Erschienen in:
01.12.2010 | Invited commentary
More radiotherapy for radiation-induced second malignancies?
verfasst von:
Silvia Formenti
Erschienen in:
Breast Cancer Research and Treatment
|
Ausgabe 3/2010
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Excerpt
Female patients who received radiotherapy for Hodgkin’s lymphoma (HL) have an increased risk of second malignancies, with breast cancer the most common solid tumor these patients develop [
1]. Age at irradiation and time since therapy appears to be the only significant risk factors for development of breast cancer after radiation for HL. For instance, results from a large epidemiological study conducted by NCI investigators from the NCI divisions of Epidemiology and Cancer Prevention predict that, for a Hodgkin’s lymphoma survivor who was treated at age 25 years during the time period between the years 1965 and 1994 and received a chest radiation dose of at least 40 Gy, the estimated cumulative absolute risks of breast cancer by age 35, 45, and 55 years are 1.4, 11.1 and 29.0%, respectively [
2]. …