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05.04.2016 | Magnetic Resonance | Ausgabe 2/2017 Open Access

European Radiology 2/2017

MRI texture analysis (MRTA) of T2-weighted images in Crohn’s disease may provide information on histological and MRI disease activity in patients undergoing ileal resection

Zeitschrift:
European Radiology > Ausgabe 2/2017
Autoren:
Jesica Makanyanga, Balaji Ganeshan, Manuel Rodriguez-Justo, Gauraang Bhatnagar, Ashley Groves, Steve Halligan, Ken Miles, Stuart A. Taylor
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1007/​s00330-016-4324-4) contains supplementary material, which is available to authorized users.

Abstract

Objectives

To associate MRI textural analysis (MRTA) with MRI and histological Crohn’s disease (CD) activity.

Methods

Sixteen patients (mean age 39.5 years, 9 male) undergoing MR enterography before ileal resection were retrospectively analysed. Thirty-six small (≤3 mm) ROIs were placed on T2-weighted images and location-matched histological acute inflammatory scores (AIS) measured. MRI activity (mural thickness, T2 signal, T1 enhancement) (CDA) was scored in large ROIs. MRTA features (mean, standard deviation, mean of positive pixels (MPP), entropy, kurtosis, skewness) were extracted using a filtration histogram technique. Spatial scale filtration (SSF) ranged from 2 to 5 mm. Regression (linear/logistic) tested associations between MRTA and AIS (small ROIs), and CDA/constituent parameters (large ROIs).

Results

Skewness (SSF = 2 mm) was associated with AIS [regression coefficient (rc) 4.27, p = 0.02]. Of 120 large ROI analyses (for each MRI, MRTA feature and SSF), 15 were significant. Entropy (SSF = 2, 3 mm) and kurtosis (SSF = 3 mm) were associated with CDA (rc 0.9, 1.0, −0.45, p = 0.006–0.01). Entropy and mean (SSF = 2–4 mm) were associated with T2 signal [odds ratio (OR) 2.32–3.16, p = 0.02–0.004], [OR 1.22–1.28, p = 0.03–0.04]. MPP (SSF = 2 mm) was associated with mural thickness (OR 0.91, p = 0.04). Kurtosis (SSF = 3 mm), standard deviation (SSF = 5 mm) were associated with decreased T1 enhancement (OR 0.59, 0.42, p = 0.004, 0.007).

Conclusions

MRTA features may be associated with CD activity.

Key Points

MR texture analysis features may be associated with Crohn’s disease histological activity.
Texture analysis features may correlate with MR-dependent Crohn’s disease activity scores.
The utility of MR texture analysis in Crohn’s disease merits further investigation.

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