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Erschienen in: Clinical Rheumatology 12/2014

01.12.2014 | Original Article

Mycobacterium tuberculosis lipoarabinomannan antibodies are associated to rheumatoid arthritis in Sardinian patients

verfasst von: G. L. Erre, D. Cossu, S. Masala, G. Mameli, M. L. Cadoni, S. Serdino, M. G. Longu, G. Passiu, L. A. Sechi

Erschienen in: Clinical Rheumatology | Ausgabe 12/2014

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Abstract

Little is known regarding the environmental factors at play in igniting rheumatoid arthritis (RA) autoimmunity, although an association between Mycobacteria and RA has been documented. This pilot study focused on examining a possible involvement of Mycobacterium tuberculosis (MTB) and Mycobacterium avium ss. paratuberculosis (MAP) in RA. We measured out the serum levels of IgG antibody against different mycobacterial antigens in Sardinian patients and controls, by an enzyme-linked immunosorbent assay. The population study was composed of 61 RA patients under different therapies and 52 healthy controls, whereas the antigens tested were MTB lipoarabinomannan (ManLAM), MAP heath shock protein 70, and MAP protein tyrosine phosphatase. The frequencies of anti-ManLAM antibodies were higher in the RA group (23 %) compared to the healthy controls (5.7 %) (AUC = 0.7; p < 0.0001), whereas serum reactivity to MAP antigens was not observed. ManLAM antigen was also detected in the plasma of three RA patients (which were anti-ManLAM antibody positive) by Western blot analysis using anti-Man-LAM monoclonal antibodies. The data produced corroborate the hypothesis of a potential association between MTB ManLAM and RA disease, but so far, further studies are necessary to understand its role in RA pathogenesis.
Literatur
2.
Zurück zum Zitat Kempsell KE, Cox CJ, McColm AA et al (2001) Detection of Mycobacterium tuberculosis group organisms in human and mouse joint tissue by reverse transcriptase PCR: prevalence in diseased synovial tissue suggests lack of specific association with rheumatoid arthritis. Infect Immun 69:1821–1831PubMedCentralPubMedCrossRef Kempsell KE, Cox CJ, McColm AA et al (2001) Detection of Mycobacterium tuberculosis group organisms in human and mouse joint tissue by reverse transcriptase PCR: prevalence in diseased synovial tissue suggests lack of specific association with rheumatoid arthritis. Infect Immun 69:1821–1831PubMedCentralPubMedCrossRef
3.
Zurück zum Zitat Wu CH, Jeng KC, Lan JL (1995) Mycobacterium tuberculosis antigen, interleukin 2 and interleukin 2 inhibitor in patients with rheumatoid arthritis. Immunol Invest 24:957–964PubMedCrossRef Wu CH, Jeng KC, Lan JL (1995) Mycobacterium tuberculosis antigen, interleukin 2 and interleukin 2 inhibitor in patients with rheumatoid arthritis. Immunol Invest 24:957–964PubMedCrossRef
4.
Zurück zum Zitat Billiau A, Matthys P (2001) Modes of action of Freund’s adjuvants in experimental models of autoimmune diseases. J Leukoc Biol 70:849–860PubMed Billiau A, Matthys P (2001) Modes of action of Freund’s adjuvants in experimental models of autoimmune diseases. J Leukoc Biol 70:849–860PubMed
5.
Zurück zum Zitat Dheda K, Van-Zyl Smit RN et al (2009) Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting. PLoS One 4(3):e4689PubMedCentralPubMedCrossRef Dheda K, Van-Zyl Smit RN et al (2009) Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting. PLoS One 4(3):e4689PubMedCentralPubMedCrossRef
6.
Zurück zum Zitat Swaminathan S, Rekha VV (2012) Antigen detection as a point-of-care test for TB: the case of lipoarabinomannan. Future Microbiol 7:559–564PubMedCrossRef Swaminathan S, Rekha VV (2012) Antigen detection as a point-of-care test for TB: the case of lipoarabinomannan. Future Microbiol 7:559–564PubMedCrossRef
7.
Zurück zum Zitat Dheda K, Ruhwald M, Theron G et al (2013) Point-of-care diagnosis of tuberculosis: past, present and future. Respirology 18:217–232PubMedCrossRef Dheda K, Ruhwald M, Theron G et al (2013) Point-of-care diagnosis of tuberculosis: past, present and future. Respirology 18:217–232PubMedCrossRef
8.
Zurück zum Zitat Chodisetti SB, Rai PK, Gowthaman U et al (2012) Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis. BMC Immunol 13:13PubMedCrossRef Chodisetti SB, Rai PK, Gowthaman U et al (2012) Potential T cell epitopes of Mycobacterium tuberculosis that can instigate molecular mimicry against host: implications in autoimmune pathogenesis. BMC Immunol 13:13PubMedCrossRef
9.
Zurück zum Zitat Cossu D, Masala S, Sechi LA (2013) A Sardinian map for multiple sclerosis. Future Microbiol 8:223–232PubMedCrossRef Cossu D, Masala S, Sechi LA (2013) A Sardinian map for multiple sclerosis. Future Microbiol 8:223–232PubMedCrossRef
10.
Zurück zum Zitat Cossu D, Masala S, Frau J et al (2013) Anti Mycobacterium avium subsp. paratuberculosis heat shock protein 70 antibodies in the sera of Sardinian patients with multiple sclerosis. J Neurol Sci 335:131–133PubMedCrossRef Cossu D, Masala S, Frau J et al (2013) Anti Mycobacterium avium subsp. paratuberculosis heat shock protein 70 antibodies in the sera of Sardinian patients with multiple sclerosis. J Neurol Sci 335:131–133PubMedCrossRef
11.
Zurück zum Zitat Bach H, Ko HH, Raizman EA et al (2011) Immunogenicity of Mycobacterium avium subsp. paratuberculosis proteins in Crohn’s disease patients. Scand J Gastroenterol 46:30–39PubMedCrossRef Bach H, Ko HH, Raizman EA et al (2011) Immunogenicity of Mycobacterium avium subsp. paratuberculosis proteins in Crohn’s disease patients. Scand J Gastroenterol 46:30–39PubMedCrossRef
12.
Zurück zum Zitat Aletha D, Neogi T, Silman A et al (2010) The 2010 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Rheumatoid Arthritis. Arthritis Rheum 62:2582–2591CrossRef Aletha D, Neogi T, Silman A et al (2010) The 2010 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Rheumatoid Arthritis. Arthritis Rheum 62:2582–2591CrossRef
13.
Zurück zum Zitat Stoop EJ, Mishra AK, Driessen NN et al (2013) Mannan core branching of lipo (arabino) mannan is required for mycobacterial virulence in the context of innate immunity. Cell Microbiol 15:2093–2108PubMedCentralPubMedCrossRef Stoop EJ, Mishra AK, Driessen NN et al (2013) Mannan core branching of lipo (arabino) mannan is required for mycobacterial virulence in the context of innate immunity. Cell Microbiol 15:2093–2108PubMedCentralPubMedCrossRef
14.
Zurück zum Zitat Wood R, Racow K, Bekker LG et al (2012) Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria. BMC Infect Dis 12:47PubMedCentralPubMedCrossRef Wood R, Racow K, Bekker LG et al (2012) Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria. BMC Infect Dis 12:47PubMedCentralPubMedCrossRef
15.
Zurück zum Zitat Simons MP, Moore JM, Kemp TJ et al (2007) Identification of the mycobacterial subcomponents involved in the release of tumor necrosis factor-related apoptosis-inducing ligand from human neutrophils. Infect Immun 75:1265–1271PubMedCentralPubMedCrossRef Simons MP, Moore JM, Kemp TJ et al (2007) Identification of the mycobacterial subcomponents involved in the release of tumor necrosis factor-related apoptosis-inducing ligand from human neutrophils. Infect Immun 75:1265–1271PubMedCentralPubMedCrossRef
Metadaten
Titel
Mycobacterium tuberculosis lipoarabinomannan antibodies are associated to rheumatoid arthritis in Sardinian patients
verfasst von
G. L. Erre
D. Cossu
S. Masala
G. Mameli
M. L. Cadoni
S. Serdino
M. G. Longu
G. Passiu
L. A. Sechi
Publikationsdatum
01.12.2014
Verlag
Springer London
Erschienen in
Clinical Rheumatology / Ausgabe 12/2014
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-014-2678-z

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