Molecular Neurodegeneration

Inhalt (126 Artikel)

Positron emission tomography tracers for synucleinopathies

Open Access
Review

Jie Xiang, Zhentao Zhang, Shengxi Wu, Keqiang Ye

VCP regulates early tau seed amplification via specific cofactors

Open Access
Research article

Sushobhna Batra, Jaime Vaquer-Alicea, Clarissa Valdez, Skyler P. Taylor, Victor A. Manon, Anthony R. Vega, Omar M. Kashmer, Sourav Kolay, Andrew Lemoff, Nigel J. Cairns, Charles L. White III, Marc I. Diamond

Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands

Open Access
Research article

Jessica A. Greven, Joshua R. Wydra, Rory A. Greer, Cynthia Zhi, David A. Price, Jordyn D. Svoboda, Christopher L. M. Camitta, Mya Washington, Daisy W. Leung, Yuhua Song, Jen Alexander-Brett, Tom J. Brett

RNA-Targeting CRISPR/CasRx system relieves disease symptoms in Huntington’s disease models

Open Access
Research article

Yingqi Lin, Caijuan Li, Yizhi Chen, Jiale Gao, Jiawei Li, Chunhui Huang, Zhaoming Liu, Wei Wang, Xiao Zheng, Xichen Song, Jianhao Wu, Jiaxi Wu, Oscar Junhong Luo, Zhuchi Tu, Shihua Li, Xiao-Jiang Li, Liangxue Lai, Sen Yan

Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis

Open Access
Research article

Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease

Open Access
Research article

Mridula Bhalla, Jinhyeong Joo, Daeun Kim, Jeong Im Shin, Yongmin Mason Park, Yeon Ha Ju, Uiyeol Park, Seonguk Yoo, Seung Jae Hyeon, Hyunbeom Lee, Junghee Lee, Hoon Ryu, C. Justin Lee

Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications

Open Access
Review

Pharaoh Fellow Mwale, Cheng-Ta Hsieh, Ting-Lin Yen, Jing-Shiun Jan, Rajeev Taliyan, Chih-Hao Yang, Wen-Bin Yang

Genetic context modulates aging and degeneration in the murine retina

Open Access
Research article

Olivia J. Marola, Michael MacLean, Travis L. Cossette, Cory A. Diemler, Amanda A. Hewes, Alaina M. Reagan, Jonathan Nyandu Kanyinda, Daniel A. Skelly, Gareth R. Howell

APOE Christchurch enhances a disease-associated microglial response to plaque but suppresses response to tau pathology

Open Access
Research article

Kristine M. Tran, Nellie E. Kwang, Claire A. Butler, Angela Gomez-Arboledas, Shimako Kawauchi, Cassandra Mar, Donna Chao, Rocio A. Barahona, Celia Da Cunha, Kate I. Tsourmas, Zechuan Shi, Shuling Wang, Sherilyn Collins, Amber Walker, Kai-Xuan Shi, Joshua A. Alcantara, Jonathan Neumann, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Lindsay A. Hohsfield, Vivek Swarup, Grant R. MacGregor, Kim N. Green

Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions

Open Access
Review

Grace Kuo, Ramhari Kumbhar, William Blair, Valina L. Dawson, Ted M. Dawson, Xiaobo Mao

Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications

Open Access
Review

Sijia He, Ziying Xu, Xianlin Han

Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions

Open Access
Review

Soumilee Chaudhuri, Minyoung Cho, Julia C. Stumpff, Paula J. Bice, Özkan İş, Nilüfer Ertekin-Taner, Andrew J. Saykin, Kwangsik Nho

Molecular and cellular characteristics of cerebrovascular cell types and their contribution to neurodegenerative diseases

Open Access
Review

Francisco J. Garcia, Myriam Heiman

Lewy body diseases and the gut

Open Access
Review

Timothy R. Sampson, Malú Gámez Tansey, Andrew B. West, Rodger A. Liddle

Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD

Open Access
Research article

Shaowei Wang, Boyang Li, Jie Li, Zhiheng Cai, Cristelle Hugo, Yi Sun, Lu Qian, Julia TCW, Helena C. Chui, Dante Dikeman, Isaac Asante, Stan G. Louie, David A. Bennett, Zoe Arvanitakis, Alan T. Remaley, Bilal E. Kerman, Hussein N. Yassine

Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice

Open Access
Research article

Ali Yousefian-Jazi, Suhyun Kim, Jiyeon Chu, Seung-Hye Choi, Phuong Thi Thanh Nguyen, Uiyeol Park, Min-gyeong Kim, Hongik Hwang, Kyungeun Lee, Yeyun Kim, Seung Jae Hyeon, Hyewhon Rhim, Hannah L. Ryu, Grewo Lim, Thor D. Stein, Kayeong Lim, Hoon Ryu, Junghee Lee

Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration

Open Access
Research article

Ting Shen, Jacob W. Vogel, Vivianna M. Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S. Phillips, Lauren Massimo, Edward B. Lee, David J. Irwin, Corey T. McMillan

The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression

Open Access
Research article

Callan L. Attwell, Inés Maldonado-Lasunción, Ruben Eggers, Bastiaan A. Bijleveld, Ward M. Ellenbroek, Natascha Siersema, Lotte Razenberg, Dédé Lamme, Nitish D. Fagoe, Ronald E. van Kesteren, August B. Smit, Joost Verhaagen, Matthew R. J. Mason

From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease

Open Access
Review

Ambra Stefani, Elena Antelmi, Dario Arnaldi, Isabelle Arnulf, Emmanuel During, Birgit Högl, Michele M. T. Hu, Alex Iranzo, Russell Luke, John Peever, Ronald B. Postuma, Aleksandar Videnovic, Ziv Gan-Or

The integrated stress response in neurodegenerative diseases

Open Access
Review

Maria Astrid Bravo-Jimenez, Shivangi Sharma, Soheila Karimi-Abdolrezaee

Mechanisms of astrocyte aging in reactivity and disease

Open Access
Review

Holly K. Gildea, Shane A. Liddelow

Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis

Open Access
Review

Shuo Zhang, Yue Gao, Yini Zhao, Timothy Y. Huang, Qiuyang Zheng, Xin Wang

18F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy

Open Access
Research article

Michael L. Alosco, Jhony Mejía Pérez, Julia E. Culhane, Ranjani Shankar, Christopher J. Nowinski, Samantha Bureau, Nidhi Mundada, Karen Smith, Alinda Amuiri, Breton Asken, Jenna R. Groh, Annalise Miner, Erika Pettway, Sydney Mosaheb, Yorghos Tripodis, Charles Windon, Gustavo Mercier, Robert A. Stern, Lea T. Grinberg, David N. Soleimani-Meigooni, Bradley T. Christian, Tobey J. Betthauser, Thor D. Stein, Ann C. McKee, Chester A. Mathis, Eric E. Abrahamson, Milos D. Ikonomovic, Sterling C. Johnson, Jesse Mez, Renaud La Joie, Daniel Schonhaut, Gil D. Rabinovici

Preclinical studies and transcriptome analysis in a model of Parkinson’s disease with dopaminergic ZNF746 expression

Open Access
Research article

Ji Hun Kim, Sumin Yang, Hyojung Kim, Dang-Khoa Vo, Han-Joo Maeng, Areum Jo, Joo-Heon Shin, Joo-Ho Shin, Hyeon-Man Baek, Gum Hwa Lee, Sung-Hyun Kim, Key-Hwan Lim, Valina L. Dawson, Ted M. Dawson, Jae-Yeol Joo, Yunjong Lee

The neuroimmune nexus: unraveling the role of the mtDNA-cGAS-STING signal pathway in Alzheimer’s disease

Open Access
Review

Shuiyue Quan, Xiaofeng Fu, Huimin Cai, Ziye Ren, Yinghao Xu, Longfei Jia

Age-dependent progression from clearance to vulnerability in the early response of periventricular microglia to α-synuclein toxic species

Open Access
Research article

Mª Salomé Sirerol-Piquer, Ana Perez-Villalba, Pere Duart-Abadia, Germán Belenguer, Ulises Gómez-Pinedo, Laura Blasco-Chamarro, Pau Carrillo-Barberà, Azucena Pérez-Cañamás, Victoria Navarro-Garrido, Benjamin Dehay, Miquel Vila, Javier Vitorica, Francisco Pérez-Sánchez, Isabel Fariñas

Inactivation of NLRP3 inflammasome by dephosphorylation at Serine 658 alleviates glial inflammation in the mouse model of Parkinson’s disease

Open Access
Research article

Rong-Xin Zhu, Rui-Xue Han, Yue-Han Chen, Lei Huang, Ting Liu, Jingwei Jiang, Cong Wang, Lei Cao, Yang Liu, Ming Lu

Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway

Open Access
Research article

Mengming Hu, Matthew B. Veldman

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases

Open Access
Research article

Lutgarde Serneels, Annerieke Sierksma, Emanuela Pasciuto, Ivana Geric, Arya Nair, Anna Martinez-Muriana, An Snellinx, Bart De Strooper

Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders

Open Access
Research article

Udit Sheth, Linn Öijerstedt, Michael G. Heckman, Launia J. White, Hilary W. Heuer, Argentina Lario Lago, Leah K. Forsberg, Kelley M. Faber, Tatiana M. Foroud, Rosa Rademakers, Eliana Marisa Ramos, Brian S. Appleby, Andrea C. Bozoki, R. Ryan Darby, Bradford C. Dickerson, Kimiko Domoto-Reilly, Douglas R. Galasko, Nupur Ghoshal, Neill R. Graff-Radford, Ian M. Grant, Chadwick M. Hales, Ging-Yuek Robin Hsiung, Edward D. Huey, David Irwin, Justin Y. Kwan, Irene Litvan, Ian R. Mackenzie, Joseph C. Masdeu, Mario F. Mendez, Chiadi U. Onyike, Belen Pascual, Peter S. Pressman, Erik D. Roberson, Allison Snyder, M. Carmela Tartaglia, William W. Seeley, Dennis W. Dickson, Howard J. Rosen, Bradley F. Boeve, Adam L. Boxer, Leonard Petrucelli, Tania F. Gendron

Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease

Open Access
Research article

Nicolai Franzmeier, Sebastian Niclas Roemer-Cassiano, Alexander Maximilian Bernhardt, Amir Dehsarvi, Anna Dewenter, Anna Steward, Davina Biel, Lukas Frontzkowski, Zeyu Zhu, Johannes Gnörich, Julia Pescoller, Fabian Wagner, Fabian Hirsch, Hannah de Bruin, Rik Ossenkoppele, Carla Palleis, Felix Strübing, Michael Schöll, Johannes Levin, Matthias Brendel, Günter U. Höglinger

Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies

Open Access
Research article

Dmytro Morderer, Melissa C. Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle R. Salemi, Brett S. Phinney, Guojun Bu, Na Zhao, Dennis W. Dickson, Melissa E. Murray, Wilfried Rossoll

Alzheimer's disease neuropathology and its estimation with fluid and imaging biomarkers

Open Access
Review

Dietmar Rudolf Thal, Koen Poesen, Rik Vandenberghe, Steffi De Meyer

A reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies

Open Access
Research article

David J. Koss, Olivia Todd, Hariharan Menon, Zoe Anderson, Tamsin Yang, Lucas Findlay, Ben Graham, Pawel Palmowski, Andrew Porter, Nicola Morrice, Lauren Walker, Johannes Attems, Simona S. Ghanem, Omar El-Agnaf, Fiona EN. LeBeau, Daniel Erskine, Tiago F. Outeiro

The role of n-3-derived specialised pro-resolving mediators (SPMs) in microglial mitochondrial respiration and inflammation resolution in Alzheimer’s disease

Open Access
Review

Mary Slayo, Christoph Rummel, Pasindu Hansana Singhaarachchi, Martin Feldotto, Sarah J. Spencer

Immune cell metabolic dysfunction in Parkinson’s disease

Open Access
Review

Julian R. Mark, Malú Gámez Tansey

Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research

Open Access
Review

Eun Sun Jung, Hayoung Choi, Inhee Mook-Jung

A stress-dependent TDP-43 SUMOylation program preserves neuronal function

Open Access
Research article

Terry R. Suk, Caroline E. Part, Jenny L. Zhang, Trina T. Nguyen, Meghan M. Heer, Alejandro Caballero-Gómez, Veronica S. Grybas, Paul M. McKeever, Benjamin Nguyen, Tahir Ali, Steve M. Callaghan, John M. Woulfe, Janice Robertson, Maxime W. C. Rousseaux

Immune modulation to treat Alzheimer’s disease

Open Access
Review

Michael R. Duggan, David G. Morgan, Brittani R. Price, Binita Rajbanshi, Alfonso Martin-Peña, Malú Gámez Tansey, Keenan A. Walker

Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement

Open Access
Research article

Natalie Grima, Andrew N. Smith, Claire E. Shepherd, Lyndal Henden, Thiri Zaw, Luke Carroll, Dominic B. Rowe, Matthew C. Kiernan, Ian P. Blair, Kelly L. Williams

ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses

Open Access
Research article

Rebecca L. Wallings, Drew A. Gillett, Hannah A. Staley, Savanna Mahn, Julian Mark, Noelle Neighbarger, Holly Kordasiewicz, Warren D. Hirst, Malú Gámez Tansey

Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease

Open Access
Letter to the Editor

Mohammed Zayed, Yong-Chan Kim, Byung-Hoon Jeong

TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies

Open Access
Review

Lianshuai Zhang, Xianyuan Xiang, Yahui Li, Guojun Bu, Xiao-Fen Chen

Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model

Open Access
Research article

Shuo Wang, Chuangye Qi, Chetan Rajpurohit, Baijayanti Ghosh, Wen Xiong, Baiping Wang, Yanyan Qi, Sung Hee Hwang, Bruce D. Hammock, Hongjie Li, Li Gan, Hui Zheng

Increased TMEM106B levels lead to lysosomal dysfunction which affects synaptic signaling and neuronal health

Open Access
Research article

Jolien Perneel, Miranda Lastra Osua, Sara Alidadiani, Nele Peeters, Linus De Witte, Bavo Heeman, Simona Manzella, Riet De Rycke, Mieu Brooks, Ralph B. Perkerson, Elke Calus, Wouter De Coster, Manuela Neumann, Ian R. A. Mackenzie, Debby Van Dam, Bob Asselbergh, Tommas Ellender, Xiaolai Zhou, Rosa Rademakers

Research models to study lewy body dementia

Open Access
Review

Suelen Lucio Boschen, Aarushi A. Mukerjee, Ayman H. Faroqi, Ben E. Rabichow, John Fryer

Apolipoprotein E in Alzheimer’s disease: molecular insights and therapeutic opportunities

Open Access
Review

Abdel Ali Belaidi, Ashley I. Bush, Scott Ayton

Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes

Open Access
Research article

Sara Gutiérrez Fernández, Cristina Gan Oria, Dieter Petit, Wim Annaert, John M. Ringman, Nick C. Fox, Natalie S. Ryan, Lucía Chávez-Gutiérrez

TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis

Open Access
Research article

Maria Vizziello, Ilaria Linda Dellarole, Arianna Ciullini, Riccardo Pascuzzo, Annalisa Lombardo, Floriana Bellandi, Luigi Celauro, Claudia Battipaglia, Emilio Ciusani, Ambra Rizzo, Marcella Catania, Grazia Devigili, Sara Adriana Della Seta, Valentina Margiotta, Monica Consonni, Veronica Faltracco, Pietro Tiraboschi, Nilo Riva, Sara Maria Silvia Portaleone, Gianluigi Zanusso, Giuseppe Legname, Giuseppe Lauria, Eleonora Dalla Bella, Fabio Moda

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease

Open Access
Research article

Henna Martiskainen, Roosa-Maria Willman, Päivi Harju, Sami Heikkinen, Mette Heiskanen, Stephan A. Müller, Rosa Sinisalo, Mari Takalo, Petra Mäkinen, Teemu Kuulasmaa, Viivi Pekkala, Ana Galván del Rey, Sini-Pauliina Juopperi, Heli Jeskanen, Inka Kervinen, Kirsi Saastamoinen, Aarno Palotie, Mark Daly, Bridget Riley-Gills, Howard Jacob, Coralie Viollet, Slavé Petrovski, Chia-Yen Chen, Sally John, George Okafo, Robert Plenge, Joseph Maranville, Mark McCarthy, Rion Pendergrass, Jonathan Davitte, Kirsi Auro, Simonne Longerich, Anders Mälarstig, Anna Vlahiotis, Katherine Klinger, Clement Chatelain, Matthias Gossel, Karol Estrada, Robert Graham, Dawn Waterworth, Chris O´Donnell, Nicole Renaud, Tomi P. Mäkelä, Jaakko Kaprio, Minna Ruddock, Petri Virolainen, Antti Hakanen, Terhi Kilpi, Markus Perola, Jukka Partanen, Taneli Raivio, Jani Tikkanen, Raisa Serpi, Kati Kristiansson, Veli-Matti Kosma, Jari Laukkanen, Marco Hautalahti, Outi Tuovila, Jeffrey Waring, Bridget Riley-Gillis, Fedik Rahimov, Ioanna Tachmazidou, Zhihao Ding, Marc Jung, Hanati Tuoken, Shameek Biswas, Neha Raghavan, Adriana Huertas-Vazquez, Jae-Hoon Sul, Xinli Hu, Åsa Hedman, Ma´en Obeidat, Jonathan Chung, Jonas Zierer, Mari Niemi, Samuli Ripatti, Johanna Schleutker, Mikko Arvas, Olli Carpén, Reetta Hinttala, Johannes Kettunen, Arto Mannermaa, Katriina Aalto-Setälä, Mika Kähönen, Johanna Mäkelä, Reetta Kälviäinen, Valtteri Julkunen, Anne Remes, Jukka Peltola, Minna Raivio, Pentti Tienari, Roosa Kallionpää, Juulia Partanen, Adam Ziemann, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Heiko Runz, Sanni Lahdenperä, Natalie Bowers, Edmond Teng, Fanli Xu, Laura Addis, John Eicher, Qingqin S. Li, Karen He, Ekaterina Khramtsova, Martti Färkkilä, Jukka Koskela, Sampsa Pikkarainen, Airi Jussila, Katri Kaukinen, Timo Blomster, Mikko Kiviniemi, Markku Voutilainen, Tim Lu, Linda McCarthy, Amy Hart, Meijian Guan, Jason Miller, Kirsi Kalpala, Melissa Miller, Kari Eklund, Antti Palomäki, Pia Isomäki, Laura Pirilä, Oili Kaipiainen-Seppänen, Johanna Huhtakangas, Nina Mars, Apinya Lertratanakul, Marla Hochfeld, Jorge Esparza Gordillo, Fabiana Farias, Nan Bing, Tarja Laitinen, Margit Pelkonen, Paula Kauppi, Hannu Kankaanranta, Terttu Harju, Riitta Lahesmaa, Hubert Chen, Joanna Betts, Rajashree Mishra, Majd Mouded, Debby Ngo, Teemu Niiranen, Felix Vaura, Veikko Salomaa, Kaj Metsärinne, Jenni Aittokallio, Jussi Hernesniemi, Daniel Gordin, Juha Sinisalo, Marja-Riitta Taskinen, Tiinamaija Tuomi, Timo Hiltunen, Amanda Elliott, Mary Pat Reeve, Sanni Ruotsalainen, Dirk Paul, Audrey Chu, Dermot Reilly, Mike Mendelson, Jaakko Parkkinen, Tuomo Meretoja, Heikki Joensuu, Johanna Mattson, Eveliina Salminen, Annika Auranen, Peeter Karihtala, Päivi Auvinen, Klaus Elenius, Esa Pitkänen, Relja Popovic, Margarete Fabre, Jennifer Schutzman, Diptee Kulkarni, Alessandro Porello, Andrey Loboda, Heli Lehtonen, Stefan McDonough, Sauli Vuoti, Kai Kaarniranta, Joni A. Turunen, Terhi Ollila, Hannu Uusitalo, Juha Karjalainen, Mengzhen Liu, Stephanie Loomis, Erich Strauss, Hao Chen, Kaisa Tasanen, Laura Huilaja, Katariina Hannula-Jouppi, Teea Salmi, Sirkku Peltonen, Leena Koulu, David Choy, Ying Wu, Pirkko Pussinen, Aino Salminen, Tuula Salo, David Rice, Pekka Nieminen, Ulla Palotie, Maria Siponen, Liisa Suominen, Päivi Mäntylä, Ulvi Gursoy, Vuokko Anttonen, Kirsi Sipilä, Rion Pendergrass, Hannele Laivuori, Venla Kurra, Laura Kotaniemi-Talonen, Oskari Heikinheimo, Ilkka Kalliala, Lauri Aaltonen, Varpu Jokimaa, Marja Vääräsmäki, Outi Uimari, Laure Morin-Papunen, Maarit Niinimäki, Terhi Piltonen, Katja Kivinen, Elisabeth Widen, Taru Tukiainen, Niko Välimäki, Eija Laakkonen, Jaakko Tyrmi, Heidi Silven, Eeva Sliz, Riikka Arffman, Susanna Savukoski, Triin Laisk, Natalia Pujol, Janet Kumar, Iiris Hovatta, Erkki Isometsä, Hanna Ollila, Jaana Suvisaari, Antti Mäkitie, Argyro Bizaki-Vallaskangas, Sanna Toppila-Salmi, Tytti Willberg, Elmo Saarentaus, Antti Aarnisalo, Elisa Rahikkala, Kristiina Aittomäki, Fredrik Åberg, Mitja Kurki, Aki Havulinna, Juha Mehtonen, Priit Palta, Shabbeer Hassan, Pietro Della Briotta Parolo, Wei Zhou, Mutaamba Maasha, Susanna Lemmelä, Manuel Rivas, Aoxing Liu, Arto Lehisto, Andrea Ganna, Vincent Llorens, Henrike Heyne, Joel Rämö, Rodos Rodosthenous, Satu Strausz, Tuula Palotie, Kimmo Palin, Javier Garcia-Tabuenca, Harri Siirtola, Tuomo Kiiskinen, Jiwoo Lee, Kristin Tsuo, Kati Hyvärinen, Jarmo Ritari, Katri Pylkäs, Minna Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Nina Pitkänen, Samuel Lessard, Clément Chatelain, Lila Kallio, Tiina Wahlfors, Eero Punkka, Sanna Siltanen, Teijo Kuopio, Anu Jalanko, Huei-Yi Shen, Risto Kajanne, Mervi Aavikko, Helen Cooper, Denise Öller, Rasko Leinonen, Henna Palin, Malla-Maria Linna, Masahiro Kanai, Zhili Zheng, L. Elisa Lahtela, Mari Kaunisto, Elina Kilpeläinen, Timo P. Sipilä, Oluwaseun Alexander Dada, Awaisa Ghazal, Anastasia Kytölä, Rigbe Weldatsadik, Kati Donner, Anu Loukola, Päivi Laiho, Tuuli Sistonen, Essi Kaiharju, Markku Laukkanen, Elina Järvensivu, Sini Lähteenmäki, Lotta Männikkö, Regis Wong, Auli Toivola, Minna Brunfeldt, Hannele Mattsson, Sami Koskelainen, Tero Hiekkalinna, Teemu Paajanen, Shuang Luo, Shanmukha Sampath Padmanabhuni, Marianna Niemi, Javier Gracia-Tabuenca, Mika Helminen, Tiina Luukkaala, Iida Vähätalo, Jyrki Tammerluoto, Sarah Smith, Tom Southerington, Petri Lehto, Marja Niiranen, Sami V. Heikkinen, Mitja I. Kurki, Jarkko Marttila, Petri I. Mäkinen, Hannah Rostalski, Tomi Hietanen, Tiia Ngandu, Jenni Lehtisalo, Céline Bellenguez, Jean-Charles Lambert, Christian Haass, Juha Rinne, Juhana Hakumäki, Tuomas Rauramaa, Johanna Krüger, Hilkka Soininen, Annakaisa Haapasalo, Stefan F. Lichtenthaler, Ville Leinonen, Eino Solje, Mikko Hiltunen

Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication

Open Access
Research article

Xiaojie Zhao, Yan Li, Siwei Zhang, Ari Sudwarts, Hanwen Zhang, Alena Kozlova, Matthew J. Moulton, Lindsey D. Goodman, Zhiping P. Pang, Alan R. Sanders, Hugo J. Bellen, Gopal Thinakaran, Jubao Duan

Cerebrospinal fluid proteome profiling across the Alzheimer’s disease continuum: a step towards solving the equation for ‘X’

Open Access
Research article

Sophia Weiner, Mathias Sauer, Laia Montoliu-Gaya, Andrea L. Benedet, Nicholas J. Ashton, Fernando Gonzalez-Ortiz, Joel Simrén, Nesrine Rahmouni, Cecile Tissot, Joseph Therriault, Stijn Servaes, Jenna Stevenson, Ville Leinonen, Tuomas Rauramaa, Mikko Hiltunen, Pedro Rosa-Neto, Kaj Blennow, Henrik Zetterberg, Johan Gobom

Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration

Open Access
Review

Elise A. Kellett, Adekunle T. Bademosi, Adam K. Walker

Cautions on utilizing plasma GFAP level as a biomarker for reactive astrocytes in neurodegenerative diseases

Open Access
Perspective

Wongu Youn, Mijin Yun, C. Justin Lee, Michael Schöll

Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis

Open Access
Perspective

John Hardy, Patrick Lewis

Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy

Open Access
Review

Neil Donison, Jacqueline Palik, Kathryn Volkening, Michael J. Strong

Mouse models of Anti-Aβ immunotherapies

Open Access
Review

Philip Pikus, R. Scott Turner, G. William Rebeck

Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosis

Open Access
Research

Adam N. Trautwig, Edward J. Fox, Eric B. Dammer, Anantharaman Shantaraman, Lingyan Ping, Duc M. Duong, Caroline M. Watson, Fang Wu, Seneshaw Asress, Qi Guo, Allan I. Levey, James J. Lah, Federico Verde, Alberto Doretti, Antonia Ratti, Nicola Ticozzi, Cindy V. Ly, Timothy M. Miller, Mark A. Garret, James D. Berry, Eleanor V. Thomas, Christina N. Fournier, Zachary T. McEachin, Nicholas T. Seyfried, Jonathan D. Glass

Mutations in NEK1 cause ciliary dysfunction as a novel pathogenic mechanism in amyotrophic lateral sclerosis

Open Access
Research article

Min-Young Noh, Seong-il Oh, Young-Eun Kim, Sun Joo Cha, Wonjae Sung, Ki-Wook Oh, Yurim Park, Ji Young Mun, Chang-Seok Ki, Minyeop Nahm, Seung Hyun Kim

Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition

Open Access
Research article

Jie Xiang, Zhengjiang Qian, Ye Xi, Yanuo Wei, Guangxing Wang, Xia Liu, Zhi-Hao Wang, Zhentao Zhang, Shengxi Wu, Keqiang Ye

Bridging systemic metabolic dysfunction and Alzheimer’s disease: the liver interface

Open Access
Review

Dan Song, Yang Li, Ling-Ling Yang, Ya-Xi Luo, Xiu-Qing Yao

Early transcriptional and cellular abnormalities in choroid plexus of a mouse model of Alzheimer’s disease

Open Access
Research article

Zhong-Jiang Yan, Maosen Ye, Jiexi Li, Deng-Feng Zhang, Yong-Gang Yao

CD2AP at the junction of nephropathy and Alzheimer’s disease

Open Access
Review

Milene Vandal, Mohsen Janmaleki, Isabel Rea, Colin Gunn, Sotaro Hirai, Jeff Biernaskie, Justin Chun, Grant Gordon, Andrey Shaw, Amir Sanati-Nezhad, Gerald Pfeffer, Frederic Calon, Minh Dang Nguyen

RNA-binding proteins in ALS and FTD: from pathogenic mechanisms to therapeutic insights

Open Access
Review

Jens Rummens, Sandrine Da Cruz

The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice

Open Access
Research article

Devi Krishna Priya Karunakaran, Makenna Ley, Joanna Guo, Ammaarah Khatri, Katherine Sadleir, Jelena Popovic, Arun Kumar Upadhyay, Jeffrey Savas, Daniele Procissi, Jasvinder Atwal, Robert Vassar

The many connections of UFMylation with Alzheimer’s disease: a comprehensive review

Open Access
Review

Tingxiang Yan, Benjamin D. Clarkson, Zhenkun Lou, Wolfdieter Springer, Fabienne C. Fiesel

Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response

Open Access
Review

Zitong Wang, Ling Zhang, Chuan Qin

Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential

Open Access
Review

Elizabeth R. Dellar, Lara Nikel, Stephanie Fowler, Björn F. Vahsen, Ruxandra Dafinca, Emily Feneberg, Kevin Talbot, Martin R. Turner, Alexander G. Thompson

Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities

Open Access
Review

Zhihai Huang, Yulan Zhang, Peibin Zou, Xuemei Zong, Quanguang Zhang

In Memoriam of Edward H. Koo, MD 1954–2025

Open Access
Editorial

Hui Zheng, Douglas Galasko, Sangram S. Sisodia

Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathy

Open Access
Research

Rowan Saloner, Kaitlin B. Casaletto, Sruti Rayaprolu, Louisa Cornelis, Paramita Chakrabarty, Jose F. Abisambra, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Joel H. Kramer, Gil D. Rabinovici, Breton M. Asken

sPLA2-IIA modifies progranulin deficiency phenotypes in mouse models

Open Access
Research

Cha Yang, Huan Du, Gwang Bin Lee, Masaaki Uematsu, Weiguo He, Etienne Doré, Weizhi Yu, Ethan J. Sanford, Marcus B. Smolka, Eric Boilard, Jeremy M. Baskin, Ling Hao, Fenghua Hu

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis

Open Access
Research article

Oliver J. Ziff, Gustavo Morrone Parfitt, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder Samra, Núria Setó-Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard, Marie-Claude Potier, John Hardy, Dervis A. Salih, Paul Whiting, Fiona Ducotterd, Rickie Patani, Selina Wray, Charles Arber

Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease

Open Access
Research article

Massimiliano Passaretti, Daniel Veréb, Mite Mijalkov, Yu-Wei Chang, Hang Zhao, Blanca Zufiria-Gerbolés, Jiawei Sun, Giovanni Volpe, Natalia Rivera, Matteo Bologna, Joana B. Pereira

Mechanisms of interventions targeting modifiable factors for dementia risk reduction

Open Access
Review

Anna Matton, Ruth Stephen, Makrina Daniilidou, Mariagnese Barbera, Vilma Alanko, Marcel Ballin, Jamie Ford, Katri Hemiö, Jenni Lehtisalo, Sabsil López Rocha, Francesca Mangialasche, Tiia Ngandu, Anna Rosenberg, Gazi Saadmaan, Chinedu Udeh-Momoh, Kerttu Uusimäki, Alina Solomon, Miia Kivipelto

The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer’s disease

Open Access
Research article

Hasibur Rehman, Shun Yan, Shalini Saggu, Mae Aida, Fang Zhang, Yang Shu, Alexis Jones, Amy Trang, Emily Dew, Wenbo Zhi, Emily T. Claeboe, Anthony J. Baucum II, Guangyu Wu, Kai Jiao, Qin Wang

Alpha-synuclein seeding amplification assays in Lewy body dementia: a brief review

Open Access
Review

Maria Bregendahl, Zeynep Bengisu Kaya, Wolfgang Singer, Pamela J. McLean

Current strategies in the management of dementia with lewy bodies and future directions based on disease pathophysiology

Open Access
Review

Daniel Erskine, John-Paul Taylor

Skin biopsy: an emerging tool for the diagnosis of protein misfolding diseases of the central nervous system

Open Access
Correspondence

Wei Zhu, Hao-Lun Sun, Yan-Jiang Wang, Xia Lei, Xian-Le Bu

Methylome analysis of FTLD patients with TDP-43 pathology identifies epigenetic signatures specific to pathological subtypes

Open Access
Research article

Cristina T. Vicente, Tejasvi Niranjan, Elise Coopman, Júlia Faura, Sara Alidadiani, Claudia Schrauwen, Billie J. Matchett, Bavo Heeman, Marleen Van den Broeck, Wouter De Coster, Thuy Nguyen, Julie S. Lau, Saurabh Baheti, Tim de Pooter, Peter De Rijk, Mojca Strazisar, Matt Baker, Mariely DeJesus-Hernandez, NiCole A. Finch, Cyril Pottier, Marka van Blitterswijk, Yan Asmann, Melissa E. Murray, Leonard Petrucelli, Andrew King, Claire Troakes, Safa Al-Sarraj, Robert A. Rissman, Annie Hiniker, Margaret Flanagan, Bret M. Evers, Charles L. White III, Carlos Cruchaga, Rudolph Castellani, Jeroen G.J. van Rooij, Merel O. Mol, Harro Seelaar, John C. van Swieten, Björn Oskarsson, Robert Ross Reichard, Aivi T. Nguyen, Keith A. Josephs, Ronald C. Petersen, Nilüfer Ertekin-Taner, Bradley F. Boeve, Neill R. Graff-Radford, Sarah Weckhuysen, Dennis W. Dickson, Rosa Rademakers

Glial phagocytosis for synapse and toxic proteins in neurodegenerative diseases

Open Access
Review

Yeseong Choi, Won-Suk Chung

Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions

Open Access
Review

Min-Young Noh, Hyuk Sung Kwon, Min-Soo Kwon, Minyeop Nahm, Hee Kyung Jin, Jae-sung Bae, Seung Hyun Kim

Proteomic landscape of Alzheimer’s disease: emerging technologies, advances and insights (2021 – 2025)

Open Access
Review

Jay M. Yarbro, Him K. Shrestha, Zhen Wang, Xue Zhang, Masihuz Zaman, Mengqi Chu, Xusheng Wang, Gang Yu, Junmin Peng

Endothelium-specific endoglin triggers astrocyte reactivity via extracellular vesicles in a mouse model of Alzheimer’s disease

Open Access
Research

Pingao Zhang, Chenghuan Song, Jiyun Shi, Zijie Wei, Jing Wang, Wanying Huang, Rui Zhang, Jintao Wang, Xiaoli Yang, Gang Wang, Xiaoling Gao, Yongfang Zhang, Hongzhuan Chen, Hao Wang

Glycerophospholipids in ALS: insights into disease mechanisms and clinical implication

Open Access
Review

Thibaut Burg, Ludo Van Den Bosch

The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases

Open Access
Review

Hideyuki Takahashi, Stephen M. Strittmatter

Retraction Note: Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5– implications for dementia with lewy bodies

Open Access
Retraction Note

Cassia R Overk, Anna Cartier, Gideon Shaked, Edward Rockenstein, Kiren Ubhi, Brian Spencer, Diana L Price, Christina Patrick, Paula Desplats, Eliezer Masliah

A manifesto for Alzheimer’s disease drug discovery in the era of disease-modifying therapies

Open Access
Review

Heike Hering, Thierry Bussiere, Chia-Chen Liu, Kelly E. Glajch, Andreas Weihofen, Jane Grogan, Dominic M. Walsh

LRRK2 kinase activity regulates Parkinson’s disease-relevant lipids at the lysosome

Open Access
Research article

Michael T. Maloney, Xiang Wang, Rajarshi Ghosh, Shan V. Andrews, Romeo Maciuca, Shababa T. Masoud, Maayan Agam, Richard M. Caprioli, Giuseppe Astarita, Vitaliy V. Bondar, John Chen, Chi-Lu Chiu, Sonnet S. Davis, Audrey Cheuk-Nga Ho, Hoang N. Nguyen, Nicholas E. Propson, Michelle L. Reyzer, Oliver B. Davis, Matthew C. Deen, Sha Zhu, Gilbert Di Paolo, David J. Vocadlo, Anthony A Estrada, Javier de Vicente, Joseph W. Lewcock, Annie Arguello, Jung H. Suh, Sarah Huntwork-Rodriguez, Anastasia G. Henry

Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein

Open Access
Review

Jingfeng Liang, Rongzhen Li, Garry Wong, Xiaobing Huang

Correction: Clinical progression and genetic pathways in body-first and brain-first Parkinson’s disease

Open Access
Correction

Massimiliano Passaretti, Daniel Veréb, Mite Mijalkov, Yu-Wei Chang, Hang Zhao, Blanca Zufiria-Gerbolés, Jiawei Sun, Giovanni Volpe, Natalia Rivera, Matteo Bologna, Joana B. Pereira

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques

Open Access
Research

Lis de Weerd, Selina Hummel, Stephan A. Müller, Iñaki Paris, Thomas Sandmann, Marie Eichholtz, Robin Gröger, Amelie L. Englert, Stephan Wagner, Connie Ha, Sonnet S. Davis, Valerie Warkins, Dan Xia, Brigitte Nuscher, Anna Berghofer, Marvin Reich, Astrid F. Feiten, Kai Schlepckow, Michael Willem, Stefan F. Lichtenthaler, Joseph W. Lewcock, Kathryn M. Monroe, Matthias Brendel, Christian Haass

Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia

Open Access
Research article

Yanaika S. Hok-A-Hin, Lisa Vermunt, Carel F.W. Peeters, Emma L. van der Ende, Sterre C.M. de Boer, Lieke H. Meeter, Julie de Houwer, Harro Seelaar, John C. van Swieten, William T. Hu, Alberto Lleó, Daniel Alcolea, Sebastiaan Engelborghs, Anne Sieben, Alice Chen-Plotkin, David J. Irwin, Wiesje M. van der Flier, Yolande A.L. Pijnenburg, Charlotte E. Teunissen, Marta del Campo

MS4A6A/Ms4a6d deficiency disrupts neuroprotective microglia functions and promotes inflammation in Alzheimer’s disease model

Open Access
Research article

Hai-Shan Jiao, Yi-Jun Ge, Liang-Yu Huang, Ying Liu, Bang-Sheng Wu, Piao-Piao Lian, Yi-Ning Hao, Shan-Shan Han, Yi-Ting Li, Kai-Min Wu, Chen-Yun Wu, Tian-Lin Cheng, Peng Yuan, Jin-Tai Yu

Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology

Open Access
Research article

Denise Balta, Anish Varghese, Susy Prieto Huarcaya, Alessandro Di Spiezio, André R. A. Marques, Enes Yağız Akdaş, Doğa Tabakacilar, Alice Drobny, Christian Werner, Wei Xiang, Rebecca Mächtel, Jan Philipp Dobert, Anna Fejtova, Franziska Richter, Melanie Küspert, Philipp Arnold, Paul Saftig, Friederike Zunke

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity

Open Access
Research article

Brandon B. Holmes, Thaddeus K. Weigel, Jesseca M. Chung, Sarah K. Kaufman, Brandon I. Apresa, James R. Byrnes, Kaan S. Kumru, Jaime Vaquer-Alicea, Ankit Gupta, Indigo V. L. Rose, Yun Zhang, Alissa L. Nana, Dina Alter, Lea T. Grinberg, Salvatore Spina, Kevin K. Leung, Bruce L. Miller, Carlo Condello, Martin Kampmann, William W. Seeley, Jaeda C. Coutinho-Budd, James A. Wells

APOE genotype influences on the brain metabolome of aging mice – role for mitochondrial energetics in mechanisms of resilience in APOE2 genotype

Open Access
Research

Kamil Borkowski, Nuanyi Liang, Na Zhao, Matthias Arnold, Kevin Huynh, Naama Karu, Siamak Mahmoudiandehkordi, Alexandra Kueider-Paisley, Takahisa Kanekiyo, Guojun Bu, Rima Kaddurah-Daouk

A novel alpha-synuclein G14R missense variant is associated with atypical neuropathological features

Open Access
Research

Christof Brücke, Mohammed Al-Azzani, Nagendran Ramalingam, Maria Ramón, Rita L. Sousa, Fiamma Buratti, Michael Zech, Kevin Sicking, Leslie Amaral, Ellen Gelpi, Aswathy Chandran, Aishwarya Agarwal, Susana R. Chaves, Claudio O. Fernández, Ulf Dettmer, Janin Lautenschläger, Markus Zweckstetter, Rubén Fernández-Busnadiego, Alexander Zimprich, Tiago Fleming Outeiro

Autophagic impairment in sleep–wake circuitry is linked to sleep loss at the early stages of Alzheimer’s disease

Open Access
Research article

Christopher Daniel Morrone, Arielle A. Tsang, W. Haung Yu

The Hippo signaling pathway as a therapeutic target in Alzheimer’s disease

Open Access
Review

Doris Chen, Stella Wigglesworth-Littlewood, Frank J. Gunn-Moore

Making tracks: microglia and the extracellular matrix

Open Access
Review

Lauren K. Wareham, David J. Calkins

Microglia networks within the tapestry of alzheimer’s disease through spatial transcriptomics

Open Access
Review

Yi Zhou, Christopher K. Glass

Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer’s disease

Open Access
Research article

Isabel Castanho, Pourya Naderi Yeganeh, Carles A. Boix, Sarah L. Morgan, Hansruedi Mathys, Dmitry Prokopenko, Bartholomew White, Larisa M. Soto, Giulia Pegoraro, Saloni Shah, Athanasios Ploumakis, Nikolas Kalavros, David A. Bennett, Christoph Lange, Doo Yeon Kim, Lars Bertram, Li-Huei Tsai, Manolis Kellis, Rudolph E. Tanzi, Winston Hide

Brain somatic mutations in Alzheimer’s disease: linking genetic mosaicism to neurodegeneration

Open Access
Review

Zuguang Li, Juan Zhang, Zhiqiang Liu, Lu Yu, Chunqing Yang, Luoman Zhang, Zhigao Xiang, Feng Hu, Nadezda Brazh, Kai Shu, Ling-Qiang Zhu, Dan Liu

Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease

Open Access
Research article

Livia La Barbera, Paraskevi Krashia, Gilda Loffredo, Emma Cauzzi, Maria Luisa De Paolis, Martina Montanari, Luana Saba, Elena Spoleti, Serena Ficchì, Claudio Zaccone, Marco De Bardi, Claudia Palazzo, Ramona Marino, Emanuele Claudio Latagliata, Stefano Puglisi-Allegra, Giovanna Borsellino, Flavio Keller, Luisa Lo Iacono, Maria Teresa Viscomi, Annalisa Nobili, Marcello D’Amelio

Correction: Lewy body dementia: exploring biomarkers and pathogenic interactions of amyloid β, tau, and α-synuclein

Open Access
Correction

Jingfeng Liang, Rongzhen Li, Garry Wong, Xiaobing Huang

Cerebrospinal fluid markers link to synaptic plasticity responses and Alzheimer’s disease genetic pathways

Open Access
Research article

Bjørn-Eivind Kirsebom, Johanna Nilsson, Ellen Vromen, Peter Mikael Arnesen, Atle Bjørnerud, Ann Brinkmalm, Geir Bråthen, Gøril Rolfseng Grøntvedt, Jonas Jarholm, Kaja Nordengen, Lene Pålhaugen, Per Selnes, Nikias Siafarikas, Ragnhild Eide Skogseth, Sandra Tecelão, Knut Waterloo, Panpan You, Henrik Zetterberg, Dag Aarsland, Betty Tijms, Pieter Jelle Visser, Kaj Blennow, Tormod Fladby

Modeling neurodegeneration in the retina and strategies for developing pan-neurodegenerative therapies

Open Access
Review

Emily L. Ward, Larry Benowitz, Thomas M. Brunner, Guojun Bu, Michel Cayouette, Valeria Canto‐Soler, Sandro Dá Mesquita, Adriana Di Polo, Aaron DiAntonio, Xin Duan, Jeffrey L. Goldberg, Zhigang He, Yang Hu, Shane A. Liddelow, Anna La Torre, Milica Margeta, Francisco Quintana, Karthik Shekhar, Beth Stevens, Sally Temple, Humsa Venkatesh, Derek Welsbie, John G. Flanagan

Synaptic dysfunction and glial activation markers throughout aging and early neurodegeneration: a longitudinal CSF biomarker-based study

Open Access
Research

Mariana I. Muñoz-García, Yuetiva Deming, Ferran Lugo-Hernández, Sterling Johnson, Sanjay Asthana, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Cynthia Carlsson, Ozioma C. Okonkwo, David Pérez-Martinez, Alberto Villarejo-Galende, Kaj Blennow, Marc Suárez-Calvet, Henrik Zetterberg, Barbara B. Bendlin, Estrella Morenas-Rodríguez

Neurotherapeutic effects of Vutiglabridin as a Paraoxonase-2 modulator in preclinical models of Parkinson’s disease

Open Access
Research article

Heeyoung An, Sora Kang, Jaejin Shin, Purum Kim, Sunpil Kim, Suyeol Im, Ji Hwan Kim, Keun Woo Lee, Dong Hwan Kim, Jung Hee Park, Min-Ho Park, Jaemin Lee, Sun Kyung Park, Kwang Pyo Kim, Hyeong Min Lee, Jae Ho Lee, Leo S. Choi, Hyun Ju Jeon, Suyeon Yellena Kim, In Young Hwang, Mridula Bhalla, Woojin Won, Hyung Soon Park, Sang-Ku Yoo, Byoung Dae Lee, C. Justin Lee, Youngmi Kim Pak

Entering the era of precision medicine to treat amyotrophic lateral sclerosis

Open Access
Review

Frances Theunissen, Loren Flynn, Alfredo Iacoangeli, Ahmad Al Khleifat, Ammar Al-Chalabi, James J. Giordano, Masha Strømme, P. Anthony Akkari

Effect of antidiabetic drugs in Alzheimer´s disease: a systematic review of preclinical and clinical studies

Open Access
Review

Miriam Corraliza-Gomez, Maria Vargas-Soria, Monica Garcia-Alloza

Modulation of O-GlcNAc cycling influences α-synuclein amplification, degradation, and associated neuroinflammatory pathology

Open Access
Research

Yongzhen Miao, Ting Zhang, Zhuoya Ma, Huanhuan Du, Qipei Gu, Mengni Jiang, Kangping Xiong, Chun-Feng Liu, Hongrui Meng

Microglia sensing of peripheral signals that bridge the brain and body

Open Access
Review

Claire E. Young, Melanie A. Samuel

Interplay between astrocyte reactivity and APOE ε4 status is associated with accelerated pTau-related tau pathology in Alzheimer’s disease

Open Access
Research article

Xiaoxie Mao, Yan Wang, Ying Luan, Ying Wang, Jie Wang, Wenlin Dai, Yihui Guan, Qi Huang, Roger N. Gunn, Rik Ossenkoppele, Binyin Li, Zijing Li, Qihao Guo, Fang Xie

C-terminus-dependent detection of lysosomal alpha-synuclein in nigral Parkinson’s disease human brain neurons

Open Access
Research

Martino L. Morella, Bana Al Khayrat, Tim E. Moors, Lisanne in’t Veld, Irene Frigerio, Vinod Udayar, Bram L. van der Gaag, Wilma D. J. van de Berg

Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies

Open Access
Review

Hiroaki Sekiya, Tomoyasu Matsubara, Michael A. DeTure, Dennis W. Dickson

M102 activates both NRF2 and HSF1 transcription factor pathways and is neuroprotective in cell and animal models of amyotrophic lateral sclerosis

Open Access
Research

Amy F. Keerie, Raquel Rua Martins, Chloe F. Allen, Katie Bowden, Sufana Al Mashhadi, Thomas Marlow, Monika Myszczynska, Nikitha Thakur, Selina N. Beal, Allan Shaw, Shivani Suresh, Scott N. McKinnon, Johnathan Cooper-Knock, Ryan J. H. West, Sam Bonsall, Alex Daniel, Tyler Wells, Vedanth Kumar, Brittany C. S. Ellis, Maureen Higgins, Albena T. Dinkova-Kostova, Tatyana A. Shelkovnikova, Ira N. Kalfus, Ning Shan, Pamela J. Shaw, Laura Ferraiuolo, Richard J. Mead

Plasma TDP-43 is a potential biomarker for advanced limbic-predominant age-related TDP-43 encephalopathy neuropathologic change

Open Access
Correspondence

Jijing Wang, Julie A. Schneider, David A. Bennett, Nicholas T. Seyfried, Tracy L. Young-Pearse, Hyun-Sik Yang

High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer’s disease phenotypes in a large mixed-dementia cohort

Open Access
Research

Katherine Gong, Jigyasha Timsina, Muhammad Ali, Yike Chen, Menghan Liu, Ciyang Wang, Cyril Pottier, Geoffrey K. Feld, Gyujin Heo, Tammie L. S. Benzinger, Cyrus A. Raji, Beau Ances, Brian A. Gordon, Julie K. Wisch, Suzanne E. Schindler, John C. Morris, David M. Holtzman, Laura Ibanez, Carlos Cruchaga

Death-associated protein kinase 1-dependent SENP1 degradation increases tau SUMOylation and leads to cognitive dysfunction in a mouse model for tauopathy

Open Access
Research

Xindong Shui, Xiaoqing Zheng, Jinfeng Wu, Mi Zhang, Gamin Kim, Renxuan Chen, Lianlian Peng, Zonghai Wang, Yameng Zheng, Ling Zhang, Ruomeng Li, Long Wang, Ying Zhou, Jungho Kim, Dongmei Chen, Tao Zhang, Tae Ho Lee

Domain mapping of disease mutations reveals pathogenic SORL1 variants in Alzheimer’s disease

Open Access
Research article

Olav M. Andersen, Matthijs W. J. de Waal, Giulia Monti, Niccolo Tesi, Anne Mette G. Jensen, Christa de Geus, Rosalina van Spaendonk, Maartje Vogel, Shahzad Ahmad, Najaf Amin, Philippe Amouyel, Gary W. Beecham, Céline Bellenguez, Claudine Berr, Joshua C. Bis, Anne Boland, Paola Bossù, Femke Bouwman, Jose Bras, Camille Charbonnier, Jordi Clarimon, Carlos Cruchaga, Antonio Daniele, Jean-François Dartigues, Stéphanie Debette, Jean-François Deleuze, Nicola Denning, Anita L. DeStefano, Oriol Dols-Icardo, Cornelia M. van Duijn, Lindsay A. Farrer, Maria Victoria Fernández, Wiesje M. van der Flier, Nick C. Fox, Daniela Galimberti, Emmanuelle Genin, Johan J. P. Gille, Benjamin Grenier-Boley, Detelina Grozeva, Yann Le Guen, Rita Guerreiro, Jonathan L. Haines, Clive Holmes, Holger Hummerich, M. Arfan Ikram, M. Kamran Ikram, Amit Kawalia, Robert Kraaij, Jean-Charles Lambert, Marc Lathrop, Afina W. Lemstra, Alberto Lleó, Richard M. Myers, Marcel M. A. M. Mannens, Rachel Marshall, Eden R. Martin, Carlo Masullo, Richard Mayeux, Simon Mead, Patrizia Mecocci, Alun Meggy, Merel O. Mol, Benedetta Nacmias, Adam C. Naj, Valerio Napolioni, J. Nicholas Cochran, Gaël Nicolas, Florence Pasquier, Pau Pastor, Margaret A. Pericak-Vance, Yolande A. L. Pijnenburg, Fabrizio Piras, Olivier Quenez, Alfredo Ramirez, Rachel Raybould, Richard Redon, Marcel J. T. Reinders, Anne-Claire Richard, Steffi G. Riedel-Heller, Fernando Rivadeneira, Jeroen G. J. van Rooij, Stéphane Rousseau, Natalie S. Ryan, Pascual Sanchez-Juan, Gerard D. Schellenberg, Philip Scheltens, Jonathan M. Schott, Sudha Seshadri, Daoud Sie, Rebecca Sims, Erik A. Sistermans, Sandro Sorbi, John C. van Swieten, Betty Tijms, André G. Uitterlinden, Pieter Jelle Visser, Michael Wagner, David Wallon, Li-San Wang, Julie Williams, Jennifer S. Yokoyama, Aline Zarea, Sven J. van der Lee, Johan G. Olsen, Marc Hulsman, Henne Holstege

Pioglitazone modulates metabolic adaptation and peripheral nerve regeneration after injury

Open Access
Research

Antonia Seitz, Taylan Özöncü, Daniela Sinske, Claudia Klugmann, Daniel Tews, Pamela Fischer-Posovszky, Bernd Knöll, Sofia Meyer zu Reckendorf

DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice

Open Access
Research

Hao Chen, Li Fan, Qi Guo, Man Ying Wong, Jingjie Zhu, Nessa Foxe, Winston Wang, Aviram Nessim, Gillian Carling, Bangyan Liu, Chloe Lopez-Lee, Yige Huang, Sadaf Amin, Tark Patel, Sue-Ann Mok, Won-min Song, Bin Zhang, Shiaoching Gong, Qin Ma, Hongjun Fu, Li Gan, Wenjie Luo

Multidomain therapy for Alzheimer’s disease: a scoping review of cognitive decline trials

Open Access
Review

Jared C. Roach, Gwênlyn Glusman, Molly K. Rapozo, David A. Merrill, Jennifer Bramen, John F. Hodes, Prabha Siddarth, Somayeh Meysami, Shannel H. K. Elhelou, Ryan M. Glatt, Lance Edens, Cory Funk, Dan Kelly, William R. Shankle, Dale Bredesen, Cyrus A. Raji, Leroy Hood

Disrupting α-Synuclein–ClpP interaction restores mitochondrial function and attenuates neuropathology in Parkinson’s disease models

Open Access
Research

Di Hu, Xiaoyan Sun, Xin Qi

Aktuelle Ausgaben

Scrollen für mehr

Benutzen Sie die Pfeiltasten für mehr

Scrollen oder Pfeiltasten für mehr

Neu im Fachgebiet Neurologie

Kombination von SGLT2-Inhibitor mit Statin ist sicher

13.01.2026
Statine
Nachrichten

Die Rhabdomyolyse ist eine gefürchtete, aber sehr seltene Nebenwirkung von Statinen. Medikamenteninteraktionen können das Risiko erhöhen. Mit SGLT2-Inhibitoren scheint dies nicht der Fall zu sein – die Ko-Therapie könnte das Risiko sogar senken.

Herzinsuffizienz: Vorsicht bei diesen Medikamenten!

12.01.2026
Herzinsuffizienz
Nachrichten

Eine Herzinsuffizienz kann durch bestimmte Medikamentenkombinationen verschlimmert oder auch getriggert werden. Ein internationales Expertengremium hat zusammengefasst, bei welchen Konstellationen erhöhte Vorsicht geboten ist.

Schützt oder schadet die menopausale Hormontherapie vor Demenz?

08.01.2026
Menopausale Hormontherapie
Nachrichten

Ob und wie sich eine menopausale Hormontherapie auf das Demenzrisiko auswirkt, ist seit Jahren umstritten. Eine systematische Übersichtsarbeit mit Metaanalyse mit Daten von über einer Million Frauen liefert Erkenntnisse und zeigt, warum die Frage noch nicht abschließend beantwortet ist.

Was 2026 in Sachen Digitalisierung und Formulare auf Praxen zukommt

Praxis und Beruf
Nachrichten

2026 bringt Neuerungen für ärztliche Praxen: Wer in seiner Praxissoftware kein (aktuelles) ePA-Modul nutzt, muss ab Januar mit Sanktionen rechnen. Zudem gibt es ein neues Formular zur Bescheinigung einer Fehlgeburt.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Bildnachweise

Die Leitlinien für Ärztinnen und Ärzte, Ältere Person sortiert Medikamente/© Przemek Klos / stock.adobe.com (Symbolbild mit Fotomodell), Ältere Dame hält Tabletten und Packungsbeilage in den Händen/© Vladimir Vladimirov / Getty Images / iStock (Symbolbild mit Fotomodell), Arzt tippt an Computer/© Gorodenkoff / Stock.adobe.com (Symbolbild mit Fotomodell)

Springer Medizin

Molecular Neurodegeneration

Inhalt (126 Artikel)

Aktuelle Ausgaben