Ausgabe 1/2019
Inhalt (50 Artikel)
Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Michael Ewers, Christian Haass
Glucose transporter 1 critically controls microglial activation through facilitating glycolysis
Luxi Wang, Sofia Pavlou, Xuan Du, Mohajeet Bhuckory, Heping Xu, Mei Chen
Recent advances and perspectives of metabolomics-based investigations in Parkinson’s disease
Yaping Shao, Weidong Le
Emerging new roles of the lysosome and neuronal ceroid lipofuscinoses
Anil B. Mukherjee, Abhilash P. Appu, Tamal Sadhukhan, Sydney Casey, Avisek Mondal, Zhongjian Zhang, Maria B. Bagh
Dementia with Lewy bodies: an update and outlook
Tiago Fleming Outeiro, David J. Koss, Daniel Erskine, Lauren Walker, Marzena Kurzawa-Akanbi, David Burn, Paul Donaghy, Christopher Morris, John-Paul Taylor, Alan Thomas, Johannes Attems, Ian McKeith
Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma
Pete A. Williams, Catherine E. Braine, Krishnakumar Kizhatil, Nicole E. Foxworth, Nicholas G. Tolman, Jeffrey M. Harder, Rebecca A. Scott, Gregory L. Sousa, Alyssa Panitch, Gareth R. Howell, Simon W. M. John
Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease
Shreaya Chakroborty, Evan S. Hill, Daniel T. Christian, Rosalind Helfrich, Shannon Riley, Corinne Schneider, Nicolas Kapecki, Sarah Mustaly-Kalimi, Figen A. Seiler, Daniel A. Peterson, Anthony R. West, Barbara M. Vertel, William N. Frost, Grace E. Stutzmann
Differences in neurotropism and neurotoxicity among retrograde viral tracers
Leqiang Sun, Yajie Tang, Keji Yan, Jinsong Yu, Yanyan Zou, Weize Xu, Ke Xiao, Zhihui Zhang, Weiming Li, Beili Wu, Zhe Hu, Kening Chen, Zhen F. Fu, Jinxia Dai, Gang Cao
Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
Jeannie Chew, Casey Cook, Tania F. Gendron, Karen Jansen-West, Giulia del Rosso, Lillian M. Daughrity, Monica Castanedes-Casey, Aishe Kurti, Jeannette N. Stankowski, Matthew D. Disney, Jeffrey D. Rothstein, Dennis W. Dickson, John D. Fryer, Yong-Jie Zhang, Leonard Petrucelli
Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau
Korey Kam, Ankit Parekh, Ram A. Sharma, Andreia Andrade, Monica Lewin, Bresne Castillo, Omonigho M. Bubu, Nicholas J. Chua, Margo D. Miller, Anna E. Mullins, Lidia Glodzik, Lisa Mosconi, Nadia Gosselin, Kulkarni Prathamesh, Zhe Chen, Kaj Blennow, Henrik Zetterberg, Nisha Bagchi, Bianca Cavedoni, David M. Rapoport, Indu Ayappa, Mony J. de Leon, Eva Petkova, Andrew W. Varga, Ricardo S. Osorio
Dural lymphatics regulate clearance of extracellular tau from the CNS
Tirth K. Patel, LeMoyne Habimana-Griffin, Xuefeng Gao, Baogang Xu, Samuel Achilefu, Kari Alitalo, Celia A. McKee, Patrick W. Sheehan, Erik S. Musiek, Chengjie Xiong, Dean Coble, David M. Holtzman
Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice
Saumi Mathews, Amanda Branch Woods, Ikumi Katano, Edward Makarov, Midhun B. Thomas, Howard E. Gendelman, Larisa Y. Poluektova, Mamoru Ito, Santhi Gorantla
Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer’s disease mouse model
Claudia Green, Astrid Sydow, Stefanie Vogel, Marta Anglada-Huguet, Dirk Wiedermann, Eckhard Mandelkow, Eva-Maria Mandelkow, Mathias Hoehn
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
S. Beltran, M. Nassif, E. Vicencio, J. Arcos, L. Labrador, B. I. Cortes, C. Cortez, C. A. Bergmann, S. Espinoza, M. F. Hernandez, J. M. Matamala, L. Bargsted, S. Matus, D. Rojas-Rivera, M. J. M. Bertrand, D. B. Medinas, C. Hetz, P. A. Manque, U. Woehlbier
Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease
Tomoko Wakabayashi, Kazuki Yamaguchi, Kentaro Matsui, Toshiharu Sano, Tetsuya Kubota, Tadafumi Hashimoto, Ayako Mano, Kaoru Yamada, Yuko Matsuo, Naoto Kubota, Takashi Kadowaki, Takeshi Iwatsubo
Glial phagocytic clearance in Parkinson’s disease
Marie-Eve Tremblay, Mark R. Cookson, Laura Civiero
A CRISPR monkey model unravels a unique function of PINK1 in primate brains
Weili Yang, Shihua Li, Xiao-Jiang Li
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
Jorge L. Del-Aguila, Bruno A. Benitez, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Fabiana H. G. Farias, Maria Victoria Fernández, Laura Ibanez, Shan Jiang, Richard J. Perrin, Nigel J. Cairns, John C. Morris, Oscar Harari, Carlos Cruchaga
The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders
Alessandro Didonna, Puneet Opal
Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors
Zoë P. Van Acker, Marine Bretou, Wim Annaert
Neuroimaging Biomarkers for Alzheimer’s Disease
Freddie Márquez, Michael A. Yassa
Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease
Luke S. Watson, Eric D. Hamlett, Tyler D. Stone, Catrina Sims-Robinson
α-synuclein in the pathophysiology of Alzheimer’s disease
Daniel Twohig, Henrietta M. Nielsen
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease
Ramsey Najm, Emily A. Jones, Yadong Huang
Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes
Maria-Adelaide Micci, Balaji Krishnan, Elizabeth Bishop, Wen-Ru Zhang, Jutatip Guptarak, Auston Grant, Olga Zolochevska, Batbayar Tumurbaatar, Whitney Franklin, Claudia Marino, Steven G. Widen, Arjun Luthra, Steven G. Kernie, Giulio Taglialatela
Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade
Erica Acquarone, Elentina K. Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D’Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorito
Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities
Valérie Bercier, Jeffrey M. Hubbard, Kevin Fidelin, Karine Duroure, Thomas O. Auer, Céline Revenu, Claire Wyart, Filippo Del Bene
Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles
Richard M. Meade, David P. Fairlie, Jody M. Mason
Correction to: Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve
Norihito Uemura, Hisashi Yagi, Maiko T. Uemura, Yusuke Hatanaka, Hodaka Yamakado, Ryosuke Takahashi
The neuropathological diagnosis of Alzheimer’s disease
Michael A. DeTure, Dennis W. Dickson
A circuit view of deep brain stimulation in Alzheimer’s disease and the possible mechanisms
Danfang Yu, Huanhuan Yan, Jun Zhou, Xiaodan Yang, Youming Lu, Yunyun Han
Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease
Sonia George, Nolwen L. Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, Emily Schulz, Steven Pierce, Amanda R. Burmeister, Zachary Madaj, Jennifer A. Steiner, Martha L. Escobar Galvis, Lena Brundin, Patrik Brundin
Impaired dopamine metabolism in Parkinson’s disease pathogenesis
Anna Masato, Nicoletta Plotegher, Daniela Boassa, Luigi Bubacco
Glucocerebrosidase and its relevance to Parkinson disease
Jenny Do, Cindy McKinney, Pankaj Sharma, Ellen Sidransky
Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
Tien-Phat V. Huynh, Chao Wang, Ainsley C. Tran, G. Travis Tabor, Thomas E. Mahan, Caroline M. Francis, Mary Beth Finn, Rebecca Spellman, Melissa Manis, Rudolph E. Tanzi, Jason D. Ulrich, David M. Holtzman
Targeting tauopathy with engineered tau-degrading intrabodies
Gilbert Gallardo, Connie H. Wong, Sara M. Ricardez, Carolyn N. Mann, Kent H. Lin, Cheryl E. G. Leyns, Hong Jiang, David M. Holtzman
Neurofilament light chain is a promising serum biomarker in spinocerebellar ataxia type 3
Quan-Fu Li, Yi Dong, Lu Yang, Juan-Juan Xie, Yin Ma, Yi-Chu Du, Hao-Ling Cheng, Wang Ni, Zhi-Ying Wu
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease
Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett, Frances M. Platt
Application of CRISPR genetic screens to investigate neurological diseases
Raphaella W. L. So, Sai Wai Chung, Heather H. C. Lau, Jeremy J. Watts, Erin Gaudette, Zaid A. M. Al-Azzawi, Jossana Bishay, Lilian Tsai-Wei Lin, Julia Joung, Xinzhu Wang, Gerold Schmitt-Ulms
Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis
Eiichi Tokuda, Yo-ichi Takei, Shinji Ohara, Noriko Fujiwara, Isao Hozumi, Yoshiaki Furukawa
Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice
Véronik Lachance, Qian Wang, Eric Sweet, Insup Choi, Cui-Zan Cai, Xu-Xu Zhuang, Yuanxi Zhang, Jessica Li Jiang, Robert D. Blitzer, Ozlem Bozdagi-Gunal, Bin Zhang, Jia-Hong Lu, Zhenyu Yue
Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury
Derek S. Welsbie, Nikolaos K. Ziogas, Leyan Xu, Byung-Jin Kim, Yusong Ge, Amit K. Patel, Jiwon Ryu, Mohamed Lehar, Athanasios S. Alexandris, Nicholas Stewart, Donald J. Zack, Vassilis E. Koliatsos
Organotypic brain slice cultures to model neurodegenerative proteinopathies
C. L. Croft, H. S. Futch, B. D. Moore, T. E. Golde
Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration
Anna M. Speicher, Heinz Wiendl, Sven G. Meuth, Matthias Pawlowski
Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice
Juan Maldonado Weng, Ishita Parikh, Ankur Naqib, Jason York, Stefan J. Green, Steven Estus, Mary Jo LaDu
BrightFocus Alzheimer’s Fast Track 2019
Keith W. Whitaker, Frank M. LaFerla, Harry W. M. Steinbusch, Cynthia A. Lemere, Diane E. Bovenkamp
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
Daniel C. Berwick, George R. Heaton, Sonia Azeggagh, Kirsten Harvey
Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
Ravi S. Pandey, Leah Graham, Asli Uyar, Christoph Preuss, Gareth R. Howell, Gregory W. Carter
Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study
Yu An, Xiaona Zhang, Ying Wang, Yushan Wang, Wen Liu, Tao Wang, Zhongsheng Qin, Rong Xiao