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Erschienen in: Rheumatology International 10/2018

15.05.2018 | Review

Monogenic systemic lupus erythematosus: insights in pathophysiology

verfasst von: Ezgi Deniz Batu

Erschienen in: Rheumatology International | Ausgabe 10/2018

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Abstract

Systemic lupus erythematosus (SLE) is a complex disease with different genetic, immunologic, and environmental factors contributing to the pathogenesis. Monogenic SLE could help us understand the main phases of immune dysregulation in SLE. The aim of this review is to summarize the current knowledge on monogenic SLE with the implications of the respective genes on disease pathogenesis. A comprehensive literature search on monogenic SLE was conducted utilizing the Cochrane Library and MEDLINE/PubMed databases. The main affected pathways in disease pathogenesis are identified as follows: complement system, apoptosis, nucleic acid degradation, nucleic acid sensing, self-tolerance, and type I interferon production. Further studies on monogenic SLE can make precision medicine possible for SLE by increasing our understanding of disease pathogenesis.
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Metadaten
Titel
Monogenic systemic lupus erythematosus: insights in pathophysiology
verfasst von
Ezgi Deniz Batu
Publikationsdatum
15.05.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Rheumatology International / Ausgabe 10/2018
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-018-4048-7

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