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Erschienen in: Heart and Vessels 11/2022

01.06.2022 | Original Article

MR-proANP measured at admission is associated with incident atrial fibrillation in STEMI patients

verfasst von: Alma Wegener, Daniel Modin, Sune Pedersen, Søren Lindberg, Manan Pareek, Kasper Iversen, Thomas Jespersen, Gunnar Gislason, Tor Biering-Sørensen

Erschienen in: Heart and Vessels | Ausgabe 11/2022

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Abstract

Atrial fibrillation (AF) is common following ST-segment elevation myocardial infarction (STEMI). Increased blood levels of mid regional pro atrial natriuretic peptide (MR-proANP) have been associated with a greater risk of incident AF. However, knowledge of the value of MR-proANP in predicting incident AF after STEMI is sparse. To assess whether MR-proANP measured at admission is associated with development of incident AF in patients with STEMI. 673 STEMI patients with no history of AF treated with primary percutaneous coronary intervention (pPCI) were prospectively enrolled from September 2006 to December 2008. Blood samples were drawn before the procedure. MR-proANP was measured by an automated processing assay. End point was incident AF. Median follow-up time was 5.5 years (interquartile-range 4.7–6.0), during which 63 patients developed AF. In a multivariable Cox regression model adjusted for relevant clinical and biochemical variables, MR-proANP was significantly associated with the development of AF (HR 1.18 per 100 pmol, 95% CI 1.11–1.28, p < 0.001). In a subgroup of patients who underwent echocardiography (N = 360), MR-proANP remained significantly associated with the development of AF (HR 1.39 per 100 pmol, 95% CI 1.13–1.71, p = 0.002) after adjusting for clinical and biochemical variables and left ventricular ejection fraction. When stratifying patients according to tertiles of MR-proANP, patients in the upper tertile displayed an 11 times greater risk of developing AF during follow-up as compared to patients in the lower tertile (HR 11.1, 95% CI 4.4–28.2, p < 0.001). Plasma MR-proANP measured at admission is an independent predictor of incident AF after STEMI.
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Metadaten
Titel
MR-proANP measured at admission is associated with incident atrial fibrillation in STEMI patients
verfasst von
Alma Wegener
Daniel Modin
Sune Pedersen
Søren Lindberg
Manan Pareek
Kasper Iversen
Thomas Jespersen
Gunnar Gislason
Tor Biering-Sørensen
Publikationsdatum
01.06.2022
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 11/2022
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-022-02099-8

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