Background
Autophagy and cancer: anti-tumorigenic effects of autophagy
Autophagy and cancer: pro-tumorigenic effects of autophagy
Autophagy and apoptosis
Natural agents as modulators of autophagic signals
Resveratrol
Apigenin
Ursolic acid
Tanshinone
Curcumin
Ginsenoside
Fisetin
Oridonin
Piperlonguminine
Honokiol
Others
Quercetin
[6]-Gingerol
Glabridin
Conclusions
Natural agents | Cancer cell line | Pathway | References |
---|---|---|---|
Resveratrol | Ovarian cancer cells | STAT3 | [52] |
Ursolic acid | Prostate cancer cell | Beclin-1/Akt/mTOR | [62] |
Colorectal cancer cells with p53 mutant | JNK | [47] | |
MCF-7 human breast cancer cells | EIF2AK3 | [63] | |
Cervical cancer cells TC-1 | ATG5 | [64] | |
Tanshione IIA | KBM-5 leukemia cells. | mTOR/p70S6K/AMPK | [68] |
Lung cancer 95D cells | ROS | [40] | |
Curcumin | Human colon cancer HCT116 cells | Transcription factor EB (TFEB) | [72] |
Human melanoma cells | AKT/mTOR | [75] | |
Ginsenoside 20(S)-Rg3 | Ovarian cancer | LC3II, ATG5, and ATG7 | [46] |
Fisetin | Prostate cancer cells | mTOR | [43] |
Oridonin | Human cervical carcinoma Hela cells | ROS | [82] |
Honokiol | Neuroblastoma cells | PI3K/Akt/mTOR | [45] |
Piperlongumine | Myeloid leukemias | P38/ROS | [88] |