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Erschienen in: Digestive Diseases and Sciences 5/2018

26.02.2018 | Original Article

Mortality from Spontaneous Bacterial Peritonitis Among Hospitalized Patients in the USA

verfasst von: Bolin Niu, Brian Kim, Berkeley N. Limketkai, Jing Sun, Zhiping Li, Tinsay Woreta, Po-Hung Chen

Erschienen in: Digestive Diseases and Sciences | Ausgabe 5/2018

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Abstract

Background and Aim

Spontaneous bacterial peritonitis (SBP) is a serious complication of cirrhosis and is associated with significant morbidity and mortality. In this study, we examined the clinical characteristics and risk factors associated with mortality in hospitalized patients presenting with SBP.

Methods

The Nationwide Inpatient Sample was queried for all hospitalizations involving SBP from 2006 to 2014 using the International Classification of Disease-9-CM Code. Logistic regression was performed to evaluate the association between SBP mortality and factors such as age, gender, race/ethnicity, and concomitant medical conditions at presentation (e.g., variceal hemorrhage, hepatic encephalopathy, acute renal failure, coagulopathy, and other infections including pneumonia). The lengths of stay (LOS) and total charges were also examined.

Results

From 2006 to 2014, there were 88,167 SBP hospitalizations with 29,963 deaths (17.6% in-hospital mortality). The mean age of patients who died in the hospital was higher (58.2 years vs. 55.8, p < 0.01) than those who survived the admission. Acute alcoholic hepatitis was noted among a higher proportion of patients who died (7.0 vs. 5.9%, p < 0.01), who were also likely to have more medical comorbidities. In multivariable analysis, older age, female gender, hepatic encephalopathy, coagulopathy, variceal hemorrhage, sepsis, pneumonia, and acute kidney injury were associated with increased in-hospital mortality. This group also had longer LOS (11.6 days vs. 9.1, p < 0.01) and higher total charges ($138,273 vs. $73,533, p < 0.01).

Conclusion

SBP is associated with significant in-hospital mortality, especially in patients with concurrent risk factors. SBP remains a significant burden to the healthcare system.
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Metadaten
Titel
Mortality from Spontaneous Bacterial Peritonitis Among Hospitalized Patients in the USA
verfasst von
Bolin Niu
Brian Kim
Berkeley N. Limketkai
Jing Sun
Zhiping Li
Tinsay Woreta
Po-Hung Chen
Publikationsdatum
26.02.2018
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 5/2018
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-018-4990-y

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