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Erschienen in: Pediatric Surgery International 2/2017

22.11.2016 | Original Article

Morbidity and healthcare costs of vascular anomalies: a national study

verfasst von: Jina Kim, Zhifei Sun, Harold J. Leraas, Uttara P. Nag, Ehsan Benrashid, Alexander C. Allori, Waleska M. Pabon-Ramos, Henry E. Rice, Cynthia K. Shortell, Elisabeth T. Tracy

Erschienen in: Pediatric Surgery International | Ausgabe 2/2017

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Abstract

Purpose

This study aimed to define morbidities and costs related to modern-day medical care for children with vascular anomalies.

Methods

We reviewed the 2003–2009 Kids’ Inpatient Database for pediatric patients (age < 21 years) hospitalized with hemangioma, arteriovenous malformation (AVM), or lymphatic malformation (LM). Patient characteristics, hospital complications, and hospital charges were compared by vascular anomaly type. Multivariable linear regression modeling was used to determine predictors of increasing hospital costs for patients with AVMs.

Results

In total, 7485 pediatric inpatients with vascular anomalies were identified. Frequently associated complications included chronic anemia (4.0%), sepsis (4.6%), and hypertension (2.4%). Children with AVM had the highest rate of in-hospital mortality, compared to those with hemangiomas or LM (1.0% vs. 0.1% vs. 0.3%, p < 0.001). AVMs were also associated with the highest median hospital charge, more than twice the cost for hemangiomas or LM ($45,875 vs. $18,909 vs. $18,919; p < 0.001).

Conclusions

There is a significant rate of morbidity in children with vascular anomalies, most often from blood loss and infection. The greater cost of AVM care may be related to the higher mortality rate, associated complications, and complexity of procedures required treating them. Cost-effective management of vascular anomalies should target prevention and the early recognition of both chronic comorbidities and acute complications.
Literatur
1.
Zurück zum Zitat Fishman SJ, Mulliken JB (1998) Vascular anomalies: a primer for pediatricians. Pediatr Clin North Am 45(6):1455–1477CrossRefPubMed Fishman SJ, Mulliken JB (1998) Vascular anomalies: a primer for pediatricians. Pediatr Clin North Am 45(6):1455–1477CrossRefPubMed
2.
Zurück zum Zitat Holmdahl K (1955) Cutaneous hemangiomas in premature and mature infants. Acta Paediatr 44(4):370–379CrossRefPubMed Holmdahl K (1955) Cutaneous hemangiomas in premature and mature infants. Acta Paediatr 44(4):370–379CrossRefPubMed
3.
Zurück zum Zitat Mulliken JB, Glowacki J (1982) Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 69(3):412–420CrossRefPubMed Mulliken JB, Glowacki J (1982) Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 69(3):412–420CrossRefPubMed
4.
Zurück zum Zitat Wassef M, Blei F, Adams D, Alomari A, Baselga E, Berenstein A, Burrows P, Frieden IJ, Garzon MC, Lopez-Gutierrez JC, Lord DJ, Mitchel S, Powell J, Prendiville J, Vikkula M (2015) Vascular anomalies classification: recommendations from the International Society for the Study of Vascular Anomalies. Pediatrics 136(1):e203–e214. doi:10.1542/peds.2014-3673 CrossRefPubMed Wassef M, Blei F, Adams D, Alomari A, Baselga E, Berenstein A, Burrows P, Frieden IJ, Garzon MC, Lopez-Gutierrez JC, Lord DJ, Mitchel S, Powell J, Prendiville J, Vikkula M (2015) Vascular anomalies classification: recommendations from the International Society for the Study of Vascular Anomalies. Pediatrics 136(1):e203–e214. doi:10.​1542/​peds.​2014-3673 CrossRefPubMed
5.
Zurück zum Zitat Enjolras O, Wassef M, Mazoyer E, Frieden IJ, Rieu PN, Drouet L, Taïeb A, Stalder J-F, Escande J-P (1997) Infants with Kasabach–Merritt syndrome do not have “true” hemangiomas. J Pediatr 130(4):631–640CrossRefPubMed Enjolras O, Wassef M, Mazoyer E, Frieden IJ, Rieu PN, Drouet L, Taïeb A, Stalder J-F, Escande J-P (1997) Infants with Kasabach–Merritt syndrome do not have “true” hemangiomas. J Pediatr 130(4):631–640CrossRefPubMed
6.
Zurück zum Zitat Sarkar M, Mulliken JB, Kozakewich HP, Robertson RL, Burrows PE (1997) Thrombocytopenic coagulopathy (Kasabach–Merritt phenomenon) is associated with kaposiform hemangioendothelioma and not with common infantile hemangioma. Plast Reconstr Surg 100(6):1377–1386CrossRefPubMed Sarkar M, Mulliken JB, Kozakewich HP, Robertson RL, Burrows PE (1997) Thrombocytopenic coagulopathy (Kasabach–Merritt phenomenon) is associated with kaposiform hemangioendothelioma and not with common infantile hemangioma. Plast Reconstr Surg 100(6):1377–1386CrossRefPubMed
7.
Zurück zum Zitat Zukerberg LR, Nickoloff BJ, Weiss SW (1993) Kaposiform hemangioendothelioma of infancy and childhood: an aggressive neoplasm associated with Kasabach–Merritt syndrome and lymphangiomatosis. Am J Surg Pathol 17(4):321–328CrossRefPubMed Zukerberg LR, Nickoloff BJ, Weiss SW (1993) Kaposiform hemangioendothelioma of infancy and childhood: an aggressive neoplasm associated with Kasabach–Merritt syndrome and lymphangiomatosis. Am J Surg Pathol 17(4):321–328CrossRefPubMed
8.
Zurück zum Zitat Arroyo-Fernandez FJ, Calderon-Seoane E, Rodriguez-Pena F, Torres-Morera LM (2015) Intraoperative fluid therapy in infants with congestive heart failure due to intracranial pial arteriovenous fistula. Rev Esp Anestesiol Reanim. doi:10.1016/j.redar.2015.07.002 PubMed Arroyo-Fernandez FJ, Calderon-Seoane E, Rodriguez-Pena F, Torres-Morera LM (2015) Intraoperative fluid therapy in infants with congestive heart failure due to intracranial pial arteriovenous fistula. Rev Esp Anestesiol Reanim. doi:10.​1016/​j.​redar.​2015.​07.​002 PubMed
9.
Zurück zum Zitat Kim J, Kim D, Do Y, Lee B, Kim Y, Shin S, Byun H, Roh H, Choo I, Hyon W (2006) Surgical treatment for congenital arteriovenous malformation: 10 years’ experience. Eur J Vasc Endovasc Surg 32(1):101–106CrossRefPubMed Kim J, Kim D, Do Y, Lee B, Kim Y, Shin S, Byun H, Roh H, Choo I, Hyon W (2006) Surgical treatment for congenital arteriovenous malformation: 10 years’ experience. Eur J Vasc Endovasc Surg 32(1):101–106CrossRefPubMed
10.
Zurück zum Zitat Lidsky ME, Spritzer CE, Shortell CK (2012) The role of dynamic contrast-enhanced agnetic resonance imaging in the diagnosis and management of patients with vascular malformations. J Vasc Surg 56(3):757–764.e751. doi:10.1016/j.jvs.2012.02.032 Lidsky ME, Spritzer CE, Shortell CK (2012) The role of dynamic contrast-enhanced agnetic resonance imaging in the diagnosis and management of patients with vascular malformations. J Vasc Surg 56(3):757–764.e751. doi:10.​1016/​j.​jvs.​2012.​02.​032
11.
13.
Zurück zum Zitat CPI Inflation Calculator Bureau of Labor Statistics, US Department of Labor. Web. 22 Aug 2015 CPI Inflation Calculator Bureau of Labor Statistics, US Department of Labor. Web. 22 Aug 2015
14.
Zurück zum Zitat Belov S (1989) Haemodynamic pathogenesis of vascular-bone syndromes in congenital vascular defects. Int Angiol J Int Union Angiol 9(3):155–161 Belov S (1989) Haemodynamic pathogenesis of vascular-bone syndromes in congenital vascular defects. Int Angiol J Int Union Angiol 9(3):155–161
15.
Zurück zum Zitat Purdy PD, Batjer HH, Samson D (1991) Management of hemorrhagic complications from preoperative embolization of arteriovenous malformations. J Neurosurg 74(2):205–211CrossRefPubMed Purdy PD, Batjer HH, Samson D (1991) Management of hemorrhagic complications from preoperative embolization of arteriovenous malformations. J Neurosurg 74(2):205–211CrossRefPubMed
17.
18.
Metadaten
Titel
Morbidity and healthcare costs of vascular anomalies: a national study
verfasst von
Jina Kim
Zhifei Sun
Harold J. Leraas
Uttara P. Nag
Ehsan Benrashid
Alexander C. Allori
Waleska M. Pabon-Ramos
Henry E. Rice
Cynthia K. Shortell
Elisabeth T. Tracy
Publikationsdatum
22.11.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Surgery International / Ausgabe 2/2017
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI
https://doi.org/10.1007/s00383-016-4007-x

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