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Neurological Sciences

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14.01.2021 | Review Article

Multidisciplinary care in Amyotrophic Lateral Sclerosis: a systematic review and meta-analysis

verfasst von: Filipe Emanuel Oliveira de Almeida, Anne Kelly do Carmo Santana, Fernanda Oliveira de Carvalho

Erschienen in: Neurological Sciences | Ausgabe 3/2021

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Abstract

Multidisciplinary care (MDC) has been the most recommended approach for symptom management in amyotrophic lateral sclerosis (ALS) but there is conflicting evidence about its effectiveness on survival and quality of life (QoL) of ALS patients. We conducted a systematic review to determine the effects of multidisciplinary care compared to general neurological care in survival and quality of life of ALS patients. A comprehensive literature search using Scopus, MEDLINE-PubMed, Cochrane, Web of Science, PEDro, and Science Direct was undertaken. Studies related to multidisciplinary care or general neurological care in ALS patients that assessed survival and quality of life and were published in the period up to and including January 2020 were included. A total of 1192 studies were initially identified, but only 6 were included. All studies that investigated survival showed and advantage of MDC over NC, and this benefit was even greater for bulbar onset patients. A meta-analysis was performed and showed a mean difference of 141.67 (CI 95%, 61.48 to 221.86), indicating that patients who received MDC had longer survival than those who underwent NC (p = 0.0005). Concerning QoL, only one study found better mental health scores related to QoL for patients under MDC. Multidisciplinary care is more effective than general neurology care at improving survival of patients with ALS, but only improves mental health outcomes related to quality of life of these patients.

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Titel: Multidisciplinary care in Amyotrophic Lateral Sclerosis: a systematic review and meta-analysis
verfasst von: Filipe Emanuel Oliveira de Almeida
Anne Kelly do Carmo Santana
Fernanda Oliveira de Carvalho
Publikationsdatum: 14.01.2021
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 3/2021
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-020-05011-2

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