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Die Onkologie

Erschienen in:

21.11.2019 | Interventionelle Radiologie | Leitthema

Bildgebung und molekulare Diagnostik in der Onkologie

Bildgeführte Interventionen

verfasst von: Dr. med. F. Schaab, Dr. med. C. G. Radosa, Dr. med. habil. J. P. Kühn, Prof. Dr. med. R. T. Hoffmann

Erschienen in: Die Onkologie | Ausgabe 1/2020

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Zusammenfassung

Hintergrund

Die interventionelle Radiologie ist ein noch junges, aber rasant wachsendes und zunehmend differenziertes Teilgebiet der Radiologie. Ihre Methoden finden Eingang in die Therapieoptionen und -leitlinien zahlreicher Tumorerkrankungen.

Ziel

In diesem Übersichtsartikel werden sowohl diagnostisch-interventionelle Verfahren, wie die bildgesteuerte Biopsie; kurative Methoden, wie die thermoablativen Verfahren der Mikrowellenablation (MWA), Radiofrequenzablation (RFA), der laserinduzierten Thermotherapie (LITT); als auch palliative Interventionen, wie die transarterielle Chemoembolisation (TACE) oder die selektive interne Radiotherapie (SIRT) jeweils mit ihren Indikationen und Komplikationen vorgestellt.

Material und Methoden

Selektive Literaturrecherche in der Datenbank PubMed sowie in wissenschaftlichen Leitlinien unter Einbezug eigener Fallbeispiele und Erfahrungen aus dem eigenen Behandlungskollektiv.

Ergebnisse und Schlussfolgerung

Die in der Zielsetzung genannten Verfahren werden methodisch vorgestellt und ihrem aktuellen klinischen Stellenwert zugeordnet. Das Angebot interventionsradiologischer Verfahren in der onkologischen Therapie wird sich aller Voraussicht nach in Zukunft noch mehr erweitern und die bereits etablierten Methoden flächendeckender verfügbar werden.

Tam AL, Lim HJ, Wistuba II et al (2016) Image-guided biopsy in the era of personalized cancer care: proceedings from the society of Interventional radiology research consensus panel. J Vasc Interv Radiol 27:8–19PubMedCrossRef

Veltri A, Bargellini I, Giorgi L et al (2017) CIRSE guidelines on percutaneous needle biopsy (PNB). Cardiovasc Intervent Radiol 40:1501–1513PubMedCrossRef

Kuhn JP, Langner S, Hegenscheid K et al (2010) Magnetic resonance-guided upper abdominal biopsies in a high-field wide-bore 3‑T MRI system: feasibility, handling, and needle artefacts. Eur Radiol 20:2414–2421PubMedCrossRef

Solomon SB, Zakowski MF, Pao W et al (2010) Core needle lung biopsy specimens: adequacy for EGFR and KRAS mutational analysis. AJR Am J Roentgenol 194:266–269PubMedPubMedCentralCrossRef

Kothary N, Lock L, Sze DY et al (2009) Computed tomography-guided percutaneous needle biopsy of pulmonary nodules: impact of nodule size on diagnostic accuracy. Clin Lung Cancer 10:360–363PubMedCrossRef

Anzidei M, Porfiri A, Andrani F et al (2017) Imaging-guided chest biopsies: techniques and clinical results. Insights Imaging 8:419–428PubMedPubMedCentralCrossRef

Otto S, Mensel B, Friedrich N et al (2015) Predictors of technical success and rate of complications of image-guided percutaneous transthoracic lung needle biopsy of pulmonary tumors. PLoS One 10:e124947PubMedPubMedCentralCrossRef

Sainani NI, Schlett CL, Hahn PF et al (2014) Computed tomography-guided percutaneous biopsy of isoattenuating focal liver lesions. Abdom Imaging 39:633–644PubMedCrossRef

Neuzillet Y, Lechevallier E, Andre M et al (2004) Accuracy and clinical role of fine needle percutaneous biopsy with computerized tomography guidance of small (less than 4.0 cm) renal masses. J Urol 171:1802–1805PubMedCrossRef

10.

Haage P, Piroth W, Staatz G et al (1999) CT-guided percutaneous biopsies for the classification of focal liver lesions: a comparison between 14 G and 18 G puncture biopsy needles. Rofo 171:44–48PubMedCrossRef

11.

Tatsumi E, Takano H, Taenaka Y et al (1991) An integrated artificial heart-lung device. ASAIO Trans 37:M301–303PubMed

12.

Kuhn JP, Puls R, Wallaschowski H et al (2008) Characteristics of necrosis after laser-induced thermotherapy in contrast-enhanced MRI and implications for treatment success. Rofo 180:816–820PubMedCrossRef

13.

Hinshaw JL, Lubner MG, Ziemlewicz TJ et al (2014) Percutaneous tumor ablation tools: microwave, radiofrequency, or cryoablation—what should you use and why? Radiographics 34:1344–1362PubMedCrossRef

14.

Rosenberg C, Kickhefel A, Mensel B et al (2013) PRFS-based MR thermometry versus an alternative T1 magnitude method—comparative performance predicting thermally induced necrosis in hepatic tumor ablation. PLoS One 8:e78559PubMedPubMedCentralCrossRef

15.

Hoffmann CO, Rosenberg C, Linder A et al (2012) Residual tumor after laser ablation of human non-small-cell lung cancer demonstrated by ex vivo staining: correlation with invasive temperature measurements. MAGMA 25:63–74PubMedCrossRef

16.

Vogl TJ, Naguib NN, Gruber-Rouh T et al (2011) Microwave ablation therapy: clinical utility in treatment of pulmonary metastases. Radiology 261:643–651PubMedCrossRef

17.

Steinke K, Habicht JM, Thomsen S et al (2002) CT-guided radiofrequency ablation of a pulmonary metastasis followed by surgical resection. Cardiovasc Intervent Radiol 25:543–546PubMedCrossRef

18.

Uhlig J, Kokabi N, Xing M et al (2018) Ablation versus resection for stage 1A renal cell carcinoma: national variation in clinical management and selected outcomes. Radiology 288:889–897PubMedCrossRef

19.

Hoffmann RT, Jakobs TF, Kubisch CH et al (2010) Radiofrequency ablation in the treatment of osteoid osteoma-5-year experience. Eur J Radiol 73:374–379PubMedCrossRef

20.

Vogel A, Cervantes A, Chau I et al (2019) Hepatocellular carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 30:871–873PubMedCrossRef

21.

Cucchetti A, Piscaglia F, Cescon M et al (2013) Cost-effectiveness of hepatic resection versus percutaneous radiofrequency ablation for early hepatocellular carcinoma. J Hepatol 59:300–307PubMedCrossRef

22.

Gillams A, Goldberg N, Ahmed M et al (2015) Thermal ablation of colorectal liver metastases: a position paper by an international panel of ablation experts, the Interventional Oncology Sans Frontieres meeting 2013. Eur Radiol 25:3438–3454PubMedPubMedCentralCrossRef

23.

Kim KH, Yoon YS, Yu CS et al (2011) Comparative analysis of radiofrequency ablation and surgical resection for colorectal liver metastases. J Korean Surg Soc 81:25–34PubMedPubMedCentralCrossRef

24.

Solbiati L, Livraghi T, Goldberg SN et al (2001) Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients. Radiology 221:159–166PubMedCrossRef

25.

Galanakis N, Kehagias E, Matthaiou N et al (2018) Transcatheter arterial chemoembolization combined with radiofrequency or microwave ablation for hepatocellular carcinoma: a review. Hepat Oncol 5:HEP7PubMedPubMedCentralCrossRef

26.

Fanali S, Cristalli M, Nardi A et al (1990) Capillary zone electrophoresis in pharmaceutical analysis. Farmaco 45:693–702PubMed

27.

Hiraki T, Gobara H, Mimura H et al (2011) Radiofrequency ablation of lung cancer at Okayama University Hospital: a review of 10 years of experience. Acta Med Okayama 65:287–297PubMed

28.

Chua TC, Thornbury K, Saxena A et al (2010) Radiofrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases. Cancer 116:2106–2114PubMedCrossRef

29.

Rosenberg C, Puls R, Hegenscheid K et al (2009) Laser ablation of metastatic lesions of the lung: long-term outcome. AJR Am J Roentgenol 192:785–792PubMedCrossRef

30.

Friedel G, Pastorino U, Buyse M et al (1999) Resection of lung metastases: long-term results and prognostic analysis based on 5206 cases—the International Registry of Lung Metastases. Zentralbl Chir 124:96–103PubMed

31.

Pfannschmidt J, Muley T, Hoffmann H et al (2003) Prognostic factors and survival after complete resection of pulmonary metastases from colorectal carcinoma: experiences in 167 patients. J Thorac Cardiovasc Surg 126:732–739PubMedCrossRef

32.

Lencioni R, Crocetti L, Cioni R et al (2008) Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study). Lancet Oncol 9:621–628PubMedCrossRef

33.

Golfieri R, Giampalma E, Renzulli M et al (2014) Randomised controlled trial of doxorubicin-eluting beads vs conventional chemoembolisation for hepatocellular carcinoma. Br J Cancer 111:255–264PubMedPubMedCentralCrossRef

34.

Kemeny NE, Niedzwiecki D, Hollis DR et al (2006) Hepatic arterial infusion versus systemic therapy for hepatic metastases from colorectal cancer: a randomized trial of efficacy, quality of life, and molecular markers (CALGB 9481). J Clin Oncol 24:1395–1403PubMedCrossRef

35.

Boige V, Malka D, Elias D et al (2008) Hepatic arterial infusion of oxaliplatin and intravenous LV5FU2 in unresectable liver metastases from colorectal cancer after systemic chemotherapy failure. Ann Surg Oncol 15:219–226PubMedCrossRef

36.

Fiorentini G, Rossi S, Dentico P et al (2003) Irinotecan hepatic arterial infusion chemotherapy for hepatic metastases from colorectal cancer: a phase II clinical study. Tumori 89:382–384PubMedCrossRef

37.

Brown DB, Nikolic B, Covey AM et al (2012) Quality improvement guidelines for transhepatic arterial chemoembolization, embolization, and chemotherapeutic infusion for hepatic malignancy. J Vasc Interv Radiol 23:287–294PubMedCrossRef

38.

Gaba RC, Lokken RP, Hickey RM et al (2017) Quality improvement guidelines for transarterial chemoembolization and embolization of hepatic malignancy. J Vasc Interv Radiol 28:1210–1223PubMedCrossRef

39.

Gaba RC (2012) Chemoembolization practice patterns and technical methods among interventional radiologists: results of an online survey. AJR Am J Roentgenol 198:692–699PubMedCrossRef

40.

Berger DH, Carrasco CH, Hohn DC et al (1995) Hepatic artery chemoembolization or embolization for primary and metastatic liver tumors: post-treatment management and complications. J Surg Oncol 60:116–121PubMedCrossRef

41.

Testa R, Testa E, Giannini E et al (2003) Trans-catheter arterial chemoembolisation for hepatocellular carcinoma in patients with viral cirrhosis: role of combined staging systems, cancer liver Italian program (CLIP) and model for end-stage liver disease (MELD), in predicting outcome after treatment. Aliment Pharmacol Ther 17:1563–1569PubMedCrossRef

42.

Georgiades CS, Hong K, D’Angelo M et al (2005) Safety and efficacy of transarterial chemoembolization in patients with unresectable hepatocellular carcinoma and portal vein thrombosis. J Vasc Interv Radiol 16:1653–1659PubMedCrossRef

43.

European Association for the Study of the Liver (2018) EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 69:182–236CrossRef

44.

Habib A, Desai K, Hickey R et al (2015) Transarterial approaches to primary and secondary hepatic malignancies. Nat Rev Clin Oncol 12:481–489PubMedCrossRef

45.

Lencioni R, de Baere T, Soulen MC et al (2016) Lipiodol transarterial chemoembolization for hepatocellular carcinoma: a systematic review of efficacy and safety data. Hepatology 64:106–116PubMedCrossRef

46.

Ray CE Jr., Edwards A, Smith MT et al (2013) Metaanalysis of survival, complications, and imaging response following chemotherapy-based transarterial therapy in patients with unresectable intrahepatic cholangiocarcinoma. J Vasc Interv Radiol 24:1218–1226PubMedCrossRef

47.

Fiorentini G, Aliberti C, Tilli M et al (2012) Intra-arterial infusion of irinotecan-loaded drug-eluting beads (DEBIRI) versus intravenous therapy (FOLFIRI) for hepatic metastases from colorectal cancer: final results of a phase III study. Anticancer Res 32:1387–1395PubMed

48.

Brown KT, Koh BY, Brody LA et al (1999) Particle embolization of hepatic neuroendocrine metastases for control of pain and hormonal symptoms. J Vasc Interv Radiol 10:397–403PubMedCrossRef

49.

Klingenstein A, Haug AR, Zech CJ et al (2013) Radioembolization as locoregional therapy of hepatic metastases in uveal melanoma patients. Cardiovasc Intervent Radiol 36:158–165PubMedCrossRef

50.

Chung JW, Park JH, Han JK et al (1996) Hepatic tumors: predisposing factors for complications of transcatheter oily chemoembolization. Radiology 198:33–40PubMedCrossRef

51.

Yu JS, Kim KW, Jeong MG et al (2002) Predisposing factors of bile duct injury after transcatheter arterial chemoembolization (TACE) for hepatic malignancy. Cardiovasc Intervent Radiol 25:270–274PubMedCrossRef

52.

Geschwind JF, Kaushik S, Ramsey DE et al (2002) Influence of a new prophylactic antibiotic therapy on the incidence of liver abscesses after chemoembolization treatment of liver tumors. J Vasc Interv Radiol 13:1163–1166PubMedCrossRef

53.

Padia SA, Lewandowski RJ, Johnson GE et al (2017) Radioembolization of hepatic malignancies: background, quality improvement guidelines, and future directions. J Vasc Interv Radiol 28:1–15PubMedCrossRef

54.

Radosa CG, Radosa JC, Grosche-Schlee S et al (2019) Holmium-166 radioembolization in hepatocellular carcinoma: feasibility and safety of a new treatment option in clinical practice. Cardiovasc Intervent Radiol 42:405–412PubMedCrossRef

55.

Voutsinas N, Lekperic S, Barazani S et al (2018) Treatment of primary liver tumors and liver metastases, part 1: nuclear medicine techniques. J Nucl Med 59:1649–1654PubMedCrossRef

56.

Carr BI (2004) Hepatic arterial 90yttrium glass microspheres (therasphere) for unresectable hepatocellular carcinoma: interim safety and survival data on 65 patients. Liver Transpl 10:S107–110PubMedCrossRef

57.

Salem R, Thurston KG (2006) Radioembolization with 90yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. Part 1: technical and methodologic considerations. J Vasc Interv Radiol 17:1251–1278PubMedCrossRef

58.

Sangro B, Salem R (2014) Transarterial chemoembolization and radioembolization. Semin Liver Dis 34:435–443PubMedCrossRef

59.

Sangro B, Gil-Alzugaray B, Rodriguez J et al (2008) Liver disease induced by radioembolization of liver tumors: description and possible risk factors. Cancer 112:1538–1546PubMedCrossRef

60.

Khan W, Sullivan KL, McCann JW et al (2011) Moxifloxacin prophylaxis for chemoembolization or embolization in patients with previous biliary interventions: a pilot study. AJR Am J Roentgenol 197:W343–345PubMedCrossRef

61.

Lencioni R, Llovet JM (2010) Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis 30:52–60PubMedCrossRef

Titel: Bildgebung und molekulare Diagnostik in der Onkologie
Bildgeführte Interventionen
verfasst von: Dr. med. F. Schaab
Dr. med. C. G. Radosa
Dr. med. habil. J. P. Kühn
Prof. Dr. med. R. T. Hoffmann
Publikationsdatum: 21.11.2019
Verlag: Springer Medizin
Schlagwörter: Interventionelle Radiologie
Angiografie
Thermotherapie
Diagnostik in der Onkologie
Diagnostik in der Onkologie
Erschienen in: Die Onkologie / Ausgabe 1/2020
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI: https://doi.org/10.1007/s00761-019-00678-5

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