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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Endocrine Disorders 1/2015

Morning blood pressure surge and target organ damage in newly diagnosed type 2 diabetic patients: a cross sectional study

Zeitschrift:
BMC Endocrine Disorders > Ausgabe 1/2015
Autoren:
Johanne M. Lyhne, Esben Laugesen, Pernille Høyem, Simon Cichosz, Jens S. Christiansen, Søren T. Knudsen, Klavs W. Hansen, Troels K. Hansen, Per L. Poulsen
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

JL, EL and PH carried out the data collection and processing. JL and SC did the calculations. EL performed the statistical analysis. TH, JSC, KH, STK and PP participated in the design of the study, the interpretation of data and the revising of the manuscript. JL and EL drafted the manuscript. All authors read and approved the final manuscript.

Abstract

Background

Type 2 diabetic patients display significantly higher incidence of cardiovascular (CV) events including stroke compared to non-diabetics. Morning blood pressure surge (MBPS) and blunted systolic night-day (SND) ratio have been associated with CV events in hypertensive patients. No studies have evaluated MBPS in newly diagnosed diabetic patients or studied the association with vascular target organ damage at this early time point of the diabetes disease.

Methods

Ambulatory blood pressure monitoring was performed in 100 patients with newly diagnosed type 2 diabetes and 100 age and sex matched controls. MBPS and SND-ratio were calculated. Markers of early vascular target organ damage included pulse wave velocity (PWV), white matter lesions (WML) on brain MRI, and urine albumin/creatinine ratio (UAE).

Results

No significant differences in MBPS were found between diabetic patients and controls. Neither MBPS or SND-ratio were associated with PWV, UAE or WML in the diabetic group independently of age, gender and 24-h systolic blood pressure. 40.2 % of diabetic patients and 25.8 % of controls were classified as non-dippers (p = 0.03).

Conclusion

MBPS and SND-ratio are not associated with subclinical markers of vascular target organ damage in our study sample of newly diagnosed type 2 diabetic patients.
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