Chandupatla, Walter Maetzler, Anja Schneider, Eckhard Mandelkow, Eva-Maria Mandelkow

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration

Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer, Bettina Schmid

01.12.2017 | Review | Ausgabe 1/2017 Open Access

NADPH oxidase in brain injury and neurodegenerative disorders

Merry W. Ma, Jing Wang, Quanguang Zhang, Ruimin Wang, Krishnan M. Dhandapani, Ratna K. Vadlamudi, Darrell W. Brann

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord

Clinton Cave, Sungjin Park, Marianeli Rodriguez, Mai Nakamura, Ahmet Hoke, Mikhail Pletnikov, Shanthini Sockanathan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

Daniel C. Berwick, Behzad Javaheri, Andrea Wetzel, Mark Hopkinson, Jonathon Nixon-Abell, Simone Grannò, Andrew A. Pitsillides, Kirsten Harvey

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

Helena Xicoy, Bé Wieringa, Gerard J.M. Martens

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease

Tim E. Moors, Jeroen J. M. Hoozemans, Angela Ingrassia, Tommaso Beccari, Lucilla Parnetti, Marie-Christine Chartier-Harlin, Wilma D. J. van de Berg

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice

Joanna E Pankiewicz, Jairo Baquero-Buitrago, Sandrine Sanchez, Jennifer Lopez-Contreras, Jungsu Kim, Patrick M. Sullivan, David M. Holtzman, Martin J. Sadowski

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Tdp-43 cryptic exons are highly variable between cell types

Yun Ha Jeong, Jonathan P. Ling, Sophie Z. Lin, Aneesh N. Donde, Kerstin E. Braunstein, Elisa Majounie, Bryan J. Traynor, Katherine D. LaClair, Thomas E. Lloyd, Philip C. Wong

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice

Anna K. Engstrom, Jessica M. Snyder, Nobuyo Maeda, Zhengui Xia

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

Katarzyna Marta Zoltowska, Masato Maesako, Iryna Lushnikova, Shuko Takeda, Laura J. Keller, Galina Skibo, Bradley T. Hyman, Oksana Berezovska

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration

Michael Lattke, Stephanie N. Reichel, Alexander Magnutzki, Alireza Abaei, Volker Rasche, Paul Walther, Dinis P. Calado, Boris Ferger, Thomas Wirth, Bernd Baumann

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice

Gunjan Dhawan Manocha, Angela Marie Floden, Kendra Lynn Puig, Kumi Nagamoto-Combs, Clemens R. Scherzer, Colin Kelly Combs

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Ex vivo 18O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway

Erik Portelius, Niklas Mattsson, Josef Pannee, Henrik Zetterberg, Magnus Gisslén, Hugo Vanderstichele, Eleni Gkanatsiou, Gabriela A. N. Crespi, Michael W. Parker, Luke A. Miles, Johan Gobom, Kaj Blennow

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Tau PET imaging: present and future directions

Laure Saint-Aubert, Laetitia Lemoine, Konstantinos Chiotis, Antoine Leuzy, Elena Rodriguez-Vieitez, Agneta Nordberg

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination

Camille Leonetti, Richard Macrez, Mathilde Pruvost, Yannick Hommet, Jérémie Bronsard, Antoine Fournier, Maxime Perrigault, Isabel Machin, Denis Vivien, Diego Clemente, Fernando De Castro, Eric Maubert, Fabian Docagne

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

Tobias Engel, Jaime Martinez-Villarreal, Christine Henke, Eva M. Jimenez-Mateos, Amaya Sanz-Rodriguez, Mariana Alves, Yasmina Hernandez-Santana, Gary P. Brennan, Aidan Kenny, Aoife Campbell, Jose J. Lucas, David C. Henshall

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

Prateep Pakavathkumar, Anastasia Noël, Clotilde Lecrux, Agne Tubeleviciute-Aydin, Edith Hamel, Jan-Eric Ahlfors, Andrea C. LeBlanc

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

Heesun Choi, Haeng Jun Kim, Jisoo Kim, Soohyun Kim, Jinhee Yang, Wonik Lee, Yeonju Park, Seung Jae Hyeon, Dong-Sup Lee, Hoon Ryu, Junho Chung, Inhee Mook-Jung

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly

Chaoran Ma, Zhaoxue Yin, Pengfei Zhu, Jiesi Luo, Xiaoming Shi, Xiang Gao

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

Francesc X. Guix, Ragna Sannerud, Fedor Berditchevski, Amaia M. Arranz, Katrien Horré, An Snellinx, Amantha Thathiah, Takaomi Saido, Takashi Saito, Sundaresan Rajesh, Michael Overduin, Samir Kumar-Singh, Enrico Radaelli, Nikky Corthout, Julien Colombelli, Sébastien Tosi, Sebastian Munck, Isabel H. Salas, Wim Annaert, Bart De Strooper

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample

Alfredo Ramos-Miguel, Jesús A. García-Sevilla, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer, M. Julia García-Fuster

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

Michal Arbel-Ornath, Eloise Hudry, Josiah R. Boivin, Tadafumi Hashimoto, Shuko Takeda, Kishore V. Kuchibhotla, Steven Hou, Carli R. Lattarulo, Arianna M. Belcher, Naomi Shakerdge, Pariss B. Trujillo, Alona Muzikansky, Rebecca A. Betensky, Bradley T. Hyman, Brian J. Bacskai

01.12.2017 | Methodology | Ausgabe 1/2017 Open Access

Separation of photoreceptor cell compartments in mouse retina for protein analysis

Kasey Rose, Steven T. Walston, Jeannie Chen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Quantitative proteomic analysis of Parkin substrates in Drosophila neurons

Aitor Martinez, Benoit Lectez, Juanma Ramirez, Oliver Popp, James D. Sutherland, Sylvie Urbé, Gunnar Dittmar, Michael J. Clague, Ugo Mayor

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model

Yi-Ling Liu, Wei-Ting Chen, Yu-Yi Lin, Po-Hung Lu, Shie-Liang Hsieh, Irene Han-Juo Cheng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration

Riccardo Natoli, Nilisha Fernando, Michele Madigan, Joshua A. Chu-Tan, Krisztina Valter, Jan Provis, Matt Rutar

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

Maya Ando, Fabienne C. Fiesel, Roman Hudec, Thomas R. Caulfield, Kotaro Ogaki, Paulina Górka-Skoczylas, Dariusz Koziorowski, Andrzej Friedman, Li Chen, Valina L. Dawson, Ted M. Dawson, Guojun Bu, Owen A. Ross, Zbigniew K. Wszolek, Wolfdieter Springer

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency

Michael G. Agadjanyan, Karen Zagorski, Irina Petrushina, Hayk Davtyan, Konstantin Kazarian, Maxim Antonenko, Joy Davis, Charles Bon, Mathew Blurton-Jones, David H. Cribbs, Anahit Ghochikyan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

Gao-Shang Chai, Qiong Feng, Zhi-Hao Wang, Yu Hu, Dong-Sheng Sun, Xiao-Guang Li, Dan Ke, Hong-Lian Li, Gong-Ping Liu, Jian-Zhi Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Dioxins and related environmental contaminants increase TDP-43 levels

Peter E. A. Ash, Elizabeth A. Stanford, Ali Al Abdulatif, Alejandra Ramirez-Cardenas, Heather I. Ballance, Samantha Boudeau, Amanda Jeh, James M. Murithi, Yorghos Tripodis, George J. Murphy, David H. Sherr, Benjamin Wolozin

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Diurnal oscillation of CSF Aβ and other AD biomarkers

Brendan P. Lucey, Anne M. Fagan, David M. Holtzman, John C. Morris, Randall J. Bateman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

Hibiki Kawamata, Pablo Peixoto, Csaba Konrad, Gloria Palomo, Kirsten Bredvik, Meri Gerges, Federica Valsecchi, Leonard Petrucelli, John M. Ravits, Anatoly Starkov, Giovanni Manfredi

01.12.2017 | Methodology | Ausgabe 1/2017 Open Access

Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129

Wen-Bo Zeng, Hai-Fei Jiang, Ya-Dong Gang, Yi-Ge Song, Zhang-Zhou Shen, Hong Yang, Xiao Dong, Yong-Lu Tian, Rong-Jun Ni, Yaping Liu, Na Tang, Xinyan Li, Xuan Jiang, Ding Gao, Michelle Androulakis, Xiao-Bin He, Hui-Min Xia, Ying-Zi Ming, Youming Lu, Jiang-Ning Zhou, Chen Zhang, Xue-Shan Xia, Yousheng Shu, Shao-Qun Zeng, Fuqiang Xu, Fei Zhao, Min-Hua Luo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

Nicholas B. Hastings, Xiaohai Wang, Lixin Song, Brent D. Butts, Diane Grotz, Richard Hargreaves, J. Fred Hess, Kwok-Lam Karen Hong, Cathy Ruey-Ruey Huang, Lynn Hyde, Maureen Laverty, Julie Lee, Diane Levitan, Sherry X. Lu, Maureen Maguire, Veeravan Mahadomrongkul, Ernest J. McEachern, Xuesong Ouyang, Thomas W. Rosahl, Harold Selnick, Michaela Stanton, Giuseppe Terracina, David J. Vocadlo, Ganfeng Wang, Joseph L. Duffy, Eric M. Parker, Lili Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

Zachary A. Sorrentino, Mieu M.T. Brooks, Vincent Hudson III, Nicola J. Rutherford, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

Takashi Miyamoto, Liana Stein, Reuben Thomas, Biljana Djukic, Praveen Taneja, Joseph Knox, Keith Vossel, Lennart Mucke

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Endoplasmic reticulum stress and inflammation in the central nervous system

Neil T. Sprenkle, Savannah G. Sims, Cristina L. Sánchez, Gordon P. Meares

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

Anastasia G. Efthymiou, Alison M. Goate

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Autoimmune antibody decline in Parkinson’s disease and Multiple System Atrophy; a step towards immunotherapeutic strategies

Tomasz Brudek, Kristian Winge, Jonas Folke, Søren Christensen, Karina Fog, Bente Pakkenberg, Lars Østergaard Pedersen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease

James A. Duce, Bruce X. Wong, Hannah Durham, Jean-Christophe Devedjian, David P. Smith, David Devos

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown Jr., Michael Benatar, Claes Wahlestedt, Christian Mueller, Zane Zeier

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

Ruohe Zhao, Wanling Hu, Julia Tsai, Wei Li, Wen-Biao Gan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway

Sang Hun Lee, David Lutz, Mohanad Mossalam, Vadim Y. Bolshakov, Michael Frotscher, Jie Shen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Targeting psychologic stress signaling pathways in Alzheimer’s disease

Hunter S. Futch, Cara L. Croft, Van Q. Truong, Eric G. Krause, Todd E. Golde

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Glial contributions to neurodegeneration in tauopathies

Cheryl E. G. Leyns, David M. Holtzman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

Ellis Patrick, Sathyapriya Rajagopal, Hon-Kit Andus Wong, Cristin McCabe, Jishu Xu, Anna Tang, Selina H. Imboywa, Julie A. Schneider, Nathalie Pochet, Anna M. Krichevsky, Lori B. Chibnik, David A. Bennett, Philip L. De Jager

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

Serena Venezia, Violetta Refolo, Alexia Polissidis, Leonidas Stefanis, Gregor K. Wenning, Nadia Stefanova

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

Anthony Bosson, Adrien Paumier, Sylvie Boisseau, Muriel Jacquier-Sarlin, Alain Buisson, Mireille Albrieux

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

Alena Salašová, Chika Yokota, David Potěšil, Zbyněk Zdráhal, Vítězslav Bryja, Ernest Arenas

01.12.2017 | Short report | Ausgabe 1/2017 Open Access

The lysosomal protein cathepsin L is a progranulin protease

Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson, Leonard Petrucelli

01.12.2017 | Review | Ausgabe 1/2017 Open Access

TREM2 in Neurodegenerative Diseases

Taylor R. Jay, Victoria E. von Saucken, Gary E. Landreth

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Intranasal insulin reverts central pathology and cognitive impairment in diabetic mother offspring

Juan Jose Ramos-Rodriguez, Daniel Sanchez-Sotano, Alberto Doblas-Marquez, Carmen Infante-Garcia, Simon Lubian-Lopez, Monica Garcia-Alloza

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis, Adriana Di Polo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Absence of CX3CR1 impairs the internalization of Tau by microglia

Marta Bolós, María Llorens-Martín, Juan Ramón Perea, Jerónimo Jurado-Arjona, Alberto Rábano, Félix Hernández, Jesús Avila

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture

Jérôme Robert, Emily B. Button, Sophie Stukas, Guilaine K. Boyce, Ebrima Gibbs, Catherine M. Cowan, Megan Gilmour, Wai Hang Cheng, Sonja K. Soo, Brian Yuen, Arvin Bahrabadi, Kevin Kang, Iva Kulic, Gordon Francis, Neil Cashman, Cheryl L. Wellington

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A

Katarina Willén, James R. Edgar, Takafumi Hasegawa, Nobuyuki Tanaka, Clare E. Futter, Gunnar K. Gouras

01.12.2017 | Short report | Ausgabe 1/2017 Open Access

Lysosomal processing of progranulin

Xiaolai Zhou, Daniel H. Paushter, Tuancheng Feng, Lirong Sun, Thomas Reinheckel, Fenghua Hu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome

Harutsugu Tatebe, Takashi Kasai, Takuma Ohmichi, Yusuke Kishi, Tomoshi Kakeya, Masaaki Waragai, Masaki Kondo, David Allsop, Takahiko Tokuda

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition

Carolyn Hollands, Matthew Kyle Tobin, Michael Hsu, Kianna Musaraca, Tzong-Shiue Yu, Rachana Mishra, Steven G. Kernie, Orly Lazarov

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

Rebecca San Gil, Lezanne Ooi, Justin J. Yerbury, Heath Ecroyd

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

Michael X. Hernandez, Shan Jiang, Tracy A. Cole, Shu-Hui Chu, Maria I. Fonseca, Melody J. Fang, Lindsay A. Hohsfield, Maria D. Torres, Kim N. Green, Rick A. Wetsel, Ali Mortazavi, Andrea J. Tenner

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Whole blood gene expression and white matter Hyperintensities

Honghuang Lin, Claudia Satizabal, Zhijun Xie, Qiong Yang, Tianxiao Huan, Roby Joehanes, Chengping Wen, Peter J. Munson, Alexa Beiser, Daniel Levy, Sudha Seshadri

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa

Huan Yang, Yingmei Fu, Xinying Liu, Pawan K. Shahi, Timur A. Mavlyutov, Jun Li, Annie Yao, Steven Z.-W. Guo, Bikash R. Pattnaik, Lian-Wang Guo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Blood hemoglobin A1c levels and amyotrophic lateral sclerosis survival

Qian-Qian Wei, Yongping Chen, Bei Cao, Ru Wei Ou, Lingyu Zhang, Yanbing Hou, Xiang Gao, Huifang Shang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Hexokinases link DJ-1 to the PINK1/parkin pathway

David N. Hauser, Adamantios Mamais, Melissa M. Conti, Christopher T. Primiani, Ravindran Kumaran, Allissa A. Dillman, Rebekah G. Langston, Alexandra Beilina, Joseph H. Garcia, Alberto Diaz-Ruiz, Michel Bernier, Fabienne C. Fiesel, Xu Hou, Wolfdieter Springer, Yan Li, Rafael de Cabo, Mark R. Cookson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury

Stephanie B. Syc-Mazurek, Kimberly A. Fernandes, Michael P. Wilson, Peter Shrager, Richard T. Libby

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

Ghazaleh Eskandari-Sedighi, Nathalie Daude, Hristina Gapeshina, David W. Sanders, Razieh Kamali-Jamil, Jing Yang, Beipei Shi, Holger Wille, Bernardino Ghetti, Marc I. Diamond, Christopher Janus, David Westaway

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Gad67 haploinsufficiency reduces amyloid pathology and rescues olfactory memory deficits in a mouse model of Alzheimer’s disease

Yue Wang, Zheng Wu, Yu-Ting Bai, Gang-Yi Wu, Gong Chen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

Shane M. Bemiller, Tyler J. McCray, Kevin Allan, Shane V. Formica, Guixiang Xu, Gina Wilson, Olga N. Kokiko-Cochran, Samuel D. Crish, Cristian A. Lasagna-Reeves, Richard M. Ransohoff, Gary E. Landreth, Bruce T. Lamb

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases

Zhi Dong Zhou, Eng-King Tan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients

Csaba Konrad, Hibiki Kawamata, Kirsten G. Bredvik, Andrea J. Arreguin, Steven A. Cajamarca, Jonathan C. Hupf, John M. Ravits, Timothy M. Miller, Nicholas J. Maragakis, Chadwick M. Hales, Jonathan D. Glass, Steven Gross, Hiroshi Mitsumoto, Giovanni Manfredi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture

Laura C. Graham, Samantha L. Eaton, Paula J. Brunton, Abdelmadjid Atrih, Colin Smith, Douglas J. Lamont, Thomas H. Gillingwater, Giuseppa Pennetta, Paul Skehel, Thomas M. Wishart

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases

Annika Sommer, Beate Winner, Iryna Prots

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

Mang Ching Lai, Anne-Laure Bechy, Franziska Denk, Emma Collins, Maria Gavriliouk, Judith B. Zaugg, Brent J. Ryan, Richard Wade-Martins, Tara M. Caffrey

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity

Wojciech Bobela, Sameer Nazeeruddin, Graham Knott, Patrick Aebischer, Bernard L. Schneider

01.12.2017 | Correction | Ausgabe 1/2017 Open Access

Correction to: Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice

Anna K. Engstrom, Jessica M. Snyder, Nobuyo Maeda, Zhengui Xia

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

Andrew T. McKenzie, Sarah Moyon, Minghui Wang, Igor Katsyv, Won-Min Song, Xianxiao Zhou, Eric B. Dammer, Duc M. Duong, Joshua Aaker, Yongzhong Zhao, Noam Beckmann, Pei Wang, Jun Zhu, James J. Lah, Nicholas T. Seyfried, Allan I. Levey, Pavel Katsel, Vahram Haroutunian, Eric E. Schadt, Brian Popko, Patrizia Casaccia, Bin Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

Franc Llorens, Katrin Thüne, Waqas Tahir, Eirini Kanata, Daniela Diaz-Lucena, Konstantinos Xanthopoulos, Eleni Kovatsi, Catharina Pleschka, Paula Garcia-Esparcia, Matthias Schmitz, Duru Ozbay, Susana Correia, Ângela Correia, Ira Milosevic, Olivier Andréoletti, Natalia Fernández-Borges, Ina M. Vorberg, Markus Glatzel, Theodoros Sklaviadis, Juan Maria Torres, Susanne Krasemann, Raquel Sánchez-Valle, Isidro Ferrer, Inga Zerr

01.12.2017 | Review | Ausgabe 1/2017 Open Access

NADPH oxidases in Parkinson’s disease: a systematic review

Karim Belarbi, Elodie Cuvelier, Alain Destée, Bernard Gressier, Marie-Christine Chartier-Harlin

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis

Yuri Ciervo, Ke Ning, Xu Jun, Pamela J. Shaw, Richard J. Mead

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

Yang Bai, Miao Li, Yanmei Zhou, Lei Ma, Qian Qiao, Wanling Hu, Wei Li, Zachary Patrick Wills, Wen-Biao Gan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A validated antibody panel for the characterization of tau post-translational modifications

Ebru Ercan, Sameh Eid, Christian Weber, Alexandra Kowalski, Maria Bichmann, Annika Behrendt, Frank Matthes, Sybille Krauss, Peter Reinhardt, Simone Fulle, Dagmar E. Ehrnhoefer

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Anti-aggregant tau mutant promotes neurogenesis

Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow, Eva-Maria Mandelkow

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Practical considerations for choosing a mouse model of Alzheimer’s disease

Joanna L. Jankowsky, Hui Zheng

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?

Zhiqiang Deng, Patricia Sheehan, Shi Chen, Zhenyu Yue

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