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Erschienen in: Pediatric Cardiology 5/2010

01.07.2010 | Original Article

Myocardial Performance in Asphyxiated Full-Term Infants Assessed by Doppler Tissue Imaging

verfasst von: Mohamed Matter, Hesham Abdel-Hady, Gehan Attia, Mona Hafez, Wael Seliem, Mohamed Al-Arman

Erschienen in: Pediatric Cardiology | Ausgabe 5/2010

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Abstract

The aim of this study was to assess myocardial performance of full-term infants with perinatal asphyxia using Doppler tissue imaging (DTI) and to correlate it with serum cardiac troponin T (cTnT) concentrations. Twenty-five asphyxiated and 20 nonasphyxiated term infants were investigated. Serum cTnT concentrations were measured between 12 and 24 h of life. Conventional two-dimensional Doppler echocardiography and DTI were done during the first 72 h of life. Right ventricular (RV) and left ventricular (LV) Tei indexes were significantly higher in asphyxiated neonates (mean ± SD: 0.45 ± 0.05 vs. 0.28 ± 0.05, P < 0.001 and 0.51 ± 0.04 vs. 0.38 ± 0.04, P < 0.001, respectively). Mitral and tricuspid systolic (Sm) velocities were significantly lower in asphyxiated neonates (mean ± SD: 5.06 ± 0.89 vs. 6.89 ± 0.94 cm/s, P < 0.001 and 5.78 ± 0.58 vs. 6.69 ± 0.87 cm/s, P < 0.001, respectively). cTnT concentrations were significantly higher in asphyxiated neonates [median (range): 0.17 (0.05–0.23) vs. 0.03 (0–0.07) μg/l, P < 0.001)], and they correlated positively with the LV Tei index (r = 0.67, P < 0.001) and the RV Tei index (r = 0.68, P < 0.001) and negatively with the mitral systolic (Sm) velocity (r = –0.68, P < 0.001) and tricuspid systolic (Sm) velocity (r = –0.41, P = 0.01). A higher cTnT was a significant predictor of mortality, whereas fractional shortening (FS) and DTI measurements did not show any significant predictive value. The DTI technique appears to be more sensitive than conventional echocardiography in the early detection of myocardial dysfunction induced by perinatal asphyxia in full-term infants.
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Metadaten
Titel
Myocardial Performance in Asphyxiated Full-Term Infants Assessed by Doppler Tissue Imaging
verfasst von
Mohamed Matter
Hesham Abdel-Hady
Gehan Attia
Mona Hafez
Wael Seliem
Mohamed Al-Arman
Publikationsdatum
01.07.2010
Verlag
Springer-Verlag
Erschienen in
Pediatric Cardiology / Ausgabe 5/2010
Print ISSN: 0172-0643
Elektronische ISSN: 1432-1971
DOI
https://doi.org/10.1007/s00246-010-9661-5

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