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Erschienen in: Rheumatology International 7/2006

01.05.2006 | Original Article

Nailfold videocapillaroscopy in patients with systemic lupus erythematosus

verfasst von: M. A. A. Dancour, J. L. P. Vaz, D. A. Bottino, E. Bouskela

Erschienen in: Rheumatology International | Ausgabe 7/2006

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Abstract

Nailfold videocapillaroscopy was performed in 21 controls (C) and 21 patients (P) with systemic lupus erythematosus (SLE) classified according to the American College of Rheumatology, with, at least, 1 year of diagnosed disease and having low activity (MEX-SLEDAI) and sequel (SLICC) indexes at the time of the examination, paired by sex and age. Red blood cell velocity (RBCV, mm/s) at rest and after the release of 60s arterial occlusion (RBCVmax, mm/s), time to reach it (TRBCVmax, s), functional capillary density (FCD, number of capillaries /mm2), afferent, apical and efferent capillary diameters (μm) (DAF, DAP and DEF, respectively) were obtained from videotapes analyzed by the CapImage software. The results did not show any significant difference between the groups that were analyzed, suggesting that morphological (capillary diameters) and functional (RBCV, RBCVmax, TRBCVmax and FCD) parameters are not affected by SLE when low activity and sequel indexes of the disease are present.
Literatur
1.
Zurück zum Zitat Grossman JM, Kalunian KC (2002) Definition, classification activity and damage indexes. In: Dubois (ed) Lupus erythematosus. Lippincott Williams& Wilkins, Philadelphia, PA, pp 19–31 Grossman JM, Kalunian KC (2002) Definition, classification activity and damage indexes. In: Dubois (ed) Lupus erythematosus. Lippincott Williams& Wilkins, Philadelphia, PA, pp 19–31
2.
Zurück zum Zitat Quismorio FP Jr, Sharma O, Koss M, Boylen T, Edmiston AW, Thornton PJ, Tatter D (1984) Immunopathologic and clinical studies in pulmonary hypertension associated with systemic lupus erythematosus. Semin Arthritis Rheum 13:349–359CrossRefPubMed Quismorio FP Jr, Sharma O, Koss M, Boylen T, Edmiston AW, Thornton PJ, Tatter D (1984) Immunopathologic and clinical studies in pulmonary hypertension associated with systemic lupus erythematosus. Semin Arthritis Rheum 13:349–359CrossRefPubMed
3.
Zurück zum Zitat Provost TT, Andreas GA, Maddison PJ, Reichlin M (1980) Lupus band test in untreated SLE patients: correlation of immunoglobulin deposition in skin of the extensor forearm with clinical renal diseases and serological abnormalities. J Invest Dermatol 74:407–412CrossRefPubMed Provost TT, Andreas GA, Maddison PJ, Reichlin M (1980) Lupus band test in untreated SLE patients: correlation of immunoglobulin deposition in skin of the extensor forearm with clinical renal diseases and serological abnormalities. J Invest Dermatol 74:407–412CrossRefPubMed
4.
Zurück zum Zitat Buchanan IS, Humpston DJ (1968) Nailfold capillaries in connective-tissue disorders. Lancet I:845–847 Buchanan IS, Humpston DJ (1968) Nailfold capillaries in connective-tissue disorders. Lancet I:845–847
5.
Zurück zum Zitat Granier F, Vayssairat M, Priollet P, Housset E (1986) Nailfold capillary microscopy in mixed connective tissue disease. Comparison with systemic sclerosis and systemic lupus erythematosus. Arthritis Rheum 29:189–195PubMedCrossRef Granier F, Vayssairat M, Priollet P, Housset E (1986) Nailfold capillary microscopy in mixed connective tissue disease. Comparison with systemic sclerosis and systemic lupus erythematosus. Arthritis Rheum 29:189–195PubMedCrossRef
6.
Zurück zum Zitat Lefford F, Edwards JC (1986) Nailfold capillary microscopy in connective tissue disease: a quantitative morphological analysis. Ann Rheum Dis 45:741–749PubMedCrossRef Lefford F, Edwards JC (1986) Nailfold capillary microscopy in connective tissue disease: a quantitative morphological analysis. Ann Rheum Dis 45:741–749PubMedCrossRef
7.
Zurück zum Zitat Maricq E, LeRoy EC, D’Angelo WA, Medsger TA, Rodnan GP, Sharp GC, Wolfe JF (1980) Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. Arthritis Rheum 23(2):183–188PubMedCrossRef Maricq E, LeRoy EC, D’Angelo WA, Medsger TA, Rodnan GP, Sharp GC, Wolfe JF (1980) Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. Arthritis Rheum 23(2):183–188PubMedCrossRef
8.
Zurück zum Zitat Fagrell B, Intaglietta M (1977) The dynamics of skin microcirculation as a tool for the study of systemic diseases. Bibl Anat 16:231–234PubMed Fagrell B, Intaglietta M (1977) The dynamics of skin microcirculation as a tool for the study of systemic diseases. Bibl Anat 16:231–234PubMed
9.
Zurück zum Zitat Kabasakal Y, Elvins DM, Ring EFJ, McHugh NJ (1996) Quantitative nailfold capillaroscopy findings in a population with connective tissue disease and in normal healthy controls. Ann Rheum Dis 55:507–512PubMed Kabasakal Y, Elvins DM, Ring EFJ, McHugh NJ (1996) Quantitative nailfold capillaroscopy findings in a population with connective tissue disease and in normal healthy controls. Ann Rheum Dis 55:507–512PubMed
10.
Zurück zum Zitat Tektonidou M, Kaskani E, Skopouli FN, Moutsopoulos HM (1999) Microvascular abnormalities in Sjögren’s syndrome: nailfold capillaroscopy. Rheumatology 38:826–830CrossRefPubMed Tektonidou M, Kaskani E, Skopouli FN, Moutsopoulos HM (1999) Microvascular abnormalities in Sjögren’s syndrome: nailfold capillaroscopy. Rheumatology 38:826–830CrossRefPubMed
11.
Zurück zum Zitat Aguiar T, Furtado E, Dorigo D, Bottino D, Bouskela E (in press) Nailfold videocapillaroscopy in primary Sjögren’s syndrome. Angiology (in press) Aguiar T, Furtado E, Dorigo D, Bottino D, Bouskela E (in press) Nailfold videocapillaroscopy in primary Sjögren’s syndrome. Angiology (in press)
12.
Zurück zum Zitat Vaz JLP, Dancour MAA, Bottino DA, Bouskela E (2004) Nailfold videocapillaroscopy in primary antiphospholipid syndrome (PAPS). Rheumatology 43:1025–1027CrossRefPubMed Vaz JLP, Dancour MAA, Bottino DA, Bouskela E (2004) Nailfold videocapillaroscopy in primary antiphospholipid syndrome (PAPS). Rheumatology 43:1025–1027CrossRefPubMed
13.
Zurück zum Zitat Bongard O, Miescher PA, Bounameaux H (1997) Altered skin microcirculation in patients with systemic lupus erythematosus. Int J Microcirc 17:184–189 Bongard O, Miescher PA, Bounameaux H (1997) Altered skin microcirculation in patients with systemic lupus erythematosus. Int J Microcirc 17:184–189
14.
Zurück zum Zitat Klyscz T, Jünger M, Jung F, Zeintl H (1997) Cap image—ein neuartiges computerunterstütztes videoanalysesystem für die dynamische kapillarmikroskopie. Biomed Tech 42:168–175CrossRef Klyscz T, Jünger M, Jung F, Zeintl H (1997) Cap image—ein neuartiges computerunterstütztes videoanalysesystem für die dynamische kapillarmikroskopie. Biomed Tech 42:168–175CrossRef
15.
Zurück zum Zitat Osler W (1904) On the visceral manifestations of the erythema group of skin diseases. Am J Med Sci 127:1–23CrossRef Osler W (1904) On the visceral manifestations of the erythema group of skin diseases. Am J Med Sci 127:1–23CrossRef
16.
Zurück zum Zitat Baehr G, Klemperer P, Schifirin A (1935) A diffuse disease of peripheral circulation usually associated with lupus erythematosus and endocarditis. Trans Assoc Am Phys 50:139–155 Baehr G, Klemperer P, Schifirin A (1935) A diffuse disease of peripheral circulation usually associated with lupus erythematosus and endocarditis. Trans Assoc Am Phys 50:139–155
17.
Zurück zum Zitat Lipowski HH, Shekh NH, Katz DM (1987) Intravital microscopy of capillary hemodynamics in sickle cell disease. J Clin Invest 80:117–127PubMedCrossRef Lipowski HH, Shekh NH, Katz DM (1987) Intravital microscopy of capillary hemodynamics in sickle cell disease. J Clin Invest 80:117–127PubMedCrossRef
18.
Zurück zum Zitat Andrade LEC, Atra E, Pucinelli ML, Ikedo F (1990) Capilaroscopia periungueal: proposição de uma nova metodologia e aplicação em indivíduos hígidos e portadores de enfermidades reumáticas. Ver Brás Reumatol 30:71–81 Andrade LEC, Atra E, Pucinelli ML, Ikedo F (1990) Capilaroscopia periungueal: proposição de uma nova metodologia e aplicação em indivíduos hígidos e portadores de enfermidades reumáticas. Ver Brás Reumatol 30:71–81
19.
Zurück zum Zitat Studer A, Hunziker T, Lüttolf O, Schmid J, Chen D, Mahler F (1991) Quantitative nailfold capillary microscopy in cutaneous and systemic lupus erythematosus and localized scleroderma. J Am Acad Dermatol 24:941–945PubMed Studer A, Hunziker T, Lüttolf O, Schmid J, Chen D, Mahler F (1991) Quantitative nailfold capillary microscopy in cutaneous and systemic lupus erythematosus and localized scleroderma. J Am Acad Dermatol 24:941–945PubMed
20.
Zurück zum Zitat Caspary L, Schmees C, Schoetensak I, Hartung K, Stannat S, Deicher H, Creutzig A, Alexander K (1991) Alterations of the nailfold capillary morphology associated with Raynaud phenomenon in patients with systemic lupus erythematosus. J Rheumatol 18:559–566PubMed Caspary L, Schmees C, Schoetensak I, Hartung K, Stannat S, Deicher H, Creutzig A, Alexander K (1991) Alterations of the nailfold capillary morphology associated with Raynaud phenomenon in patients with systemic lupus erythematosus. J Rheumatol 18:559–566PubMed
21.
Zurück zum Zitat Pallis M, Hopkinson N, Powell R (1991) Nailfold capillary density as a possible indicator of pulmonary capillary loss in systemic lupus erythematosus but not in mixed connective tissue disease. J Rheumatol 18:1532–1536PubMed Pallis M, Hopkinson N, Powell R (1991) Nailfold capillary density as a possible indicator of pulmonary capillary loss in systemic lupus erythematosus but not in mixed connective tissue disease. J Rheumatol 18:1532–1536PubMed
22.
Zurück zum Zitat Fahrig C, Heidrich H, Voigt B (1995) Capillary microscopy of the nailfold in healthy subjects. Int J Microcirc 15:287–292 Fahrig C, Heidrich H, Voigt B (1995) Capillary microscopy of the nailfold in healthy subjects. Int J Microcirc 15:287–292
23.
Zurück zum Zitat Gibson WC, Bosley PGHJ, Griffiths RS (1956) Photomicrographic studies on the nailbed capillary networks in human control subjects. J Nerv Ment Dis 123:219–231PubMedCrossRef Gibson WC, Bosley PGHJ, Griffiths RS (1956) Photomicrographic studies on the nailbed capillary networks in human control subjects. J Nerv Ment Dis 123:219–231PubMedCrossRef
24.
Zurück zum Zitat Pallis M, Hopkinson N, Lowe J, Powell R (1994) An electron microscopy study of muscle capillary wall thickening in systemic lupus erythematosus. Lupus 3:401–407PubMed Pallis M, Hopkinson N, Lowe J, Powell R (1994) An electron microscopy study of muscle capillary wall thickening in systemic lupus erythematosus. Lupus 3:401–407PubMed
25.
Zurück zum Zitat Von Bierbrauer A, Barth P, Willert J, Baerwald C, Mennel HD, Schmidt JA (1998) Electron microscopy and capillaroscopy guided nailfold biopsy in connective tissue diseases: detection of ultrastructural changes of the microcirculatory vessels. Br J Rheumatol 37:1272–1278CrossRefPubMed Von Bierbrauer A, Barth P, Willert J, Baerwald C, Mennel HD, Schmidt JA (1998) Electron microscopy and capillaroscopy guided nailfold biopsy in connective tissue diseases: detection of ultrastructural changes of the microcirculatory vessels. Br J Rheumatol 37:1272–1278CrossRefPubMed
Metadaten
Titel
Nailfold videocapillaroscopy in patients with systemic lupus erythematosus
verfasst von
M. A. A. Dancour
J. L. P. Vaz
D. A. Bottino
E. Bouskela
Publikationsdatum
01.05.2006
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 7/2006
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-005-0033-z

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