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28.11.2016 | Original Article | Ausgabe 4/2017

International Journal of Colorectal Disease 4/2017

Multiple behavioral factors are associated with occurrence of large, flat colorectal polyps

Zeitschrift:
International Journal of Colorectal Disease > Ausgabe 4/2017
Autoren:
Tianzuo Zhan, Felix Hahn, Thomas Hielscher, Asmé Bilge, Jürgen Grüger, Jürgen Weers, Johannes Betge, Timo Gaiser, Georg Kähler, Matthias P. Ebert, Sebastian Belle
Wichtige Hinweise
T.Z. and F.H. contributed equally to this work.

Abstract

Purpose

The prevalence of advanced dysplasia and synchronous lesions is particularly high in patients with large, flat colorectal polyps. However, the impact of lifestyle on the development of such polyps is poorly investigated. Hence, this study aims to identify associations between behavioral factors and the occurrence of large, flat colorectal polyps.

Methods

Behavioral factors were retrospectively analyzed in patients with large, flat polyps and control patients with at most one diminutive polyp. Information on lifestyle factors, comorbidities, and demographic parameters were determined by a structured, self-administered questionnaire.

Results

Questionnaires of 350 patients with large, flat polyps and 489 control patients were included in the analysis. Most large, flat colorectal polyps contained adenoma with low-grade neoplasia and were located in the right colon. Multivariate analysis showed that advanced age (per 1-year increase—OR 1.09, CI 1.07–1.11, p < 0.0001), frequent cigarette smoking (OR 2.04, CI 1.25–3.32, p = 0.0041), daily consumption of red meat (OR 3.61, CI 1.00–12.96, p = 0.0492), and frequent bowel movements (OR 1.62, CI 1.13–2.33, p = 0.0093) were independent risk factors for occurrence of large, flat colorectal polyps. In contrast, frequent intake of cereals (OR 0.62, CI 0.44–0.88, p = 0.0074) was associated with a reduced risk.

Conclusion

Multiple behavioral factors modulate the risk for developing large, flat colorectal polyps. This knowledge can be used to improve prevention of colorectal cancer.

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Zusatzmaterial
Supplementary Table 1 (DOCX 81 kb)
384_2016_2717_MOESM1_ESM.docx
Supplementary Table 2 (DOCX 26 kb)
384_2016_2717_MOESM2_ESM.docx
Supplementary Table 3 (DOCX 79 kb)
384_2016_2717_MOESM3_ESM.docx
Literatur
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