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Molecular Neurodegeneration

Ausgabe 1/2024

Inhalt (100 Artikel)

Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer’s disease

  • Open Access
  • Research article

Lihua Wang, Niko-Petteri Nykänen, Daniel Western, Priyanka Gorijala, Jigyasha Timsina, Fuhai Li, Zhaohua Wang, Muhammad Ali, Chengran Yang, Menghan Liu, William Brock, Marta Marquié, Mercè Boada, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Agustín Ruiz, Raquel Puerta, Adelina Orellana, Jarod Rutledge, Hamilton Oh, Michael D Greicius, Yann Le Guen, Richard J. Perrin, Tony Wyss-Coray, Angela Jefferson, Timothy J. Hohman, Neill Graff-Radford, Hiroshi Mori, Alison Goate, Johannes Levin, Yun Ju Sung, Carlos Cruchaga

Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology

  • Open Access
  • Research article

Joseph Therriault, Marcel S. Woo, Gemma Salvadó, Johan Gobom, Thomas K. Karikari, Shorena Janelidze, Stijn Servaes, Nesrine Rahmouni, Cécile Tissot, Nicholas J. Ashton, Andréa Lessa Benedet, Laia Montoliu-Gaya, Arthur C. Macedo, Firoza Z. Lussier, Jenna Stevenson, Paolo Vitali, Manuel A. Friese, Gassan Massarweh, Jean-Paul Soucy, Tharick A. Pascoal, Erik Stomrud, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Serge Gauthier, Henrik Zetterberg, Oskar Hansson, Kaj Blennow, Pedro Rosa-Neto

Blood platelet factor 4: the elixir of brain rejuvenation

  • Open Access
  • Commentary

José M. Izquierdo

Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models

  • Open Access
  • Review

Gowoon Son, Thomas C. Neylan, Lea T. Grinberg

Brain clearance of protein aggregates: a close-up on astrocytes

  • Open Access
  • Review

Veronica Giusti, Gurkirat Kaur, Elena Giusto, Laura Civiero

Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer’s disease

  • Open Access
  • Research article

Maria Calvo-Rodriguez, Elizabeth K. Kharitonova, Austin C. Snyder, Steven S. Hou, Maria Virtudes Sanchez-Mico, Sudeshna Das, Zhanyun Fan, Hamid Shirani, K. Peter R. Nilsson, Alberto Serrano-Pozo, Brian J. Bacskai

Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution

  • Open Access
  • Research article

Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt

Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD

  • Open Access
  • Review

Bilal Khalil, Miriam Linsenmeier, Courtney L. Smith, James Shorter, Wilfried Rossoll

Fluid biomarkers for amyotrophic lateral sclerosis: a review

  • Open Access
  • Review

Katherine E. Irwin, Udit Sheth, Philip C. Wong, Tania F. Gendron

Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy

  • Open Access
  • Research article

Michael L. Alosco, Micaela White, Carter Bell, Farwa Faheem, Yorghos Tripodis, Eukyung Yhang, Zachary Baucom, Brett Martin, Joseph Palmisano, Kristen Dams-O’Connor, John F. Crary, Lee E. Goldstein, Douglas I. Katz, Brigid Dwyer, Daniel H. Daneshvar, Christopher Nowinski, Robert C. Cantu, Neil W. Kowall, Robert A. Stern, Victor E. Alvarez, Bertrand Russell Huber, Thor D. Stein, Ann C. McKee, Jesse Mez

Collagen in the central nervous system: contributions to neurodegeneration and promise as a therapeutic target

  • Open Access
  • Review

Lauren K. Wareham, Robert O. Baratta, Brian J. Del Buono, Eric Schlumpf, David J. Calkins

Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models

  • Open Access
  • Research article

Aitor Martinez, Alvaro Sanchez-Martinez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Felix, Po-Lin Chen, Chun-Hong Chen, Alexander J. Whitworth

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

  • Open Access
  • Research article

Sen Yang, Zhen-Xian Niou, Andrea Enriquez, Jacob LaMar, Jui-Yen Huang, Karen Ling, Paymaan Jafar-Nejad, Jonathan Gilley, Michael P. Coleman, Jason M. Tennessen, Vidhya Rangaraju, Hui-Chen Lu

Microglial ferroptotic stress causes non-cell autonomous neuronal death

  • Open Access
  • Research article

Jeffrey R. Liddell, James B. W. Hilton, Kai Kysenius, Jessica L. Billings, Sara Nikseresht, Lachlan E. McInnes, Dominic J. Hare, Bence Paul, Stephen W. Mercer, Abdel A. Belaidi, Scott Ayton, Blaine R. Roberts, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Peter J. Crouch

CSF protein ratios with enhanced potential to reflect Alzheimer’s disease pathology and neurodegeneration

  • Open Access
  • Research article

Sára Mravinacová, Vilma Alanko, Sofia Bergström, Claire Bridel, Yolande Pijnenburg, Göran Hagman, Miia Kivipelto, Charlotte Teunissen, Peter Nilsson, Anna Matton, Anna Månberg

Unraveling the dual nature of brain CD8+ T cells in Alzheimer’s disease

  • Open Access
  • Perspective

Dan Hu, Howard L. Weiner

Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model

  • Open Access
  • Correction

Grace M. Lloyd, Jess-Karan S. Dhillon, Kimberly-Marie M. Gorion, Cara Riffe, Susan E. Fromholt, Yuxing Xia, Benoit I. Giasson, David R. Borchelt

Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner

  • Open Access
  • Research article

Megan E. Bosch, Hemraj B. Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M. Shaik, Ian Q. Weigle, Can Zhang, Jack Osborn, Aishwarya Nambiar, Priyam Patel, Samira Parhizkar, Xiaoqiong Zhang, Marie L. Laury, Prasenjit Mondal, Ashley Gomm, Matthew John Schipma, Dania Mallah, Oleg Butovsky, Eugene B. Chang, Rudolph E. Tanzi, Jack A. Gilbert, David M. Holtzman, Sangram S. Sisodia

Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease

  • Open Access
  • Research article

Juan Lantero-Rodriguez, Gemma Salvadó, Anniina Snellman, Laia Montoliu-Gaya, Wagner S. Brum, Andrea L. Benedet, Niklas Mattsson-Carlgren, Pontus Tideman, Shorena Janelidze, Sebastian Palmqvist, Erik Stomrud, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Oskar Hansson

Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases

  • Open Access
  • Review

Dillon J. Rinauro, Fabrizio Chiti, Michele Vendruscolo, Ryan Limbocker

Correction: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

  • Open Access
  • Correction

Jun Yup Lee, Dylan J. Harney, Jonathan D. Teo, John B. Kwok, Greg T. Sutherland, Mark Larance, Anthony S. Don

GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice

  • Open Access
  • Research article

Ilaria Gregorio, Loris Russo, Enrica Torretta, Pietro Barbacini, Gabriella Contarini, Giada Pacinelli, Dario Bizzotto, Manuela Moriggi, Paola Braghetta, Francesco Papaleo, Cecilia Gelfi, Enrico Moro, Matilde Cescon

Updates on mouse models of Alzheimer’s disease

  • Open Access
  • Review

Michael Z. Zhong, Thomas Peng, Mariana Lemos Duarte, Minghui Wang, Dongming Cai

APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12

  • Open Access
  • Research article

Jordy Sepulveda, Jennifer Yejean Kim, Joseph Binder, Stefano Vicini, G. William Rebeck

Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

  • Open Access
  • Research article

Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee, Hyewon Park, Juhee Shin, Dayoung Kim, Jaewon Beom, Yoon Young Yi, Deepak Prasad Gupta, Gyun Jee Song, Won-Suk Chung, C. Justin Lee, Dong Woon Kim

A partial Drp1 knockout improves autophagy flux independent of mitochondrial function

  • Open Access
  • Research article

Rebecca Z. Fan, Carolina Sportelli, Yanhao Lai, Said S. Salehe, Jennifer R. Pinnell, Harry J. Brown, Jason R. Richardson, Shouqing Luo, Kim Tieu

Correction: Blood–brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

  • Open Access
  • Correction

Qingyi Ma, Zhen Zhao, Abhay P. Sagare, Yingxi Wu, Min Wang, Nelly Chuqui Owens, Philip B. Verghese, Joachim Herz, David M. Holtzman, Berislav V. Zlokovic

Correction: Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution

  • Open Access
  • Correction

Araks Martirosyan, Rizwan Ansari, Francisco Pestana, Katja Hebestreit, Hayk Gasparyan, Razmik Aleksanyan, Silvia Hnatova, Suresh Poovathingal, Catherine Marneffe, Dietmar R. Thal, Andrew Kottick, Victor J. Hanson-Smith, Sebastian Guelfi, William Plumbly, T. Grant Belgard, Emmanouil Metzakopian, Matthew G. Holt

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

  • Open Access
  • Letter to the Editor

Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong-Jie Zhang, Leonard Petrucelli

The endotoxin hypothesis of Alzheimer’s disease

  • Open Access
  • Review

Guy C. Brown, Michael T. Heneka

An adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders

  • Open Access
  • Research article

Marie-France Dorion, Diana Casas, Irina Shlaifer, Moein Yaqubi, Peter Fleming, Nathan Karpilovsky, Carol X.-Q. Chen, Michael Nicouleau, Valerio E. C. Piscopo, Emma J. MacDougall, Aeshah Alluli, Taylor M. Goldsmith, Alexandria Schneider, Samuel Dorion, Nathalia Aprahamian, Adam MacDonald, Rhalena A. Thomas, Roy W. R. Dudley, Jeffrey A. Hall, Edward A. Fon, Jack P. Antel, Jo Anne Stratton, Thomas M. Durcan, Roberta La Piana, Luke M. Healy

Regulatory T cells limit age-associated retinal inflammation and neurodegeneration

  • Open Access
  • Research article

María Llorián-Salvador, Alerie G. de la Fuente, Christopher E. McMurran, Amy Dashwood, James Dooley, Adrian Liston, Rosana Penalva, Yvonne Dombrowski, Alan W. Stitt, Denise C. Fitzgerald

The concept of resilience to Alzheimer’s Disease: current definitions and cellular and molecular mechanisms

  • Open Access
  • Review

Luuk E. de Vries, Inge Huitinga, Helmut W. Kessels, Dick F. Swaab, Joost Verhaagen

Mitovesicles secreted into the extracellular space of brains with mitochondrial dysfunction impair synaptic plasticity

  • Open Access
  • Research article

Pasquale D’Acunzo, Elentina K. Argyrousi, Jonathan M. Ungania, Yohan Kim, Steven DeRosa, Monika Pawlik, Chris N. Goulbourne, Ottavio Arancio, Efrat Levy

Gut microbiota-host lipid crosstalk in Alzheimer’s disease: implications for disease progression and therapeutics

  • Open Access
  • Review

Ya-Xi Luo, Ling-Ling Yang, Xiu-Qing Yao

Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration

  • Open Access
  • Review

Asmaa Yehia, Osama A. Abulseoud

Regulation of human microglial gene expression and function via RNAase-H active antisense oligonucleotides in vivo in Alzheimer’s disease

  • Open Access
  • Research article

Lina Vandermeulen, Ivana Geric, Laura Fumagalli, Mohamed Kreir, Ashley Lu, Annelies Nonneman, Jessie Premereur, Leen Wolfs, Rafaela Policarpo, Nicola Fattorelli, An De Bondt, Ilse Van Den Wyngaert, Bob Asselbergh, Mark Fiers, Bart De Strooper, Constantin d’Ydewalle, Renzo Mancuso

Adaptive immune changes associate with clinical progression of Alzheimer’s disease

  • Open Access
  • Research article

Lynn van Olst, Alwin Kamermans, Sem Halters, Susanne M. A. van der Pol, Ernesto Rodriguez, Inge M. W. Verberk, Sanne G. S. Verberk, Danielle W. R. Wessels, Carla Rodriguez-Mogeda, Jan Verhoeff, Dorine Wouters, Jan Van den Bossche, Juan J. Garcia-Vallejo, Afina W. Lemstra, Maarten E. Witte, Wiesje M. van der Flier, Charlotte E. Teunissen, Helga E. de Vries

Correction: Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

  • Open Access
  • Correction

Erica Acquarone, Elentina K. Argyrousi, Manon van den Berg, Walter Gulisano, Mauro Fà, Agnieszka Staniszewski, Elisa Calcagno, Elisa Zuccarello, Luciano D’Adamio, Shi-Xian Deng, Daniela Puzzo, Ottavio Arancio, Jole Fiorito

Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting

  • Open Access
  • Guideline

Xuemei Zeng, Yijun Chen, Anuradha Sehrawat, Jihui Lee, Tara K. Lafferty, Julia Kofler, Sarah B. Berman, Robert A. Sweet, Dana L. Tudorascu, William E. Klunk, Milos D. Ikonomovic, Anna Pfister, Henrik Zetterberg, Beth E. Snitz, Anne D. Cohen, Victor L. Villemagne, Tharick A. Pascoal, M. llyas Kamboh, Oscar I. Lopez, Kaj Blennow, Thomas K. Karikari

Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology

  • Open Access
  • Research article

Rebecca L. Winfree, Emma Nolan, Logan Dumitrescu, Kaj Blennow, Henrik Zetterberg, Katherine A. Gifford, Kimberly R. Pechman, Mabel Seto, Vladislav A. Petyuk, Yanling Wang, Julie Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman

Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice

  • Open Access
  • Research article

Ghazaleh Eskandari-Sedighi, Madeline Crichton, Sameera Zia, Erik Gomez-Cardona, Leonardo M. Cortez, Zain H. Patel, Kei Takahashi-Yamashiro, Chris D. St. Laurent, Gaurav Sidhu, Susmita Sarkar, Vivian Aghanya, Valerie L. Sim, Qiumin Tan, Olivier Julien, Jason R. Plemel, Matthew S. Macauley

Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases

  • Open Access
  • Review

Chiara Pedicone, Sarah A. Weitzman, Alan E. Renton, Alison M. Goate

Single-domain antibody-based protein degrader for synucleinopathies

  • Open Access
  • Research article

Yixiang Jiang, Yan Lin, Amber M. Tetlow, Ruimin Pan, Changyi Ji, Xiang-Peng Kong, Erin E. Congdon, Einar M. Sigurdsson

Elevated nuclear TDP-43 induces constitutive exon skipping

  • Open Access
  • Research article

Rogger P. Carmen-Orozco, William Tsao, Yingzhi Ye, Irika R. Sinha, Koping Chang, Vickie T. Trinh, William Chung, Kyra Bowden, Juan C. Troncoso, Seth Blackshaw, Lindsey R. Hayes, Shuying Sun, Philip C. Wong, Jonathan P. Ling

Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS

  • Open Access
  • Research article

Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W. Cleveland, James Shorter, Sandrine Da Cruz

Single molecule array measures of LRRK2 kinase activity in serum link Parkinson’s disease severity to peripheral inflammation

  • Open Access
  • Research article

Yuan Yuan, Huizhong Li, Kashyap Sreeram, Tuyana Malankhanova, Ravindra Boddu, Samuel Strader, Allison Chang, Nicole Bryant, Talene A. Yacoubian, David G. Standaert, Madalynn Erb, Darren J. Moore, Laurie H. Sanders, Michael W. Lutz, Dmitry Velmeshev, Andrew B. West

Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging

  • Open Access
  • Research article

Ethan R. Roy, Sanming Li, Sepideh Saroukhani, Yanyu Wang, Wei Cao

Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration

  • Open Access
  • Research article

Juan Ignacio Jiménez-Loygorri, Álvaro Viedma-Poyatos, Raquel Gómez-Sintes, Patricia Boya

Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits

  • Open Access
  • Research article

Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid

Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury

  • Open Access
  • Research article

Celeste Parra Bravo, Karen Krukowski, Sarah Barker, Chao Wang, Yaqiao Li, Li Fan, Edwin Vázquez-Rosa, Min-Kyoo Shin, Man Ying Wong, Louise D. McCullough, Ryan S. Kitagawa, H. Alex Choi, Angela Cacace, Subhash C. Sinha, Andrew A. Pieper, Susanna Rosi, Xu Chen, Li Gan

Correction: Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress

  • Open Access
  • Correction

Ken Uekawa, Yorito Hattori, Sung Ji Ahn, James Seo, Nicole Casey, Antoine Anfray, Ping Zhou, Wenjie Luo, Josef Anrather, Laibaik Park, Costantino Iadecola

The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells

  • Open Access
  • Review

Omri Zveik, Ariel Rechtman, Tal Ganz, Adi Vaknin-Dembinsky

Tau protein profiling in tauopathies: a human brain study

  • Open Access
  • Research article

Juan Lantero-Rodriguez, Elena Camporesi, Laia Montoliu-Gaya, Johan Gobom, Diana Piotrowska, Maria Olsson, Irena Matečko Burmann, Bruno Becker, Ann Brinkmalm, Björn M. Burmann, Michael Perkinton, Nicholas J. Ashton, Nick C. Fox, Tammaryn Lashley, Henrik Zetterberg, Kaj Blennow, Gunnar Brinkmalm

Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease

  • Open Access
  • Research article

Suhyun Kim, Heejung Chun, Yunha Kim, Yeyun Kim, Uiyeol Park, Jiyeon Chu, Mridula Bhalla, Seung-Hye Choi, Ali Yousefian-Jazi, Sojung Kim, Seung Jae Hyeon, Seungchan Kim, Yeonseo Kim, Yeon Ha Ju, Seung Eun Lee, Hyunbeom Lee, Kyungeun Lee, Soo-Jin Oh, Eun Mi Hwang, Junghee Lee, C. Justin Lee, Hoon Ryu

Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

  • Open Access
  • Correction

Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong-Jie Zhang, Leonard Petrucelli

Therapeutic potential of APP antisense oligonucleotides for Alzheimer’s disease and down syndrome-related Alzheimer’s disease

  • Open Access
  • Research highlight

Srishruthi Thirumalai, Rickie Patani, Christy Hung

Astrocyte reactivity is associated with tau tangle load and cortical thinning in Alzheimer’s disease

  • Open Access
  • Research article

Tengfei Guo, Anqi Li, Pan Sun, Zhengbo He, Yue Cai, Guoyu Lan, Lin Liu, Jieyin Li, Jie Yang, Yalin Zhu, Ruiyue Zhao, Xuhui Chen, Dai Shi, Zhen Liu, Qingyong Wang, Linsen Xu, Liemin Zhou, Pengcheng Ran, Xinlu Wang, Kun Sun, Jie Lu, Ying Han

Single-cell peripheral immunoprofiling of Lewy body and Parkinson’s disease in a multi-site cohort

  • Open Access
  • Research article

Thanaphong Phongpreecha, Kavita Mathi, Brenna Cholerton, Eddie J. Fox, Natalia Sigal, Camilo Espinosa, Momsen Reincke, Philip Chung, Ling-Jen Hwang, Chandresh R. Gajera, Eloise Berson, Amalia Perna, Feng Xie, Chi-Hung Shu, Debapriya Hazra, Divya Channappa, Jeffrey E. Dunn, Lucas B. Kipp, Kathleen L. Poston, Kathleen S. Montine, Holden T. Maecker, Nima Aghaeepour, Thomas J. Montine

Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease

  • Open Access
  • Research article

Anantharaman Shantaraman, Eric B. Dammer, Obiadada Ugochukwu, Duc M. Duong, Luming Yin, E. Kathleen Carter, Marla Gearing, Alice Chen-Plotkin, Edward B. Lee, John Q. Trojanowski, David A. Bennett, James J. Lah, Allan I. Levey, Nicholas T. Seyfried, Lenora Higginbotham

Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy

  • Open Access
  • Research article

Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper, Bernardino F. Ghetti, Kathy L. Newell, Claire Troakes, Justo G. de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G. Beach, Geidy E. Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A. Ross, Douglas Galasko, Adam L. Boxer, Bruce L. Miller, Willian W. Seeley, Vivanna M. Van Deerlin, Edward B. Lee, Charles L. White III, Huw Morris, Rohan de Silva, John F. Crary, Alison M. Goate, Jeffrey S. Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C. Naj, Li-San Wang, Clifton Dalgard, Dennis W. Dickson, Günter U. Höglinger, Gerard D. Schellenberg, Daniel H. Geschwind, Wan-Ping Lee

Pathological characteristics of axons and alterations of proteomic and lipidomic profiles in midbrain dopaminergic neurodegeneration induced by WDR45-deficiency

  • Open Access
  • Research article

Panpan Wang, Yaping Shao, Murad Al-Nusaif, Jun Zhang, Huijia Yang, Yuting Yang, Kunhyok Kim, Song Li, Cong Liu, Huaibin Cai, Weidong Le

Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease

  • Open Access
  • Research article

Qiang Chen, Luis Aguirre, Guoming Liang, Huanhuan Zhao, Tao Dong, Felix Borrego, Itziar de Rojas, Qichan Hu, Christopher Reyes, Ling-Yan Su, Bao Zhang, James D. Lechleiter, Harald H. H. Göring, Philip L. De Jager, Joel E. Kleinman, Thomas M. Hyde, Pan P. Li, Agustín Ruiz, Daniel R. Weinberger, Sudha Seshadri, Liang Ma

Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

  • Open Access
  • Research article

Artem Zatcepin, Johannes Gnörich, Boris-Stephan Rauchmann, Laura M. Bartos, Stephan Wagner, Nicolai Franzmeier, Maura Malpetti, Xianyuan Xiang, Yuan Shi, Samira Parhizkar, Maximilian Grosch, Karin Wind-Mark, Sebastian T. Kunte, Leonie Beyer, Carolin Meyer, Desirée Brösamle, Ann-Christin Wendeln, Collins Osei-Sarpong, Steffanie Heindl, Arthur Liesz, Sophia Stoecklein, Gloria Biechele, Anika Finze, Florian Eckenweber, Simon Lindner, Axel Rominger, Peter Bartenstein, Michael Willem, Sabina Tahirovic, Jochen Herms, Katharina Buerger, Mikael Simons, Christian Haass, Rainer Rupprecht, Markus J. Riemenschneider, Nathalie L. Albert, Marc Beyer, Jonas J. Neher, Lars Paeger, Johannes Levin, Günter U. Höglinger, Robert Perneczky, Sibylle I. Ziegler, Matthias Brendel

One immune cell to bind them all: platelet contribution to neurodegenerative disease

  • Open Access
  • Review

Gabriela Rodriguez Moore, Isabel Melo-Escobar, David Stegner, Oliver Bracko

Clarifying the association of CSF Aβ, tau, BACE1, and neurogranin with AT(N) stages in Alzheimer disease

  • Open Access
  • Research article

Sylvain Lehmann, Susanna Schraen-Maschke, Luc Buée, Jean-Sébastien Vidal, Constance Delaby, Christophe Hirtz, Frédéric Blanc, Claire Paquet, Bernadette Allinquant, Stéphanie Bombois, Audrey Gabelle, Olivier Hanon

Heparin-enriched plasma proteome is significantly altered in Alzheimer’s disease

  • Open Access
  • Research article

Qi Guo, Lingyan Ping, Eric B. Dammer, Duc M. Duong, Luming Yin, Kaiming Xu, Anantharaman Shantaraman, Edward J. Fox, Todd E Golde, Erik C.B. Johnson, Blaine R. Roberts, James J. Lah, Allan I. Levey, Nicholas T. Seyfried

Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer’s disease

  • Open Access
  • Research article

Xuemei Zeng, Tara K. Lafferty, Anuradha Sehrawat, Yijun Chen, Pamela C. L. Ferreira, Bruna Bellaver, Guilherme Povala, M. Ilyas Kamboh, William E. Klunk, Ann D. Cohen, Oscar L. Lopez, Milos D. Ikonomovic, Tharick A. Pascoal, Mary Ganguli, Victor L. Villemagne, Beth E. Snitz, Thomas K. Karikari

α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease

  • Open Access
  • Research article

Fanni F. Geibl, Martin T. Henrich, Zhong Xie, Enrico Zampese, Jun Ueda, Tatiana Tkatch, David L. Wokosin, Elena Nasiri, Constantin A. Grotmann, Valina L. Dawson, Ted M. Dawson, Navdeep S. Chandel, Wolfgang H. Oertel, D. James Surmeier

Correction: Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner

  • Open Access
  • Correction

Megan E. Bosch, Hemraj B. Dodiya, Julia Michalkiewicz, Choonghee Lee, Shabana M. Shaik, Ian Q. Weigle, Can Zhang, Jack Osborn, Aishwarya Nambiar, Priyam Patel, Samira Parhizkar, Xiaoqiong Zhang, Marie L. Laury, Prasenjit Mondal, Ashley Gomm, Matthew John Schipma, Dania Mallah, Oleg Butovsky, Eugene B. Chang, Rudolph E. Tanzi, Jack A. Gilbert, David M. Holtzman, Sangram S. Sisodia

Correction: Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s disease

  • Open Access
  • Correction

Anantharaman Shantaraman, Eric B. Dammer, Obiadada Ugochukwu, Duc M. Duong, Luming Yin, E. Kathleen Carter, Marla Gearing, Alice Chen-Plotkin, Edward B. Lee, John Q. Trojanowski, David A. Bennett, James J. Lah, Allan I. Levey, Nicholas T. Seyfried, Lenora Higginbotham

A perspective on Alzheimer’s disease: exploring the potential of terminal/paradoxical lucidity and psychedelics

  • Open Access
  • Perspective

Cong Lin, Xiubo Du, Xiaohui Wang

Correction: Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy

  • Open Access
  • Correction

Hui Wang, Timothy S. Chang, Beth A. Dombroski, Po-Liang Cheng, Vishakha Patil, Leopoldo Valiente-Banuet, Kurt Farrell, Catriona Mclean, Laura Molina-Porcel, Alex Rajput, Peter Paul De Deyn, Nathalie Le Bastard, Marla Gearing, Laura Donker Kaat, John C. Van Swieten, Elise Dopper, Bernardino F. Ghetti, Kathy L. Newell, Claire Troakes, Justo G. de Yébenes, Alberto Rábano-Gutierrez, Tina Meller, Wolfgang H. Oertel, Gesine Respondek, Maria Stamelou, Thomas Arzberger, Sigrun Roeber, Ulrich Müller, Franziska Hopfner, Pau Pastor, Alexis Brice, Alexandra Durr, Isabelle Le Ber, Thomas G. Beach, Geidy E. Serrano, Lili-Naz Hazrati, Irene Litvan, Rosa Rademakers, Owen A. Ross, Douglas Galasko, Adam L. Boxer, Bruce L. Miller, Willian W. Seeley, Vivanna M. Van Deerlin, Edward B. Lee, Charles L. White III, Huw Morris, Rohan de Silva, John F. Crary, Alison M. Goate, Jeffrey S. Friedman, Yuk Yee Leung, Giovanni Coppola, Adam C. Naj, Li-San Wang, Clifton Dalgard, Dennis W. Dickson, Günter U. Höglinger, Gerard D. Schellenberg, Daniel H. Geschwind, Wan-Ping Lee

Retraction Note: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD

  • Open Access
  • Retraction Note

Michiyo Iba, Ross A. McDevitt, Changyoun Kim, Roshni Roy, Dimitra Sarantopoulou, Ella Tommer, Byron Siegars, Michelle Sallin, Somin Kwon, Jyoti Misra Sen, Ranjan Sen, Eliezer Masliah

Increased expression of mesencephalic astrocyte-derived neurotrophic factor (MANF) contributes to synapse loss in Alzheimer’s disease

  • Open Access
  • Research article

Yiran Zhang, Xiusheng Chen, Laiqiang Chen, Mingting Shao, Wenzhen Zhu, Tingting Xing, Tingting Guo, Qingqing Jia, Huiming Yang, Peng Yin, Xiao-Xin Yan, Jiandong Yu, Shihua Li, Xiao-Jiang Li, Su Yang

Comparing anti-tau antibodies under clinical trials and their epitopes on tau pathologies

  • Open Access
  • Letter to the Editor

Ha-Lim Song, Min-Seok Kim, Woo-Young Cho, Ye-Seul Yoo, Jae-You Kim, Tae-Wook Kim, Hyori Kim, Dong-Hou Kim, Seung-Yong Yoon

Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer’s disease

  • Open Access
  • Research article

Xavier Taylor, Harun N. Noristani, Griffin J. Fitzgerald, Herold Oluoch, Nick Babb, Tyler McGathey, Lindsay Carter, Justin T. Hole, Pascale N. Lacor, Ronald B. DeMattos, Yaming Wang

Gut-first Parkinson’s disease is encoded by gut dysbiome

  • Open Access
  • Research article

Mário F. Munoz-Pinto, Emanuel Candeias, Inês Melo-Marques, A. Raquel Esteves, Ana Maranha, João D. Magalhães, Diogo Reis Carneiro, Mariana Sant’Anna, A. Raquel Pereira-Santos, António E Abreu, Daniela Nunes-Costa, Susana Alarico, Igor Tiago, Ana Morgadinho, João Lemos, Pedro N. Figueiredo, Cristina Januário, Nuno Empadinhas, Sandra Morais Cardoso

HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease

  • Open Access
  • Perspective

Ellen A. Albagli, Anna Calliari, Tania F. Gendron, Yong-Jie Zhang

Repetitive transcranial magnetic stimulation alleviates motor impairment in Parkinson’s disease: association with peripheral inflammatory regulatory T-cells and SYT6

  • Open Access
  • Research article

Fen Xie, Bibiao Shen, Yuqi Luo, Hang Zhou, Zhenchao Xie, Shuzhen Zhu, Xiaobo Wei, Zihan Chang, Zhaohua Zhu, Changhai Ding, Kunlin Jin, Chengwu Yang, Lucia Batzu, K Ray Chaudhuri, Ling-Ling Chan, Eng-King Tan, Qing Wang

Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience

  • Open Access
  • Research article

Keenan A. Walker, Yang An, Abhay Moghekar, Ruin Moaddel, Michael R. Duggan, Zhongsheng Peng, Qu Tian, Luke C. Pilling, Shannon M. Drouin, Mark A. Espeland, Stephen R Rapp, Kathleen M Hayden, Aladdin H. Shadyab, Ramon Casanova, Madhav Thambisetty, Peter R. Rapp, Dimitrios Kapogiannis, Luigi Ferrucci, Susan M. Resnick

CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals

  • Open Access
  • Letter to the Editor

Marta del Campo, Carlos Quesada, Lisa Vermunt, Carel F. W. Peeters, Yanaika S. Hok-A-Hin, Calvin Trieu, Anouk den Braber, Inge M. W. Verberk, Pieter J. Visser, Betty M. Tijms, Wiesje M. van der Flier, Charlotte E. Teunissen

Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease

  • Open Access
  • Research article

Akihiro Ishii, Joseph A. Pathoulas, Omar MoustafaFathy Omar, Yingying Ge, Annie Y. Yao, Tressa Pantalena, Neeraj Singh, John Zhou, Wanxia He, Patrick Murphy, Riqiang Yan, Xiangyou Hu

Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?

  • Open Access
  • Perspective

Sharyn L. Rossi, Diane E. Bovenkamp

Stearoyl-CoA desaturase-1: a potential therapeutic target for neurological disorders

  • Open Access
  • Review

Melanie Loix, Sam Vanherle, Marta Turri, Stephan Kemp, Karl J. L. Fernandes, Jerome J. A. Hendriks, Jeroen F. J. Bogie

Regulation of disease-associated microglia in the optic nerve by lipoxin B4 and ocular hypertension

  • Open Access
  • Research article

Shubham Maurya, Maggie Lin, Shruthi Karnam, Tanirika Singh, Matangi Kumar, Emily Ward, Jeremy Sivak, John G. Flanagan, Karsten Gronert

Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson’s and other related neurodegenerative diseases

  • Open Access
  • Review

Zainab Riaz, Gabriel S. Richardson, Huajun Jin, Gary Zenitsky, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy

The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

  • Open Access
  • Research article

Jace Jones-Tabah, Kathy He, Nathan Karpilovsky, Konstantin Senkevich, Ghislaine Deyab, Isabella Pietrantonio, Thomas Goiran, Yuting Cousineau, Daria Nikanorova, Taylor Goldsmith, Esther del Cid Pellitero, Carol X.-Q. Chen, Wen Luo, Zhipeng You, Narges Abdian, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Stanley Fahn, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Lior Greenbaum, Sharon Hassin-Baer, Roy N. Alcalay, Austen Milnerwood, Thomas M. Durcan, Ziv Gan-Or, Edward A. Fon

A novel AAV Vector for gene therapy of RPE-related retinal degenerative diseases via intravitreal delivery

  • Open Access
  • Letter to the Editor

Yajun Gong, Xianyu Huang, Tianxiang Tu, Cenfeng Chu, Chunrui Xian, Yushun Yuan, Xin Fu, Ruobi Li, Guisheng Zhong, Xiaolai Zhou

Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB

  • Open Access
  • Research article

Benjamin E. Clarke, Oliver J. Ziff, Giulia Tyzack, Marija Petrić Howe, Yiran Wang, Pierre Klein, Claudia A. Smith, Cameron A. Hall, Adel Helmy, Michael Howell, Gavin Kelly, Rickie Patani

NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson’s disease-like phenotypes in mice

  • Open Access
  • Research article

Haitao Tu, Xin Yi Yeo, Zhi-Wei Zhang, Wei Zhou, Jayne Yi Tan, Li Chi, Sook-Yoong Chia, Zhihong Li, Aik Yong Sim, Brijesh Kumar Singh, Dongrui Ma, Zhidong Zhou, Isabelle Bonne, Shuo-Chien Ling, Adeline S.L. Ng, Sangyong Jung, Eng-King Tan, Li Zeng

Seeding activity of skin misfolded tau as a biomarker for tauopathies

  • Open Access
  • Research article

Zerui Wang, Ling Wu, Maria Gerasimenko, Tricia Gilliland, Zahid Syed Ali Shah, Evalynn Lomax, Yirong Yang, Steven A. Gunzler, Vincenzo Donadio, Rocco Liguori, Bin Xu, Wen-Quan Zou

Aging-associated sensory decline and Alzheimer’s disease

  • Open Access
  • Review

Suji Hong, Seung-Hyun Baek, Mitchell K. P. Lai, Thiruma V. Arumugam, Dong-Gyu Jo

Correction: The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

  • Open Access
  • Correction

Jace Jones-Tabah, Kathy He, Nathan Karpilovsky, Konstantin Senkevich, Ghislaine Deyab, Isabella Pietrantonio, Thomas Goiran, Yuting Cousineau, Daria Nikanorova, Taylor Goldsmith, Esther del Cid Pellitero, Carol X.-Q. Chen, Wen Luo, Zhipeng You, Narges Abdian, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Stanley Fahn, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Lior Greenbaum, Sharon Hassin-Baer, Roy N. Alcalay, Austen Milnerwood, Thomas M. Durcan, Ziv Gan-Or, Edward A. Fon

Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis

  • Open Access
  • Research article

Lingliang Zhang, Lingling Huang, Yuhang Zhou, Jian Meng, Liang Zhang, Yunqiang Zhou, Naizhen Zheng, Tiantian Guo, Shanshan Zhao, Zijie Wang, Yuanhui Huo, Yingjun Zhao, Xiao-fen Chen, Honghua Zheng, David M. Holtzman, Yun-wu Zhang

Mystery of gamma wave stimulation in brain disorders

  • Open Access
  • Review

Qianting Deng, Chongyun Wu, Emily Parker, Jing Zhu, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang

The UFMylation pathway is impaired in Alzheimer’s disease

  • Open Access
  • Research article

Tingxiang Yan, Michael G. Heckman, Emily C. Craver, Chia-Chen Liu, Bailey D. Rawlinson, Xue Wang, Melissa E. Murray, Dennis W. Dickson, Nilufer Ertekin-Taner, Zhenkun Lou, Guojun Bu, Wolfdieter Springer, Fabienne C. Fiesel

Dementia with lewy bodies patients with high tau levels display unique proteome profiles

  • Open Access
  • Research article

Sinead Greally, Mukesh Kumar, Christoph Schlaffner, Hanne van der Heijden, Elisabeth S. Lawton, Deeptarup Biswas, Sabina Berretta, Hanno Steen, Judith A. Steen

Targeted long-read sequencing to quantify methylation of the C9orf72 repeat expansion

  • Open Access
  • Research article

Evan Udine, NiCole A. Finch, Mariely DeJesus-Hernandez, Jazmyne L. Jackson, Matthew C. Baker, Siva Arumugam Saravanaperumal, Eric Wieben, Mark T.W. Ebbert, Jaimin Shah, Leonard Petrucelli, Rosa Rademakers, Björn Oskarsson, Marka van Blitterswijk

Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons

  • Open Access
  • Research article

Amir T. Marvian, Tabea Strauss, Qilin Tang, Benjamin J. Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S. Sutherland, William A. McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F. Lichtenthaler, Wolfgang Wurst, Sigrid Schwarz, Günter Höglinger

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Die Leitlinien für Ärztinnen und Ärzte, Untersuchung eines adipösen Kindes/© Colourbox (Symbolbild mit Fotomodell), Senior mit Parkinson hält den Löffel mit zwei Händen/© MarianVejcik / Getty Images / iStock (Symbolbild mit Fotomodell), Störung der Lidhebung bei Myasthenia gravis/© Alessandro Grandini / stock.adobe.com (Symbolbild mit Fotomodell), Person hält ein Glas Milch in beiden Händen/© Africa Studio / stock.adobe.com (Symbolbild mit Fotomodell)