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13.10.2018 | Original Contributions

Multimodal Postoperative Pain Control Is Effective and Reduces Opioid Use After Laparoscopic Roux-en-Y Gastric Bypass

Obesity Surgery
Ryan D. Horsley, Ellen D. Vogels, Daaron A. P. McField, David M. Parker, Charles Medico, James Dove, Marcus Fluck, Jon D. Gabrielsen, Michael R. Gionfriddo, Anthony T. Petrick
Wichtige Hinweise
This manuscript was presented as a poster at ASMBS Obesity Week 2016


Among patients undergoing laparoscopic Roux-en-Y gastric bypass, an opioid-sparing multimodal pain protocol utilizing scheduled oral acetaminophen and celecoxib reduces oral morphine equivalent use and length of stay without compromising pain control compared to an opioid-based regimen.



Opioids have been the mainstay for postoperative pain relief for many decades. Recently, opioid-related adverse events and death have been linked to postoperative dependency. Multimodal approaches to postoperative pain control may be part of the solution to this health care crisis. The safety and effectiveness of multimodal pain control regimens after laparoscopic Roux-en-Y gastric bypass (LRYGB) has not been well studied. The primary aim of our study was to determine if an evidence-based, multimodal pain regimen during hospitalization could decrease the total oral morphine equivalent (TME) use after LRYGB.

Study Design

We conducted a retrospective cohort study comparing outcomes prior to the implementation of a multimodal pain protocol (December 2010–December 2012) to those after implementation (April 2013–July 2015). The protocol utilized oral celecoxib and scheduled oral acetaminophen for pain control, with opioids used only as needed for breakthrough pain. Data was extracted from an electronic medical record and an institutionally maintained database of all patients undergoing bariatric surgery at a single center.


Compared to controls, the multimodal pain regimen significantly reduced TME used and maximum pain scores with no change in mean pain scores. Multimodal pain protocol patients had a shorter length of stay with no increase in bleeding complications or marginal ulcer rates.


An opioid-sparing multimodal pain regimen adequately controls pain while reducing TME use. The regimen appears to be safe and was associated with a reduced length of stay in patients undergoing LRYGB.

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