The authors declare that they have no competing interests.
HU and YU served as the guarantor of the paper and takes responsibility for the integrity of the work as a whole. HU and YU drafted the manuscript. FN, MK, and MN participated in data collection. All authors read and approved the final manuscript.
Nontuberculous mycobacteria are well known to be a cause of hot tub lung, however, to our knowledge, there exists no case report of humidifier lung induced by mycobacteria.
A case of a nonimmunocompromised female patient with Mycobacterium gordonae-induced humidifier lung is described. She spontaneously recovered after discontinuing ultrasonic humidifier use. When subjected to a provocation test, she demonstrated acute respiratory distress with signs and symptoms, consistent with hypersensitivity pneumonitis. Before and after the provocation test, water in the humidifier reservoir revealed only Mycobacterium gordonae by the microbiologic analyses.
To our knowledge, this is the first report of humidifier lung induced by nontuberculous mycobacteria. Although nontuberculous mycobacteria are well-known to be agents of hot tub lung or metal working fluid lung, physicians should also consider the pathogen as a cause of hypersensitivity lung reaction associated with humidifier use.
Wilson RW, Steingrube VA, Böttger EC, Springer B, Brown-Elliott BA, Vincent V, et al. Mycobacterium immunogenum sp. nov., a novel species related to Mycobacterium abscessus and associated with clinical disease, pseudo-outbreaks and contaminated metalworking fluids: an international cooperative study on mycobacterial taxonomy. Int J Syst Evol Microbiol. 2001;51:1751–64. CrossRefPubMed
Shiue ST, Scherzer HH, DeGraff JAC, Cole SR. Hypersensitivity pneumonitis associated with the use of ultrasonic humidifiers. N Y State J Med. 1990;90:263–5. PubMed
- Mycobacterium gordonae-induced humidifier lung
- BioMed Central
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