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Journal of Assisted Reproduction and Genetics

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04.07.2017 | Embryo Biology

Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos

verfasst von: Jingye Zhang, Wenrong Tao, Hui Liu, Guanling Yu, Mei Li, Shuiying Ma, Keliang Wu

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 9/2017

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Abstract

Purpose

This study aimed to test whether there is an association between embryo morphokinetic parameters and ploidy status.

Methods

Patients with high risk of aneuploidy were analyzed by time-lapse microscopy combined with preimplantation genetic screening (PGS). Accordingly, 256 blastocysts from 75 patients were subjected to trophectoderm biopsy and microarray comparative genomic hybridization (array-CGH). Blastocyst development process was analyzed using time-lapse images.

Results

Morphokinetic parameters: tPNf, t2, t3, t4, t5, t8, t9, tcom, tM, tSB, tB, tEB, CC1, CC2, CC3, S2, S3, t5-t2, and tB-tSB showed no significant difference in euploid embryos compared to aneuploid counterparts. In addition, two risk models based on previously published morphokinetic parameters failed to segregate euploid from aneuploid embryos.

Conclusions

Morphokinetic parameters subjected to investigation in the present study failed to improve the chance of selecting euploid embryos.

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Titel: Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos
verfasst von: Jingye Zhang
Wenrong Tao
Hui Liu
Guanling Yu
Mei Li
Shuiying Ma
Keliang Wu
Publikationsdatum: 04.07.2017
Verlag: Springer US
Erschienen in: Journal of Assisted Reproduction and Genetics / Ausgabe 9/2017
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-017-0965-8

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Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos

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Purpose

Methods

Results

Conclusions

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