Erschienen in:
01.06.2005 | Poster Presentation
Myoepithelial cell layer disruption and human breast cancer invasion
verfasst von:
YG Man, QX Sang
Erschienen in:
Breast Cancer Research
|
Sonderheft 2/2005
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Excerpt
Human breast luminal epithelium and the stromal compartment are separated by a layer of myoepithelial (ME) cells and basement membrane, whose disruption is required for tumor invasion. Basement membrane degradation has been ascribed largely to an overproduction of proteases by the tumor and stromal cells. However, the causes and phenotypes of ME cell layer disruption and its contribution to the initiation of tumor invasion remain to be further explored. …