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Erschienen in: Abdominal Radiology 7/2020

24.09.2019 | Review

MRI findings of nonobstructive azoospermia: lesions in and out of pelvic cavity

verfasst von: Yang Peng, Longyuan Ouyang, Zhi Lin, Fan Zhang, Huanjun Wang, Jian Guan

Erschienen in: Abdominal Radiology | Ausgabe 7/2020

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Abstract

Nonobstructive azoospermia (NOA) can be caused by various diseases, including congenital disorders, endocrine disorders, infections, tumor or tumor-like diseases, vascular diseases, etc. Diagnosis of the underlying cause of NOA is complicated and challenging. In this study, we introduce an MR examination protocol for the etiological diagnosis of NOA, and demonstrate a series of NOA patients with different causes and imaging findings. Except for lesions of testes, the patients may also combine abnormalities of adrenal glands and central nervous system. In such cases, the patients could benefit from additional abdominal and intracranial scans.
Literatur
3.
Zurück zum Zitat Roucher-Boulez F, Mallet-Motak D, Samara-Boustani D, Jilani H, Ladjouze A, Souchon PF, Simon D, Nivot S, Heinrichs C, Ronze M, Bertagna X, Groisne L, Leheup B, Naud-Saudreau C, Blondin G, Lefevre C, Lemarchand L, Morel Y (2016) NNT mutations: a cause of primary adrenal insufficiency, oxidative stress and extra-adrenal defects. European journal of endocrinology 175 (1):73-84. https://doi.org/10.1530/eje-16-0056 CrossRefPubMed Roucher-Boulez F, Mallet-Motak D, Samara-Boustani D, Jilani H, Ladjouze A, Souchon PF, Simon D, Nivot S, Heinrichs C, Ronze M, Bertagna X, Groisne L, Leheup B, Naud-Saudreau C, Blondin G, Lefevre C, Lemarchand L, Morel Y (2016) NNT mutations: a cause of primary adrenal insufficiency, oxidative stress and extra-adrenal defects. European journal of endocrinology 175 (1):73-84. https://​doi.​org/​10.​1530/​eje-16-0056 CrossRefPubMed
4.
Zurück zum Zitat Santi D, Spaggiari G, Casarini L, Fanelli F, Mezzullo M, Pagotto U, Granata ARM, Carani C, Simoni M (2017) Central hypogonadism due to a giant, “silent” FSH-secreting, atypical pituitary adenoma: effects of adenoma dissection and short-term Leydig cell stimulation by luteinizing hormone (LH) and human chorionic gonadotropin (hCG). The aging male : the official journal of the International Society for the Study of the Aging Male 20 (2):96-101. https://doi.org/10.1080/13685538.2016.1276161 CrossRef Santi D, Spaggiari G, Casarini L, Fanelli F, Mezzullo M, Pagotto U, Granata ARM, Carani C, Simoni M (2017) Central hypogonadism due to a giant, “silent” FSH-secreting, atypical pituitary adenoma: effects of adenoma dissection and short-term Leydig cell stimulation by luteinizing hormone (LH) and human chorionic gonadotropin (hCG). The aging male : the official journal of the International Society for the Study of the Aging Male 20 (2):96-101. https://​doi.​org/​10.​1080/​13685538.​2016.​1276161 CrossRef
12.
Zurück zum Zitat Ntorkou A, Tsili AC, Goussia A, Astrakas LG, Maliakas V, Sofikitis N, Argyropoulou MI (2019) Testicular Apparent Diffusion Coefficient and Magnetization Transfer Ratio: Can These MRI Parameters Be Used to Predict Successful Sperm Retrieval in Nonobstructive Azoospermia? AJR American journal of roentgenology:1-9. https://doi.org/10.2214/ajr.18.20816 Ntorkou A, Tsili AC, Goussia A, Astrakas LG, Maliakas V, Sofikitis N, Argyropoulou MI (2019) Testicular Apparent Diffusion Coefficient and Magnetization Transfer Ratio: Can These MRI Parameters Be Used to Predict Successful Sperm Retrieval in Nonobstructive Azoospermia? AJR American journal of roentgenology:1-9. https://​doi.​org/​10.​2214/​ajr.​18.​20816
16.
17.
19.
Zurück zum Zitat Pierik FH, Van Ginneken AM, Dohle GR, Vreeburg JT, Weber RF (2000) The advantages of standardized evaluation of male infertility. International journal of andrology 23 (6):340-346CrossRef Pierik FH, Van Ginneken AM, Dohle GR, Vreeburg JT, Weber RF (2000) The advantages of standardized evaluation of male infertility. International journal of andrology 23 (6):340-346CrossRef
20.
Zurück zum Zitat Beard CM, Benson RC, Jr., Kelalis PP, Elveback LR, Kurland LT (1977) The incidence and outcome of mumps orchitis in Rochester, Minnesota, 1935 to 1974. Mayo Clinic proceedings 52 (1):3-7PubMed Beard CM, Benson RC, Jr., Kelalis PP, Elveback LR, Kurland LT (1977) The incidence and outcome of mumps orchitis in Rochester, Minnesota, 1935 to 1974. Mayo Clinic proceedings 52 (1):3-7PubMed
21.
Zurück zum Zitat Paulsen CA, Gordon DL, Carpenter RW, Gandy HM, Drucker WD (1968) Klinefelter’s syndrome and its variants: a hormonal and chromosomal study. Recent progress in hormone research 24:321-363PubMed Paulsen CA, Gordon DL, Carpenter RW, Gandy HM, Drucker WD (1968) Klinefelter’s syndrome and its variants: a hormonal and chromosomal study. Recent progress in hormone research 24:321-363PubMed
23.
Zurück zum Zitat Zhang S, An Y, Li J, Guo J, Zhou G, Li J, Xu Y (2015) Relation between the testicular sperm assay and sex hormone level in patients with azoospermia induced by mumps. International journal of clinical and experimental medicine 8 (11):21669-21673PubMedPubMedCentral Zhang S, An Y, Li J, Guo J, Zhou G, Li J, Xu Y (2015) Relation between the testicular sperm assay and sex hormone level in patients with azoospermia induced by mumps. International journal of clinical and experimental medicine 8 (11):21669-21673PubMedPubMedCentral
26.
Zurück zum Zitat Ferlin A, Arredi B, Speltra E, Cazzadore C, Selice R, Garolla A, Lenzi A, Foresta C (2007) Molecular and clinical characterization of Y chromosome microdeletions in infertile men: a 10-year experience in Italy. The Journal of clinical endocrinology and metabolism 92 (3):762-770. https://doi.org/10.1210/jc.2006-1981 CrossRefPubMed Ferlin A, Arredi B, Speltra E, Cazzadore C, Selice R, Garolla A, Lenzi A, Foresta C (2007) Molecular and clinical characterization of Y chromosome microdeletions in infertile men: a 10-year experience in Italy. The Journal of clinical endocrinology and metabolism 92 (3):762-770. https://​doi.​org/​10.​1210/​jc.​2006-1981 CrossRefPubMed
28.
Zurück zum Zitat Krausz C, Giachini C, Xue Y, O’Bryan MK, Gromoll J, Rajpert-de Meyts E, Oliva R, Aknin-Seifer I, Erdei E, Jorgensen N, Simoni M, Ballesca JL, Levy R, Balercia G, Piomboni P, Nieschlag E, Forti G, McLachlan R, Tyler-Smith C (2009) Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background. Journal of medical genetics 46 (1):21-31. https://doi.org/10.1136/jmg.2008.059915 CrossRefPubMed Krausz C, Giachini C, Xue Y, O’Bryan MK, Gromoll J, Rajpert-de Meyts E, Oliva R, Aknin-Seifer I, Erdei E, Jorgensen N, Simoni M, Ballesca JL, Levy R, Balercia G, Piomboni P, Nieschlag E, Forti G, McLachlan R, Tyler-Smith C (2009) Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background. Journal of medical genetics 46 (1):21-31. https://​doi.​org/​10.​1136/​jmg.​2008.​059915 CrossRefPubMed
32.
Zurück zum Zitat Hu Z, Xia Y, Guo X, Dai J, Li H, Hu H, Jiang Y, Lu F, Wu Y, Yang X, Li H, Yao B, Lu C, Xiong C, Li Z, Gui Y, Liu J, Zhou Z, Shen H, Wang X, Sha J (2011) A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nature genetics 44 (2):183-186. https://doi.org/10.1038/ng.1040 CrossRefPubMed Hu Z, Xia Y, Guo X, Dai J, Li H, Hu H, Jiang Y, Lu F, Wu Y, Yang X, Li H, Yao B, Lu C, Xiong C, Li Z, Gui Y, Liu J, Zhou Z, Shen H, Wang X, Sha J (2011) A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nature genetics 44 (2):183-186. https://​doi.​org/​10.​1038/​ng.​1040 CrossRefPubMed
35.
Zurück zum Zitat Heidelbaugh JJ (2016) Endocrinology Update: Testicular Hypogonadism. FP essentials 451:31-41PubMed Heidelbaugh JJ (2016) Endocrinology Update: Testicular Hypogonadism. FP essentials 451:31-41PubMed
37.
38.
Zurück zum Zitat Bouchard P, Lagoguey M, Brailly S, Schaison G (1985) Gonadotropin-releasing hormone pulsatile administration restores luteinizing hormone pulsatility and normal testosterone levels in males with hyperprolactinemia. The Journal of clinical endocrinology and metabolism 60 (2):258-262. https://doi.org/10.1210/jcem-60-2-258 CrossRefPubMed Bouchard P, Lagoguey M, Brailly S, Schaison G (1985) Gonadotropin-releasing hormone pulsatile administration restores luteinizing hormone pulsatility and normal testosterone levels in males with hyperprolactinemia. The Journal of clinical endocrinology and metabolism 60 (2):258-262. https://​doi.​org/​10.​1210/​jcem-60-2-258 CrossRefPubMed
40.
Zurück zum Zitat MacAdams MR, White RH, Chipps BE (1986) Reduction of serum testosterone levels during chronic glucocorticoid therapy. Annals of internal medicine 104 (5):648-651CrossRef MacAdams MR, White RH, Chipps BE (1986) Reduction of serum testosterone levels during chronic glucocorticoid therapy. Annals of internal medicine 104 (5):648-651CrossRef
42.
Zurück zum Zitat Tanriverdi F, Dokmetas HS, Kebapci N, Kilicli F, Atmaca H, Yarman S, Ertorer ME, Erturk E, Bayram F, Tugrul A, Culha C, Cakir M, Mert M, Aydin H, Taskale M, Ersoz N, Canturk Z, Anaforoglu I, Ozkaya M, Oruk G, Hekimsoy Z, Kelestimur F, Erbas T (2014) Etiology of hypopituitarism in tertiary care institutions in Turkish population: analysis of 773 patients from Pituitary Study Group database. Endocrine 47 (1):198-205. https://doi.org/10.1007/s12020-013-0127-4 CrossRefPubMed Tanriverdi F, Dokmetas HS, Kebapci N, Kilicli F, Atmaca H, Yarman S, Ertorer ME, Erturk E, Bayram F, Tugrul A, Culha C, Cakir M, Mert M, Aydin H, Taskale M, Ersoz N, Canturk Z, Anaforoglu I, Ozkaya M, Oruk G, Hekimsoy Z, Kelestimur F, Erbas T (2014) Etiology of hypopituitarism in tertiary care institutions in Turkish population: analysis of 773 patients from Pituitary Study Group database. Endocrine 47 (1):198-205. https://​doi.​org/​10.​1007/​s12020-013-0127-4 CrossRefPubMed
47.
Zurück zum Zitat Hardelin JP, Dode C (2008) The complex genetics of Kallmann syndrome: KAL1, FGFR1, FGF8, PROKR2, PROK2, et al. Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2 (4-5):181-193. https://doi.org/10.1159/000152034 Hardelin JP, Dode C (2008) The complex genetics of Kallmann syndrome: KAL1, FGFR1, FGF8, PROKR2, PROK2, et al. Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2 (4-5):181-193. https://​doi.​org/​10.​1159/​000152034
52.
Zurück zum Zitat Morley JE, Distiller LA, Sagel J, Kok SH, Kay G, Carr P, Katz M (1977) Hormonal changes associated with testicular atrophy and gynaecomastia in patients with leprosy. Clinical endocrinology 6 (4):299-303CrossRef Morley JE, Distiller LA, Sagel J, Kok SH, Kay G, Carr P, Katz M (1977) Hormonal changes associated with testicular atrophy and gynaecomastia in patients with leprosy. Clinical endocrinology 6 (4):299-303CrossRef
58.
Zurück zum Zitat Muller J, Skakkebaek NE (1984) Abnormal germ cells in maldescended testes: a study of cell density, nuclear size and deoxyribonucleic acid content in testicular biopsies from 50 boys. The Journal of urology 131 (4):730-733CrossRef Muller J, Skakkebaek NE (1984) Abnormal germ cells in maldescended testes: a study of cell density, nuclear size and deoxyribonucleic acid content in testicular biopsies from 50 boys. The Journal of urology 131 (4):730-733CrossRef
59.
Zurück zum Zitat Schindler AM, Diaz P, Cuendet A, Sizonenko PC (1987) Cryptorchidism: a morphological study of 670 biopsies. Helvetica paediatrica acta 42 (2-3):145-158PubMed Schindler AM, Diaz P, Cuendet A, Sizonenko PC (1987) Cryptorchidism: a morphological study of 670 biopsies. Helvetica paediatrica acta 42 (2-3):145-158PubMed
61.
Zurück zum Zitat Claahsen-van der Grinten HL, Sweep FC, Blickman JG, Hermus AR, Otten BJ (2007) Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. European journal of endocrinology 157 (3):339-344. https://doi.org/10.1530/eje-07-0201 CrossRefPubMed Claahsen-van der Grinten HL, Sweep FC, Blickman JG, Hermus AR, Otten BJ (2007) Prevalence of testicular adrenal rest tumours in male children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. European journal of endocrinology 157 (3):339-344. https://​doi.​org/​10.​1530/​eje-07-0201 CrossRefPubMed
69.
Zurück zum Zitat Barratt CLR, Bjorndahl L, De Jonge CJ, Lamb DJ, Osorio Martini F, McLachlan R, Oates RD, van der Poel S, St John B, Sigman M, Sokol R, Tournaye H (2017) The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities. Human reproduction update 23 (6):660-680. https://doi.org/10.1093/humupd/dmx021 CrossRefPubMedPubMedCentral Barratt CLR, Bjorndahl L, De Jonge CJ, Lamb DJ, Osorio Martini F, McLachlan R, Oates RD, van der Poel S, St John B, Sigman M, Sokol R, Tournaye H (2017) The diagnosis of male infertility: an analysis of the evidence to support the development of global WHO guidance-challenges and future research opportunities. Human reproduction update 23 (6):660-680. https://​doi.​org/​10.​1093/​humupd/​dmx021 CrossRefPubMedPubMedCentral
Metadaten
Titel
MRI findings of nonobstructive azoospermia: lesions in and out of pelvic cavity
verfasst von
Yang Peng
Longyuan Ouyang
Zhi Lin
Fan Zhang
Huanjun Wang
Jian Guan
Publikationsdatum
24.09.2019
Verlag
Springer US
Erschienen in
Abdominal Radiology / Ausgabe 7/2020
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-019-02232-8

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