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Cancer and Metastasis Reviews

Erschienen in:

16.10.2017 | NON-THEMATIC REVIEW

Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers

verfasst von: Lon Wolf R. Fong, David C. Yang, Ching-Hsien Chen

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 4/2017

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Abstract

Emerging evidence implicates myristoylated alanine-rich C-kinase substrate (MARCKS), a major substrate of protein kinase C (PKC), in a critical role for cancer development and progression. MARCKS is tethered to the plasma membrane but can shuttle between the cytosol and plasma membrane via the myristoyl-electrostatic switch. Phosphorylation of MARCKS by PKC leads to its translocation from the plasma membrane to the cytosol where it functions in actin cytoskeletal remodeling, Ca²⁺ signaling through binding to calmodulin, and regulation of exocytic vesicle release in secretory cells such as neurons and airway goblet cells. Although the contribution of MARCKS to various cellular processes has been extensively studied, its roles in neoplastic disease have been conflicting. This review highlights the molecular and functional differences of MARCKS that exist between normal and tumor cells. We also discuss the recent advances in the potential roles of MARCKS in tumorigenesis, metastasis, and resistance to anti-cancer therapies, with a focus on addressing the inconsistent results regarding the function of MARCKS as a promoter or inhibitor of oncogenesis.

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Titel: Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers
verfasst von: Lon Wolf R. Fong
David C. Yang
Ching-Hsien Chen
Publikationsdatum: 16.10.2017
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 4/2017
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-017-9709-6

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Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers

Abstract

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Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Adjuvante Brustkrebstherapie: Doppelt hält besser

Manche Gestagene können das Risiko für Meningeome erhöhen

Einladung zum PSA-Screening senkt die Krebssterblichkeit

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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