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01.12.2012 | Methodology | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

Mosquito transmission of the rodent malaria parasite Plasmodium chabaudi

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Philip J Spence, William Jarra, Prisca Lévy, Wiebke Nahrendorf, Jean Langhorne
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2875-11-407) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

PJS, WJ and JL designed the study; PJS and WJ developed the protocol; PJS, WJ, PL and WN performed the experiments; PJS analysed the data; PJS wrote the manuscript; all authors read and approved the final manuscript.

Abstract

Background

Serial blood passage of Plasmodium increases virulence, whilst mosquito transmission inherently regulates parasite virulence within the mammalian host. It is, therefore, imperative that all aspects of experimental malaria research are studied in the context of the complete Plasmodium life cycle.

Methods

Plasmodium chabaudi chabaudi displays many characteristics associated with human Plasmodium infection of natural mosquito vectors and the mammalian host, and thus provides a unique opportunity to study the pathogenesis of malaria in a single infection setting. An optimized protocol that permits efficient and reproducible vector transmission of P. c. chabaudi via Anopheles stephensi was developed.

Results and conclusions

This protocol was utilized for mosquito transmission of genetically distinct P. c. chabaudi isolates, highlighting differential parasite virulence within the mosquito vector and the spectrum of host susceptibility to infection initiated via the natural route, mosquito bite. An apposite experimental system in which to delineate the pathogenesis of malaria is described in detail.
Zusatzmaterial
Authors’ original file for figure 1
12936_2012_2559_MOESM1_ESM.pdf
Authors’ original file for figure 2
12936_2012_2559_MOESM2_ESM.pdf
Authors’ original file for figure 3
12936_2012_2559_MOESM3_ESM.pdf
Literatur
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