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Head and Neck Pathology

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10.01.2017 | Sine qua non Clinicopathologic Correlation

Multiple Oral Mucosal Hamartomas in a 34-Year Old Female

verfasst von: Jeffrey A. Elo, Ho-Hyun Sun, Joel M. Laudenbach, Hardev M. Singh

Erschienen in: Head and Neck Pathology | Ausgabe 3/2017

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Abstract

A case of Cowden syndrome (CS) is described in a 34-year-old African American female who reported a history of breast and thyroid malignancies. Clinical examination demonstrated multiple soft, white-pink papules across multiple mucosal surfaces of the oral cavity. Microscopy of the lesions revealed hyperkeratotic surface squamous epithelium with papillomatosis and acanthosis along with elongated rete processes. A genomic polymerase chain reaction direct sequencing using the patient’s blood was positive for mutations of the PTEN gene typical of CS.

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Titel: Multiple Oral Mucosal Hamartomas in a 34-Year Old Female
verfasst von: Jeffrey A. Elo
Ho-Hyun Sun
Joel M. Laudenbach
Hardev M. Singh
Publikationsdatum: 10.01.2017
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 3/2017
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-016-0777-7

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