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Erschienen in: International Urogynecology Journal 6/2005

01.12.2005 | Original Article

Morphology of the suburethral pubocervical fascia in women with stress urinary incontinence: a comparison of histologic and MRI findings

verfasst von: R Tunn, M Rieprich, O Kaufmann, A Gauruder-Burmester, D Beyersdorff

Erschienen in: International Urogynecology Journal | Ausgabe 6/2005

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Abstract

To correlate MRI with histologic findings of the suburethral pubocervical fascia in women with urodynamic stress incontinence. Thirty-one women with urodynamically proven stress urinary incontinence without relevant prolapse underwent preoperative MRI. Tissue specimens obtained from the pubocervical fascia were examined immunohistochemically (types I and III collagen, smooth muscle actin) and the results compared with the MRI findings. MRI demonstrated an intact pubocervical fascia in 61.3% of the cases and a fascial defect in 38.7%. A fascial defect demonstrated by MRI was associated with a decrease in actin (P<0.09) and an increase in collagen III (P<0.01) compared to an intact fascia. In women with stress urinary incontinence, smooth muscle actin in the pubocervical fascia is decreased, changed in structure, and replaced by type III collagen. MRI allows evaluation of the pubocervical fascia and its morphologic changes.
Literatur
1.
Zurück zum Zitat DeLancey JOL (1994) Structural support of the urethra as it relates to stress urinary incontinence: the hammock hypothesis. Am J Obstet Gynecol 170(6):1713–1723PubMed DeLancey JOL (1994) Structural support of the urethra as it relates to stress urinary incontinence: the hammock hypothesis. Am J Obstet Gynecol 170(6):1713–1723PubMed
2.
Zurück zum Zitat Papa Petros PE, Ulmsten U (1990) An integral theory of female urinary incontinence. Acta Obstet Gynecol Scand 69(Suppl 153):7–31PubMed Papa Petros PE, Ulmsten U (1990) An integral theory of female urinary incontinence. Acta Obstet Gynecol Scand 69(Suppl 153):7–31PubMed
3.
Zurück zum Zitat Richter K, Frick H (1990) Die Anatomie der Fascia pelvis visceralis aus didaktischer Sicht. Geburtsh. u. Frauenheilk 45:282–287 Richter K, Frick H (1990) Die Anatomie der Fascia pelvis visceralis aus didaktischer Sicht. Geburtsh. u. Frauenheilk 45:282–287
4.
Zurück zum Zitat Schmeiser G, Putz R (2000) Anatomie und Funktion des Beckenbodens. Radiologie 40:429–436CrossRef Schmeiser G, Putz R (2000) Anatomie und Funktion des Beckenbodens. Radiologie 40:429–436CrossRef
5.
Zurück zum Zitat Ivanov A, Tunn R, Lüning M, Pfister C (1992) Weiblicher Beckenboden und Urethra: MRT-Normalbild und anatomische Korrelationen. Radiol Diagnos 33(6):397–405 Ivanov A, Tunn R, Lüning M, Pfister C (1992) Weiblicher Beckenboden und Urethra: MRT-Normalbild und anatomische Korrelationen. Radiol Diagnos 33(6):397–405
6.
Zurück zum Zitat Klutke CG, Siegel CL (1995) Functional female pelvic anatomy. Urol Clin North Am 22(3):487–498PubMed Klutke CG, Siegel CL (1995) Functional female pelvic anatomy. Urol Clin North Am 22(3):487–498PubMed
7.
Zurück zum Zitat Terminologia Anatomica (1998) Thieme; Stuttgart, New York Terminologia Anatomica (1998) Thieme; Stuttgart, New York
8.
Zurück zum Zitat Borenstein R, Elchalal U, Goldchmit R, Rosenman D, Ben-Hur H, Katz Z (1992) The importance of the endopelvic fascia repair during vaginal hysterectomy. Surg Gynecol Obstet 175(6):551–4PubMed Borenstein R, Elchalal U, Goldchmit R, Rosenman D, Ben-Hur H, Katz Z (1992) The importance of the endopelvic fascia repair during vaginal hysterectomy. Surg Gynecol Obstet 175(6):551–4PubMed
9.
Zurück zum Zitat Cruikshank SH, Kovac SR (1996) Anterior vaginal wall culdeplasty at vaginal hysterectomy to prevent posthysterectomy anterior vaginal wall prolapse. Am J Obstet Gynecol 174(6):1863–1872PubMed Cruikshank SH, Kovac SR (1996) Anterior vaginal wall culdeplasty at vaginal hysterectomy to prevent posthysterectomy anterior vaginal wall prolapse. Am J Obstet Gynecol 174(6):1863–1872PubMed
10.
Zurück zum Zitat DeLancey JOL (1992) Anatomic aspects of vaginal eversion after hysterectomy. Am J Obstet Gynecol 166(6):1717–1728PubMed DeLancey JOL (1992) Anatomic aspects of vaginal eversion after hysterectomy. Am J Obstet Gynecol 166(6):1717–1728PubMed
11.
Zurück zum Zitat DeLancey JOL (1994) The anatomy of the pelvic floor. Current Opinion in Obstet Gynecol 6:313–316 DeLancey JOL (1994) The anatomy of the pelvic floor. Current Opinion in Obstet Gynecol 6:313–316
12.
Zurück zum Zitat Fischer A, Lange R, Harlfinger W (2000) Urogynäkologie 2000 in Praxis und Klinik - Was nehmen wir mit ins neue Jahrtausend? Teil 2: Diagnostik und Therapie in der Klinik. Frauenarzt 41(6):723–733 Fischer A, Lange R, Harlfinger W (2000) Urogynäkologie 2000 in Praxis und Klinik - Was nehmen wir mit ins neue Jahrtausend? Teil 2: Diagnostik und Therapie in der Klinik. Frauenarzt 41(6):723–733
13.
Zurück zum Zitat Handa VL, Harris TA, Ostergard DR (1996) Protecting the pelvic floor: Obstetric management to prevent incontinence and pelvic organ prolapse. Obstet Gynecol 88(3):470–478CrossRefPubMed Handa VL, Harris TA, Ostergard DR (1996) Protecting the pelvic floor: Obstetric management to prevent incontinence and pelvic organ prolapse. Obstet Gynecol 88(3):470–478CrossRefPubMed
14.
Zurück zum Zitat Kohli N, Sze EHM, Roat TW, Karram MM (1996) Incidence of recurrent cystocele after anterior colporraphy with and without concomitant transvaginal needle suspension. Am J Obstet Gynecol 175(6):1476–1482PubMed Kohli N, Sze EHM, Roat TW, Karram MM (1996) Incidence of recurrent cystocele after anterior colporraphy with and without concomitant transvaginal needle suspension. Am J Obstet Gynecol 175(6):1476–1482PubMed
15.
Zurück zum Zitat Raz S, Little NA, Juma S, Sussmann EM (1991) Repair of severe anterior vaginal wall prolapse (grade IV cystourethrocele). J Urol 146:988–992PubMed Raz S, Little NA, Juma S, Sussmann EM (1991) Repair of severe anterior vaginal wall prolapse (grade IV cystourethrocele). J Urol 146:988–992PubMed
16.
Zurück zum Zitat Ross JW (1997) Apical vault repair - the cornerstone or pelvic vault reconstruction. Int Urogynecol J Pelvic Floor Dysfunct 8(3):146–52PubMed Ross JW (1997) Apical vault repair - the cornerstone or pelvic vault reconstruction. Int Urogynecol J Pelvic Floor Dysfunct 8(3):146–52PubMed
17.
Zurück zum Zitat Smith ARB (1994) Role of connective tissue and muscle in pelvic floor dysfunction. Curr Opin Obstet Gynecol 6:317–319PubMed Smith ARB (1994) Role of connective tissue and muscle in pelvic floor dysfunction. Curr Opin Obstet Gynecol 6:317–319PubMed
18.
Zurück zum Zitat Ingelman-Sundberg A (1952) Urinary incontinence in women, excluding fistulas. Acta Obstet Gynecol Scand 31:266–299PubMed Ingelman-Sundberg A (1952) Urinary incontinence in women, excluding fistulas. Acta Obstet Gynecol Scand 31:266–299PubMed
19.
Zurück zum Zitat Bucher O, Wartenberg H (1997) Kreislaufapparat. In: Bucher O, Wartenberg H (eds) Cytologie, Histologie und mikroskopische Anatomie des Menschen. 12. Aufl.. Bern; Göttingen; Toronto; Seattle. Huber, pp 229–244 Bucher O, Wartenberg H (1997) Kreislaufapparat. In: Bucher O, Wartenberg H (eds) Cytologie, Histologie und mikroskopische Anatomie des Menschen. 12. Aufl.. Bern; Göttingen; Toronto; Seattle. Huber, pp 229–244
20.
Zurück zum Zitat Bucher O, Wartenberg H (1997) Muskelgewebe. In: Bucher O, Wartenberg H. Cytologie, Histologie und mikroskopische Anatomie des Menschen. 12. Aufl.. Bern; Göttingen; Toronto; Seattle. Huber, pp 141–153 Bucher O, Wartenberg H (1997) Muskelgewebe. In: Bucher O, Wartenberg H. Cytologie, Histologie und mikroskopische Anatomie des Menschen. 12. Aufl.. Bern; Göttingen; Toronto; Seattle. Huber, pp 141–153
21.
Zurück zum Zitat Bortz J, Lienert GA (1998) Testmethoden für Häufigkeiten und Rangdaten. In: Bortz J, Lienert GA (eds) Kurzgefaßte Statistik für die klinische Forschung. Springer; Berlin Heidelberg, NewYork, pp 51–189 Bortz J, Lienert GA (1998) Testmethoden für Häufigkeiten und Rangdaten. In: Bortz J, Lienert GA (eds) Kurzgefaßte Statistik für die klinische Forschung. Springer; Berlin Heidelberg, NewYork, pp 51–189
22.
Zurück zum Zitat Hricak H, Secaf E, Buckley DW, Brown JJ, Tanagho EA, McAninch JW (1991) Female urethra: MR imaging. Radiology 178:527–535PubMed Hricak H, Secaf E, Buckley DW, Brown JJ, Tanagho EA, McAninch JW (1991) Female urethra: MR imaging. Radiology 178:527–535PubMed
23.
Zurück zum Zitat Aronson MP, Bates SM, Jacoby AF, Chelmow D, Sant GR (1995) Periurethral and paravaginal anatomy: an endovaginal magnetic resonance imaging study. Am J Obstet Gynecol 173(6):1702–1710CrossRefPubMed Aronson MP, Bates SM, Jacoby AF, Chelmow D, Sant GR (1995) Periurethral and paravaginal anatomy: an endovaginal magnetic resonance imaging study. Am J Obstet Gynecol 173(6):1702–1710CrossRefPubMed
24.
Zurück zum Zitat Tunn R, Paris St, Fischer W, Hamm B, Kuchinke J (1998) Static magnetic resonance imaging of the pelvic floor muscle morphology in women with stress urinary incontinence and pelvic prolapse. Neurourol Urodynam 17:579–589CrossRef Tunn R, Paris St, Fischer W, Hamm B, Kuchinke J (1998) Static magnetic resonance imaging of the pelvic floor muscle morphology in women with stress urinary incontinence and pelvic prolapse. Neurourol Urodynam 17:579–589CrossRef
25.
Zurück zum Zitat Krantz KE (1951) The anatomy of the urethra and anterior vaginal wall. Am J Obstet Gynec 62(2):374–386PubMed Krantz KE (1951) The anatomy of the urethra and anterior vaginal wall. Am J Obstet Gynec 62(2):374–386PubMed
26.
Zurück zum Zitat Tunn R, DeLancey JOL, Howard D, Thorp JM, Ashton-Miller JA, Quint LE (1999) MR imaging of levator ani muscle recovery following vaginal delivery. Int Urogynecol J 10:1–8CrossRef Tunn R, DeLancey JOL, Howard D, Thorp JM, Ashton-Miller JA, Quint LE (1999) MR imaging of levator ani muscle recovery following vaginal delivery. Int Urogynecol J 10:1–8CrossRef
27.
Zurück zum Zitat Falconer C, Blomgren B, Johansson O, Ulmsten U, Malmström A, Westergren-Thorsson G, Ekman-Ordeberg G (1998) Different organization of collagen fibrils in stress-incontinent women of fertile age. Acta Obstet Gynecol Scand 77:87–94CrossRefPubMed Falconer C, Blomgren B, Johansson O, Ulmsten U, Malmström A, Westergren-Thorsson G, Ekman-Ordeberg G (1998) Different organization of collagen fibrils in stress-incontinent women of fertile age. Acta Obstet Gynecol Scand 77:87–94CrossRefPubMed
28.
Zurück zum Zitat Duance VC, Stephens HR, Dunn M, Bailey AJ, Dubowitz V (1980) A role for collagen in the pathogenesis of muscular dystrophy? Nature 284:470–473CrossRefPubMed Duance VC, Stephens HR, Dunn M, Bailey AJ, Dubowitz V (1980) A role for collagen in the pathogenesis of muscular dystrophy? Nature 284:470–473CrossRefPubMed
29.
Zurück zum Zitat Morley R, Cumming J (1993) Changes in collagen type in patients with stress incontinence (abstract). Int Urogynecol J 4(5):319 Morley R, Cumming J (1993) Changes in collagen type in patients with stress incontinence (abstract). Int Urogynecol J 4(5):319
30.
Zurück zum Zitat Carlile A, Davies I, Rigby A, Brocklehurst JC (1988) Age changes in the human female urethra: a morphometric study. J Urol 139:532–535PubMed Carlile A, Davies I, Rigby A, Brocklehurst JC (1988) Age changes in the human female urethra: a morphometric study. J Urol 139:532–535PubMed
31.
Zurück zum Zitat Rother P, Löffler S, Dorschner W, Reibiger I, Bengs T (1996) Anatomic basis of micturition and urinary bladder continence. Muscle system in urinary bladder neck during ageing. Surg Radiol Anat 18:173–177PubMed Rother P, Löffler S, Dorschner W, Reibiger I, Bengs T (1996) Anatomic basis of micturition and urinary bladder continence. Muscle system in urinary bladder neck during ageing. Surg Radiol Anat 18:173–177PubMed
32.
Zurück zum Zitat DeLancey JOL (1990) Histology of the connection between the vagina and levator ani muscle. J Reprod Med 35(8):765–771PubMed DeLancey JOL (1990) Histology of the connection between the vagina and levator ani muscle. J Reprod Med 35(8):765–771PubMed
33.
Zurück zum Zitat Papa Petros PE (1998) The pubourethral ligaments - an anatomical and histological study in the live patient. Int Urogynecol J 9:154–157 Papa Petros PE (1998) The pubourethral ligaments - an anatomical and histological study in the live patient. Int Urogynecol J 9:154–157
34.
Zurück zum Zitat Durfee RB (1965) Anterior vaginal suspension operation for treatment of stress incontinence. Am J Obstet Gynec 92(5):610–619PubMed Durfee RB (1965) Anterior vaginal suspension operation for treatment of stress incontinence. Am J Obstet Gynec 92(5):610–619PubMed
35.
Zurück zum Zitat DeLancey JOL (1986) Correlative study of paraurethral anatomy. Obstet Gynecol 68(1):91–97PubMed DeLancey JOL (1986) Correlative study of paraurethral anatomy. Obstet Gynecol 68(1):91–97PubMed
36.
Zurück zum Zitat Wilson PD, Dixon JS, Brown ADG, Gosling JA (1983) Posterior pubo-urethral ligaments in normal and genuine stress incontinent women. J Urol 130:802–805PubMed Wilson PD, Dixon JS, Brown ADG, Gosling JA (1983) Posterior pubo-urethral ligaments in normal and genuine stress incontinent women. J Urol 130:802–805PubMed
37.
Zurück zum Zitat Gosling JA (1985) The structure of the female lower urinary tract and pelvis floor. Urol Clin North Am 12(2):207–214PubMed Gosling JA (1985) The structure of the female lower urinary tract and pelvis floor. Urol Clin North Am 12(2):207–214PubMed
38.
Zurück zum Zitat Hale DS, Benson JT, Brubaker L, Heidkamp MC, Russell B (1999) Histologic analysis of needle biopsy of urethral sphincter from women with normal and stress incontinence with comparison of electromyographic findings. Am J Obstet Gynecol 180:342–8PubMed Hale DS, Benson JT, Brubaker L, Heidkamp MC, Russell B (1999) Histologic analysis of needle biopsy of urethral sphincter from women with normal and stress incontinence with comparison of electromyographic findings. Am J Obstet Gynecol 180:342–8PubMed
39.
Zurück zum Zitat Bergman A, Elia G, Cheung D, Perelman N, Nimni ME (1994) Biochemical composition of collagen in continent and stress urinary incontinent women. Gynecol Obstet Invest 37:48–51PubMed Bergman A, Elia G, Cheung D, Perelman N, Nimni ME (1994) Biochemical composition of collagen in continent and stress urinary incontinent women. Gynecol Obstet Invest 37:48–51PubMed
40.
Zurück zum Zitat Falconer C, Ekman G, Malmström A, Ulmsten U (1994) Decreased collagen synthesis in stress-incontinent women. Obstet Gynecol 84(4,1):583–586PubMed Falconer C, Ekman G, Malmström A, Ulmsten U (1994) Decreased collagen synthesis in stress-incontinent women. Obstet Gynecol 84(4,1):583–586PubMed
41.
Zurück zum Zitat Ulmsten U, Ekman G, Giertz G, Malmström A (1987) Different biochemical composition of connective tissue in continent and stress incontinent women. Acta Obstet Gynecol Scand 66:455–457PubMed Ulmsten U, Ekman G, Giertz G, Malmström A (1987) Different biochemical composition of connective tissue in continent and stress incontinent women. Acta Obstet Gynecol Scand 66:455–457PubMed
Metadaten
Titel
Morphology of the suburethral pubocervical fascia in women with stress urinary incontinence: a comparison of histologic and MRI findings
verfasst von
R Tunn
M Rieprich
O Kaufmann
A Gauruder-Burmester
D Beyersdorff
Publikationsdatum
01.12.2005
Erschienen in
International Urogynecology Journal / Ausgabe 6/2005
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-005-1302-9

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