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01.08.2012 | Leitthema

Nah-Infrarot-Lasertherapie beim akuten Schlaganfall

From bench to bedside

verfasst von: Prof. Dr. P.D. Schellinger, M. Köhrmann

Erschienen in: Der Nervenarzt | Ausgabe 8/2012

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Zusammenfassung

Nah-Infrarot-Lasertherapie (NIRLT) als transkranielle Lasertherapie (TLT) wird gegenwärtig als neuroreparativer/neuroprotektiver Therapieansatz bei Patienten mit akutem Schlaganfall in einer Phase-III-Studie (NEST-3) evaluiert. In dieser Übersicht stellen wir den theoretischen Hintergrund, experimentelle Studien, translationale Forschung und das klinische Studienprogramm dar.

Detaboada L, Ilic S, Leichliter-Martha S et al (2006) Transcranial application of low-energy laser irradiation improves neurological deficits in rats following acute stroke. Lasers Surg Med 38:70–73PubMedCrossRef

Drochioiu G (2010) Laser-induced ATP formation: mechanism and consequences. Photomed Laser Surg 28:573–574PubMedCrossRef

Hashmi JT, Huang YY, Osmani BZ et al (2010) Role of low-level laser therapy in neurorehabilitation. PMR 2:292–305

Hashmi JT, Huang YY, Sharma SK et al (2010) Effect of pulsing in low-level light therapy. Lasers Surg Med 42:450–466PubMedCrossRef

Huang Y, Hamblin M, De Taboada L (2010) Low level laser therapy for stroke and central nervous system. In: Tuchin V (Hrsg) Handbook of photonics for biomedical science. CRC Press, S 717–737

Ilic S, Leichliter S, Streeter J et al (2006) Effects of power densities, continuous and pulse frequencies, and number of sessions of low-level laser therapy on intact rat brain. Photomed Laser Surg 24:458–466PubMedCrossRef

Karu T (1989) Laser biostimulation: a photobiological phenomenon. J Photochem Photobiol B 3:638–640PubMedCrossRef

Karu T (2010) Mitochondrial mechanisms of photobiomodulation in context of new data about multiple roles of ATP. Photomed Laser Surg 28:159–160PubMedCrossRef

Lampl Y, Zivin JA, Fisher M et al (2007) Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke 38:1843–1849PubMedCrossRef

10.

Lapchak PA (2010) A new embolus injection method to evaluate intracerebral hemorrhage in New Zealand white rabbits. Brain Res 1349:129–136PubMedCrossRef

11.

Lapchak PA (2010) Taking a light approach to treating acute ischemic stroke patients: transcranial near-infrared laser therapy translational science. Ann Med 42:576–586PubMedCrossRef

12.

Lapchak PA (2012) Transcranial near-infrared laser therapy applied to promote clinical recovery in acute and chronic neurodegenerative diseases. Expert Rev Med Devices 9:71–83PubMedCrossRef

13.

Lapchak PA (2010) Translational stroke research using a rabbit embolic stroke model: a correlative analysis hypothesis for novel therapy development. Transl Stroke Res 1:96–107PubMedCrossRef

14.

Lapchak PA, Araujo DM (2007) Advances in hemorrhagic stroke therapy: conventional and novel approaches. Expert Opin Emerg Drugs 12:389–406PubMedCrossRef

15.

Lapchak PA, Araujo DM (2007) Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin Emerg Drugs 12:97–112PubMedCrossRef

16.

Lapchak PA, De Taboada L (2010) Transcranial near infrared laser treatment (NILT) increases cortical adenosine-5’-triphosphate (ATP) content following embolic strokes in rabbits. Brain Res 1306:100–105PubMedCrossRef

17.

Lapchak PA, Han MK, Salgado KF et al (2008) Safety profile of transcranial near-infrared laser therapy administered in combination with thrombolytic therapy to embolized rabbits. Stroke 39:3073–3078PubMedCrossRef

18.

Lapchak PA, Salgado KF, Chao CH et al (2007) Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: an extended therapeutic window study using continuous and pulse frequency delivery modes. Neuroscience 148:907–914PubMedCrossRef

19.

Lapchak PA, Wei J, Zivin JA (2004) Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits. Stroke 35:1985–1988PubMedCrossRef

20.

Leung MC, Lo SC, Siu FK et al (2002) Treatment of experimentally induced transient cerebral ischemia with low energy laser inhibits nitric oxide synthase activity and up-regulates the expression of transforming growth factor-beta 1. Lasers Surg Med 31:283–288PubMedCrossRef

21.

Liang HL, Whelan HT, Eells JT et al (2008) Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Neuroscience 153:963–974PubMedCrossRef

22.

Mochizuki-Oda N, Kataoka Y, Cui Y et al (2002) Effects of near-infra-red laser irradiation on adenosine triphosphate and adenosine diphosphate contents of rat brain tissue. Neurosci Lett 323:207–210PubMedCrossRef

23.

Moore P, Ridgway TD, Higbee RG et al (2005) Effect of wavelength on low-intensity laser irradiation-stimulated cell proliferation in vitro. Lasers Surg Med 36:8–12PubMedCrossRef

24.

Nest-3 Available at: http://clinicaltrials.gov/ct2/show/NCT01120301?term=nest+3&rank=1. Last checked April 27th 2012

25.

Oron A, Oron U, Chen J et al (2006) Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits. Stroke 37:2620–2624PubMedCrossRef

26.

Saver JL, Albers GW, Dunn B et al (2009) Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials. Stroke 40:2594–2600PubMedCrossRef

27.

Streeter J, De Taboada L, Oron U (2004) Mechanisms of action of light therapy for stroke and acute myocardial infarction. Mitochondrion 4:569–576PubMedCrossRef

28.

Sutherland JC (2002) Biological effects of polychromatic light. Photochem Photobiol 76:164–170PubMedCrossRef

29.

Uozumi Y, Nawashiro H, Sato S et al (2010) Targeted increase in cerebral blood flow by transcranial near-infrared laser irradiation. Lasers Surg Med 42:566–576PubMedCrossRef

30.

Zhang Q, Ma H, Nioka S et al (2000) Study of near infrared technology for intracranial hematoma detection. J Biomed Opt 5:206–213PubMedCrossRef

31.

Zivin J, RS, AS et al (2012) NeuroThera® Efficacy and Safety Trial – 3 (NEST-3) A double-blind, randomized, sham-controlled, parallel group, multicenter, pivotal study to assess the safety and efficacy of transcranial laser therapy with the NeuroThera® Laser System for the treatment of acute ischemic stroke within 24 h of stroke onset. Int J Stroke in press

32.

Zivin JA, Albers GW, Bornstein N et al (2009) Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke 40:1359–1364PubMedCrossRef

Titel: Nah-Infrarot-Lasertherapie beim akuten Schlaganfall
From bench to bedside
verfasst von: Prof. Dr. P.D. Schellinger
M. Köhrmann
Publikationsdatum: 01.08.2012
Verlag: Springer-Verlag
Erschienen in: Der Nervenarzt / Ausgabe 8/2012
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI: https://doi.org/10.1007/s00115-012-3567-9

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