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Erschienen in: European Radiology 6/2018

26.01.2018 | Neuro

Multiparametric MRI as a potential surrogate endpoint for decision-making in early treatment response following concurrent chemoradiotherapy in patients with newly diagnosed glioblastoma: a systematic review and meta-analysis

verfasst von: Chong Hyun Suh, Ho Sung Kim, Seung Chai Jung, Choong Gon Choi, Sang Joon Kim

Erschienen in: European Radiology | Ausgabe 6/2018

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Abstract

Objective

To evaluate the value of multiparametric MRI for determination of early treatment response following concurrent chemoradiotherapy in patients with newly diagnosed glioblastoma.

Methods

A computerized search of Ovid-MEDLINE and EMBASE up to 1 October 2017 was performed to find studies on the diagnostic performance of multiparametric MRI for differentiating true progression from pseudoprogression. The beginning search date was not specified. Pooled estimates of sensitivity and specificity were obtained using hierarchical logistic regression modeling. We performed meta-regression and sensitivity analyses to explain the effects of the study heterogeneity.

Results

Nine studies including 456 patients were included. Pooled sensitivity and specificity were 84 % (95 % CI 74–91) and 95 % (95 % CI 83–99), respectively. Area under the hierarchical summary receiver operating characteristic curve was 0.95 (95 % CI 0.92–0.96). Meta-regression showed true progression in the study population, the mean age and the reference standard were significant factors affecting heterogeneity.

Conclusion

Multiparametric MRI may be used as a potential surrogate endpoint for assessment of early treatment response, especially in the differentiation of true progression from pseudoprogression. However, based on the current evidence, monoparametric and multiparametric MRI perform equally in the clinical context. Further evaluation will be needed.

Key Points

Multiparametric MRI shows high diagnostic performance for early treatment response in glioblastoma.
Multiparametric MRI could differentiate true progression from pseudoprogression in newly diagnosed glioblastoma.
The normalized rCBV derived from DSC was the most commonly used parameter.
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Metadaten
Titel
Multiparametric MRI as a potential surrogate endpoint for decision-making in early treatment response following concurrent chemoradiotherapy in patients with newly diagnosed glioblastoma: a systematic review and meta-analysis
verfasst von
Chong Hyun Suh
Ho Sung Kim
Seung Chai Jung
Choong Gon Choi
Sang Joon Kim
Publikationsdatum
26.01.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 6/2018
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-017-5262-5

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