Background
Materials and methods
Theory
The radiomic tissue signature model
The tissue signature probability matrix features
Tissue signature first order statistics features
Tissue signature co-occurrence matrix features
Tissue signature complex interaction network analysis features
First order TSCIN features
Second order TSCIN features
Clinical data
Clinical data
Informed consent
Clinical breast data set
Pharmacokinetic (PK) contrast enhancement parameters
Multiparametric radiomic analysis
Classification
Statistical analysis
Results
Malignant characteristics | IDC | IDC + DCIS | IDC + ILC | ILC | Others |
---|---|---|---|---|---|
N = 29 (30%) | N = 34 (35%) | N = 17 (18%) | N = 12 (12%) | N = 5 (5%) | |
Age, yearsa | 50 ± 12 | 55 ± 8 | 50 ± 11 | 55 ± 8 | 56 ± 9 |
Tumor size (cm) | 3.2 ± 2.1 | 2.3 ± 1.7 | 2.8 ± 1.3 | 2.9 ± 2.0 | 2.9 ± 1.7 |
Phenotypes | |||||
Luminal Ab | 18 | 15 | 8 | 11 | 2 |
Luminal Bb | 1 | 9 | 7 | 1 | 2 |
HER2+ b | 4 | 2 | 0 | 0 | 0 |
Triple negativeb | 6 | 8 | 2 | 0 | 1 |
Benign characteristics | Benign breast tissue | Stable imaging | Fibroadenoma | Sclerosing adenosis | Papilloma | Fibrocystic changes |
---|---|---|---|---|---|---|
N = 14 (35%) | N = 10 (24%) | N = 10 (24%) | N = 3 (7%) | N = 2 (5%) | N = 2 (5%) | |
Age, yearsa | 50 ± 7 | 53 ± 13 | 46 ± 14 | 47 ± 13 | 46 ± 8 | 48 ± 2 |
Benign tumor | Malignant tumor | p value | AUC | |
---|---|---|---|---|
MRI metrics | ||||
ADC map values (× 10–3 mm2/s) | 1.89 ± 0.10 | 1.15 ± 0.03 | 0.0001 | |
Ktrans (1/sec) | 0.27 ± 0.05 | 0.80 ± 0.32 | 0.005 | |
Single parameter entropy | ||||
Entropy T1 | 4.14 ± 0.11 | 4.66 ± 0.06 | 0.00008 | 0.72 (0.64–0.79) |
Entropy T2 | 4.98 ± 0.12 | 5.42 ± 0.06 | 0.002 | 0.68 (0.59–0.75) |
Entropy b0 | 4.44 ± 0.17 | 5.06 ± 0.09 | 0.002 | 0.67 (0.59–0.75) |
Entropy b600 | 3.00 ± 0.20 | 3.77 ± 0.09 | 0.0009 | 0.67 (0.59–0.75) |
Entropy ADC | 4.90 ± 0.12 | 5.40 ± 0.06 | 0.0004 | 0.70 (0.62–0.77) |
Entropy post-contrast DCE (High spatial resolution) | 5.00 ± 0.10 | 5.54 ± 0.05 | 0.00001 | 0.75 (0.67–0.82) |
Entropy PK-DCE Pre | 4.32 ± 0.12 | 4.65 ± 0.05 | 0.02 | 0.62 (0.54–0.70) |
Entropy PK-DCE post (wash-in) | 4.89 ± 0.08 | 5.30 ± 0.05 | 0.00006 | 0.72 (0.64–0.79) |
Entropy PK-DCE post (wash-out) | 4.90 ± 0.09 | 5.24 ± 0.04 | 0.00007 | 0.69 (0.60–0.76) |
Multiparametric entropy | ||||
TSPM entropy (all Parameters) | 7.06 ± 0.27 | 8.93 ± 0.17 | < 0.00001 | 0.82 (0.74–0.88) |
TSPM entropy (PK-DCE) | 7.06 ± 0.27 | 8.92 ± 0.17 | < 0.00001 | 0.82 (0.74–0.88) |
TSPM entropy (high spatial resolution DCE) | 6.74 ± 0.19 | 8.28 ± 0.12 | < 0.00001 | 0.82 (0.75–0.88) |
TSPM entropy (DWI) | 6.66 ± 0.22 | 8.20 ± 0.15 | < 0.00001 | 0.78 (0.70–0.85) |
Glandular tissue benign patients | Glandular tissue malignant patients | p value | |
---|---|---|---|
Single parameter entropy | |||
Entropy T1 | 5.29 ± 0.11 | 5.12 ± 0.06 | 0.20 |
Entropy T2 | 5.37 ± 0.10 | 5.32 ± 0.06 | 0.68 |
Entropy b0 | 5.19 ± 0.24 | 4.89 ± 0.10 | 0.27 |
Entropy b600 | 3.46 ± 0.24 | 3.13 ± 0.10 | 0.20 |
Entropy ADC | 5.27 ± 0.28 | 5.39 ± 0.16 | 0.71 |
Entropy post-contrast DCE (high spatial resolution) | 5.13 ± 0.10 | 5.00 ± 0.06 | 0.26 |
Entropy PK-DCE pre | 5.24 ± 0.12 | 5.12 ± 0.05 | 0.38 |
Entropy PK-DCE post (wash-in) | 5.28 ± 0.11 | 5.18 ± 0.05 | 0.40 |
Entropy PK-DCE post (wash-out) | 5.30 ± 0.10 | 5.24 ± 0.05 | 0.60 |
Multiparametric entropy | |||
TSPM entropy (all Parameters) | 10.93 ± 0.34 | 10.64 ± 0.17 | 0.46 |
TSPM entropy (PK-DCE) | 10.92 ± 0.34 | 10.64 ± 0.17 | 0.47 |
TSPM entropy (high spatial resolution DCE) | 9.17 ± 0.17 | 9.04 ± 0.10 | 0.51 |
TSPM Entropy (DWI) | 9.31 ± 0.35 | 9.06 ± 0.18 | 0.54 |
S. No | mpRad radiomic feature | Benign tumor | Malignant tumor | p value | AUC |
---|---|---|---|---|---|
1 | TSPM entropy (all parameters) | 7.06 ± 0.27 | 8.93 ± 0.17 | < 0.00001 | 0.82 (0.74–0.88) |
2 | TSPM entropy (DCE) | 7.06 ± 0.27 | 8.92 ± 0.17 | < 0.00001 | 0.82 (0.74–0.88) |
3 | TSPM entropy (HiRes) | 6.74 ± 0.19 | 8.28 ± 0.12 | < 0.00001 | 0.82 (0.75–0.88) |
4 | TSPM entropy (DWI) | 6.66 ± 0.22 | 8.20 ± 0.15 | < 0.00001 | 0.78 (0.70–0.85) |
5 | TSCIN DWI maximum | 0.44 ± 0.02 | 0.34 ± 0.01 | < 0.00001 | 0.77 (0.69–0.83) |
6 | TSCIN DWI standard deviation | 0.18 ± 0.01 | 0.12 ± 0.00 | < 0.00001 | 0.79 (0.71–0.85) |
7 | TSCIN DWI range | 0.34 ± 0.02 | 0.24 ± 0.01 | < 0.00001 | 0.79 (0.71–0.85) |
8 | TSCIN DWI median absolute deviation | 0.13 ± 0.01 | 0.09 ± 0.00 | < 0.00001 | 0.78 (0.70–0.84) |
9 | TSCIN DCE kurtosis | 2.63 ± 0.14 | 3.37 ± 0.08 | 0.00004 | 0.76 (0.68–0.83) |
10 | TSCIN DCE skewness | − 0.69 ± 0.07 | − 1.06 ± 0.04 | 0.00001 | 0.75 (0.67–0.82) |