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Erschienen in: Breast Cancer Research 2/2005

01.06.2005 | Poster Presentation

Myoepithelial cell layer disruption and human breast cancer invasion

verfasst von: YG Man, QX Sang

Erschienen in: Breast Cancer Research | Sonderheft 2/2005

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Excerpt

Human breast luminal epithelium and the stromal compartment are separated by a layer of myoepithelial (ME) cells and basement membrane, whose disruption is required for tumor invasion. Basement membrane degradation has been ascribed largely to an overproduction of proteases by the tumor and stromal cells. However, the causes and phenotypes of ME cell layer disruption and its contribution to the initiation of tumor invasion remain to be further explored. …
Literatur
1.
Zurück zum Zitat Man YG, Sang QX: The significance of focal myoepithelial cell layer disruptions in human breast tumor invasion: a paradigm shift from the 'protease-centered' hypothesis [review]. Exp Cell Res. 2004, 301: 103-118. 10.1016/j.yexcr.2004.08.037.CrossRefPubMed Man YG, Sang QX: The significance of focal myoepithelial cell layer disruptions in human breast tumor invasion: a paradigm shift from the 'protease-centered' hypothesis [review]. Exp Cell Res. 2004, 301: 103-118. 10.1016/j.yexcr.2004.08.037.CrossRefPubMed
2.
Zurück zum Zitat Man YG, Shen T, Sang QX, Berg PE, Schwartz AM: Cell clusters in a subset of in situ breast tumors show an unusual growth pattern: implications for invasion and metastasis. Cancer Detect Prevent. 2005, Man YG, Shen T, Sang QX, Berg PE, Schwartz AM: Cell clusters in a subset of in situ breast tumors show an unusual growth pattern: implications for invasion and metastasis. Cancer Detect Prevent. 2005,
Metadaten
Titel
Myoepithelial cell layer disruption and human breast cancer invasion
verfasst von
YG Man
QX Sang
Publikationsdatum
01.06.2005
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe Sonderheft 2/2005
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1128

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