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European Journal of Clinical Microbiology & Infectious Diseases
Erschienen in:

27.01.2022 | Original Article

Mortality-associated factors of candidemia: a multi-center prospective cohort in Turkey

verfasst von: Murat Kutlu, Selda Sayın-Kutlu, Sema Alp-Çavuş, Şerife Barçın Öztürk, Meltem Taşbakan, Betil Özhak, Onur Kaya, Oya Eren Kutsoylu, Şebnem Şenol-Akar, Özge Turhan, Gülşen Mermut, Bülent Ertuğrul, Hüsnü Pullukcu, Çiğdem Banu Çetin, Vildan Avkan-Oğuz, Nur Yapar, Dilek Yeşim-Metin, Çağrı Ergin

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 4/2022

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Abstract

Candidemia may present as severe and life-threatening infections and is associated with a high mortality rate. This study aimed to evaluate the risk factors associated with 30-day mortality in patients with candidemia. A multi-center prospective observational study was conducted in seven university hospitals in six provinces in the western part of Turkey. Patient data were collected with a structured form between January 2018 and April 2019. In total, 425 episodes of candidemia were observed during the study period. Two hundred forty-one patients died within 30 days, and the 30-day crude mortality rate was 56.7%. Multivariable analysis found that SOFA score (OR: 1.28, CI: 1.154–1.420, p < 0.001), parenteral nutrition (OR: 3.9, CI: 1.752–8.810, p = 0.001), previous antibacterial treatment (OR: 9.32, CI: 1.634–53.744, p = 0.012), newly developed renal failure after candidemia (OR: 2.7, CI: 1.079–6.761, p = 0.034), and newly developed thrombocytopenia after candidemia (OR: 2.6, CI: 1. 057–6.439, p = 0.038) were significantly associated with 30-day mortality. Central venous catheter removal was the only factor protective against mortality (OR: 0.34, CI:0.147–0.768, p = 0.010) in multivariable analysis. Candidemia mortality is high in patients with high SOFA scores, those receiving TPN therapy, and those who previously received antibacterial therapy. Renal failure and thrombocytopenia developing after candidemia should be followed carefully in patients. Antifungal therapy and removing the central venous catheter are essential in the management of candidemia.
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Metadaten
Titel
Mortality-associated factors of candidemia: a multi-center prospective cohort in Turkey
verfasst von
Murat Kutlu
Selda Sayın-Kutlu
Sema Alp-Çavuş
Şerife Barçın Öztürk
Meltem Taşbakan
Betil Özhak
Onur Kaya
Oya Eren Kutsoylu
Şebnem Şenol-Akar
Özge Turhan
Gülşen Mermut
Bülent Ertuğrul
Hüsnü Pullukcu
Çiğdem Banu Çetin
Vildan Avkan-Oğuz
Nur Yapar
Dilek Yeşim-Metin
Çağrı Ergin
Publikationsdatum
27.01.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 4/2022
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-021-04394-0

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