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Molecular Neurodegeneration

Ausgabe 1/2019

Inhalt (50 Artikel)

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

  • Open Access
  • Research article

Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Michael Ewers, Christian Haass

Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

  • Open Access
  • Research article

Luxi Wang, Sofia Pavlou, Xuan Du, Mohajeet Bhuckory, Heping Xu, Mei Chen

Emerging new roles of the lysosome and neuronal ceroid lipofuscinoses

  • Open Access
  • Review

Anil B. Mukherjee, Abhilash P. Appu, Tamal Sadhukhan, Sydney Casey, Avisek Mondal, Zhongjian Zhang, Maria B. Bagh

Dementia with Lewy bodies: an update and outlook

  • Open Access
  • Review

Tiago Fleming Outeiro, David J. Koss, Daniel Erskine, Lauren Walker, Marzena Kurzawa-Akanbi, David Burn, Paul Donaghy, Christopher Morris, John-Paul Taylor, Alan Thomas, Johannes Attems, Ian McKeith

Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

  • Open Access
  • Research article

Pete A. Williams, Catherine E. Braine, Krishnakumar Kizhatil, Nicole E. Foxworth, Nicholas G. Tolman, Jeffrey M. Harder, Rebecca A. Scott, Gregory L. Sousa, Alyssa Panitch, Gareth R. Howell, Simon W. M. John

Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease

  • Open Access
  • Research article

Shreaya Chakroborty, Evan S. Hill, Daniel T. Christian, Rosalind Helfrich, Shannon Riley, Corinne Schneider, Nicolas Kapecki, Sarah Mustaly-Kalimi, Figen A. Seiler, Daniel A. Peterson, Anthony R. West, Barbara M. Vertel, William N. Frost, Grace E. Stutzmann

Differences in neurotropism and neurotoxicity among retrograde viral tracers

  • Open Access
  • Methodology

Leqiang Sun, Yajie Tang, Keji Yan, Jinsong Yu, Yanyan Zou, Weize Xu, Ke Xiao, Zhihui Zhang, Weiming Li, Beili Wu, Zhe Hu, Kening Chen, Zhen F. Fu, Jinxia Dai, Gang Cao

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

  • Open Access
  • Research article

Jeannie Chew, Casey Cook, Tania F. Gendron, Karen Jansen-West, Giulia del Rosso, Lillian M. Daughrity, Monica Castanedes-Casey, Aishe Kurti, Jeannette N. Stankowski, Matthew D. Disney, Jeffrey D. Rothstein, Dennis W. Dickson, John D. Fryer, Yong-Jie Zhang, Leonard Petrucelli

Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau

  • Open Access
  • Research article

Korey Kam, Ankit Parekh, Ram A. Sharma, Andreia Andrade, Monica Lewin, Bresne Castillo, Omonigho M. Bubu, Nicholas J. Chua, Margo D. Miller, Anna E. Mullins, Lidia Glodzik, Lisa Mosconi, Nadia Gosselin, Kulkarni Prathamesh, Zhe Chen, Kaj Blennow, Henrik Zetterberg, Nisha Bagchi, Bianca Cavedoni, David M. Rapoport, Indu Ayappa, Mony J. de Leon, Eva Petkova, Andrew W. Varga, Ricardo S. Osorio

Dural lymphatics regulate clearance of extracellular tau from the CNS

  • Open Access
  • Research article

Tirth K. Patel, LeMoyne Habimana-Griffin, Xuefeng Gao, Baogang Xu, Samuel Achilefu, Kari Alitalo, Celia A. McKee, Patrick W. Sheehan, Erik S. Musiek, Chengjie Xiong, Dean Coble, David M. Holtzman

Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice

  • Open Access
  • Research article

Saumi Mathews, Amanda Branch Woods, Ikumi Katano, Edward Makarov, Midhun B. Thomas, Howard E. Gendelman, Larisa Y. Poluektova, Mamoru Ito, Santhi Gorantla

Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer’s disease mouse model

  • Open Access
  • Research article

Claudia Green, Astrid Sydow, Stefanie Vogel, Marta Anglada-Huguet, Dirk Wiedermann, Eckhard Mandelkow, Eva-Maria Mandelkow, Mathias Hoehn

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis

  • Open Access
  • Research article

S. Beltran, M. Nassif, E. Vicencio, J. Arcos, L. Labrador, B. I. Cortes, C. Cortez, C. A. Bergmann, S. Espinoza, M. F. Hernandez, J. M. Matamala, L. Bargsted, S. Matus, D. Rojas-Rivera, M. J. M. Bertrand, D. B. Medinas, C. Hetz, P. A. Manque, U. Woehlbier

Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

  • Open Access
  • Research article

Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsubo

Glial phagocytic clearance in Parkinson’s disease

  • Open Access
  • Review

Marie-Eve Tremblay, Mark R. Cookson, Laura Civiero

A CRISPR monkey model unravels a unique function of PINK1 in primate brains

  • Open Access
  • Commentary

Weili Yang, Shihua Li, Xiao-Jiang Li

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

  • Open Access
  • Research article

Jorge L. Del-Aguila, Bruno A. Benitez, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Fabiana H. G. Farias, Maria Victoria Fernández, Laura Ibanez, Shan Jiang, Richard J. Perrin, Nigel J. Cairns, John C. Morris, Oscar Harari, Carlos Cruchaga

Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

  • Open Access
  • Review

Zoë P. Van Acker, Marine Bretou, Wim Annaert

Neuroimaging Biomarkers for Alzheimer’s Disease

  • Open Access
  • Review

Freddie Márquez, Michael A. Yassa

Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease

  • Open Access
  • Review

Luke S. Watson, Eric D. Hamlett, Tyler D. Stone, Catrina Sims-Robinson

α-synuclein in the pathophysiology of Alzheimer’s disease

  • Open Access
  • Review

Daniel Twohig, Henrietta M. Nielsen

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

  • Open Access
  • Review

Ramsey Najm, Emily A. Jones, Yadong Huang

Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes

  • Open Access
  • Research article

Maria-Adelaide Micci, Balaji Krishnan, Elizabeth Bishop, Wen-Ru Zhang, Jutatip Guptarak, Auston Grant, Olga Zolochevska, Batbayar Tumurbaatar, Whitney Franklin, Claudia Marino, Steven G. Widen, Arjun Luthra, Steven G. Kernie, Giulio Taglialatela

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

  • Open Access
  • Research article

Erica Acquarone, Elentina K. Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D’Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorito

Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities

  • Open Access
  • Research article

Valérie Bercier, Jeffrey M. Hubbard, Kevin Fidelin, Karine Duroure, Thomas O. Auer, Céline Revenu, Claire Wyart, Filippo Del Bene

Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles

  • Open Access
  • Review

Richard M. Meade, David P. Fairlie, Jody M. Mason

Correction to: Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

  • Open Access
  • Correction

Norihito Uemura, Hisashi Yagi, Maiko T. Uemura, Yusuke Hatanaka, Hodaka Yamakado, Ryosuke Takahashi

The neuropathological diagnosis of Alzheimer’s disease

  • Open Access
  • Review

Michael A. DeTure, Dennis W. Dickson

A circuit view of deep brain stimulation in Alzheimer’s disease and the possible mechanisms

  • Open Access
  • Review

Danfang Yu, Huanhuan Yan, Jun Zhou, Xiaodan Yang, Youming Lu, Yunyun Han

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

  • Open Access
  • Research article

Sonia George, Nolwen L. Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, Emily Schulz, Steven Pierce, Amanda R. Burmeister, Zachary Madaj, Jennifer A. Steiner, Martha L. Escobar Galvis, Lena Brundin, Patrik Brundin

Impaired dopamine metabolism in Parkinson’s disease pathogenesis

  • Open Access
  • Review

Anna Masato, Nicoletta Plotegher, Daniela Boassa, Luigi Bubacco

Glucocerebrosidase and its relevance to Parkinson disease

  • Open Access
  • Review

Jenny Do, Cindy McKinney, Pankaj Sharma, Ellen Sidransky

Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

  • Open Access
  • Research article

Tien-Phat V. Huynh, Chao Wang, Ainsley C. Tran, G. Travis Tabor, Thomas E. Mahan, Caroline M. Francis, Mary Beth Finn, Rebecca Spellman, Melissa Manis, Rudolph E. Tanzi, Jason D. Ulrich, David M. Holtzman

Targeting tauopathy with engineered tau-degrading intrabodies

  • Open Access
  • Research article

Gilbert Gallardo, Connie H. Wong, Sara M. Ricardez, Carolyn N. Mann, Kent H. Lin, Cheryl E. G. Leyns, Hong Jiang, David M. Holtzman

Neurofilament light chain is a promising serum biomarker in spinocerebellar ataxia type 3

  • Open Access
  • Research article

Quan-Fu Li, Yi Dong, Lu Yang, Juan-Juan Xie, Yin Ma, Yi-Chu Du, Hao-Ling Cheng, Wang Ni, Zhi-Ying Wu

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease

  • Open Access
  • Research article

Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett, Frances M. Platt

Application of CRISPR genetic screens to investigate neurological diseases

  • Open Access
  • Review

Raphaella W. L. So, Sai Wai Chung, Heather H. C. Lau, Jeremy J. Watts, Erin Gaudette, Zaid A. M. Al-Azzawi, Jossana Bishay, Lilian Tsai-Wei Lin, Julia Joung, Xinzhu Wang, Gerold Schmitt-Ulms

Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis

  • Open Access
  • Research article

Eiichi Tokuda, Yo-ichi Takei, Shinji Ohara, Noriko Fujiwara, Isao Hozumi, Yoshiaki Furukawa

Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

  • Open Access
  • Research article

Véronik Lachance, Qian Wang, Eric Sweet, Insup Choi, Cui-Zan Cai, Xu-Xu Zhuang, Yuanxi Zhang, Jessica Li Jiang, Robert D. Blitzer, Ozlem Bozdagi-Gunal, Bin Zhang, Jia-Hong Lu, Zhenyu Yue

Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury

  • Open Access
  • Research article

Derek S. Welsbie, Nikolaos K. Ziogas, Leyan Xu, Byung-Jin Kim, Yusong Ge, Amit K. Patel, Jiwon Ryu, Mohamed Lehar, Athanasios S. Alexandris, Nicholas Stewart, Donald J. Zack, Vassilis E. Koliatsos

Organotypic brain slice cultures to model neurodegenerative proteinopathies

  • Open Access
  • Review

C. L. Croft, H. S. Futch, B. D. Moore, T. E. Golde

Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration

  • Open Access
  • Review

Anna M. Speicher, Heinz Wiendl, Sven G. Meuth, Matthias Pawlowski

Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice

  • Open Access
  • Short report

Juan Maldonado Weng, Ishita Parikh, Ankur Naqib, Jason York, Stefan J. Green, Steven Estus, Mary Jo LaDu

BrightFocus Alzheimer’s Fast Track 2019

  • Open Access
  • Meeting report

Keith W. Whitaker, Frank M. LaFerla, Harry W. M. Steinbusch, Cynthia A. Lemere, Diane E. Bovenkamp

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same

  • Open Access
  • Review

Daniel C. Berwick, George R. Heaton, Sonia Azeggagh, Kirsten Harvey

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

  • Open Access
  • Research article

Ravi S. Pandey, Leah Graham, Asli Uyar, Christoph Preuss, Gareth R. Howell, Gregory W. Carter

Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study

  • Open Access
  • Research article

Yu An, Xiaona Zhang, Ying Wang, Yushan Wang, Wen Liu, Tao Wang, Zhongsheng Qin, Rong Xiao

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Bildnachweise
Die Leitlinien für Ärztinnen und Ärzte, Untersuchung eines adipösen Kindes/© Colourbox (Symbolbild mit Fotomodell), Senior mit Parkinson hält den Löffel mit zwei Händen/© MarianVejcik / Getty Images / iStock (Symbolbild mit Fotomodell), Störung der Lidhebung bei Myasthenia gravis/© Alessandro Grandini / stock.adobe.com (Symbolbild mit Fotomodell), Person hält ein Glas Milch in beiden Händen/© Africa Studio / stock.adobe.com (Symbolbild mit Fotomodell)