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Molecular Neurodegeneration

Ausgabe 1/2017

Inhalt (90 Artikel)

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice

  • Open Access
  • Research article

Emily J. Koller, Mieu M. T. Brooks, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

  • Open Access
  • Research article

Eiichi Tokuda, Itsuki Anzai, Takao Nomura, Keisuke Toichi, Masahiko Watanabe, Shinji Ohara, Seiji Watanabe, Koji Yamanaka, Yuta Morisaki, Hidemi Misawa, Yoshiaki Furukawa

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

  • Open Access
  • Erratum

Thiyagaragan M. Achariyar, Baoman Li, Weiguo Peng, Philip B. Verghese, Yang Shi, Evan McConnell, Abdellatif Benraiss, Tristan Kasper, Wei Song, Takahiro Takano, David M. Holtzman, Maiken Nedergaard, Rashid Deane

Erratum to: The impact of glutamine supplementation on the symptoms of ataxia-telangiectasia: a preclinical assessment

  • Open Access
  • Erratum

Jianmin Chen, Yanping Chen, Graham Vail, Heiman Chow, Yang Zhang, Lauren Louie, Jiali Li, Ronald P. Hart, Mark R. Plummer, Karl Herrup

The release and trans-synaptic transmission of Tau via exosomes

  • Open Access
  • Research article

Yipeng Wang, Varun Balaji, Senthilvelrajan Kaniyappan, Lars Krüger, Stephan Irsen, Katharina Tepper, RamReddy Chandupatla, Walter Maetzler, Anja Schneider, Eckhard Mandelkow, Eva-Maria Mandelkow

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration

  • Open Access
  • Research article

Yu Ohki, Andrea Wenninger-Weinzierl, Alexander Hruscha, Kazuhide Asakawa, Koichi Kawakami, Christian Haass, Dieter Edbauer, Bettina Schmid

NADPH oxidase in brain injury and neurodegenerative disorders

  • Open Access
  • Review

Merry W. Ma, Jing Wang, Quanguang Zhang, Ruimin Wang, Krishnan M. Dhandapani, Ratna K. Vadlamudi, Darrell W. Brann

GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord

  • Open Access
  • Research article

Clinton Cave, Sungjin Park, Marianeli Rodriguez, Mai Nakamura, Ahmet Hoke, Mikhail Pletnikov, Shanthini Sockanathan

Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling

  • Open Access
  • Research article

Daniel C. Berwick, Behzad Javaheri, Andrea Wetzel, Mark Hopkinson, Jonathon Nixon-Abell, Simone Grannò, Andrew A. Pitsillides, Kirsten Harvey

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

  • Open Access
  • Review

Helena Xicoy, Bé Wieringa, Gerard J.M. Martens

Therapeutic potential of autophagy-enhancing agents in Parkinson’s disease

  • Open Access
  • Review

Tim E. Moors, Jeroen J. M. Hoozemans, Angela Ingrassia, Tommaso Beccari, Lucilla Parnetti, Marie-Christine Chartier-Harlin, Wilma D. J. van de Berg

APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice

  • Open Access
  • Research article

Joanna E Pankiewicz, Jairo Baquero-Buitrago, Sandrine Sanchez, Jennifer Lopez-Contreras, Jungsu Kim, Patrick M. Sullivan, David M. Holtzman, Martin J. Sadowski

Tdp-43 cryptic exons are highly variable between cell types

  • Open Access
  • Research article

Yun Ha Jeong, Jonathan P. Ling, Sophie Z. Lin, Aneesh N. Donde, Kerstin E. Braunstein, Elisa Majounie, Bryan J. Traynor, Katherine D. LaClair, Thomas E. Lloyd, Philip C. Wong

Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice

  • Open Access
  • Research article

Anna K. Engstrom, Jessica M. Snyder, Nobuyo Maeda, Zhengui Xia

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

  • Open Access
  • Research article

Katarzyna Marta Zoltowska, Masato Maesako, Iryna Lushnikova, Shuko Takeda, Laura J. Keller, Galina Skibo, Bradley T. Hyman, Oksana Berezovska

Transient IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration

  • Open Access
  • Research article

Michael Lattke, Stephanie N. Reichel, Alexander Magnutzki, Alireza Abaei, Volker Rasche, Paul Walther, Dinis P. Calado, Boris Ferger, Thomas Wirth, Bernd Baumann

Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice

  • Open Access
  • Research article

Gunjan Dhawan Manocha, Angela Marie Floden, Kendra Lynn Puig, Kumi Nagamoto-Combs, Clemens R. Scherzer, Colin Kelly Combs

Ex vivo 18O-labeling mass spectrometry identifies a peripheral amyloid β clearance pathway

  • Open Access
  • Research article

Erik Portelius, Niklas Mattsson, Josef Pannee, Henrik Zetterberg, Magnus Gisslén, Hugo Vanderstichele, Eleni Gkanatsiou, Gabriela A. N. Crespi, Michael W. Parker, Luke A. Miles, Johan Gobom, Kaj Blennow

Tau PET imaging: present and future directions

  • Open Access
  • Review

Laure Saint-Aubert, Laetitia Lemoine, Konstantinos Chiotis, Antoine Leuzy, Elena Rodriguez-Vieitez, Agneta Nordberg

Tissue-type plasminogen activator exerts EGF-like chemokinetic effects on oligodendrocytes in white matter (re)myelination

  • Open Access
  • Research article

Camille Leonetti, Richard Macrez, Mathilde Pruvost, Yannick Hommet, Jérémie Bronsard, Antoine Fournier, Maxime Perrigault, Isabel Machin, Denis Vivien, Diego Clemente, Fernando De Castro, Eric Maubert, Fabian Docagne

Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

  • Open Access
  • Research article

Tobias Engel, Jaime Martinez-Villarreal, Christine Henke, Eva M. Jimenez-Mateos, Amaya Sanz-Rodriguez, Mariana Alves, Yasmina Hernandez-Santana, Gary P. Brennan, Aidan Kenny, Aoife Campbell, Jose J. Lucas, David C. Henshall

Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice

  • Open Access
  • Research article

Prateep Pakavathkumar, Anastasia Noël, Clotilde Lecrux, Agne Tubeleviciute-Aydin, Edith Hamel, Jan-Eric Ahlfors, Andrea C. LeBlanc

Increased acetylation of Peroxiredoxin1 by HDAC6 inhibition leads to recovery of Aβ-induced impaired axonal transport

  • Open Access
  • Research article

Heesun Choi, Haeng Jun Kim, Jisoo Kim, Soohyun Kim, Jinhee Yang, Wonik Lee, Yeonju Park, Seung Jae Hyeon, Dong-Sup Lee, Hoon Ryu, Junho Chung, Inhee Mook-Jung

Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly

  • Open Access
  • Research article

Chaoran Ma, Zhaoxue Yin, Pengfei Zhu, Jiesi Luo, Xiaoming Shi, Xiang Gao

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments

  • Open Access
  • Research article

Francesc X. Guix, Ragna Sannerud, Fedor Berditchevski, Amaia M. Arranz, Katrien Horré, An Snellinx, Amantha Thathiah, Takaomi Saido, Takashi Saito, Sundaresan Rajesh, Michael Overduin, Samir Kumar-Singh, Enrico Radaelli, Nikky Corthout, Julien Colombelli, Sébastien Tosi, Sebastian Munck, Isabel H. Salas, Wim Annaert, Bart De Strooper

Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample

  • Open Access
  • Research article

Alfredo Ramos-Miguel, Jesús A. García-Sevilla, Alasdair M. Barr, Thomas A. Bayer, Peter Falkai, Sue E. Leurgans, Julie A. Schneider, David A. Bennett, William G. Honer, M. Julia García-Fuster

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

  • Open Access
  • Research article

Michal Arbel-Ornath, Eloise Hudry, Josiah R. Boivin, Tadafumi Hashimoto, Shuko Takeda, Kishore V. Kuchibhotla, Steven Hou, Carli R. Lattarulo, Arianna M. Belcher, Naomi Shakerdge, Pariss B. Trujillo, Alona Muzikansky, Rebecca A. Betensky, Bradley T. Hyman, Brian J. Bacskai

Separation of photoreceptor cell compartments in mouse retina for protein analysis

  • Open Access
  • Methodology

Kasey Rose, Steven T. Walston, Jeannie Chen

Quantitative proteomic analysis of Parkin substrates in Drosophila neurons

  • Open Access
  • Research article

Aitor Martinez, Benoit Lectez, Juanma Ramirez, Oliver Popp, James D. Sutherland, Sylvie Urbé, Gunnar Dittmar, Michael J. Clague, Ugo Mayor

Amelioration of amyloid-β-induced deficits by DcR3 in an Alzheimer’s disease model

  • Open Access
  • Research article

Yi-Ling Liu, Wei-Ting Chen, Yu-Yi Lin, Po-Hung Lu, Shie-Liang Hsieh, Irene Han-Juo Cheng

Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration

  • Open Access
  • Research article

Riccardo Natoli, Nilisha Fernando, Michele Madigan, Joshua A. Chu-Tan, Krisztina Valter, Jan Provis, Matt Rutar

The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity

  • Open Access
  • Research article

Maya Ando, Fabienne C. Fiesel, Roman Hudec, Thomas R. Caulfield, Kotaro Ogaki, Paulina Górka-Skoczylas, Dariusz Koziorowski, Andrzej Friedman, Li Chen, Valina L. Dawson, Ted M. Dawson, Guojun Bu, Owen A. Ross, Zbigniew K. Wszolek, Wolfdieter Springer

Humanized monoclonal antibody armanezumab specific to N-terminus of pathological tau: characterization and therapeutic potency

  • Open Access
  • Research article

Michael G. Agadjanyan, Karen Zagorski, Irina Petrushina, Hayk Davtyan, Konstantin Kazarian, Maxim Antonenko, Joy Davis, Charles Bon, Mathew Blurton-Jones, David H. Cribbs, Anahit Ghochikyan

Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model

  • Open Access
  • Research article

Gao-Shang Chai, Qiong Feng, Zhi-Hao Wang, Yu Hu, Dong-Sheng Sun, Xiao-Guang Li, Dan Ke, Hong-Lian Li, Gong-Ping Liu, Jian-Zhi Wang

Dioxins and related environmental contaminants increase TDP-43 levels

  • Open Access
  • Research article

Peter E. A. Ash, Elizabeth A. Stanford, Ali Al Abdulatif, Alejandra Ramirez-Cardenas, Heather I. Ballance, Samantha Boudeau, Amanda Jeh, James M. Murithi, Yorghos Tripodis, George J. Murphy, David H. Sherr, Benjamin Wolozin

Diurnal oscillation of CSF Aβ and other AD biomarkers

  • Open Access
  • Commentary

Brendan P. Lucey, Anne M. Fagan, David M. Holtzman, John C. Morris, Randall J. Bateman

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

  • Open Access
  • Research article

Hibiki Kawamata, Pablo Peixoto, Csaba Konrad, Gloria Palomo, Kirsten Bredvik, Meri Gerges, Federica Valsecchi, Leonard Petrucelli, John M. Ravits, Anatoly Starkov, Giovanni Manfredi

Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129

  • Open Access
  • Methodology

Wen-Bo Zeng, Hai-Fei Jiang, Ya-Dong Gang, Yi-Ge Song, Zhang-Zhou Shen, Hong Yang, Xiao Dong, Yong-Lu Tian, Rong-Jun Ni, Yaping Liu, Na Tang, Xinyan Li, Xuan Jiang, Ding Gao, Michelle Androulakis, Xiao-Bin He, Hui-Min Xia, Ying-Zi Ming, Youming Lu, Jiang-Ning Zhou, Chen Zhang, Xue-Shan Xia, Yousheng Shu, Shao-Qun Zeng, Fuqiang Xu, Fei Zhao, Min-Hua Luo

Inhibition of O-GlcNAcase leads to elevation of O-GlcNAc tau and reduction of tauopathy and cerebrospinal fluid tau in rTg4510 mice

  • Open Access
  • Research article

Nicholas B. Hastings, Xiaohai Wang, Lixin Song, Brent D. Butts, Diane Grotz, Richard Hargreaves, J. Fred Hess, Kwok-Lam Karen Hong, Cathy Ruey-Ruey Huang, Lynn Hyde, Maureen Laverty, Julie Lee, Diane Levitan, Sherry X. Lu, Maureen Maguire, Veeravan Mahadomrongkul, Ernest J. McEachern, Xuesong Ouyang, Thomas W. Rosahl, Harold Selnick, Michaela Stanton, Giuseppe Terracina, David J. Vocadlo, Ganfeng Wang, Joseph L. Duffy, Eric M. Parker, Lili Zhang

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

  • Open Access
  • Research article

Zachary A. Sorrentino, Mieu M.T. Brooks, Vincent Hudson III, Nicola J. Rutherford, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty

Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

  • Open Access
  • Research article

Takashi Miyamoto, Liana Stein, Reuben Thomas, Biljana Djukic, Praveen Taneja, Joseph Knox, Keith Vossel, Lennart Mucke

Endoplasmic reticulum stress and inflammation in the central nervous system

  • Open Access
  • Review

Neil T. Sprenkle, Savannah G. Sims, Cristina L. Sánchez, Gordon P. Meares

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

  • Open Access
  • Review

Anastasia G. Efthymiou, Alison M. Goate

Autoimmune antibody decline in Parkinson’s disease and Multiple System Atrophy; a step towards immunotherapeutic strategies

  • Open Access
  • Research article

Tomasz Brudek, Kristian Winge, Jonas Folke, Søren Christensen, Karina Fog, Bente Pakkenberg, Lars Østergaard Pedersen

Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease

  • Open Access
  • Review

James A. Duce, Bruce X. Wong, Hannah Durham, Jean-Christophe Devedjian, David P. Smith, David Devos

A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

  • Open Access
  • Research article

Rustam Esanov, Gabriela Toro Cabrera, Nadja S. Andrade, Tania F. Gendron, Robert H. Brown Jr., Michael Benatar, Claes Wahlestedt, Christian Mueller, Zane Zeier

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

  • Open Access
  • Research article

Ruohe Zhao, Wanling Hu, Julia Tsai, Wei Li, Wen-Biao Gan

Presenilins regulate synaptic plasticity and mitochondrial calcium homeostasis in the hippocampal mossy fiber pathway

  • Open Access
  • Research article

Sang Hun Lee, David Lutz, Mohanad Mossalam, Vadim Y. Bolshakov, Michael Frotscher, Jie Shen

Targeting psychologic stress signaling pathways in Alzheimer’s disease

  • Open Access
  • Review

Hunter S. Futch, Cara L. Croft, Van Q. Truong, Eric G. Krause, Todd E. Golde

Glial contributions to neurodegeneration in tauopathies

  • Open Access
  • Review

Cheryl E. G. Leyns, David M. Holtzman

Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer’s disease

  • Open Access
  • Research article

Ellis Patrick, Sathyapriya Rajagopal, Hon-Kit Andus Wong, Cristin McCabe, Jishu Xu, Anna Tang, Selina H. Imboywa, Julie A. Schneider, Nathalie Pochet, Anna M. Krichevsky, Lori B. Chibnik, David A. Bennett, Philip L. De Jager

Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy

  • Open Access
  • Research article

Serena Venezia, Violetta Refolo, Alexia Polissidis, Leonidas Stefanis, Gregor K. Wenning, Nadia Stefanova

TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

  • Open Access
  • Research article

Anthony Bosson, Adrien Paumier, Sylvie Boisseau, Muriel Jacquier-Sarlin, Alain Buisson, Mireille Albrieux

A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway

  • Open Access
  • Research article

Alena Salašová, Chika Yokota, David Potěšil, Zbyněk Zdráhal, Vítězslav Bryja, Ernest Arenas

The lysosomal protein cathepsin L is a progranulin protease

  • Open Access
  • Short report

Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, Casey N. Cook, Ying-Wai Lam, Sandra Almeida, Yari Carlomagno, Kwok-Fai Lau, Mercedes Prudencio, Fen-Biao Gao, Matthew Bogyo, Dennis W. Dickson, Leonard Petrucelli

TREM2 in Neurodegenerative Diseases

  • Open Access
  • Review

Taylor R. Jay, Victoria E. von Saucken, Gary E. Landreth

Intranasal insulin reverts central pathology and cognitive impairment in diabetic mother offspring

  • Open Access
  • Research article

Juan Jose Ramos-Rodriguez, Daniel Sanchez-Sotano, Alberto Doblas-Marquez, Carmen Infante-Garcia, Simon Lubian-Lopez, Monica Garcia-Alloza

Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease

  • Open Access
  • Research article

Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis, Adriana Di Polo

Absence of CX3CR1 impairs the internalization of Tau by microglia

  • Open Access
  • Research article

Marta Bolós, María Llorens-Martín, Juan Ramón Perea, Jerónimo Jurado-Arjona, Alberto Rábano, Félix Hernández, Jesús Avila

High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture

  • Open Access
  • Research article

Jérôme Robert, Emily B. Button, Sophie Stukas, Guilaine K. Boyce, Ebrima Gibbs, Catherine M. Cowan, Megan Gilmour, Wai Hang Cheng, Sonja K. Soo, Brian Yuen, Arvin Bahrabadi, Kevin Kang, Iva Kulic, Gordon Francis, Neil Cashman, Cheryl L. Wellington

Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A

  • Open Access
  • Research article

Katarina Willén, James R. Edgar, Takafumi Hasegawa, Nobuyuki Tanaka, Clare E. Futter, Gunnar K. Gouras

Lysosomal processing of progranulin

  • Open Access
  • Short report

Xiaolai Zhou, Daniel H. Paushter, Tuancheng Feng, Lirong Sun, Thomas Reinheckel, Fenghua Hu

Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer’s disease and down syndrome

  • Open Access
  • Research article

Harutsugu Tatebe, Takashi Kasai, Takuma Ohmichi, Yusuke Kishi, Tomoshi Kakeya, Masaaki Waragai, Masaki Kondo, David Allsop, Takahiko Tokuda

Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer’s disease by compromising hippocampal inhibition

  • Open Access
  • Research article

Carolyn Hollands, Matthew Kyle Tobin, Michael Hsu, Kianna Musaraca, Tzong-Shiue Yu, Rachana Mishra, Steven G. Kernie, Orly Lazarov

The heat shock response in neurons and astroglia and its role in neurodegenerative diseases

  • Open Access
  • Review

Rebecca San Gil, Lezanne Ooi, Justin J. Yerbury, Heath Ecroyd

Prevention of C5aR1 signaling delays microglial inflammatory polarization, favors clearance pathways and suppresses cognitive loss

  • Open Access
  • Research article

Michael X. Hernandez, Shan Jiang, Tracy A. Cole, Shu-Hui Chu, Maria I. Fonseca, Melody J. Fang, Lindsay A. Hohsfield, Maria D. Torres, Kim N. Green, Rick A. Wetsel, Ali Mortazavi, Andrea J. Tenner

Whole blood gene expression and white matter Hyperintensities

  • Open Access
  • Research article

Honghuang Lin, Claudia Satizabal, Zhijun Xie, Qiong Yang, Tianxiao Huan, Roby Joehanes, Chengping Wen, Peter J. Munson, Alexa Beiser, Daniel Levy, Sudha Seshadri

Role of the sigma-1 receptor chaperone in rod and cone photoreceptor degenerations in a mouse model of retinitis pigmentosa

  • Open Access
  • Research article

Huan Yang, Yingmei Fu, Xinying Liu, Pawan K. Shahi, Timur A. Mavlyutov, Jun Li, Annie Yao, Steven Z.-W. Guo, Bikash R. Pattnaik, Lian-Wang Guo

Blood hemoglobin A1c levels and amyotrophic lateral sclerosis survival

  • Open Access
  • Research article

Qian-Qian Wei, Yongping Chen, Bei Cao, Ru Wei Ou, Lingyu Zhang, Yanbing Hou, Xiang Gao, Huifang Shang

Hexokinases link DJ-1 to the PINK1/parkin pathway

  • Open Access
  • Research article

David N. Hauser, Adamantios Mamais, Melissa M. Conti, Christopher T. Primiani, Ravindran Kumaran, Allissa A. Dillman, Rebekah G. Langston, Alexandra Beilina, Joseph H. Garcia, Alberto Diaz-Ruiz, Michel Bernier, Fabienne C. Fiesel, Xu Hou, Wolfdieter Springer, Yan Li, Rafael de Cabo, Mark R. Cookson

Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury

  • Open Access
  • Research article

Stephanie B. Syc-Mazurek, Kimberly A. Fernandes, Michael P. Wilson, Peter Shrager, Richard T. Libby

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

  • Open Access
  • Research article

Ghazaleh Eskandari-Sedighi, Nathalie Daude, Hristina Gapeshina, David W. Sanders, Razieh Kamali-Jamil, Jing Yang, Beipei Shi, Holger Wille, Bernardino Ghetti, Marc I. Diamond, Christopher Janus, David Westaway

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

  • Open Access
  • Research article

Shane M. Bemiller, Tyler J. McCray, Kevin Allan, Shane V. Formica, Guixiang Xu, Gina Wilson, Olga N. Kokiko-Cochran, Samuel D. Crish, Cristian A. Lasagna-Reeves, Richard M. Ransohoff, Gary E. Landreth, Bruce T. Lamb

Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients

  • Open Access
  • Research article

Csaba Konrad, Hibiki Kawamata, Kirsten G. Bredvik, Andrea J. Arreguin, Steven A. Cajamarca, Jonathan C. Hupf, John M. Ravits, Timothy M. Miller, Nicholas J. Maragakis, Chadwick M. Hales, Jonathan D. Glass, Steven Gross, Hiroshi Mitsumoto, Giovanni Manfredi

Proteomic profiling of neuronal mitochondria reveals modulators of synaptic architecture

  • Open Access
  • Research article

Laura C. Graham, Samantha L. Eaton, Paula J. Brunton, Abdelmadjid Atrih, Colin Smith, Douglas J. Lamont, Thomas H. Gillingwater, Giuseppa Pennetta, Paul Skehel, Thomas M. Wishart

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases

  • Open Access
  • Review

Annika Sommer, Beate Winner, Iryna Prots

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

  • Open Access
  • Research article

Mang Ching Lai, Anne-Laure Bechy, Franziska Denk, Emma Collins, Maria Gavriliouk, Judith B. Zaugg, Brent J. Ryan, Richard Wade-Martins, Tara M. Caffrey

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity

  • Open Access
  • Research article

Wojciech Bobela, Sameer Nazeeruddin, Graham Knott, Patrick Aebischer, Bernard L. Schneider

Correction to: Gene-environment interaction between lead and Apolipoprotein E4 causes cognitive behavior deficits in mice

  • Open Access
  • Correction

Anna K. Engstrom, Jessica M. Snyder, Nobuyo Maeda, Zhengui Xia

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

  • Open Access
  • Research article

Andrew T. McKenzie, Sarah Moyon, Minghui Wang, Igor Katsyv, Won-Min Song, Xianxiao Zhou, Eric B. Dammer, Duc M. Duong, Joshua Aaker, Yongzhong Zhao, Noam Beckmann, Pei Wang, Jun Zhu, James J. Lah, Nicholas T. Seyfried, Allan I. Levey, Pavel Katsel, Vahram Haroutunian, Eric E. Schadt, Brian Popko, Patrizia Casaccia, Bin Zhang

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

  • Open Access
  • Research article

Franc Llorens, Katrin Thüne, Waqas Tahir, Eirini Kanata, Daniela Diaz-Lucena, Konstantinos Xanthopoulos, Eleni Kovatsi, Catharina Pleschka, Paula Garcia-Esparcia, Matthias Schmitz, Duru Ozbay, Susana Correia, Ângela Correia, Ira Milosevic, Olivier Andréoletti, Natalia Fernández-Borges, Ina M. Vorberg, Markus Glatzel, Theodoros Sklaviadis, Juan Maria Torres, Susanne Krasemann, Raquel Sánchez-Valle, Isidro Ferrer, Inga Zerr

NADPH oxidases in Parkinson’s disease: a systematic review

  • Open Access
  • Review

Karim Belarbi, Elodie Cuvelier, Alain Destée, Bernard Gressier, Marie-Christine Chartier-Harlin

Advances, challenges and future directions for stem cell therapy in amyotrophic lateral sclerosis

  • Open Access
  • Review

Yuri Ciervo, Ke Ning, Xu Jun, Pamela J. Shaw, Richard J. Mead

Abnormal dendritic calcium activity and synaptic depotentiation occur early in a mouse model of Alzheimer’s disease

  • Open Access
  • Research article

Yang Bai, Miao Li, Yanmei Zhou, Lei Ma, Qian Qiao, Wanling Hu, Wei Li, Zachary Patrick Wills, Wen-Biao Gan

A validated antibody panel for the characterization of tau post-translational modifications

  • Open Access
  • Research article

Ebru Ercan, Sameh Eid, Christian Weber, Alexandra Kowalski, Maria Bichmann, Annika Behrendt, Frank Matthes, Sybille Krauss, Peter Reinhardt, Simone Fulle, Dagmar E. Ehrnhoefer

Anti-aggregant tau mutant promotes neurogenesis

  • Open Access
  • Research article

Maria Joseph, Marta Anglada-Huguet, Katharina Paesler, Eckhard Mandelkow, Eva-Maria Mandelkow

Practical considerations for choosing a mouse model of Alzheimer’s disease

  • Open Access
  • Review

Joanna L. Jankowsky, Hui Zheng

Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?

  • Open Access
  • Review

Zhiqiang Deng, Patricia Sheehan, Shi Chen, Zhenyu Yue

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Wie sehr Menschen mit Parkinson von körperlicher Aktivität, mediterraner Ernährung und Entspannungsübungen profitieren, zeigt ein Review im Fachblatt „Lancet“. Betroffene können mit entsprechenden Maßnahmen eine deutlich verbesserte Lebensqualität erreichen.

RNA-basierte CAR-T-Zell-Therapie hält Myasthenie in Schach

Eine gegen BCMA gerichtete Therapie mit CAR-T-Zellen kann eine schwere Myasthenia gravis über ein Jahr hinweg gut kontrollieren. Der RNA-basierte Ansatz verursacht zudem kaum Nebenwirkungen, erfordert aber sechs wöchentliche Infusionen.

Demenzrisiko: Keine Angst vor fettem Käse!

  • 14.01.2026
  • Demenz
  • Nachrichten

Wer sich täglich ein Stück fetten Käse gönnt oder auf fette Sahne schwört, darf sich über ein vermindertes Demenzrisiko freuen. Dass Milchfett vor Demenz schützt, lässt sich daraus allerdings nicht unbedingt schließen.

Update Neurologie

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Bildnachweise
Die Leitlinien für Ärztinnen und Ärzte, Untersuchung eines adipösen Kindes/© Colourbox (Symbolbild mit Fotomodell), Senior mit Parkinson hält den Löffel mit zwei Händen/© MarianVejcik / Getty Images / iStock (Symbolbild mit Fotomodell), Störung der Lidhebung bei Myasthenia gravis/© Alessandro Grandini / stock.adobe.com (Symbolbild mit Fotomodell), Person hält ein Glas Milch in beiden Händen/© Africa Studio / stock.adobe.com (Symbolbild mit Fotomodell)