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01.12.2017 | Research article | Ausgabe 1/2017 Open Access

BMC Ophthalmology 1/2017

Mortality in patients treated with intravitreal bevacizumab for age-related macular degeneration

Zeitschrift:
BMC Ophthalmology > Ausgabe 1/2017
Autoren:
Joel Hanhart, Doron S. Comaneshter, Yossi Freier Dror, Shlomo Vinker

Abstract

Background

The aim of this study is to analyze mortality in patients treated with bevacizumab for wet AMD.

Methods

We conducted a retrospective case-control study between patients who received intravitreal injections of bevacizumab as the sole treatment for exudative AMD between September 2008 and October 2014 (n = 5385) and age and gender matched controls (n = 10,756). All individuals included in the study were reviewed for sociodemographic data and comorbidities. Survival analysis was performed using adjusted Cox regression, using relevant adjusted variables.

Results

During follow-up (maximum: 73 months), 1063 (19.7%) individuals after bevacizumab died compared with 1298 (12.1%) in the control group (P < .001). After adjusted Cox survival regression, mortality differed significantly between the groups, Odds ratio = 1.69, (95% C.I. 1.54–1.84), P < .001.

Conclusions

We found an increased long-term mortality in individuals with wet AMD treated with bevacizumab compared to a same age and gender group without wet AMD.
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