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Erschienen in: DNP – Die Neurologie & Psychiatrie 6/2019

01.12.2019 | Multiple Sklerose | Zertifizierte Fortbildung

Multiple Sklerose

Zeitgemäße MS-Therapie

verfasst von: Prof. Dr. med. Mathias Mäurer

Erschienen in: DNP – Die Neurologie & Psychiatrie | Ausgabe 6/2019

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Zusammenfassung

Die Therapie der Multiplen Sklerose hat in den letzten 20 Jahren große Fortschritte gemacht und ist insbesondere in den vergangenen zehn Jahren vielfältiger geworden. In der Behandlung wird zwischen milden/moderaten und hochaktiven Verläufen unterschieden. Die Revision der McDonald-Kriterien in den Jahren 2010 und 2017 erlaubt eine frühe Diagnosestellung und damit eine frühzeitige Therapie.
Literatur
1.
Zurück zum Zitat Petersen G, Wittmann R, Arndt V, Göpffarth D. Epidemiology of multiple sclerosis in Germany: regional differences and drug prescription in the claims data of the statutory health insurance. Nervenarzt. 2014 Aug;85(8):990–8CrossRef Petersen G, Wittmann R, Arndt V, Göpffarth D. Epidemiology of multiple sclerosis in Germany: regional differences and drug prescription in the claims data of the statutory health insurance. Nervenarzt. 2014 Aug;85(8):990–8CrossRef
2.
Zurück zum Zitat Haghikia A, Linker RA. Nutrition, microbiome and multiple sclerosis: Current knowledge from basic research and clinical practice. Nervenarzt. 2018 Apr;89(4):463–71CrossRef Haghikia A, Linker RA. Nutrition, microbiome and multiple sclerosis: Current knowledge from basic research and clinical practice. Nervenarzt. 2018 Apr;89(4):463–71CrossRef
3.
Zurück zum Zitat Confavreux C, Vukusic S, Moreau T, Adeleine P. Relapses and progression of disability in multiple sclerosis. N Engl J Med. 2000 Nov 16;343(20):1430–8CrossRef Confavreux C, Vukusic S, Moreau T, Adeleine P. Relapses and progression of disability in multiple sclerosis. N Engl J Med. 2000 Nov 16;343(20):1430–8CrossRef
4.
Zurück zum Zitat Leray E, Yaouanq J, Le Page E, Coustans M, Laplaud D, Oger J, Edan G. Evidence for a two-stage disability progression in multiple sclerosis. Brain. 2010 Jul;133(Pt 7):1900–13CrossRef Leray E, Yaouanq J, Le Page E, Coustans M, Laplaud D, Oger J, Edan G. Evidence for a two-stage disability progression in multiple sclerosis. Brain. 2010 Jul;133(Pt 7):1900–13CrossRef
6.
Zurück zum Zitat Weinshenker BG, Bass B, Rice GP, Noseworthy J, Carriere W, Baskerville J, Ebers GC.The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain. 1989 Feb;112 ( Pt 1):133–46CrossRef Weinshenker BG, Bass B, Rice GP, Noseworthy J, Carriere W, Baskerville J, Ebers GC.The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain. 1989 Feb;112 ( Pt 1):133–46CrossRef
7.
Zurück zum Zitat University of California, San Francisco MS-EPIC Team: Cree BA, Gourraud PA, Oksenberg JR, Bevan C, Crabtree-Hartman E, Gelfand JM, et. al. Long-term evolution of multiple sclerosis disability in the treatment era. Ann Neurol. 2016 Oct;80(4):499–510CrossRef University of California, San Francisco MS-EPIC Team: Cree BA, Gourraud PA, Oksenberg JR, Bevan C, Crabtree-Hartman E, Gelfand JM, et. al. Long-term evolution of multiple sclerosis disability in the treatment era. Ann Neurol. 2016 Oct;80(4):499–510CrossRef
8.
Zurück zum Zitat Frischer JM, Weigand SD, Guo Y, Kale N, Parisi JE, Pirko I, Mandrekar J, Bramow S, Metz I, Brück W, Lassmann H, Lucchinetti CF. Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque. Ann Neurol. 2015 Nov;78(5):710–21CrossRef Frischer JM, Weigand SD, Guo Y, Kale N, Parisi JE, Pirko I, Mandrekar J, Bramow S, Metz I, Brück W, Lassmann H, Lucchinetti CF. Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque. Ann Neurol. 2015 Nov;78(5):710–21CrossRef
9.
Zurück zum Zitat Antel J, Antel S, Caramanos Z, Arnold DL, Kuhlmann T. Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity? Acta Neuropathol. 2012 May;123(5):627–38CrossRef Antel J, Antel S, Caramanos Z, Arnold DL, Kuhlmann T. Primary progressive multiple sclerosis: part of the MS disease spectrum or separate disease entity? Acta Neuropathol. 2012 May;123(5):627–38CrossRef
10.
Zurück zum Zitat Lublin FD, Reingold SC, Cohen JA, Cutter GR, Sørensen PS, Thompson AJ et. al. Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology. 2014 Jul 15;83(3):278–86CrossRef Lublin FD, Reingold SC, Cohen JA, Cutter GR, Sørensen PS, Thompson AJ et. al. Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology. 2014 Jul 15;83(3):278–86CrossRef
11.
Zurück zum Zitat Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018 Feb;17(2):162–73CrossRef Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Lancet Neurol. 2018 Feb;17(2):162–73CrossRef
12.
Zurück zum Zitat Correia I, Ribeiro JJ, Isidoro L, Batista S, Nunes C, Macário C, Borges C, Tomaz J, Sousa L Plasma exchange in severe acute relapses of multiple sclerosis - Results from a Portuguese cohort. Mult Scler Relat Disord. 2018 Correia I, Ribeiro JJ, Isidoro L, Batista S, Nunes C, Macário C, Borges C, Tomaz J, Sousa L Plasma exchange in severe acute relapses of multiple sclerosis - Results from a Portuguese cohort. Mult Scler Relat Disord. 2018
13.
Zurück zum Zitat Stork L, Brück W, von Gottberg P, Pulkowski U, Kirsten F, Glatzel M, et al. Severe meningo-/encephalitis after daclizumab therapy for multiple sclerosis. Mult Scler. 2019 Jan 18:1352458518819098 Stork L, Brück W, von Gottberg P, Pulkowski U, Kirsten F, Glatzel M, et al. Severe meningo-/encephalitis after daclizumab therapy for multiple sclerosis. Mult Scler. 2019 Jan 18:1352458518819098
14.
Zurück zum Zitat Filippi M, Bar-Or A, Piehl F, Preziosa P, Solari A, Vukusic S, Rocca MA. Multiple sclerosis. Nat Rev Dis Primers. 2018 Nov 8;4(1):4CrossRef Filippi M, Bar-Or A, Piehl F, Preziosa P, Solari A, Vukusic S, Rocca MA. Multiple sclerosis. Nat Rev Dis Primers. 2018 Nov 8;4(1):4CrossRef
15.
Zurück zum Zitat Montalban X, Gold R, Thompson AJ, et al. ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis. Eur J Neurol 2018; 25:215–37CrossRef Montalban X, Gold R, Thompson AJ, et al. ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis. Eur J Neurol 2018; 25:215–37CrossRef
17.
Zurück zum Zitat Colligan E, Metzler A, Tiryaki E. Shared decision-making in multiple sclerosis. Mult Scler. 2017 Feb;23(2):185–90CrossRef Colligan E, Metzler A, Tiryaki E. Shared decision-making in multiple sclerosis. Mult Scler. 2017 Feb;23(2):185–90CrossRef
18.
Zurück zum Zitat Polman CH, O’Connor PW, Havrdova E, et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006;354:899–910CrossRef Polman CH, O’Connor PW, Havrdova E, et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006;354:899–910CrossRef
19.
Zurück zum Zitat Kappos L, Radue EW, O’Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387–401CrossRef Kappos L, Radue EW, O’Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387–401CrossRef
20.
Zurück zum Zitat Cohen JA, Coles AJ, Arnold DL, et al. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. Lancet 2012;380:1819–28CrossRef Cohen JA, Coles AJ, Arnold DL, et al. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. Lancet 2012;380:1819–28CrossRef
21.
Zurück zum Zitat Rote-Hand-Brief Lemtrada® — Alemtuzumab. April 2019. Online: www.pei.de (Letzter Zugriff: 08.05.2019) Rote-Hand-Brief Lemtrada® — Alemtuzumab. April 2019. Online: www.​pei.​de (Letzter Zugriff: 08.05.2019)
22.
Zurück zum Zitat Giovannoni G, Soelberg Sorensen P, Cook S, Rammohan K, et al. Safety and efficacy of cladribine tablets in patients with relapsing-remitting multiple sclerosis: Results from the randomized extension trial of the CLARITY study. Mult Scler 2018;24:1594–1604CrossRef Giovannoni G, Soelberg Sorensen P, Cook S, Rammohan K, et al. Safety and efficacy of cladribine tablets in patients with relapsing-remitting multiple sclerosis: Results from the randomized extension trial of the CLARITY study. Mult Scler 2018;24:1594–1604CrossRef
23.
Zurück zum Zitat Hauser SL, Bar-Or A, Comi G, et al. Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis. N Engl J Med 2017;376:221–34CrossRef Hauser SL, Bar-Or A, Comi G, et al. Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis. N Engl J Med 2017;376:221–34CrossRef
24.
Zurück zum Zitat Brown JWL, Coles A, Horakova D, et al. Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis. JAMA 2019;321:175–87CrossRef Brown JWL, Coles A, Horakova D, et al. Association of Initial Disease-Modifying Therapy With Later Conversion to Secondary Progressive Multiple Sclerosis. JAMA 2019;321:175–87CrossRef
25.
Zurück zum Zitat Ontaneda D, Tallantyre E, Kalincik T, Planchon SM, Evangelou N.Early highly effective versus escalation treatment approaches in relapsing multiple sclerosis. Lancet Neurol. 2019 Jul 30. pii: S1474-4422(19)30151-6 Ontaneda D, Tallantyre E, Kalincik T, Planchon SM, Evangelou N.Early highly effective versus escalation treatment approaches in relapsing multiple sclerosis. Lancet Neurol. 2019 Jul 30. pii: S1474-4422(19)30151-6
Metadaten
Titel
Multiple Sklerose
Zeitgemäße MS-Therapie
verfasst von
Prof. Dr. med. Mathias Mäurer
Publikationsdatum
01.12.2019
Verlag
Springer Medizin
Erschienen in
DNP – Die Neurologie & Psychiatrie / Ausgabe 6/2019
Print ISSN: 2731-8168
Elektronische ISSN: 2731-8176
DOI
https://doi.org/10.1007/s15202-019-2117-8

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