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01.12.2014 | Review | Ausgabe 1/2014 Open Access

World Journal of Surgical Oncology 1/2014

Natriuretic peptide receptor A as a novel target for cancer

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2014
Autoren:
Jia Zhang, Zhilong Zhao, Jiansheng Wang
Wichtige Hinweise

Competing interests

The authors declare that they have no competing of interests.

Authors’ contributions

JZ and ZZ wrote the paper. JW reviewed and edited the manuscript. All authors read and approved the final manuscript.

Abstract

The receptor for the cardiac hormone atrial natriuretic peptide (ANP), natriuretic peptide receptor A (NPR-A), has been reported to be expressed in lung cancer, prostate cancer and ovarian cancer. NPR-A expression and signaling is important for tumor growth; its deficiency protects C57BL/6 mice from lung, skin and ovarian cancers. This suggests that NPR-A is a new marker and a new target for cancer therapy. Recently, NPR-A has been demonstrated to be expressed in pre-implantation embryos and in embryonic stem cells, which has a novel role in the maintenance of self-renewal and pluripotency of embryonic stem cells. A nanoparticle-formulated interfering RNA for NPR-A attenuated B16 melanoma tumors in mice. Ectopic expression of a plasmid encoding NP73-102, the NH2-terminal peptide of the ANP prohormone which downregulates NPR-A expression, also suppressed lung metastasis of A549 cells in nude mice and tumorigenesis of Line 1 cells in immunocompetent BALB/c mice. These results suggest that NPR-A is involved in tumorigenesis and a new target for cancer therapy. This review focuses on structure, abnormal functions and carcinogenic mechanisms of NPR-A to investigate its role in tumorigenesis.
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