Danny Claessens and Kim Bekelaar contributed equally to the manuscript.
Seizures after intracerebral hemorrhage are repeatedly seen. Whether the development of seizures after intracerebral hemorrhage affects survival in the long term is unknown. This study aims to determine the relation between seizures (i.e., with and without anti-epileptic therapy) and long-term mortality risk in a large patient population with intracerebral hemorrhage. We retrospectively included patients with a non-traumatic ICH in all three hospitals in the South Limburg region in the Netherlands between January 1st 2004 and December 31st 2009, and we assessed all-cause mortality until March 14th 2016. Patient who did not survive the first seven days after intracerebral hemorrhage were excluded from analyses. We used Cox multivariate analyses to determine independent predictors of mortality. Of 1214 patients, 783 hemorrhagic stroke patients fulfilled the inclusion criteria, amongst whom 37 (4.7%) patients developed early seizures (within 7 days after hemorrhage) and 77 (9.8%) developed late seizures (more than 7 days after hemorrhage). Seizure development was not significantly related to mortality risk after correction for conventional vascular risk factors and hemorrhage severity. However, we found a small but independent relation between the use of anti-epileptic drugs and a lower long-term mortality (HR = 0.32, 95% CI 0.11–0.91). In our large population, seizures and epilepsy did not relate independently to an increased mortality risk after hemorrhage.
Ikram MA, Wieberdink RG, Koudstaal PJ (2012) International epidemiology of intracerebral hemorrhage. Current Atheroscler Rep 14(4):300–306 CrossRef
Agrawal A, Timothy J, Pandit L, Manju M (2006) Post-traumatic epilepsy: an overview. Clin Neurol and Neurosurg 108(5):433–439 CrossRef
Arntz RM, Rutten-Jacobs LC, Maaijwee NA, Schoonderwaldt HC, Dorresteijn LD, van Dijk EJ et al (2015) Poststroke epilepsy is associated with a high mortality after a stroke at young age: follow-up of transient ischemic attack and stroke patients and unelucidated risk factor evaluation study. Stroke 46(8):2309–2311 CrossRefPubMed
Fisher RS, Cross JH, D’Souza C, French JA, Haut SR et al (2017) ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia 58(4):512–521 CrossRef
Guidelines for epidemiologic studies on epilepsy, Commission on epidemiology and prognosis (1993) International league against epilepsy. Epilepsia 34(4):592–596 CrossRef
- Mortality after primary intracerebral hemorrhage in relation to post-stroke seizures
Floris H. B. M. Schreuder
Bianca T. A. de Greef
Mariëlle C. G. Vlooswijk
Robert J. van Oostenbrugge
Rob P. W. Rouhl
- Springer Berlin Heidelberg
Neu im Fachgebiet Neurologie
Meistgelesene Bücher in der Neurologie