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Molecular Neurodegeneration

Ausgabe 1/2023

Inhalt (100 Artikel)

APOE effects on regional tau in preclinical Alzheimer’s disease

  • Open Access
  • Research article

Christina B. Young, Emily Johns, Gabriel Kennedy, Michael E. Belloy, Philip S. Insel, Michael D. Greicius, Reisa A. Sperling, Keith A. Johnson, Kathleen L. Poston, Elizabeth C. Mormino

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer’s disease related proteins

  • Open Access
  • Research article

Stephanie R. Oatman, Joseph S. Reddy, Zachary Quicksall, Minerva M. Carrasquillo, Xue Wang, Chia-Chen Liu, Yu Yamazaki, Thuy T. Nguyen, Kimberly Malphrus, Michael Heckman, Kristi Biswas, Kwangsik Nho, Matthew Baker, Yuka A. Martens, Na Zhao, Jun Pyo Kim, Shannon L. Risacher, Rosa Rademakers, Andrew J. Saykin, Michael DeTure, Melissa E. Murray, Takahisa Kanekiyo, Dennis W. Dickson, Guojun Bu, Mariet Allen, Nilüfer Ertekin-Taner

Alzheimer’s disease: targeting the peripheral circulation

  • Open Access
  • Research highlight

Zhi-Hao Liu, Yan-Jiang Wang, Xian-Le Bu

Advances in sequencing technologies for amyotrophic lateral sclerosis research

  • Open Access
  • Review

Evan Udine, Angita Jain, Marka van Blitterswijk

FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

  • Open Access
  • Research Article

Katarina Stoklund Dittlau, Lisanne Terrie, Pieter Baatsen, Axelle Kerstens, Lim De Swert, Rekin’s Janky, Nikky Corthout, Pegah Masrori, Philip Van Damme, Poul Hyttel, Morten Meyer, Lieven Thorrez, Kristine Freude, Ludo Van Den Bosch

In memoriam of Huaxi Xu, PhD, 1964–2022

  • Open Access
  • Obituary

Guojun Bu, Hui Zheng

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier

  • Open Access
  • Research article

Kassandra Kisler, Abhay P. Sagare, Divna Lazic, Sam Bazzi, Erica Lawson, Ching-Ju Hsu, Yaoming Wang, Anita Ramanathan, Amy R. Nelson, Zhen Zhao, Berislav V. Zlokovic

Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

  • Open Access
  • Research article

Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun Bu

The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored

  • Open Access
  • Review

Sidhanth Chandra, Sangram S. Sisodia, Robert J. Vassar

Common mouse models of tauopathy reflect early but not late human disease

  • Open Access
  • Research article

Kathrin Wenger, Arthur Viode, Christoph N. Schlaffner, Patrick van Zalm, Long Cheng, Tammy Dellovade, Xavier Langlois, Anthony Bannon, Rui Chang, Theresa R. Connors, Derek Oakley, Bernhard Renard, Juri Rappsilber, Bradley Hyman, Hanno Steen, Judith A. Steen

Translational molecular imaging and drug development in Parkinson’s disease

  • Open Access
  • Review

Achi Haider, Nehal H. Elghazawy, Alyaa Dawoud, Catherine Gebhard, Thomas Wichmann, Wolfgang Sippl, Marius Hoener, Ernest Arenas, Steven H. Liang

A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques

  • Open Access
  • Research article

Kristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine S. Sakr, Angela Gomez-Arboledas, Miguel A. Arreola, Celia da Cunha, Jimmy Phan, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Jonathan Neumann, Ghassan Filimban, Zechuan Shi, Giedre Milinkeviciute, Dominic I. Javonillo, Katelynn Tran, Magdalena Gantuz, Stefania Forner, Vivek Swarup, Andrea J. Tenner, Frank M. LaFerla, Marcelo A. Wood, Ali Mortazavi, Grant R. MacGregor, Kim N. Green

The Alzheimer’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

  • Open Access
  • Research article

Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler

Correction: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier

  • Open Access
  • Correction

Kassandra Kisler, Abhay P. Sagare, Divna Lazic, Sam Bazzi, Erica Lawson, Ching-Ju Hsu, Yaoming Wang, Anita Ramanathan, Amy R. Nelson, Zhen Zhao, Berislav V. Zlokovic

Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation

  • Open Access
  • Research article

Vyara Todorova, Mia Fee Stauffacher, Luca Ravotto, Sarah Nötzli, Duygu Karademir, Lynn J. A. Ebner, Cornelia Imsand, Luca Merolla, Stefanie M. Hauck, Marijana Samardzija, Aiman S. Saab, L. Felipe Barros, Bruno Weber, Christian Grimm

The era of cryptic exons: implications for ALS-FTD

  • Open Access
  • Review

Puja R. Mehta, Anna-Leigh Brown, Michael E. Ward, Pietro Fratta

Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

  • Open Access
  • Research article

Monica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Xin Bao, Megan E. Bosch, Choonghee Lee, Hong Jiang, Javier Remolina Serrano, Ernesto R. Gonzales, Michal Kipnis, David M. Holtzman

Plasma phospho-tau in Alzheimer’s disease: towards diagnostic and therapeutic trial applications

  • Open Access
  • Review

Fernando Gonzalez-Ortiz, Przemysław R. Kac, Wagner S. Brum, Henrik Zetterberg, Kaj Blennow, Thomas K. Karikari

hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer’s disease and potential therapeutics

  • Open Access
  • Perspective

Julia TCW, Amaia M. Arranz

Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays

  • Open Access
  • Research article

Giovanni Bellomo, Silvia Paciotti, Luis Concha-Marambio, Domenico Rizzo, Anna Lidia Wojdaƚa, Davide Chiasserini, Leonardo Gatticchi, Linda Cerofolini, Stefano Giuntini, Chiara Maria Giulia De Luca, Yihua Ma, Carly M. Farris, Giuseppe Pieraccini, Sara Bologna, Marta Filidei, Enrico Ravera, Moreno Lelli, Fabio Moda, Marco Fragai, Lucilla Parnetti, Claudio Luchinat

Insights from new in vivo models of TREM2 variants

  • Open Access
  • Commentary

Nimansha Jain, David M. Holtzman

Using mass spectrometry to validate mouse models of tauopathy

  • Open Access
  • Research highlight

Yan Yan, Casey N. Cook

Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation

  • Open Access
  • Research article

Dongqin Wu, Nana Yu, Yang Gao, Rui Xiong, Luping Liu, Huiyang Lei, Sen Jin, Jiale Liu, Yingzhou Liu, Jiazhao Xie, Enjie Liu, Qiuzhi Zhou, Yanchao Liu, Shihong Li, Linyu Wei, Jingru Lv, Huilin Yu, Wenbo Zeng, Qiang Zhou, Fuqiang Xu, Min-Hua Luo, Yao Zhang, Ying Yang, Jian-Zhi Wang

NF-κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss

  • Open Access
  • Research article

Judith Stefanie Schlett, Melanie Mettang, Aladdin Skaf, Pavel Schweizer, Alina Errerd, Ephraim Alemayehu Mulugeta, Tabea Melissa Hein, Konstantinos Tsesmelis, Miltiadis Tsesmelis, Ulrike F. G. Büttner, Heinrich Wendt, Alireza Abaei, Volker Rasche, Vivien Prex, Ester Nespoli, Najwa Ouali Alami, Daniel Tews, Paul Walther, Deniz Yilmazer-Hanke, Franz Oswald, Leda Dimou, Thomas Wirth, Bernd Baumann

Carriers of the p.P522R variant in PLCγ2 have a slightly more responsive immune system

  • Open Access
  • Research article

Annieck M. Diks, Cristina Teodosio, Bas de Mooij, Rick J. Groenland, Brigitta A. E. Naber, Inge F. de Laat, Sandra A. Vloemans, Susan Rohde, Marien I. de Jonge, Linda Lorenz, Debbie Horsten, Jacques J. M. van Dongen, Magdalena A. Berkowska, Henne Holstege

Leveraging the glymphatic and meningeal lymphatic systems as therapeutic strategies in Alzheimer’s disease: an updated overview of nonpharmacological therapies

  • Open Access
  • Review

Douglas A. Formolo, Jiasui Yu, Kangguang Lin, Hector W. H. Tsang, Haining Ou, Georg S. Kranz, Suk-Yu Yau

Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease

  • Open Access
  • Review

Christopher Daniel Morrone, Radha Raghuraman, S. Abid Hussaini, Wai Haung Yu

Correction: Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

  • Open Access
  • Correction

Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Aishe Kurti, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Fuyao Li, Kai Chen, Francis Shue, Maxwell V. Dacquel, John Fryer, Akhilesh Pandey, Na Zhao, Guojun Bu

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

  • Open Access
  • Research article

Paul J. Sampognaro, Shruti Arya, Giselle M. Knudsen, Emma L. Gunderson, Angelica Sandoval-Perez, Molly Hodul, Kathryn Bowles, Charles S. Craik, Matthew P. Jacobson, Aimee W. Kao

Opinion: more mouse models and more translation needed for ALS

  • Open Access
  • Review

Elizabeth M.C. Fisher, Linda Greensmith, Andrea Malaspina, Pietro Fratta, Michael G. Hanna, Giampietro Schiavo, Adrian M. Isaacs, Richard W. Orrell, Thomas J. Cunningham, Abraham Acevedo Arozena

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

  • Open Access
  • Research article

John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko, Xiangyou Hu, Riqiang Yan

Neuropathology of incidental Lewy body & prodromal Parkinson’s disease

  • Open Access
  • Review

Thomas Koeglsperger, Svenja-Lotta Rumpf, Patricia Schließer, Felix L. Struebing, Matthias Brendel, Johannes Levin, Claudia Trenkwalder, Günter U. Höglinger, Jochen Herms

Correction: Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors

  • Open Access
  • Correction

Xinyan Li, Wenting Chen, Xian Huang, Wei Jing, Tongmei Zhang, Quntao Yu, Hongyan Yu, Hao Li, Qing Tian, Yumei Ding, Youming Lu

Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

  • Open Access
  • Correction

Paul J. Sampognaro, Shruti Arya, Giselle M. Knudsen, Emma L. Gunderson, Angelica Sandoval-Perez, Molly Hodul, Kathryn Bowles, Charles S. Craik, Matthew P. Jacobson, Aimee W. Kao

Looking for answers far away from the soma—the (un)known axonal functions of TDP-43, and their contribution to early NMJ disruption in ALS

  • Open Access
  • Review

Ariel Ionescu, Topaz Altman, Eran Perlson

Resistant and Resilient mutations in protection against familial Alzheimer’s disease: learning from nature

  • Open Access
  • Perspective

Diego Sepulveda-Falla

The role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap

  • Open Access
  • Review

Keenan A. Walker, Lydia M. Le Page, Niccolò Terrando, Michael R. Duggan, Michael T. Heneka, Brianne M. Bettcher

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

  • Open Access
  • Research article

Michal Nemergut, Sérgio M. Marques, Lukas Uhrik, Tereza Vanova, Marketa Nezvedova, Darshak Chandulal Gadara, Durga Jha, Jan Tulis, Veronika Novakova, Joan Planas-Iglesias, Antonin Kunka, Anthony Legrand, Hana Hribkova, Veronika Pospisilova, Jiri Sedmik, Jan Raska, Zbynek Prokop, Jiri Damborsky, Dasa Bohaciakova, Zdenek Spacil, Lenka Hernychova, David Bednar, Martin Marek

Sex specific molecular networks and key drivers of Alzheimer’s disease

  • Open Access
  • Research article

Lei Guo, Jiqing Cao, Jianwei Hou, Yonghe Li, Min Huang, Li Zhu, Larry Zhang, Yeji Lee, Mariana Lemos Duarte, Xianxiao Zhou, Minghui Wang, Chia-Chen Liu, Yuka Martens, Michael Chao, Alison Goate, Guojun Bu, Vahram Haroutunian, Dongming Cai, Bin Zhang

A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores

  • Open Access
  • Research article

Moonil Kang, Ting Fang Alvin Ang, Sherral A. Devine, Richard Sherva, Shubhabrata Mukherjee, Emily H. Trittschuh, Laura E. Gibbons, Phoebe Scollard, Michael Lee, Seo-Eun Choi, Brandon Klinedinst, Connie Nakano, Logan C. Dumitrescu, Alaina Durant, Timothy J. Hohman, Michael L. Cuccaro, Andrew J. Saykin, Walter A. Kukull, David A. Bennett, Li-San Wang, Richard P. Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Paul K. Crane, Rhoda Au, Kathryn L. Lunetta, Jesse B. Mez, Lindsay A. Farrer

Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology

  • Open Access
  • Research article

Jihoon Lee, Ki Woon Sung, Eun-Jin Bae, Dabin Yoon, Dasarang Kim, Jin Saem Lee, Da-ha Park, Daniel Youngjae Park, Su Ran Mun, Soon Chul Kwon, Hye Yeon Kim, Joo-Ok Min, Seung-Jae Lee, Young Ho Suh, Yong Tae Kwon

Anti-amyloid therapies for Alzheimer disease: finally, good news for patients

  • Open Access
  • Perspective

Vijay K. Ramanan, Gregory S. Day

Extrasynaptic NMDA receptors in acute and chronic excitotoxicity: implications for preventive treatments of ischemic stroke and late-onset Alzheimer’s disease

  • Open Access
  • Review

Shan P. Yu, Michael Q. Jiang, Seong S. Shim, Soheila Pourkhodadad, Ling Wei

Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease

  • Open Access
  • Research article

Yogesh Singh, Christoph Trautwein, Joan Romani, Madhuri S. Salker, Peter H. Neckel, Isabel Fraccaroli, Mahkameh Abeditashi, Nils Woerner, Jakob Admard, Achal Dhariwal, Morten K. D. Dueholm, Karl-Herbert Schäfer, Florian Lang, Daniel E. Otzen, Hilal A. Lashuel, Olaf Riess, Nicolas Casadei

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

  • Open Access
  • Research article

Sidhanth Chandra, Antonio Di Meco, Hemraj B. Dodiya, Jelena Popovic, Leah K. Cuddy, Ian Q. Weigle, Xiaoqiong Zhang, Katherine Sadleir, Sangram S. Sisodia, Robert Vassar

Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

  • Open Access
  • Review

Yasuteru Inoue, Francis Shue, Guojun Bu, Takahisa Kanekiyo

ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

  • Open Access
  • Research article

Yingbin Lin, Anlan Lin, Lili Cai, Weibin Huang, Shanzhi Yan, Yuanxiang Wei, Xinglin Ruan, Wenting Fang, Xiaoman Dai, Jinbo Cheng, Jie Zhang, Wanjin Chen, Qinyong Ye, Xiaochun Chen, Jing Zhang

Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer’s disease

  • Open Access
  • Research article

Erica S. Modeste, Lingyan Ping, Caroline M. Watson, Duc M. Duong, Eric B. Dammer, Erik C. B. Johnson, Blaine R. Roberts, James J. Lah, Allan I. Levey, Nicholas T. Seyfried

Axonal energy metabolism, and the effects in aging and neurodegenerative diseases

  • Open Access
  • Review

Sen Yang, Jung Hyun Park, Hui-Chen Lu

Optimizing detection of Alzheimer’s disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO

  • Open Access
  • Research article

Zahinoor Ismail, Rebeca Leon, Byron Creese, Clive Ballard, Philippe Robert, Eric E. Smith

VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson’s disease

  • Open Access
  • Research article

Xi Chen, Elpida Tsika, Nathan Levine, Darren J. Moore

Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases

  • Open Access
  • Review

Siwei Chu, Xinyi Xie, Carla Payan, Ursula Stochaj

Specific detection of tau seeding activity in Alzheimer’s disease using rationally designed biosensor cells

  • Open Access
  • Methodology

Aurelien Lathuiliere, Youhwa Jo, Romain Perbet, Cameron Donahue, Caitlin Commins, Noé Quittot, Zhanyun Fan, Rachel E. Bennett, Bradley T. Hyman

TMEM106B aggregation in neurodegenerative diseases: linking genetics to function

  • Open Access
  • Review

Hai-Shan Jiao, Peng Yuan, Jin-Tai Yu

Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease

  • Open Access
  • Review

Shanon Rego, Guadalupe Sanchez, Sandro Da Mesquita

Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease

  • Open Access
  • Research article

Michele M. Comerota, Manasee Gedam, Wen Xiong, Feng Jin, Lisheng Deng, Meng C. Wang, Jin Wang, Hui Zheng

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

  • Open Access
  • Research article

Virginia Estades Ayuso, Sarah Pickles, Tiffany Todd, Mei Yue, Karen Jansen-West, Yuping Song, Jesús González Bejarano, Bailey Rawlinson, Michael DeTure, Neill R. Graff-Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Dennis W. Dickson, Keith A. Josephs, Leonard Petrucelli, Mercedes Prudencio

Translation dysregulation in neurodegenerative diseases: a focus on ALS

  • Open Access
  • Review

Shaopeng Wang, Shuying Sun

Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer’s disease mice

  • Open Access
  • Research article

Xavier Taylor, Isaiah M. Clark, Griffin J. Fitzgerald, Herold Oluoch, Justin T. Hole, Ronald B. DeMattos, Yaming Wang, Feng Pan

Tracking reactive astrogliosis in autosomal dominant and sporadic Alzheimer’s disease with multi-modal PET and plasma GFAP

  • Open Access
  • Research article

Konstantinos Chiotis, Charlotte Johansson, Elena Rodriguez-Vieitez, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Caroline Graff, Agneta Nordberg

Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

  • Open Access
  • Research article

Arun Upadhyay, Deepak Chhangani, Nalini R. Rao, Julia Kofler, Robert Vassar, Diego E. Rincon-Limas, Jeffrey N. Savas

Regulation of the hippocampal translatome by Apoer2-ICD release

  • Open Access
  • Research article

Catherine R. Wasser, Gordon C. Werthmann, Eric M. Hall, Kristina Kuhbandner, Connie H. Wong, Murat S. Durakoglugil, Joachim Herz

The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

  • Open Access
  • Research article

Jun Yup Lee, Dylan J Harney, Jonathan D Teo, John B Kwok, Greg T. Sutherland, Mark Larance, Anthony S Don

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

  • Open Access
  • Review

Jonathan R. Soucy, Erika A. Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A. Saleem, Xue-Wei Wang, Juilette Wohlschlegel, Abdelrahman Y. Fouda, Ajay Ashok, Ala Moshiri, Alain Chedotal, Amberlynn A. Reed, Amjad Askary, An-Jey A. Su, Anna La Torre, Archana Jalligampala, Ariadna Silva-Lepe, Arupratan Das, Barbara Wirostko, Benjamin J. Frankfort, Benjamin Sivyer, Bhagwat Alapure, Brent Young, Brian Clark, Bryan William Jones, Chase Hellmer, Claire Mitchell, Claire Ufongene, Dan Goldman, David Feldheim, David H. Gutmann, David J. Calkins, David Krizaj, David M. Gamm, Diana C. Lozano, Diane E. Bovenkamp, Dong Feng Chen, Elena Vecino Cordero, Ephraim F. Trakhtenberg, Feng Tian, Fengquan Zhou, Gillian J. McLellan, Harry A. Quigley, Hashem Abu Serhan, James R. Tribble, Jason Meyer, Jeff Gross, Jeff S. Mumm, Jeremy M. Sivak, Jingliang Simon Zhang, Jiun L. Do, Jonathan Crowston, Julie Chen, Juliette McGregor, Kalyan C. Vinnakota, Kang-Chieh Huang, Karen Peynshaert, Katherine E. Uyhazi, Keith Martin, Ken Muller, Kevin K. Park, Kin-Sang Cho, Kun-Che Chang, Larry Benowitz, Leonard A. Levin, Levi Todd, Lies De Groef, Lieve Moons, Luis Alarcon-Martinez, Mandeep S. Singh, Manuel Vidal-Sanz, Mariana S. Silveira, Marina Pavlou, Matthew B. Veldman, Matthew Van Hook, Melanie Samuel, Mengming Hu, Micalla Peng, Michael Young, Michel Cayouette, Mohammad H. Geranmayeh, Mollie Woodworth, Monica Vetter, Nicholas R. Marsh-Armstrong, Pete A. Williams, Pratheepa Kumari Rasiah, Preeti Subramanian, Qi N. Cui, Rebecca M. Sappington, Reem Amine, Richard Eva, Robert J. Johnston Jr, Roman J. Giger, Ross Ethier, Sadaf Abed, Sehrish Nizar Ali Momin, Seth Blackshaw, Shane A. Liddelow, Stella Mary, Stephen Atolagbe, Supraja Varadarajan, Tareq I. Nabhan, Tasneem Khatib, Tasneem Putliwala Sharma, Thomas Brunner, Tom Greenwell, Tonia S. Rex, Trent Watkins, Tudor C. Badea, V. Vrathasha, Venkata Ramana Murthy Chavali, Viviane M. Oliveira-Valença, Wai Lydia Tai, Wyndham M. Batchelor, Xian-Jie Yang, Yong Park, Yuan Pan, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K. Gokoffski, Jeffrey L. Goldberg, William Guido, Alex L. Kolodkin, Carol A. Mason, Yvonne Ou, Thomas A. Reh, Ahmara G. Ross, Brian C. Samuels, Derek Welsbie, Donald J. Zack, Thomas V. Johnson

The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease

  • Open Access
  • Research article

Amanda L. Wright, Lyndsey M. Konen, Bruce G. Mockett, Gary P. Morris, Anurag Singh, Lisseth Estefania Burbano, Luke Milham, Monica Hoang, Raphael Zinn, Rose Chesworth, Richard P. Tan, Gordon A. Royle, Ian Clark, Steven Petrou, Wickliffe C. Abraham, Bryce Vissel

News & views: anti-amyloid antibodies and novel emerging approaches to Alzheimer’s disease in 2023

  • Open Access
  • Editorial

Sam Gandy

BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps

  • Open Access
  • Research article

Margaret E. Maes, Ryan J. Donahue, Cassandra L. Schlamp, Olivia J. Marola, Richard T. Libby, Robert W. Nickells

Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure

  • Open Access
  • Research article

Arpan G. Mazumder, Amélie M. Julé, Daniel Sun

Correction: Targeted degradation of ⍺-synuclein aggregates in Parkinson’s disease using the AUTOTAC technology

  • Open Access
  • Correction

Jihoon Lee, Ki Woon Sung, Eun-Jin Bae, Dabin Yoon, Dasarang Kim, Jin Saem Lee, Da-ha Park, Daniel Youngjae Park, Su Ran Mun, Soon Chul Kwon, Hye Yeon Kim, Joo-Ok Min, Seung-Jae Lee, Young Ho Suh, Yong Tae Kwon

A microglial activity state biomarker panel differentiates FTD-granulin and Alzheimer’s disease patients from controls

  • Open Access
  • Research article

Ida Pesämaa, Stephan A. Müller, Sophie Robinson, Alana Darcher, Dominik Paquet, Henrik Zetterberg, Stefan F. Lichtenthaler, Christian Haass

TDP-43 pathology is associated with increased tau burdens and seeding

  • Open Access
  • Research article

Sandra O. Tomé, Grigoria Tsaka, Alicja Ronisz, Simona Ospitalieri, Klara Gawor, Luis Aragão Gomes, Markus Otto, Christine A. F. von Arnim, Philip Van Damme, Ludo Van Den Bosch, Estifanos Ghebremedhin, Celeste Laureyssen, Kristel Sleegers, Rik Vandenberghe, Frederic Rousseau, Joost Schymkowitz, Dietmar Rudolf Thal

Correction: Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts

  • Open Access
  • Correction

Pierre De Rossi, Virginie Buggia-Prévot, Benjamin L. L. Clayton, Jared B. Vasquez, Carson van Sanford, Robert J. Andrew, Ruben Lesnick, Alexandra Botté, Carole Deyts, Someya Salem, Eshaan Rao, Richard C. Rice, Angèle Parent, Satyabrata Kar, Brian Popko, Peter Pytel, Steven Estus, Gopal Thinakaran

Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress

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Ken Uekawa, Yorito Hattori, Sung Ji Ahn, James Seo, Nicole Casey, Antoine Anfray, Ping Zhou, Wenjie Luo, Josef Anrather, Laibaik Park, Costantino Iadecola

Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come

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  • Research highlight

John J. Alam, Ralph A. Nixon

Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms

  • Open Access
  • Review

Manling Xie, Praveen N. Pallegar, Sebastian Parusel, Aivi T. Nguyen, Long-Jun Wu

Mechanisms of ARIA: is it time to focus on the unique immune environment of the neurovascular unit?

  • Open Access
  • Research highlight

Kate E. Foley, Erica M. Weekman, Donna M. Wilcock

Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis

  • Open Access
  • Research article

Chunyu Li, Qianqian Wei, Yanbing Hou, Junyu Lin, Ruwei Ou, Lingyu Zhang, Qirui Jiang, Yi Xiao, Kuncheng Liu, Xueping Chen, TianMi Yang, Wei Song, Bi Zhao, Ying Wu, Huifang Shang

cGAS-STING triggers inflammaging-associated neurodegeneration

  • Open Access
  • Research highlight

José M. Izquierdo

Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders

  • Open Access
  • Review

Yige Huang, Bangyan Liu, Subhash C. Sinha, Sadaf Amin, Li Gan

Peptide-based approaches to directly target alpha-synuclein in Parkinson’s disease

  • Open Access
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Scott G. Allen, Richard M. Meade, Lucy L. White Stenner, Jody M. Mason

Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come

  • Open Access
  • Correction

John J. Alam, Ralph A. Nixon

Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies

  • Open Access
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Yuwei Jiang, Lesley T. MacNeil

Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential

  • Open Access
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Martin T. Henrich, Wolfgang H. Oertel, D. James Surmeier, Fanni F. Geibl

α-Synuclein serine129 phosphorylation – the physiology of pathology

  • Open Access
  • Editorial

Nagendran Ramalingam, Ulf Dettmer

Altered plasma protein profiles in genetic FTD – a GENFI study

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  • Research article

Abbe Ullgren, Linn Öijerstedt, Jennie Olofsson, Sofia Bergström, Julia Remnestål, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Matthis Synofzik, Daniela Galimberti, James B. Rowe, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tirabosch, Isabel Santana, Simon Ducharme, Chris R. Butler, Alexander Gerhard, Markus Otto, Arabella Bouzigues, Lucy Russell, Imogen J. Swift, Aitana Sogorb-Esteve, Carolin Heller, Jonathan D. Rohrer, Anna Månberg, Peter Nilsson, Caroline Graff, Sónia Afonso, Maria Rosario Almeida, Sarah Anderl-Straub, Christin Andersson, Anna Antonell, Andrea Arighi, Mircea Balasa, Myriam Barandiaran, Nuria Bargalló, Robart Bartha, Benjamin Bender, Emanuele Buratti, Luisa Benussi, Maxime Bertoux, Giuliano Binetti, Sandra Black, Martina Bocchetta, Sergi Borrego-Ecija, Jose Bras, Rose Bruffaerts, Marta Cañada, Valentina Cantoni, Paola Caroppo, David Cash, Miguel Castelo-Branco, Rhian Convery, Thomas Cope, Vincent Deramecourt, Giuseppe Di Fede, Alina Díez, Chiara Fenoglio, Catarina B. Ferreira, Nick Fox, Morris Freedman, Giorgio Fumagalli, Aurélie Funkiewiez, Alazne Gabilondo, Roberto Gasparotti, Serge Gauthier, Antonella Alberici, Giorgio Giaccone, Ana Gorostidi, Caroline Greaves, Rita Guerreiro, Begoña Indakoetxea, Vesna Jelic, Hans-Otto Karnath, Ron Keren, Gregory Kuchcinski, Tobias Langheinrich, Thibaud Lebouvier, Maria João Leitão, Albert Lladó, Carolina Maruta, Lieke Meeter, Gabriel Miltenberger, Rick van Minkelen, Sara Mitchell, Katrina Moore, Jennifer Nicholas, Jaume Olives, Sebastien Ourselin, Alessandro Padovani, Jessica Panman, Janne M. Papma, Georgia Peakman, Michela Pievani, Yolande Pijnenburg, Enrico Premi, Sara Prioni, Rosa Rademakers, Veronica Redaelli, Daisy Rinaldi, Tim Rittman, Ekaterina Rogaeva, Adeline Rollin, Pedro Rosa-Neto, Giacomina Rossi, Martin Rosser, Elio Scarpini, Elisa Semler, Rachelle Shafei, Christen Shoesmith, Miguel Tábuas-Pereira, Mikel Tainta, Ricardo Taipa, David Tang-Wai, David L. Thomas, Paul Thompson, Håkan Thonberg, Carolyn Timberlake, Emily Todd, Philip Van Damme, Mathieu Vandenbulcke, Michele Veldsman, Ana Verdelho, Jorge Villanua, Jason Warren, Carlo Wilke, Ione Woollacott, Henrik Zetterberg, Miren Zulaica, João Durães, Marisa Lima, João Lemos

Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia

  • Open Access
  • Review

Tetiana Poliakova, Cheryl L. Wellington

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

  • Open Access
  • Research article

Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward, Ling Hao

Donald Lowell Price, M.D. In memoriam

  • Open Access
  • Obituary

Sangram Sisodia, Philip C. Wong

Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

  • Open Access
  • Review

Gizem Terzioglu, Tracy L. Young-Pearse

Alzheimer’s genes in microglia: a risk worth investigating

  • Open Access
  • Review

Ari Sudwarts, Gopal Thinakaran

Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains

  • Open Access
  • Research article

Morgan Bérard, Laura Martínez-Drudis, Razan Sheta, Omar M. A. El-Agnaf, Abid Oueslati

Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants

  • Open Access
  • Letter to the Editor

Karen Y. He, Ekaterina A. Khramtsova, Alfredo Cabrera-Socorro, Yanfei Zhang, Shuwei Li, Brice A. J. Sarver, Bart Smets, Qingqin S. Li, Louis De Muynck, Antonio R. Parrado, Simon Lovestone, Mary Helen Black

Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model

  • Open Access
  • Research article

Qiuchen Zhao, Megi Maci, Morgan R. Miller, Heng Zhou, Fang Zhang, Moustafa Algamal, Yee Fun Lee, Steven S. Hou, Stephen J. Perle, Hoang Le, Alyssa N. Russ, Eng H. Lo, Dmitry Gerashchenko, Stephen N. Gomperts, Brian J. Bacskai, Ksenia V. Kastanenka

MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease

  • Open Access
  • Research article

Lu Geng, Wenqing Gao, Hexige Saiyin, Yuanyuan Li, Yu Zeng, Zhifei Zhang, Xue Li, Zuolong Liu, Qiang Gao, Ping An, Ning Jiang, Xiaofei Yu, Xiangjun Chen, Suhua Li, Lei Chen, Boxun Lu, Aiqun Li, Guoyuan Chen, Yidong Shen, Haibing Zhang, Mei Tian, Zhuohua Zhang, Jixi Li

Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome

  • Open Access
  • Research article

Shabana M. Shaik, Yajun Cao, Joseph V. Gogola, Hemraj B. Dodiya, Xulun Zhang, Hejer Boutej, Weinong Han, Jasna Kriz, Sangram S. Sisodia

Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

  • Open Access
  • Correction

Saadia Hasan, Michael S. Fernandopulle, Stewart W. Humble, Ashley M. Frankenfield, Haorong Li, Ryan Prestil, Kory R. Johnson, Brent J. Ryan, Richard Wade-Martins, Michael E. Ward, Ling Hao

Amyloid-β specific regulatory T cells attenuate Alzheimer’s disease pathobiology in APP/PS1 mice

  • Open Access
  • Research article

Pravin Yeapuri, Jatin Machhi, Yaman Lu, Mai Mohamed Abdelmoaty, Rana Kadry, Milankumar Patel, Shaurav Bhattarai, Eugene Lu, Krista L. Namminga, Katherine E. Olson, Emma G. Foster, R. Lee Mosley, Howard E. Gendelman

Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease

  • Open Access
  • Research article

Peter R Millar, Brian A Gordon, Julie K Wisch, Stephanie A Schultz, Tammie LS Benzinger, Carlos Cruchaga, Jason J Hassenstab, Laura Ibanez, Celeste Karch, Jorge J Llibre-Guerra, John C Morris, Richard J Perrin, Charlene Supnet-Bell, Chengjie Xiong, Ricardo F Allegri, Sarah B Berman, Jasmeer P Chhatwal, Patricio A Chrem Mendez, Gregory S Day, Anna Hofmann, Takeshi Ikeuchi, Mathias Jucker, Jae-Hong Lee, Johannes Levin, Francisco Lopera, Yoshiki Niimi, Victor J Sánchez-González, Peter R Schofield, Ana Luisa Sosa-Ortiz, Jonathan Vöglein, Randall J Bateman, Beau M Ances, Eric M McDade

Microglial APOE4: more is less and less is more

  • Open Access
  • Editorial

Ghazaleh Eskandari-Sedighi, Mathew Blurton-Jones

Untargeted serum metabolomics reveals novel metabolite associations and disruptions in amino acid and lipid metabolism in Parkinson’s disease

  • Open Access
  • Research article

Kimberly C. Paul, Keren Zhang, Douglas I. Walker, Janet Sinsheimer, Yu Yu, Cynthia Kusters, Irish Del Rosario, Aline Duarte Folle, Adrienne M. Keener, Jeff Bronstein, Dean P. Jones, Beate Ritz

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Gesunder Lebensstil bei Parkinson essenziell

Wie sehr Menschen mit Parkinson von körperlicher Aktivität, mediterraner Ernährung und Entspannungsübungen profitieren, zeigt ein Review im Fachblatt „Lancet“. Betroffene können mit entsprechenden Maßnahmen eine deutlich verbesserte Lebensqualität erreichen.

RNA-basierte CAR-T-Zell-Therapie hält Myasthenie in Schach

Eine gegen BCMA gerichtete Therapie mit CAR-T-Zellen kann eine schwere Myasthenia gravis über ein Jahr hinweg gut kontrollieren. Der RNA-basierte Ansatz verursacht zudem kaum Nebenwirkungen, erfordert aber sechs wöchentliche Infusionen.

Kombination von SGLT2-Inhibitor mit Statin ist sicher

Die Rhabdomyolyse ist eine gefürchtete, aber sehr seltene Nebenwirkung von Statinen. Medikamenteninteraktionen können das Risiko erhöhen. Mit SGLT2-Inhibitoren scheint dies nicht der Fall zu sein – die Ko-Therapie könnte das Risiko sogar senken.

Herzinsuffizienz: Vorsicht bei diesen Medikamenten!

Eine Herzinsuffizienz kann durch bestimmte Medikamentenkombinationen verschlimmert oder auch getriggert werden. Ein internationales Expertengremium hat zusammengefasst, bei welchen Konstellationen erhöhte Vorsicht geboten ist.

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Die Leitlinien für Ärztinnen und Ärzte, Senior mit Parkinson hält den Löffel mit zwei Händen/© MarianVejcik / Getty Images / iStock (Symbolbild mit Fotomodell), Störung der Lidhebung bei Myasthenia gravis/© Alessandro Grandini / stock.adobe.com (Symbolbild mit Fotomodell), Ältere Person sortiert Medikamente/© Przemek Klos / stock.adobe.com (Symbolbild mit Fotomodell)