Background
Methods
Protocol and registration
Eligibility criteria
Types of studies
Types of participants
Types of intervention
Types of outcome measures
Sources of information
Search
-
PubMed/Medline: (esophagus OR esophageal) AND (neoplasms OR cancer OR squamous cell carcinoma OR dysplasia OR dysplastic) AND (narrow band imaging OR optical imaging OR nbi OR chromoendoscopy OR lugol OR iodine OR virtual imaging OR fice OR flexible spectral imaging color enhancement OR i-scan OR bli OR blue laser imaging OR endoscopy OR endoscopic) AND (diagnosis/broad[filter]);
-
LILACS and Cochrane/CENTRAL: Esophageal cancer AND (narrow band imaging OR NBI);
-
Scopus: (esophagus OR esophageal) AND (neoplasms OR cancer OR squamous cell carcinoma OR dysplasia OR dysplastic) AND (narrow band imaging OR optical imaging OR nbi OR chromoendoscopy OR lugol OR iodine OR virtual imaging OR fice OR flexible spectral imaging color enhancement OR i-scan OR bli OR blue laser imaging OR endoscopy OR endoscopic);
-
Cinahl: (Esophageal cancer or esophageal Squamous Cell carcinoma) and (narrow band imaging or nbi).
Study selection
Data collection process
Data items
Risk of bias in individual studies
Summary measures and planned methods of analysis
Results
Study selection
Study characteristics
Study | Patients included in the analysis | Gold standard | Interval | Study design | Study inclusion criteria | Tests methods |
---|---|---|---|---|---|---|
Goda 2015 | 294 | Histology | Two different groups | Prospective randomized | HNSCC/ESCC previous endoscopic resection | NBI x Lugol |
Nagami 2014 | 202 | Histology | Sequential approach | Cross-sectional | HNSCC/ESCC previous endoscopic resection | NBI x Lugol |
Takahashi 2014 | 285 | Histology | Sequential approach | Cross-sectional | HNSCC/ESCC | NBI x Lugol |
Wang 2014 | 500 | Histology | Sequential approach | Cross-sectional | HNSCC | NBI x Lugol |
Ide 2013 | 43 | Histology | Sequential approach | Cross-sectional | Achalasia | NBI x Lugol |
Kawai 2012 | 103 | Histology | Sequential approach | Cross-sectional | General population | NBI x Lugol |
Ide 2011 | 129 | Histology | Sequential approach | Cross-sectional | HNSCC | NBI x Lugol |
Lecleire2011 | 30 | Histology | Sequential approach | Cross-sectional | Cured ESCC without esophagectomy | NBI x Lugol |
Takenaka 2009 | 142 | Histology | Sequential approach | Cross-sectional | HNSCC | NBI x Lugol |
Huang 2009 | 90 | Histology | Sequential approach | Cross-sectional | Early ESCC or precancerous | NBI x Lugol |
Lee 2009 | 44 | Histology | Sequential approach | Cross-sectional | HNSCC | NBI x Lugol |
Kuraoka 2009 | 49 | Histology | Sequential approach | Cross-sectional | High risk patient for ESCC | NBI x Lugol |
Total | 1911 |
Risk of bias within studies (Table 2)
Goda 2015 | Nagami 2014 | Takahashi 2014 | Wang 2014 | Ide 2013 | Kawai 2012 | Ide 2011 | Lecleire 2011 | Takenaka 2009 | Huang 2009 | Lee 2009 | Kuraoka 2009 | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PATIENT SELECTION | Signaling questions | Was a consecutive or random sample of patients enrolled? | Yes | Unclear | Unclear | Yes | Yes | Yes | Yes | Unclear | Unclear | Unclear | Yes | Unclear |
Was a case-control design avoided? | No | No | No | No | No | No | No | No | No | No | No | No | ||
Did the study avoided inappropriate exclusions? | No | No | No | No | No | Yes | No | No | No | No | No | Unclear | ||
Risk of bias | Could the selection of patients have introduced bias? | Low | Low | Low | Low | Low | Moderate | Low | Low | Low | Moderate | Low | Moderate | |
Concerns regarding applicability | Are there concerns that the included patients do not match the review question? | Low | Low | Low | Low | Low | High | Low | Low | Low | High | Low | Low | |
INDEX TEST | Signaling questions | Were the index test results interpreted without knowledge of the results of the reference standard? | Yes | Yes | Yes | Unclear | Yes | Yes | Yes | Yes | Yes | No | Yes | Yes |
If a threshold was used, was it prespecified? | Yes | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | Yes | Yes | Yes | ||
Risk of bias | Could the conduct or interpretation of the index test have introduced bias? | Low | Low | Low | Low | Low | Moderate | Low | Low | Low | Moderate | Low | Low | |
Concerns regarding applicability | Are there concerns that the index test, its conduct, or its interpretation differ from the review question? | High | Low | High | Low | Low | Unclear | Low | Low | Low | Low | Low | Low | |
REFERENCE STANDARD | Signaling questions | Is the reference standard likely to correctly classify the target condition? | Yes | Yes | Yes | Yes | Yes | No | Yes | Yes | Yes | No | Yes | Unclear |
Were the references standard results interpreted without knowledge of the results of the index test? | Yes | Yes | Yes | Unclear | Unclear | Unclear | Unclear | Yes | Yes | Unclear | Unclear | Unclear | ||
Risk of bias | Could the reference standard, its conduct, or its interpretation have introduced bias? | Low | Low | Low | Low | Low | High | Low | Low | Low | High | Low | Unclear | |
Concerns regarding applicability | Are there concerns that the target condition as defined by the reference standard does not match the review question? | Low | Low | Low | Low | Low | High | Low | Low | Low | High | Low | Unclear | |
FLOW AND TIMING | Signaling questions | Was there an appropriate interval between index test(s) and reference standard? | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Did all patients receive a reference standard? | No | No | No | No | No | No | No | No | No | Unclear | No | Unclear | ||
Did all patients receive the same reference standard? | Yes | Yes | Yes | Yes | Yes | No | No | Yes | No | Yes | Yes | Yes | ||
Were all patients included in the analysis? | No | No | Yes | No | No | No | No | Yes | No | Yes | No | Unclear | ||
Risk of bias | Could the patient flow have introduced bias? | Moderate | Moderate | Low | Moderate | Moderate | High | Moderate | Low | High | Low | Moderate | Low |