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Erschienen in: CardioVasc 4/2021

29.09.2021 | Herzinsuffizienz | Zertifizierte Fortbildung

ARNI, SGLT2-Hemmer, Guanylatzyklase- und Myosin-Aktivatoren

Innovationen in der medikamentösen Therapie der Herzinsuffizienz

verfasst von: Dr. med. Amr Abdin, Prof. Dr. med. Michael Böhm

Erschienen in: CardioVasc | Ausgabe 4/2021

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Die Behandlung der chronischen Herzinsuffizienz hat durch die neuen Therapieansätze wie ARNI und SGLT2-Inhibitoren zu einer Senkung der Mortalität und der Krankenhausaufnahme bei Patienten mit reduzierter Ejektionsfraktion geführt. In jüngster Zeit wurden weitere potenzielle Behandlungsmechanismen wie die Guanylatzyklase-Stimulatoren und die kardialen Myosin-Aktivatoren erforscht. …
Literatur
1.
Zurück zum Zitat Abdin A et al. Timely and individualized heart failure management: need for implementation into the new guidelines. Clin Res Cardiol. 2021;13;1-9 Abdin A et al. Timely and individualized heart failure management: need for implementation into the new guidelines. Clin Res Cardiol. 2021;13;1-9
2.
Zurück zum Zitat Ponikowski P et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the heart failure association (HFA) of the ESC. Eur Heart J. 2016;37:2129-200 Ponikowski P et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the heart failure association (HFA) of the ESC. Eur Heart J. 2016;37:2129-200
4.
Zurück zum Zitat Chioncel O et al. Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2017;19:1574-85 Chioncel O et al. Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: an analysis of the ESC Heart Failure Long-Term Registry. Eur J Heart Fail. 2017;19:1574-85
5.
Zurück zum Zitat McMurray JJ et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;371:993-1004 McMurray JJ et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;371:993-1004
6.
Zurück zum Zitat Solomon SD et al. Angiotensin-neprilysin inhibition in heart failure with preserved ejection fraction. N Engl J Med. 2019;381:1609-20 Solomon SD et al. Angiotensin-neprilysin inhibition in heart failure with preserved ejection fraction. N Engl J Med. 2019;381:1609-20
7.
Zurück zum Zitat McMurray JJ et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet. 2003;362:767-71 McMurray JJ et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial. Lancet. 2003;362:767-71
8.
Zurück zum Zitat Anker SD et al. Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR-Preserved trial. Eur J Heart Fail. 2020;22(12):2383-92 Anker SD et al. Baseline characteristics of patients with heart failure with preserved ejection fraction in the EMPEROR-Preserved trial. Eur J Heart Fail. 2020;22(12):2383-92
9.
Zurück zum Zitat Solomon SD et al. Sacubitril/valsartan across the spectrum of ejection fraction in heart failure. Circulation. 2020;141:352-61 Solomon SD et al. Sacubitril/valsartan across the spectrum of ejection fraction in heart failure. Circulation. 2020;141:352-61
10.
Zurück zum Zitat Solomon SD et al. Influence of ejection fraction on outcomes and efficacy of spironolactone in patients with heart failure with preserved ejection fraction. Eur Heart J. 2016;37:455-62 Solomon SD et al. Influence of ejection fraction on outcomes and efficacy of spironolactone in patients with heart failure with preserved ejection fraction. Eur Heart J. 2016;37:455-62
11.
Zurück zum Zitat Cleland JGF et al. Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: an individual patient-level analysis of double-blind randomized trials. Eur Heart J. 2018;39:26-35 Cleland JGF et al. Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: an individual patient-level analysis of double-blind randomized trials. Eur Heart J. 2018;39:26-35
12.
Zurück zum Zitat Böhm M et al. Ejection fraction in heart failure revisited- where does the evidence start? Eur Heart J. 2020;41:2363-5 Böhm M et al. Ejection fraction in heart failure revisited- where does the evidence start? Eur Heart J. 2020;41:2363-5
13.
Zurück zum Zitat Zelniker TA et al. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. Lancet. 2019;393:31-9 Zelniker TA et al. SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials. Lancet. 2019;393:31-9
14.
Zurück zum Zitat McMurray JJV et al. Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med. 2019;381:1995-2008 McMurray JJV et al. Dapagliflozin in patients with heart failure and reduced ejection fraction. N Engl J Med. 2019;381:1995-2008
15.
Zurück zum Zitat Packer M et al. Cardiovascular and renal outcomes with empagliflozin in heart failure. N Engl J Med. 2020;383:1413-24 Packer M et al. Cardiovascular and renal outcomes with empagliflozin in heart failure. N Engl J Med. 2020;383:1413-24
16.
Zurück zum Zitat Zannad F et al. SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: a meta-analysis of the EMPEROR-Reduced and DAPA-HF trials. Lancet. 2020;396:819-29 Zannad F et al. SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: a meta-analysis of the EMPEROR-Reduced and DAPA-HF trials. Lancet. 2020;396:819-29
17.
Zurück zum Zitat Docherty KF et al. Effects of dapagliflozin in DAPA-HF according to background heart failure therapy. Eur. Heart J. 2020;41:2379-92 Docherty KF et al. Effects of dapagliflozin in DAPA-HF according to background heart failure therapy. Eur. Heart J. 2020;41:2379-92
18.
Zurück zum Zitat Zannad F et al. Cardiac and kidney benefits of empagliflozin in heart failure across the spectrum of kidney function: Insights from the EMPEROR-Reduced trial. Circulation. 2021;143(4):310-21 Zannad F et al. Cardiac and kidney benefits of empagliflozin in heart failure across the spectrum of kidney function: Insights from the EMPEROR-Reduced trial. Circulation. 2021;143(4):310-21
19.
Zurück zum Zitat Petrie MC et al. Effect of dapagliflozin on worsening heart failure and cardiovascular death in patients with heart failure with and without diabetes. JAMA. 2020;323:1353-68 Petrie MC et al. Effect of dapagliflozin on worsening heart failure and cardiovascular death in patients with heart failure with and without diabetes. JAMA. 2020;323:1353-68
20.
Zurück zum Zitat Anker SD et al. EMPEROR-Reduced Trial Committees and Investigators. Effect of empagliflozin on cardiovascular and renal outcomes in patients with heart failure by baseline diabetes status - Results from the EMPEROR-Reduced Trial. Circulation. 2021;143(4):337-49 Anker SD et al. EMPEROR-Reduced Trial Committees and Investigators. Effect of empagliflozin on cardiovascular and renal outcomes in patients with heart failure by baseline diabetes status - Results from the EMPEROR-Reduced Trial. Circulation. 2021;143(4):337-49
21.
Zurück zum Zitat Serenelli M et al. Effect of dapagliflozin according to baseline systolic blood pressure in the Dapagliflozin and prevention of adverse outcomes in heart failure trial (DAPA-HF). Eur Heart J. 2020;41:3402-18 Serenelli M et al. Effect of dapagliflozin according to baseline systolic blood pressure in the Dapagliflozin and prevention of adverse outcomes in heart failure trial (DAPA-HF). Eur Heart J. 2020;41:3402-18
22.
Zurück zum Zitat McEwan P et al. Cost-effectiveness of dapagliflozin as a treatment for heart failure with reduced ejection fraction: a multinational health-economic analysis of DAPA-HF. Eur J Heart Fail. 2020;22:2147-56 McEwan P et al. Cost-effectiveness of dapagliflozin as a treatment for heart failure with reduced ejection fraction: a multinational health-economic analysis of DAPA-HF. Eur J Heart Fail. 2020;22:2147-56
23.
Zurück zum Zitat Bhatt DL et al. Sotagliflozin in patients with diabetes and chronic kidney disease. N Engl J Med. 2021;384:129-39 Bhatt DL et al. Sotagliflozin in patients with diabetes and chronic kidney disease. N Engl J Med. 2021;384:129-39
24.
Zurück zum Zitat Bhatt DL et al. Sotagliflozin in patients with diabetes and recent worsening heart failure. N Engl J Med. 2021;384:117-28 Bhatt DL et al. Sotagliflozin in patients with diabetes and recent worsening heart failure. N Engl J Med. 2021;384:117-28
25.
Zurück zum Zitat Stasch JP et al. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation. 2011;123:2263-73 Stasch JP et al. Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease. Circulation. 2011;123:2263-73
26.
Zurück zum Zitat Armstrong PW et al. Vericiguat in patients with heart failure and reduced ejection fraction. N Engl J Med. 2020;382:1883-93 Armstrong PW et al. Vericiguat in patients with heart failure and reduced ejection fraction. N Engl J Med. 2020;382:1883-93
27.
Zurück zum Zitat Teerlink JR et al. Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction: GALACTIC-HF baseline characteristics and comparison with contemporary clinical trials. Eur J Heart Fail. 2020;22:2160-71 Teerlink JR et al. Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction: GALACTIC-HF baseline characteristics and comparison with contemporary clinical trials. Eur J Heart Fail. 2020;22:2160-71
28.
Zurück zum Zitat Teerlink JR et al. Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure. N Engl J Med. 2021;384(2):105-16 Teerlink JR et al. Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure. N Engl J Med. 2021;384(2):105-16
29.
Zurück zum Zitat Ponikowski P et al. Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial. Lancet. 2020;396:1895-904 Ponikowski P et al. Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial. Lancet. 2020;396:1895-904
30.
Zurück zum Zitat Anker SD et al. Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: An Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J. 2020;41:2109-17 Anker SD et al. Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: An Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J. 2020;41:2109-17
31.
Zurück zum Zitat Böhm M et al. Systolic blood pressure, cardiovascular outcomes and efficacy and safety of sacubitril/valsartan (LCZ696) in patients with chronic heart failure and reduced ejection fraction: results from PARADIGM-HF. Eur Heart J. 20174;38(15):1132-43 Böhm M et al. Systolic blood pressure, cardiovascular outcomes and efficacy and safety of sacubitril/valsartan (LCZ696) in patients with chronic heart failure and reduced ejection fraction: results from PARADIGM-HF. Eur Heart J. 20174;38(15):1132-43
32.
Zurück zum Zitat Anker SD et al. Maintenance of serum potassium with sodium zirconium cyclosilicate (ZS-9) in heart failure patients: results from a phase 3 randomized, double-blind, placebo-controlled trial. Eur J Heart Fail. 2015;17:1050-6 Anker SD et al. Maintenance of serum potassium with sodium zirconium cyclosilicate (ZS-9) in heart failure patients: results from a phase 3 randomized, double-blind, placebo-controlled trial. Eur J Heart Fail. 2015;17:1050-6
33.
Zurück zum Zitat Vaduganathan M et al. Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomized controlled trials. Lance.t 2020; 396:121-8 Vaduganathan M et al. Estimating lifetime benefits of comprehensive disease-modifying pharmacological therapies in patients with heart failure with reduced ejection fraction: a comparative analysis of three randomized controlled trials. Lance.t 2020; 396:121-8
34.
Zurück zum Zitat Halliday BP et al. Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial. Lancet. 2019; 393:61-73 Halliday BP et al. Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial. Lancet. 2019; 393:61-73
Metadaten
Titel
ARNI, SGLT2-Hemmer, Guanylatzyklase- und Myosin-Aktivatoren
Innovationen in der medikamentösen Therapie der Herzinsuffizienz
verfasst von
Dr. med. Amr Abdin
Prof. Dr. med. Michael Böhm
Publikationsdatum
29.09.2021
Verlag
Springer Medizin
Schlagwort
Herzinsuffizienz
Erschienen in
CardioVasc / Ausgabe 4/2021
Print ISSN: 1617-4933
Elektronische ISSN: 1618-3851
DOI
https://doi.org/10.1007/s15027-021-3544-y

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