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Cancer Immunology, Immunotherapy
Erschienen in: Cancer Immunology, Immunotherapy 1/2012

01.01.2012 | Focussed Research Review

Muscle CARs and TcRs: turbo-charged technologies for the (T cell) masses

verfasst von: Michael Kalos

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 1/2012

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Abstract

A central role for T cells in the control of cancer has been supported by both animal models and clinical observations. Accordingly, the development of potent anti-tumor T cell immunity has been a long-standing objective of immunotherapy. Emerging data from clinical trials that test T cell immune-modulatory agents and genetically engineered and re-targeted T cells have begun to realize the profound potential of T cell immunotherapy to target cancer. This review will focus on a description of recent conceptual and technological advances for the genetic engineering of T cells to enhance anti-tumor T cell immunity through the introduction of tumor-specific receptors, both Chimeric Antigen Receptors (CAR) and T cell receptors (TcR), as well as an overview of emerging data from ongoing clinical trials that highlight the potential of these approaches to effect dramatic and potent anti-tumor immunity.
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Metadaten
Titel
Muscle CARs and TcRs: turbo-charged technologies for the (T cell) masses
verfasst von
Michael Kalos
Publikationsdatum
01.01.2012
Verlag
Springer-Verlag
Erschienen in
Cancer Immunology, Immunotherapy / Ausgabe 1/2012
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI
https://doi.org/10.1007/s00262-011-1173-5

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