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01.03.2012 | Head and Neck | Ausgabe 3/2012

European Archives of Oto-Rhino-Laryngology 3/2012

MRI-derived tumor thickness: an important predictor of outcome for T4a-staged tongue carcinoma

Zeitschrift:
European Archives of Oto-Rhino-Laryngology > Ausgabe 3/2012
Autoren:
Wei-Lin Chen, Chin-Chuan Su, Chih-Ming Chen, Ming-Che Lee, Hui-Chuan Chen, Mu-Kuan Chen

Abstract

The objectives of this paper are to evaluate the heterogeneity of magnetic resonance imaging (MRI)-derived tumor thickness within tumors of the same T4a-staged tongue carcinoma and to elucidate the effects of tumor thickness on treatment outcomes. A sequential and prospectively maintained head and neck cancer database was retrospectively searched for newly diagnosed tongue carcinoma treated with surgery between 2003 and 2006. Fifty-eight patients with newly diagnosed T4a-staged tongue carcinoma were included in this study. Tumor thickness was obtained from preoperative magnetic resonance imaging. The mean MRI-derived tumor thickness was 22.29 mm. The patients with long tumor thickness (>26 mm) were associated with a significantly poor disease-specific survival (P = 0.015). The 2-year disease-specific survival rates were 72% in patients with short tumor thickness and only 27% in patients with long tumor thickness within the same T4a-staged disease. A substantial variation in MRI-derived tumor thickness was present within the same T4a-staged tongue carcinoma, and tumor thickness represented an important prognostic factor.

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